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Volumn 11, Issue 3, 2012, Pages 353-360

Bone mechanotransduction may require augmentation in order to strengthen the senescent skeleton

Author keywords

Age related; Exercise; Mechanotransduction; Periosteal modeling; Pharmaceutical augmentation

Indexed keywords

AGING; BONE CONDUCTION; BONE STRENGTH; BONE STRUCTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; EXERCISE; GENE EXPRESSION; HUMAN; IN VITRO STUDY; MECHANOTRANSDUCTION; NONHUMAN; PERIOSTEUM; REVIEW; SIGNAL TRANSDUCTION; SKELETON;

EID: 84860919988     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2011.12.007     Document Type: Review
Times cited : (39)

References (98)
  • 1
    • 0033773314 scopus 로고    scopus 로고
    • A neuro (endo)crine regulation of bone remodeling
    • Amling M., Takeda S., Karsenty G. A neuro (endo)crine regulation of bone remodeling. Bioessays 2000, 22(11):970-975.
    • (2000) Bioessays , vol.22 , Issue.11 , pp. 970-975
    • Amling, M.1    Takeda, S.2    Karsenty, G.3
  • 2
    • 77950529259 scopus 로고    scopus 로고
    • Optimum frequency of exercise for bone health: randomised controlled trial of a high-impact unilateral intervention
    • Bailey C.A., Brooke-Wavell K. Optimum frequency of exercise for bone health: randomised controlled trial of a high-impact unilateral intervention. Bone 2010, 46(4):1043-1049.
    • (2010) Bone , vol.46 , Issue.4 , pp. 1043-1049
    • Bailey, C.A.1    Brooke-Wavell, K.2
  • 3
    • 67650476919 scopus 로고    scopus 로고
    • Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants
    • Bain S.D., Jerome C., Shen V., Dupin-Roger I., Ammann P. Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants. Osteoporos. Int. 2009, 20(8):1417-1428.
    • (2009) Osteoporos. Int. , vol.20 , Issue.8 , pp. 1417-1428
    • Bain, S.D.1    Jerome, C.2    Shen, V.3    Dupin-Roger, I.4    Ammann, P.5
  • 4
    • 0024510729 scopus 로고
    • Correlation between alkaline and acid phosphatase activities and age-related osteopenia in murine vertebrae
    • Bar-Shira-Maymon B., Coleman R., Steinhagen-Thiessen E., Silbermann M. Correlation between alkaline and acid phosphatase activities and age-related osteopenia in murine vertebrae. Calcif. Tissue Int. 1989, 44(2):99-107.
    • (1989) Calcif. Tissue Int. , vol.44 , Issue.2 , pp. 99-107
    • Bar-Shira-Maymon, B.1    Coleman, R.2    Steinhagen-Thiessen, E.3    Silbermann, M.4
  • 5
    • 0019511337 scopus 로고
    • Homeostatic removal of senescent murine erythrocytes by splenic macrophages
    • Bennett G.D., Kay M.M. Homeostatic removal of senescent murine erythrocytes by splenic macrophages. Exp. Hematol. 1981, 9(3):297-307.
    • (1981) Exp. Hematol. , vol.9 , Issue.3 , pp. 297-307
    • Bennett, G.D.1    Kay, M.M.2
  • 8
    • 77950940515 scopus 로고    scopus 로고
    • In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization
    • Boivin G., Farlay D., Khebbab M.T., Jaurand X., Delmas P.D., Meunier P.J. In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Osteoporos. Int. 2010, 21(4):667-677.
    • (2010) Osteoporos. Int. , vol.21 , Issue.4 , pp. 667-677
    • Boivin, G.1    Farlay, D.2    Khebbab, M.T.3    Jaurand, X.4    Delmas, P.D.5    Meunier, P.J.6
  • 9
    • 0020532761 scopus 로고
    • X-ray diffraction studies of the crystallinity of bone mineral in newly synthesized and density fractionated bone
    • Bonar L.C., Roufosse A.H., Sabine W.K., Grynpas M.D., Glimcher M.J. X-ray diffraction studies of the crystallinity of bone mineral in newly synthesized and density fractionated bone. Calcif. Tissue Int. 1983, 35(2):202-209.
    • (1983) Calcif. Tissue Int. , vol.35 , Issue.2 , pp. 202-209
    • Bonar, L.C.1    Roufosse, A.H.2    Sabine, W.K.3    Grynpas, M.D.4    Glimcher, M.J.5
  • 10
    • 77956807497 scopus 로고    scopus 로고
    • Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression
    • Brodt M.D., Silva M.J. Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression. J. Bone Miner. Res. 2010, 25(9):2006-2015.
