Dendrimers based drug delivery systems

Research Journal of Pharmacy and Technology

Volumn 5, Issue 3, 2012, Pages 307-316

  Syed, Izhar Ahmed ^a   Rao, Yamsani Madhusudan ^b  

^a SR College of Pharmacy   (India)

^b KAKATIYA UNIVERSITY   (India)

Author keywords

Dendrimers; PAMAM dendrimer's cascade molecules

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; DENDRIMER; DIFLUNISAL; FLUOROURACIL; INDOMETACIN; KETOPROFEN; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; POLYAMIDOAMINE; PRODRUG; VIVAGEL;

BIOSAFETY; CHEMICAL COMPOSITION; CLINICAL EFFECTIVENESS; COST BENEFIT ANALYSIS; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RESEARCH; DRUG SOLUBILITY; DRUG STABILITY; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR WEIGHT; NANOENCAPSULATION; NANOPHARMACEUTICS; NEUTRON CAPTURE THERAPY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHARMACEUTICAL ENGINEERING; PHYSICAL CHEMISTRY; REVIEW; RISK ASSESSMENT; RISK FACTOR; SLOW DRUG RELEASE; STRUCTURE ANALYSIS; SURFACE PROPERTY;

EID: 84860998636     PISSN: 0974360X     EISSN: 09743618     Source Type: Journal    
DOI: None     Document Type: Review

References (93)

