Bone structure and metabolism in a rodent model of male senile osteoporosis

Experimental Gerontology

Volumn 42, Issue 11, 2007, Pages 1099-1108

  Pietschmann, Peter ^a,b   Skalicky, Monika ^c   Kneissel, Michaela ^d   Rauner, Martina ^b   Hofbauer, Günther ^b   Stupphann, Daniela ^a   Viidik, Andrus ^e,f  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d NOVARTIS PHARMA AG   (Switzerland)

^e AARHUS UNIVERSITY   (Denmark)

^f SMZ Sophienspital   (Austria)

Author keywords

Bone formation; Bone resorption; Bone structure; Male osteoporosis; Osteoclast generation; Osteoporosis; RANKL

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE MASS; BONE MATRIX; BONE METABOLISM; BONE MINERALIZATION; BONE STRUCTURE; BONE TURNOVER; CANCELLOUS BONE; CONTROLLED STUDY; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RAT; SENILE OSTEOPOROSIS; SPRAGUE DAWLEY RAT; TIBIA; TRABECULAR BONE;

ADIPONECTIN; AGING; ANIMALS; BIOLOGICAL MARKERS; BONE RESORPTION; CYTOKINES; IMMUNOPHENOTYPING; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MALE; MODELS, ANIMAL; OSTEOBLASTS; OSTEOCLASTS; OSTEOPOROSIS; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY; TIBIA; TOMOGRAPHY, X-RAY COMPUTED;

ANIMALIA; MAMMALIA; RATTUS; RODENTIA;

EID: 35448955695     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2007.08.008     Document Type: Article

References (63)