    • (2010) J. Bone Miner. Res. , vol.25 , Issue.9 , pp. 2006-2015
    • Brodt, M.D.1    Silva, M.J.2
  • 12
    • 0032895922 scopus 로고    scopus 로고
    • Mechanotransduction in bone-role of the lacuno-canalicular network
    • Burger E.H., Klein-Nulend J. Mechanotransduction in bone-role of the lacuno-canalicular network. FASEB J. 1999, 13(Suppl):S101-S112.
    • (1999) FASEB J. , vol.13 , Issue.SUPPL.
    • Burger, E.H.1    Klein-Nulend, J.2
  • 13
    • 24144464218 scopus 로고    scopus 로고
    • Aging increases stromal/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse
    • Cao J.J., Wronski T.J., Iwaniec U., Phleger L., Kurimoto P., Boudignon B., Halloran B.P. Aging increases stromal/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse. J. Bone Miner. Res. 2005, 20(9):1659-1668.
    • (2005) J. Bone Miner. Res. , vol.20 , Issue.9 , pp. 1659-1668
    • Cao, J.J.1    Wronski, T.J.2    Iwaniec, U.3    Phleger, L.4    Kurimoto, P.5    Boudignon, B.6    Halloran, B.P.7
  • 14
    • 57649237947 scopus 로고    scopus 로고
    • Beta-catenin levels influence rapid mechanical responses in osteoblasts
    • Case N., Ma M., Sen B., Xie Z., Gross T.S., Rubin J. Beta-catenin levels influence rapid mechanical responses in osteoblasts. J. Biol. Chem. 2008, 283(43):29196-29205.
    • (2008) J. Biol. Chem. , vol.283 , Issue.43 , pp. 29196-29205
    • Case, N.1    Ma, M.2    Sen, B.3    Xie, Z.4    Gross, T.S.5    Rubin, J.6
  • 16
  • 18
    • 78649697897 scopus 로고    scopus 로고
    • Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture
    • Di Monaco M., Vallero F., Di Monaco R., Tappero R. Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture. Arch. Gerontol. Geriatr. 2011, 52(1):71-74.
    • (2011) Arch. Gerontol. Geriatr. , vol.52 , Issue.1 , pp. 71-74
    • Di Monaco, M.1    Vallero, F.2    Di Monaco, R.3    Tappero, R.4
  • 19
    • 0035199411 scopus 로고    scopus 로고
    • Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent
    • Donahue S.W., Jacobs C.R., Donahue H.J. Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am. J. Physiol. Cell Physiol. 2001, 281(5):C1635-C1641.
    • (2001) Am. J. Physiol. Cell Physiol. , vol.281 , Issue.5
    • Donahue, S.W.1    Jacobs, C.R.2    Donahue, H.J.3
  • 20
    • 0027210068 scopus 로고
    • Osteocyte death and hip fracture
    • [discussion S116-117]
    • Dunstan C.R., Somers N.M., Evans R.A. Osteocyte death and hip fracture. Calcif. Tissue Int. 1993, 53(Suppl 1):S113-S116. [discussion S116-117].
    • (1993) Calcif. Tissue Int. , vol.53 , Issue.SUPPL. 1
    • Dunstan, C.R.1    Somers, N.M.2    Evans, R.A.3
  • 21
    • 50949118377 scopus 로고    scopus 로고
    • Regulation of bone remodeling by the central and peripheral nervous system
    • Elefteriou F. Regulation of bone remodeling by the central and peripheral nervous system. Arch. Biochem. Biophys. 2008, 473(2):231-236.
    • (2008) Arch. Biochem. Biophys. , vol.473 , Issue.2 , pp. 231-236
    • Elefteriou, F.1
  • 22
    • 0027249345 scopus 로고
    • Physical activity and bone mass: exercises in futility?
    • Forwood M.R., Burr D.B. Physical activity and bone mass: exercises in futility?. Bone Miner. 1993, 21(2):89-112.
    • (1993) Bone Miner. , vol.21 , Issue.2 , pp. 89-112
    • Forwood, M.R.1    Burr, D.B.2
  • 23
    • 79952705322 scopus 로고    scopus 로고
    • Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: results from the Women's Health and Aging Study (WHAS) II
    • Frisoli A., Chaves P.H., Ingham S.J., Fried L.P. Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: results from the Women's Health and Aging Study (WHAS) II. Bone 2011, 48(4):952-957.