1. D.A. Tomalia, J.M.J. Frechet, Discovery of dendrimers and dendritic polymers: a brief historical perspective, J. Polym.Sci., Part A: Polym. Chem. 2002; 40: 2719-2728.
2. E. Buhleier, E. Wehner, F. Vogtle, Synthesis 1978;78.
3. D.A. Tomalia, et al, A new class of polymers starburst-dendritic macromolecules, Polym. J. 1985;17: 117-132.
4. D.A. Tomalia, et al., Dendritic macromolecules-synthesis of starburst dendrimers, Macromolecules. 1986; 19: 2466-2468.
5. G.R. Newkome, et al., Cascade molecules: 2. Synthesis and characterization of a benzene [9]3-arborol, J. Am. Chem. Soc. 1986; 108: 849-850.
6. G.R. Newkome, et al. 1. Cascade molecules-a new approach to micelles-arborol, J. Org. Chem. 1985; 50:2003-2004.
7. E.R. Gillies, J.M. Frechet, Dendrimers and dendritic polymers in drug delivery, Drug Discovery Today 2005; 10: 35-43.
8. U. Boas, P.M. Heegaard, Dendrimers in drug research, Chem.Soc. Rev. 2004; 33: 43-63.
9. L.J. Twyman, A.S. King, I.K. Martin, Catalysis inside dendrimers, Chem. Soc. Rev. 2002; 31: 69-82.
10. J.D. Eichman, et al, The use of PAMAM dendrimers in the efficient transfer of genetic material into cells, Pharm. Sci. Technol. Today 2000; 3: 232-245.
11. R.F. Barth, A.H. Soloway, Boron neutron capture therapy of primary and metastatic brain tumors, Mol. Chem. Neuropathol. 1994; 21: 139-154.
12. S. Hecht, J.M. Frechet, Dendritic encapsulation of function: applying nature's site isolation principle from biomimetics to materials science, Angew. Chem., Int. Ed. Engl. 2001; 40: 74-91.
13. M.J. Cloninger, Biological applications of dendrimers, Curr. Opin. Chem. Biol. 2002; 6: 742-748.
14. D.A. Tomalia and I. Majoros, Dendrimeric supramolecular and supramacromolecular assemblies, (Reprinted from Supramolecular Polymers, Marcel Dekker, Inc.: New York, 2002; 359-434, J. Macromol. Sci.-Polym. Rev. 2003; 43: 411-477.
15. C.J. Hawker, J.M.J. Frechet, preparation of polymers with controlled molecular architecture-a new convergent approach to dendritic macromolecules, J. Am. Chem. Soc. 1990; 112:7638-7647.
16. R. Esfand and D. A. Tomalia, Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications DDT. 2001; 6:427-436.
17. T. Sakthivel and AT. Florence. Dendrimers and dendron. Facets of pharmaceutical nanotechonology. Drug Delivery Technology 2003;3;73-78.
18. Morawetz, H. Polymers. The Origin and Growth of a Science, Wiley.1985.
19. Hsieh, H.L. and Quirk, R.P. Anionic Polymerization: Principles and Practical Applications, Marcel Dekker. 1996.
20. Matyjaszewski, K. Cationic Polymerizations: Principles and Practical Applications, Marcel Dekker, 1996. 1-768.
21. Matyjaszewski, K. Controlled Radical Polymerization, ACS. 1997.
22. Tomalia, D.A. Dendrimer molecules. Sci. Am., 1995; 27:262-266.
23. Tomalia, D.A. et al. A new class of polymers: starburst dendritic macromolecules. Polym. J.1985; 17:117-132.
24. Tomalia, D.A. Starburst dendrimers -Nanoscopic supermolecules according to dendritic rules and principles. Macromol. Symp. 1996; 101: 243-255.
25. Hawker, C.J. and Fréchet, J.M.J. Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules. J. Am. Chem. Soc. 1990; 112: 7638-7647.
26. Tomalia, D.A. and Durst, H.D. Genealogically directed synthesis: starburst/cascade dendrimers and hyperbranched structures. In Topics in Current Chemistry: Supramolecular Chemistry I - Directed Synthesis and Molecular Recognition Weber, E., ed. Springer-Verlag.1993; 165:193-313.
27. Newkome G.R. et al. Dendritic Molecules, VCH. 1996.
28. Bosman, A.W. et al. About dendrimers: structure, physical properties and applications. Chem. Rev. 1999; 99: 1665-1688.
29. Tomalia, D.A. and Majoros, I Dendrimeric supramolecular and supra macromolecular assemblies. In Supramolecular Polymers (Ciferri, A., ed.) Marcel Dekker, 2000; 359-435.
30. Fischer M. and Vögtle, F. Dendrimers: from design to application - a progress report. Angew. Chem., Int. Ed. Engl. 1999; 38: 884-905.
31. Esfand R and Tomalia DA. Laboratory synthesis of poly(amidoamine) (PAMAM) dendrimers. In:,. Dendrimers and other dendritic polymers. Edited by Fréchet JMJ and Tomalia DA. Chichester, Wiley. 2001; 587-604.
32. Frechet JMJ, Ihre H, and Davey M. Preparation of frechet-type polyether dendrons and aliphatic polyester dendrimers by convergent growth: an experimental primer. Dendrimers and other dendritic polymers. Edited by Fréchet JMJ, Tomalia DA.Chichester: Wiley; 2001; 569-86.
33. van Genderen MHP,et al. Synthesis and characterization of poly(propylene imine) 322 D.A. Tomalia/Prog. Polym. Sci.2005; 30: 294-324 dendrimers.
34. Dendrimers and other dendritic polymers. Edited by Fréchet JMJ, Tomalia DA. Chichester: Wiley; 2001; 605-616.
35. Tomalia D.A. and Esfand, R. Dendrons, dendrimers and dendrigrafts. Chem. Ind. 1997; 11: 416-420.
36. Loup C, et al, Preparation of water soluble cationic phosphorus containing dendrimers as DNA transfecting agents, Chem Eur. J. 1999;5: 3644-3650.
37. Frechet J.M.J. Functional polymers and dendrimers: Reactivity, molecular architecture, and interfacial energy. Science. 1994; 263: 1710-1715.
38. Mourey, et al. Unique behaviour of dendritic macromolecules: Intrinsic viscosity of polyether dendrimers. Macromolecules 1992; 25: 2401-2406.
39. Alper, J., et al. Rising chemical "stars" could play many roles. Science.1991; 251: 1562-1564.
40. Jansen, J.F.G.A., et al. Encapsulation of guest molecules into a dendritic box. Science 1994; 266: 1226-1229.
41. Jansen, J.F.G.A. and Meijer, E.W. The dendritic box: Shape-selective liberation of encapsulated guests. J. Am. Chem. Soc. 1995; 117: 4417-4418.
42. Frechet J.M., et al. Functional polymers and dendrimers: reactivity, molecular architecture, and interfacial energy, Science. 1994; 263: 1710-1715.
43. Bielinska A., et al., Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers, Nucleic Acids Res. 1996; 24: 2176-2182.
44. Newkome GR, Moorefield CN, and Vogtle F: Dendrimers and Dendrons: Concepts, Synthesis, Applications. New York: Wiley-VCH; 2001.
45. Mammen M, Choi S-K, and Whitesides GM: Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew Chem Int Ed. Engl 1998; 37: 2754-2794.
46. Lundquist JJ, Toone EJ: The cluster glycoside effect. Chem Rev 2002; 102: 555-578.
47. Woller EK, Cloninger MC: The lectin-binding properties of six generations of mannose-functionalized dendrimers. Org Lett 2002; 4:7-10.
48. Woller EK, Cloninger MC: Mannose functionalization of a sixth generation dendrimer. Bio macromolecules 2001; 2:1052-1054.
49. Baek M-G, Roy R: Synthesis and protein binding properties of T-antigen containing glycol PAMAM dendrimers. Bio org Med Chem 2002, 10:11-17
50. Sadler K, Tam JP: Peptide dendrimers: applications and synthesis. Rev Mol Biotechnol 2002; 90:195-229.
51. Tam JP, Lu Y-A, and Yang J-L: Antimicrobial dendrimeric peptides. Eur J Biochem 2002; 269:923-932.
52. Kasai S, et al: Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin. Bioorg Med Chem Lett 2002; 12:951-954.
53. Cattani-Scholz A, et al: Photoresponsive dendritic azobenzene peptides. ChemBioChem 2002; 2:542-549.
54. Ronn LCB, et al: Increased intracellular calcium is required for neurite outgrowth induced by a synthetic peptide ligand of NCAM. FEBS Lett 2002; 518: 60-66.
55. Chaves F, et al: Synthesis, isolation and characterization of Plasmodium falciparum antigenic tetrabranched peptide dendrimers obtained by thiazolidine linkages. J Pept Res 2001; 58: 307-316.
56. Sarracino DA, Richert C: Synthesis and nuclease stability of trilysyl dendrimer-oligodeoxyribonucleotide hybrids. Bio org Med Chem Lett 2001; 11: 1733-1736.
57. Higashi N, Koga T,and Niwa M: Nanofabrication of helical peptide shelled dendrimers. J Nanosci Nanotechnol 2001; 3: 309-315.
58. Higashi N, Koga T, and Niwa M: Enantioselective binding and stable encapsulation of a-amino acids in a helical Poly(L-glutamic acid)-shelled dendrimer in aqueous solutions. Chem Bio Chem 2002; 3:448-454.
59. Monaghan S, et al: Solid-phase synthesis of peptide-dendrimer conjugates for an investigation of integrin binding. ARKIVOC 2001; 2:U42-U49.
60. Boas U, et al: New dendrimer-peptide host-guest complexes: towards dendrimers as peptide carriers. Chem Bio Chem 2002; 3:433-439.
61. Klajnert B, Bryszewska M: Fluorescence studies of PAMAM dendrimers interactions with bovine serum albumin. Bioelectrochemistry 2002; 55:33-35.
62. Cho JK, et al: Preparation of tris-based dendrimer-grafted core-shell type resin for solid-phase peptide synthesis. Tetrahedron Lett 2001; 42:7443-7445.
63. Stiriba S-E, Frey H, and Haag R: Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy. Angew Chem Int Ed Engl 2002; 41:1329-1334.
64. Gebhart CL, Kabanov AV: Evaluation of polyplexes as gene transfer agents. J Controlled Release 2001; 73:401-416.