    • (2011) Bone , vol.48 , Issue.4 , pp. 952-957
    • Frisoli, A.1    Chaves, P.H.2    Ingham, S.J.3    Fried, L.P.4
  • 24
    • 0032531278 scopus 로고    scopus 로고
    • Bone loss (osteopenia) in old male mice results from diminished activity and availability of TGF-beta
    • Gazit D., Zilberman Y., Ebner R., Kahn A. Bone loss (osteopenia) in old male mice results from diminished activity and availability of TGF-beta. J. Cell. Biochem. 1998, 70(4):478-488.
    • (1998) J. Cell. Biochem. , vol.70 , Issue.4 , pp. 478-488
    • Gazit, D.1    Zilberman, Y.2    Ebner, R.3    Kahn, A.4
  • 25
    • 24644473706 scopus 로고    scopus 로고
    • Bone strength index in adolescent girls: does physical activity make a difference?
    • [discussion 627]
    • Greene D.A., Naughton G.A., Briody J.N., Kemp A., Woodhead H., Corrigan L. Bone strength index in adolescent girls: does physical activity make a difference?. Br. J. Sports Med. 2005, 39(9):622-627. [discussion 627].
    • (2005) Br. J. Sports Med. , vol.39 , Issue.9 , pp. 622-627
    • Greene, D.A.1    Naughton, G.A.2    Briody, J.N.3    Kemp, A.4    Woodhead, H.5    Corrigan, L.6
  • 26
    • 0036179760 scopus 로고    scopus 로고
    • Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction
    • Gross T.S., Srinivasan S., Liu C.C., Clemens T.L., Bain S.D. Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction. J. Bone Miner. Res. 2002, 17(3):493-501.
    • (2002) J. Bone Miner. Res. , vol.17 , Issue.3 , pp. 493-501
    • Gross, T.S.1    Srinivasan, S.2    Liu, C.C.3    Clemens, T.L.4    Bain, S.D.5
  • 27
    • 84856984276 scopus 로고    scopus 로고
    • Bone cross-sectional geometry in male runners, gymnasts, swimmers and non-athletic controls: a hip-structural analysis study
    • Hind K., Gannon L., Whatley E., Cooke C., Truscott J. Bone cross-sectional geometry in male runners, gymnasts, swimmers and non-athletic controls: a hip-structural analysis study. Eur. J. Appl. Physiol. 2011.
    • (2011) Eur. J. Appl. Physiol.
    • Hind, K.1    Gannon, L.2    Whatley, E.3    Cooke, C.4    Truscott, J.5
  • 29
    • 25444434346 scopus 로고    scopus 로고
    • The benefit of combining non-mechanical agents with mechanical loading: a perspective based on the Utah Paradigm of Skeletal Physiology
    • Jee W.S., Tian X.Y. The benefit of combining non-mechanical agents with mechanical loading: a perspective based on the Utah Paradigm of Skeletal Physiology. J. Musculoskel. Neuron Interact. 2005, 5(2):110-118.
    • (2005) J. Musculoskel. Neuron Interact. , vol.5 , Issue.2 , pp. 110-118
    • Jee, W.S.1    Tian, X.Y.2
  • 30
    • 78349266526 scopus 로고    scopus 로고
    • Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration
    • Jilka R.L., Almeida M., Ambrogini E., Han L., Roberson P.K., Weinstein R.S., Manolagas S.C. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration. Aging Cell 2010, 9(5):851-867.
    • (2010) Aging Cell , vol.9 , Issue.5 , pp. 851-867
    • Jilka, R.L.1    Almeida, M.2    Ambrogini, E.3    Han, L.4    Roberson, P.K.5    Weinstein, R.S.6    Manolagas, S.C.7
  • 31
    • 58349093551 scopus 로고    scopus 로고
    • Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts
    • Jilka R.L., O'Brien C.A., Ali A.A., Roberson P.K., Weinstein R.S., Manolagas S.C. Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts. Bone 2009, 44(2):275-286.
    • (2009) Bone , vol.44 , Issue.2 , pp. 275-286
    • Jilka, R.L.1    O'Brien, C.A.2    Ali, A.A.3    Roberson, P.K.4    Weinstein, R.S.5    Manolagas, S.C.6
  • 32
    • 0031976864 scopus 로고    scopus 로고
    • Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines
    • Jilka R.L., Weinstein R.S., Bellido T., Parfitt A.M., Manolagas S.C. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J. Bone Miner. Res. 1998, 13(5):793-802.
    • (1998) J. Bone Miner. Res. , vol.13 , Issue.5 , pp. 793-802
    • Jilka, R.L.1    Weinstein, R.S.2    Bellido, T.3    Parfitt, A.M.4    Manolagas, S.C.5
  • 33
    • 0036676971 scopus 로고    scopus 로고
    • Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton
    • Judex S., Donahue L.R., Rubin C. Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J. 2002, 16(10):1280-1282.
    • (2002) FASEB J. , vol.16 , Issue.10 , pp. 1280-1282
    • Judex, S.1    Donahue, L.R.2    Rubin, C.3
  • 34
    • 33847665080 scopus 로고    scopus 로고
    • A multi-component exercise regimen to prevent functional decline and bone fragility in home-dwelling elderly women: randomized, controlled trial
    • Karinkanta S., Heinonen A., Sievanen H., Uusi-Rasi K., Pasanen M., Ojala K., Fogelholm M., Kannus P. A multi-component exercise regimen to prevent functional decline and bone fragility in home-dwelling elderly women: randomized, controlled trial. Osteoporos. Int. 2007, 18(4):453-462.
    • (2007) Osteoporos. Int. , vol.18 , Issue.4 , pp. 453-462
    • Karinkanta, S.1    Heinonen, A.2    Sievanen, H.3    Uusi-Rasi, K.4    Pasanen, M.5    Ojala, K.6    Fogelholm, M.7    Kannus, P.8
  • 35
    • 0033605601 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinases in cultured rat hippocampal neurons
    • 2+/calmodulin-dependent protein kinases in cultured rat hippocampal neurons. J. Biol. Chem. 1999, 274(13):9061-9067.
    • (1999) J. Biol. Chem. , vol.274 , Issue.13 , pp. 9061-9067
    • Kasahara, J.1    Fukunaga, K.2    Miyamoto, E.3
  • 37
    • 0037302016 scopus 로고    scopus 로고
    • Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls
    • Kontulainen S., Sievanen H., Kannus P., Pasanen M., Vuori I. Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J. Bone Miner. Res. 2003, 18(2):352-359.
    • (2003) J. Bone Miner. Res. , vol.18 , Issue.2 , pp. 352-359
    • Kontulainen, S.1    Sievanen, H.2    Kannus, P.3    Pasanen, M.4    Vuori, I.5
  • 38
    • 0033216535 scopus 로고    scopus 로고
    • 2+-induced p38/SAPK signalling inhibited by the immunosuppressant cyclosporin A in human peripheral blood mononuclear cells
    • 2+-induced p38/SAPK signalling inhibited by the immunosuppressant cyclosporin A in human peripheral blood mononuclear cells. Eur. J. Biochem. 1999, 265(3):1075-1084.
    • (1999) Eur. J. Biochem. , vol.265 , Issue.3 , pp. 1075-1084
    • Kreideweiss, S.1    Ahlers, C.2    Nordheim, A.3    Ruhlmann, A.4
  • 39
    • 79953874882 scopus 로고    scopus 로고
    • Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial
    • Kukuljan S., Nowson C.A., Sanders K.M., Nicholson G.C., Seibel M.J., Salmon J., Daly R.M. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial. J. Clin. Endocrinol. Metab. 2011.
    • (2011) J. Clin. Endocrinol. Metab.
    • Kukuljan, S.1    Nowson, C.A.2    Sanders, K.M.3    Nicholson, G.C.4    Seibel, M.J.5    Salmon, J.6    Daly, R.M.7
  • 40
    • 49749143702 scopus 로고    scopus 로고
    • Pathogenesis of age-related osteoporosis: impaired mechano-responsiveness of bone is not the culprit
    • Leppanen O.V., Sievanen H., Jokihaara J., Pajamaki I., Kannus P., Jarvinen T.L. Pathogenesis of age-related osteoporosis: impaired mechano-responsiveness of bone is not the culprit. PLoS One 2008, 3(7):e2540.
    • (2008) PLoS One , vol.3 , Issue.7
    • Leppanen, O.V.1    Sievanen, H.2    Jokihaara, J.3    Pajamaki, I.4    Kannus, P.5    Jarvinen, T.L.6
  • 41
    • 84866630067 scopus 로고    scopus 로고
    • Tai chi as an intervention to improve balance and reduce falls in older adults: A systematic and meta-analytical review
    • Leung D.P., Chan C.K., Tsang H.W., Tsang W.W., Jones A.Y. Tai chi as an intervention to improve balance and reduce falls in older adults: A systematic and meta-analytical review. Altern. Ther. Health Med. 2011, 17(1):40-48.
    • (2011) Altern. Ther. Health Med. , vol.17 , Issue.1 , pp. 40-48
    • Leung, D.P.1    Chan, C.K.2    Tsang, H.W.3    Tsang, W.W.4    Jones, A.Y.5
  • 43
    • 70349934212 scopus 로고    scopus 로고
    • Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    • Lin C., Jiang X., Dai Z., Guo X., Weng T., Wang J., Li Y., Feng G., Gao X., He L. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J. Bone Miner. Res. 2009, 24(10):1651-1661.