65. De Jong G, et al: Efficient in-vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers. Chromosome Res 2001; 9:475-485.
66. Sato N, et al.: Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice. Clin Cancer Res 2001; 7:3606-3612.
67. Gossl I, et al: Molecular structure of single DNA complexes with positively charged dendronized polymers. J Am Chem Soc 2002; 124:6860-6865.
68. Wang Y, et al: Combination of electroporation and DNA/dendrimer complexes enhances gene transfer into murine cardiac transplants. Am J Transplant 2001; 1:334-338.
69. Roessler BJ, et al: Substituted P-cyclodextrins interact with PAMAM dendrimer-DNA complexes and modify transfection efficiency. Biochem Biophys Res Commun 2001; 283:124-129.
70. Arima H, et al.: Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-, β-, and γ-cyclodextrins. Bioconjugate Chem 2001; 12:476.
71. Luo D, et al: Poly (ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA delivery. Macromolecules 2002; 35:3456-3462.
72. Florence AT, Hussain N: Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev 2001; 50:S69-S89.
73. Esfand R, Tomalia DA: Poly(amidoamine) (PAM AM) dendrimers:from biomimicry to drug delivery and biomedical applications. Drug Discov Today 2001; 6:427-436.
74. Goller R, et al: Phosphorus dendrimers as new tools to deliver active substances. Tetrahedron Lett 2001; 42:3587-3590.
75. McWatt M, Boons G-J: Parallel combinatorial synthesis of glycodendrimers and their hydrogelation properties. Eur J Org Chem 2001; 25: 35-2545.
76. Tripathi PK, et al: Dendrimer grafts for delivery of 5-flurouracil. Pharmazie 2002; 57:261-264.
77. Khopade AJ, et al: Effect of dendrimer on entrapment and release of bioactive from liposomes. Int. J. Pharm 2002; 232:157-162.
78. Marmillon C, et al: Organophosphorus dendrimers as new gelators for hydrogels. Angew Chem Int Ed Engl 2001; 40:2626-2629.
79. Battah SH, et al: Synthesis and biological studies of 5-aminolevulinic acid-containing dendrimers for photodynamic therapy. Bio conjugate Chem 2001, 12:980-988.
80. Liu M, Kono K, and Frechet JMJ. J Control Rel 2000; 65:121.
81. Y. Cheng et al., Transdermal Delivery of Nonsteroidal Anti-Inflammatory Drugs Mediated by Polyamidoamine (PAMAM) Dendrimers, J. Pharm. Sci. 2007; 96 (3): 595-602.
82. A. S. Chauhan et al., Dendrimer-Mediated Transdermal Delivery: Enhanced Bioavailability of Indomethacin, J. Control. Rel. 2003; 90 (3): 335-343.
83. N. Bourne et al., Dendrimers, a New Class of Candidate Topical Microbicides with Activity against Herpes Simplex Virus Infection. Antimicrobial Agents and Chemotherapy, Antimicrob. Agents Chemother. 2000; 4 (9): 2471-2474.
84. Barth, R.F. et al. Boron neutron capture therapy for cancer. Realities and prospects. Cancer. 1992; 70: 2995-3007
85. Hawthorne, M.F. The role of chemistry in the development of boron neutron capture therapy of cancer. Angew. Chem. Int. Ed. Engl. 1993; 32, 950-984
86. Barth, R.F. et al. Delivery of Boron-10 for Neutron Capture Therapy by Means of Polyclonal and Monoclonal Antibodies: Progress and Problems, Nishimura Co. Ltd. 1986.
87. Alam, F. et al. Dicesium N-succinimidyl 3-(undecahydro closododecaboranyldithio) propionate, a novel heterobifunctional boronating agent. J. Med. Chem. 1985; 28, 522-525.
88. Barth, R.F. et al. Boronated starburst dendrimer-monoclonal antibody immunoconjugates: evaluation as a potential delivery system for neutron capture therapy. Bioconjug. Chem. 1994; 5, 58-66.
89. Sauter, G. et al. Patterns of epidermal growth factor receptor amplification in malignant gliomas. Am. J. Pathol. 1996; 148, 1047-1053.
90. Capala, J. et al. Boronated epidermal growth factor as a potential targeting agent for boron neutron capture therapy of brain tumors. Bioconjug. Chem. 1996; 7, 7-15
91. Yang, W. et al. Intratumoral delivery of boronated epidermal growth factor for neutron capture therapy of brain tumors. Cancer Res. 1997;57, 4333-4339.
92. Nemoto, H. et al. Synthesis of a watersoluble O-carbaborane bearing a uracil moiety via a palladium-catalyzed reaction under essentially neutral conditions. Chem. Commun. 1994; 577-578.
93. Newkome, G.R. et al. Chemistry within a unimolecular micelle precursor: boron superclusters by site- and depth-specific transformations of dendrimers. Angew. Chem. Int. Ed. Engl. 1994; 33, 666-668.