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.10 , pp. 1651-1661
    • Lin, C.1    Jiang, X.2    Dai, Z.3    Guo, X.4    Weng, T.5    Wang, J.6    Li, Y.7    Feng, G.8    Gao, X.9    He, L.10
  • 44
    • 38149139351 scopus 로고    scopus 로고
    • Tai Chi Chuan exercises in enhancing bone mineral density in active seniors
    • Lui P.P., Qin L., Chan K.M. Tai Chi Chuan exercises in enhancing bone mineral density in active seniors. Clin. Sports Med. 2008, 27(1):75-86.
    • (2008) Clin. Sports Med. , vol.27 , Issue.1 , pp. 75-86
    • Lui, P.P.1    Qin, L.2    Chan, K.M.3
  • 45
    • 0032970789 scopus 로고    scopus 로고
    • Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone
    • Ma Y., Jee W.S., Yuan Z., Wei W., Chen H., Pun S., Liang H., Lin C. Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone. J. Bone Miner. Res. 1999, 14(3):439-448.
    • (1999) J. Bone Miner. Res. , vol.14 , Issue.3 , pp. 439-448
    • Ma, Y.1    Jee, W.S.2    Yuan, Z.3    Wei, W.4    Chen, H.5    Pun, S.6    Liang, H.7    Lin, C.8
  • 48
    • 0035971436 scopus 로고    scopus 로고
    • Partners in transcription: NFAT and AP-1
    • Macian F., Lopez-Rodriguez C., Rao A. Partners in transcription: NFAT and AP-1. Oncogene 2001, 20(19):2476-2489.
    • (2001) Oncogene , vol.20 , Issue.19 , pp. 2476-2489
    • Macian, F.1    Lopez-Rodriguez, C.2    Rao, A.3
  • 49
    • 1642390377 scopus 로고    scopus 로고
    • Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys
    • MacKelvie K.J., Petit M.A., Khan K.M., Beck T.J., McKay H.A. Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. Bone 2004, 34(4):755-764.
    • (2004) Bone , vol.34 , Issue.4 , pp. 755-764
    • MacKelvie, K.J.1    Petit, M.A.2    Khan, K.M.3    Beck, T.J.4    McKay, H.A.5
  • 50
    • 35648929883 scopus 로고    scopus 로고
    • Gone with the Wnts: {beta}-catenin, TCF, FOXO, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
    • Manolagas S.C., Almeida M. Gone with the Wnts: {beta}-catenin, TCF, FOXO, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol. Endocrinol. 2007.
    • (2007) Mol. Endocrinol.
    • Manolagas, S.C.1    Almeida, M.2
  • 52
    • 0034045947 scopus 로고    scopus 로고
    • Mechanisms of action of cyclosporine?
    • Matsuda S., Koyasu S. Mechanisms of action of cyclosporine?. Immunopharmacology 2000, 47(2-3):119-125.
    • (2000) Immunopharmacology , vol.47 , Issue.2-3 , pp. 119-125
    • Matsuda, S.1    Koyasu, S.2
  • 54
    • 0036755267 scopus 로고    scopus 로고
    • Bipedal stance exercise and prostaglandin E2 (PGE(2)) and its synergistic effect in increasing bone mass and in lowering the PGE(2) dose required to prevent ovariectomized-induced cancellous bone loss in aged rats
    • Mo A., Yao W., Li C., Tian X., Su M., Ling Y., Zhang Q., Setterberg R., Jee W. Bipedal stance exercise and prostaglandin E2 (PGE(2)) and its synergistic effect in increasing bone mass and in lowering the PGE(2) dose required to prevent ovariectomized-induced cancellous bone loss in aged rats. Bone 2002, 31(3):402.
    • (2002) Bone , vol.31 , Issue.3 , pp. 402
    • Mo, A.1    Yao, W.2    Li, C.3    Tian, X.4    Su, M.5    Ling, Y.6    Zhang, Q.7    Setterberg, R.8    Jee, W.9
  • 56
    • 3042839273 scopus 로고    scopus 로고
    • Muscle weakness and falls in older adults: a systematic review and meta-analysis
    • Moreland J.D., Richardson J.A., Goldsmith C.H., Clase C.M. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J. Am. Geriatr. Soc. 2004, 52(7):1121-1129.
    • (2004) J. Am. Geriatr. Soc. , vol.52 , Issue.7 , pp. 1121-1129
    • Moreland, J.D.1    Richardson, J.A.2    Goldsmith, C.H.3    Clase, C.M.4
  • 58
    • 0028219486 scopus 로고
    • Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging
    • Nicolas V., Prewett A., Bettica P., Mohan S., Finkelman R.D., Baylink D.J., Farley J.R. Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging. J. Clin. Endocrinol. Metab. 1994, 78(5):1011-1016.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , Issue.5 , pp. 1011-1016
    • Nicolas, V.1    Prewett, A.2    Bettica, P.3    Mohan, S.4    Finkelman, R.D.5    Baylink, D.J.6    Farley, J.R.7
  • 59
    • 77954679311 scopus 로고    scopus 로고
    • Targeted exercise against osteoporosis: a systematic review and meta-analysis for optimising bone strength throughout life
    • Nikander R., Sievanen H., Heinonen A., Daly R.M., Uusi-Rasi K., Kannus P. Targeted exercise against osteoporosis: a systematic review and meta-analysis for optimising bone strength throughout life. BMC Med. 2010, 8:47.
    • (2010) BMC Med. , vol.8 , pp. 47
    • Nikander, R.1    Sievanen, H.2    Heinonen, A.3    Daly, R.M.4    Uusi-Rasi, K.5    Kannus, P.6
  • 60
    • 78650958526 scopus 로고    scopus 로고
    • Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    • Padhi D., Jang G., Stouch B., Fang L., Posvar E. Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J. Bone Miner. Res. 2011, 26(1):19-26.
    • (2011) J. Bone Miner. Res. , vol.26 , Issue.1 , pp. 19-26
    • Padhi, D.1    Jang, G.2    Stouch, B.3    Fang, L.4    Posvar, E.5
  • 61
    • 0031586364 scopus 로고    scopus 로고
    • The increase in the induction of IL-2 expression with caloric restriction is correlated to changes in the transcription factor NFAT
    • Pahlavani M.A., Harris M.D., Richardson A. The increase in the induction of IL-2 expression with caloric restriction is correlated to changes in the transcription factor NFAT. Cell. Immunol. 1997, 180(1):10-19.
    • (1997) Cell. Immunol. , vol.180 , Issue.1 , pp. 10-19
    • Pahlavani, M.A.1    Harris, M.D.2    Richardson, A.3
  • 62
    • 0032704885 scopus 로고    scopus 로고
    • Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells
    • Pahlavani M.A., Vargas D.M. Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells. Mech. Ageing Dev. 1999, 112(1):59-74.
    • (1999) Mech. Ageing Dev. , vol.112 , Issue.1 , pp. 59-74
    • Pahlavani, M.A.1    Vargas, D.M.2
  • 63
    • 0034079487 scopus 로고    scopus 로고
    • Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat T cells
    • Pahlavani M.A., Vargas D.M. Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat T cells. Proc. Soc. Exp. Biol. Med. 2000, 223(2):163-169.
    • (2000) Proc. Soc. Exp. Biol. Med. , vol.223 , Issue.2 , pp. 163-169
    • Pahlavani, M.A.1    Vargas, D.M.2
  • 64
    • 0021222303 scopus 로고
    • Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences
    • Parfitt A.M. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif. Tissue Int. 1984, 36(Suppl 1):S123-S128.
    • (1984) Calcif. Tissue Int. , vol.36 , Issue.SUPPL. 1
    • Parfitt, A.M.1
  • 65
    • 0027207351 scopus 로고
    • Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age
    • Pfeilschifter J., Diel I., Pilz U., Brunotte K., Naumann A., Ziegler R. Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age. J. Bone Miner. Res. 1993, 8(6):707-717.
    • (1993) J. Bone Miner. Res. , vol.8 , Issue.6 , pp. 707-717
    • Pfeilschifter, J.1    Diel, I.2    Pilz, U.3    Brunotte, K.4    Naumann, A.5    Ziegler, R.6
  • 67
    • 77955985077 scopus 로고    scopus 로고
    • Mathematical modeling in bone biology: from intracellular signaling to tissue mechanics
    • Pivonka P., Komarova S.V. Mathematical modeling in bone biology: from intracellular signaling to tissue mechanics. Bone 2010, 47(2):181-189.
    • (2010) Bone , vol.47 , Issue.2 , pp. 181-189
    • Pivonka, P.1    Komarova, S.V.2
  • 68
    • 40849084994 scopus 로고    scopus 로고
    • 32 wk old C3H/HeJ mice actively respond to mechanical loading
    • Poliachik S.L., Threet D., Srinivasan S., Gross T.S. 32 wk old C3H/HeJ mice actively respond to mechanical loading. Bone 2008, 42(4):653-659.
    • (2008) Bone , vol.42 , Issue.4 , pp. 653-659
    • Poliachik, S.L.1    Threet, D.2    Srinivasan, S.3    Gross, T.S.4
  • 69
    • 0025161874 scopus 로고
    • Bone mechanical properties after exercise training in young and old rats
    • Raab D.M., Smith E.L., Crenshaw T.D., Thomas D.P. Bone mechanical properties after exercise training in young and old rats. J. Appl. Physiol. 1990, 68(1):130-134.
    • (1990) J. Appl. Physiol. , vol.68 , Issue.1 , pp. 130-134
    • Raab, D.M.1    Smith, E.L.2    Crenshaw, T.D.3    Thomas, D.P.4
  • 70
    • 33645452566 scopus 로고    scopus 로고
    • MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation
    • Riddle R.C., Taylor A.F., Genetos D.C., Donahue H.J. MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am. J. Physiol. Cell Physiol. 2006, 290(3):C776-C784.
    • (2006) Am. J. Physiol. Cell Physiol. , vol.290 , Issue.3
    • Riddle, R.C.1    Taylor, A.F.2    Genetos, D.C.3    Donahue, H.J.4
  • 71
    • 0022625922 scopus 로고
    • Involutional osteoporosis
    • Riggs B.L., Melton L.J. Involutional osteoporosis. N. Engl. J. Med. 1986, 314(26):1676-1686.
    • (1986) N. Engl. J. Med. , vol.314 , Issue.26 , pp. 1676-1686
    • Riggs, B.L.1    Melton, L.J.2
  • 73
    • 0035992661 scopus 로고    scopus 로고
    • Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts
    • Robling A.G., Hinant F.M., Burr D.B., Turner C.H. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J. Bone Miner. Res. 2002, 17(8):1545-1554.
    • (2002) J. Bone Miner. Res. , vol.17 , Issue.8 , pp. 1545-1554
    • Robling, A.G.1    Hinant, F.M.2    Burr, D.B.3    Turner, C.H.4
  • 75
    • 0024496975 scopus 로고
    • Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study
    • Rozman C., Feliu E., Berga L., Reverter J.C., Climent C., Ferran M.J. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Exp. Hematol. 1989, 17(1):34-37.
    • (1989) Exp. Hematol. , vol.17 , Issue.1 , pp. 34-37
    • Rozman, C.1    Feliu, E.2    Berga, L.3    Reverter, J.C.4    Climent, C.5    Ferran, M.J.6
  • 76
    • 0035833434 scopus 로고    scopus 로고
    • Anabolism. Low mechanical signals strengthen long bones
    • Rubin C., Turner A.S., Bain S., Mallinckrodt C., McLeod K. Anabolism. Low mechanical signals strengthen long bones. Nature 2001, 412(6847):603-604.
    • (2001) Nature , vol.412 , Issue.6847 , pp. 603-604
    • Rubin, C.1    Turner, A.S.2    Bain, S.3    Mallinckrodt, C.4    McLeod, K.5
  • 77
    • 0026607457 scopus 로고
    • Suppression of the osteogenic response in the aging skeleton
    • Rubin C.T., Bain S.D., McLeod K.J. Suppression of the osteogenic response in the aging skeleton. Calcif. Tissue Int. 1992, 50(4):306-313.
    • (1992) Calcif. Tissue Int. , vol.50 , Issue.4 , pp. 306-313
    • Rubin, C.T.1    Bain, S.D.2    McLeod, K.J.3
  • 78
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • Rubin C.T., Lanyon L.E. Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. Am. 1984, 66(3):397-402.
    • (1984) J. Bone Joint Surg. Am. , vol.66 , Issue.3 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 80
    • 22044451748 scopus 로고    scopus 로고
    • Cellular accommodation and the response of bone to mechanical loading
    • Schriefer J.L., Warden S.J., Saxon L.K., Robling A.G., Turner C.H. Cellular accommodation and the response of bone to mechanical loading. J. Biomech. 2005, 38(9):1838-1845.
    • (2005) J. Biomech. , vol.38 , Issue.9 , pp. 1838-1845
    • Schriefer, J.L.1    Warden, S.J.2    Saxon, L.K.3    Robling, A.G.4    Turner, C.H.5
  • 83
    • 0141796803 scopus 로고    scopus 로고
    • Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5-year-old children
    • Specker B., Binkley T. Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5-year-old children. J. Bone Miner. Res. 2003, 18(5):885-892.
    • (2003) J. Bone Miner. Res. , vol.18 , Issue.5 , pp. 885-892
    • Specker, B.1    Binkley, T.2
  • 84
    • 0347627147 scopus 로고    scopus 로고
    • Enabling bone formation in the aged skeleton via rest-inserted mechanical loading
    • Srinivasan S., Agans S.C., King K.A., Moy N.Y., Poliachik S.L., Gross T.S. Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. Bone 2003, 33(6):946-955.
    • (2003) Bone , vol.33 , Issue.6 , pp. 946-955
    • Srinivasan, S.1    Agans, S.C.2    King, K.A.3    Moy, N.Y.4    Poliachik, S.L.5    Gross, T.S.6
  • 85
    • 34247891505 scopus 로고    scopus 로고
    • Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles
    • Srinivasan S., Ausk B.J., Poliachik S.L., Warner S.E., Richardson T.S., Gross T.S. Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles. J. Appl. Physiol. 2007, 102(5):1945-1952.
    • (2007) J. Appl. Physiol. , vol.102 , Issue.5 , pp. 1945-1952
    • Srinivasan, S.1    Ausk, B.J.2    Poliachik, S.L.3    Warner, S.E.4    Richardson, T.S.5    Gross, T.S.6
  • 87
    • 52449085471 scopus 로고    scopus 로고
    • Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    • Sugiyama T., Saxon L.K., Zaman G., Moustafa A., Sunters A., Price J.S., Lanyon L.E. Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice. Bone 2008, 43(2):238-248.
    • (2008) Bone , vol.43 , Issue.2 , pp. 238-248
    • Sugiyama, T.1    Saxon, L.K.2    Zaman, G.3    Moustafa, A.4    Sunters, A.5    Price, J.S.6    Lanyon, L.E.7
  • 88
    • 0029135308 scopus 로고
    • Aging changes mechanical loading thresholds for bone formation in rats
    • Turner C.H., Takano Y., Owan I. Aging changes mechanical loading thresholds for bone formation in rats. J. Bone Miner. Res. 1995, 10(10):1544-1549.
    • (1995) J. Bone Miner. Res. , vol.10 , Issue.10 , pp. 1544-1549
    • Turner, C.H.1    Takano, Y.2    Owan, I.3
  • 92
    • 33846585414 scopus 로고    scopus 로고
    • Effect of impact exercise and its intensity on bone geometry at weight-bearing tibia and femur
    • Vainionpaa A., Korpelainen R., Sievanen H., Vihriala E., Leppaluoto J., Jamsa T. Effect of impact exercise and its intensity on bone geometry at weight-bearing tibia and femur. Bone 2007, 40(3):604-611.
    • (2007) Bone , vol.40 , Issue.3 , pp. 604-611
    • Vainionpaa, A.1    Korpelainen, R.2    Sievanen, H.3    Vihriala, E.4    Leppaluoto, J.5    Jamsa, T.6
  • 93
    • 0034010683 scopus 로고    scopus 로고
    • Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age
    • Vashishth D., Verborgt O., Divine G., Schaffler M.B., Fyhrie D.P. Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. Bone 2000, 26(4):375-380.
    • (2000) Bone , vol.26 , Issue.4 , pp. 375-380
    • Vashishth, D.1    Verborgt, O.2    Divine, G.3    Schaffler, M.B.4    Fyhrie, D.P.5
  • 94
    • 1942473176 scopus 로고    scopus 로고
    • Prevention of falls and fall-related fractures in community-dwelling older adults: a meta-analysis of estimates of effectiveness based on recent guidelines
    • Weatherall M. Prevention of falls and fall-related fractures in community-dwelling older adults: a meta-analysis of estimates of effectiveness based on recent guidelines. Intern. Med. J. 2004, 34(3):102-108.
    • (2004) Intern. Med. J. , vol.34 , Issue.3 , pp. 102-108
    • Weatherall, M.1
  • 95
    • 0029935914 scopus 로고    scopus 로고
    • Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT
    • Whisler R.L., Beiqing L., Chen M. Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell Immunol. 1996, 169(2):185-195.
    • (1996) Cell Immunol. , vol.169 , Issue.2 , pp. 185-195
    • Whisler, R.L.1    Beiqing, L.2    Chen, M.3
  • 97
    • 34248674384 scopus 로고    scopus 로고
    • Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation
    • Yeo H., Beck L.H., McDonald J.M., Zayzafoon M. Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation. Bone 2007, 40(6):1502-1516.
    • (2007) Bone , vol.40 , Issue.6 , pp. 1502-1516
    • Yeo, H.1    Beck, L.H.2    McDonald, J.M.3    Zayzafoon, M.4


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