1. Abrahamsen B., Hjelmborg J., Kostenuik P., Stilgren L.S., Kyvik K., Adamu S., and Langdahl B.L. Circulating amounts of osteoprotegerin and RANK ligand: genetic influence and relationship with BMD assessed in female twins. Bone 36 (2005) 727-735
2. Amin S. Male osteoporosis: epidemiology and pathophysiology. Curr. Osteoporos. Rep. 1 (2003) 71-77
3. Anonymous. Osteoporosis prevention, diagnosis and therapy. JAMA 285 (2001) 785-795
4. Buhling F., Gerber A., Hackel C., Kruger S., Kohnlein T., Bromme D., Reinhold D., Ansorge S., and Welte T. Expression of cathepsin K in lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 20 (1999) 612-619
5. Cao J., Wronski T.J., Iwaniec U., Phleger L., Kurimoto P., Boudignon B., and Halloran B.P. Aging increases stromal/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse. J. Bone Miner. Res. 20 (2005) 1659-1668
6. Cao J., Venton L., Sakata T., and Halloran B. Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice. J. Bone Miner. Res. 18 (2003) 270-277
7. Cauley J.A. Osteoporosis in Men: prevalence and investiagtion. Clin. Cornerstone 8 (2006) S20-S25
8. Clowes J.A., Khosla S., and Eastell R. Potential role of pancreatic and enteric hormones in regulating bone turnover. J. Bone. Miner. Res. 20 (2005) 1497-1502
9. Ducy P., Schinke T., and Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science 289 (2000) 1501-1504
10. Eghbali-Fatourechi G., Khosla S., Sanyal A., Boyle W.J., Lacey D.L., and Riggs B.L. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J. Clin. Invest. 111 (2003) 1221-1230
11. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottavini E., and De Benedictis G. Inflamm-aging. An evolutionary perspective on immunoscenescene. Ann NY Acad Sci 908 (2000) 244-254
12. Franceschi C., Valensin S., Bonafe M., Paolosso G., Yashin A.I., Monti D., and De Benedictis G. The network and the remodeling theories of aging: historical background and new perspectives. Exp. Gerontol. 35 (2000) 879-896
13. Fowlkes J.L., Thrailkill K.M., Liu L., Wahl E.C., Bunn R.C., Cockrell G.E., Perrien D.S., Aronson J., and Lumpkin C.K. Effects of systemic and local administration of recombinant human IGF-1 (hrIGF-1) on de novo bone formation in an aged mouse model. J. Bone. Miner. Res. 21 (2006) 1359-1366
14. Gilbert L., He X., Farmer P., Boden S., Kozlowski M., Rubin J., and Nanes M.S. Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology 141 (2000) 3956-3964
15. Groessner-Scheiber B., Krukowski M., Lyons C., and Osdoby P. Osteoclast recruitment in response to human bone matrix is age related. Mech. Ageing Dev. 62 (1992) 143-154
16. Halleen J.M., Tiitinen S.L., Ylipahkala H., Fagerlund K.M., and Vaananen H.K. Tartrate-resistant acid phosphatase 5 b (TRAP5b) as a marker of bone resorption. Clin. Lab. 52 (2006) 499-509
17. Hansalik M., Skalicky M., and Viidik A. Impairment of water maze behaviour with ageing is counteracted by maze learning earlier in life but not by physical exercise, food restriction or housing conditions. Exp. Geront. 42 (2006) 169-174
18. Hofbauer L.C., and Schoppet M. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA 292 (2004) 490-495
19. Holloway W., Collier F.M., Aitken C.J., Myers D.E., Hodge J.M., Malakellis M., Gough T.J., Collier G.R., and Nicholson G.C. Leptin inhibits osteoclast generation. J. Bone Miner. Res. 17 (2002) 200-209
20. Jilka R.L., Weinstein R.S., Bellido T., Parfitt A.M., and Manolagas S.C. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J. Bone Miner. Res. 13 (1998) 793-802
21. Kakaguchi H., Manabe N., Miyaura C., Chikuda H., Nakamura K., and Kuro-o M. Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. J. Clin. Invest. 104 (1999) 229-237
22. Kalu D.N., Liu C.C., Hardin R.R., and Hollis B.W. The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 124 (1989) 7-16
23. Kerschan-Schindl K., Wendlova J., Kudlacek S., Gleiss A., Woloszcuk W., and Pietschmann P. Serum levels of RANKL in healthy women and men. Osteoporosis Int. 17 (2006) S216
24. Kerschan-Schindl K., Hawa G., Kudlacek S., Woloszuczuk W., and Pietschmann P. Serum levels of cathepsin K decrease with age in both women and men. Exp. Gerontol. 40 (2005) 532-535
25. Kneissel M., Boyde A., and Gasser J.A. Bone tissue and mineralization in aged estrogen-depleted rats after 9 month intermittent treatment with PTH analogue SDZ PTS 893 or hPTH-(1-34). Bone 28 (2001) 237-250
26. Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., Morony S., Oliveirados-Santos A.J., Van G., Itie A., Khoo W., Wakeham A., Dunstan C.R., Lacey D.L., Mak T.W., Boyle W.J., and Penninger J.M. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397 (1999) 315-323
27. Korenman SG., Morley JE., Mooradian AD., Davis SS., Kaiser FE., Silver AJ., Viosca SP., and Garza D. Secondary hypogonadism in older men: its relation to impotence. J. Clin. Endocrinol. Metab. 71 4 (1990) 963-969
28. Koshihara Y., Suematsu A., Feng D., Okawara R., Ishibashi H., and Yamamoto S. Osteoclastogenic potential of bone marrow cells increases with age in elderly women with fracture. Mech. Ageing Dev. 123 (2002) 1321-1331
29. Kovacs E.J. Aging, traumatic injury, and estrogen treatment. Exp. Gerontol. 40 (2005) 549-555
30. Kukita T., Kukita A., Hata K., and Kurisu K. 12-O-Tetradecanoylphorbol-13-acetate inhibits osteoclast-like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons. Endocrinology 130 (1992) 577-584
31. Lam K.S., and Xu A. Adiponectin: protection of the endothelium. Curr. Diab. Rep. 5 (2005) 254-259
32. Liu J.M., Zhao H.Y., Ning G., Zhao Y.J., Chen Y., Zhang Z.H., Sun L.H., Xu M.Y., and Chen C.L. Relationships between the changes of serum levels of OPG and RANKL with age, menopause, bone chemical markers and bone mineral density in Chinese women aged 20-75. Calcif. Tissue Int. 76 (2005) 1-6
33. Lombardi G., Tauchmanova L., Di Somma C., Musella T., Rota F., Ravanelli M.C., and Colao A. Somatopause: dismetabolic and bone effects. J. Endocrinol. Invest. 28 (2005) 36-42
34. Makhluf H.A., Mueller S.M., Mizuno S., and Glowacki J. Age-related decline in osteoprotegerin expression by human bone marrow cells cultured in three-dimensional collagen sponges. BBRC 268 (2000) 669-672
35. Mastrogiacomo I., Feghali G., Foresta C., and Ruzza G. Andropause: incidence and pathogenesis. Arch. Androl. 9 4 (1982) 293-296
36. Miller S.C., Bowman B.M., and Jee W.S. Available animal models of osteopenia - small and large. Bone 17 (1995) 117S-123S
37. Narath E., Skalicky M., and Viidik A. Voluntary and forced exercise influence the survival and body composition of ageing male rats differently. Exp. Gerontol. 36 (2001) 1699-1711
38. Novelli M., Pocai A., Skalicky M., Viidik A., Bergamini E., and Masiello P. Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing rats. Exp. Gerontol. 39 (2004) 1333-1340
39. Obermayer-Pietsch B. Genetics of osteoporosis. Wien Med Wochenschr 156 (2006) 162-167
40. Oshima K., Nampei A., Matsuda M., Iwaki M., Fukuhara A., Hashimoto J., Yashikawa H., and Shimomura I. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. BBRC 331 (2005) 520-526
41. Patel M.B.R., Arden N.K., Masterson L.M., Phillips D.I.W., Swaminathan R., Syddall H.E., Byrne C.D., Wood P.J., Cooper C., and Holf R.I.G. Investigating the role of growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD). Bone 37 (2005) 833-841
42. Patsch J., Muschitz C., Resch H., and Pietschmann P. Of mice and men: pathophysiology of male osteoporosis. JMHG 4 (2007) 87-93
43. Perkins S.L., Gibbons R., Kling S., and Kahn A.J. Age-related bone loss in mice is associated with an increased osteoclast progenitor pool. Bone 15 (1994) 65-72
44. Pietschmann P., and Kerschan-Schindl K. Osteoporosis: gender-specific aspects. Wien Med. Wochenschr. 154 (2004) 411-415
45. Pietschmann P., Gollob E., Brosch S., Hahn P., Kudlacek S., Willheim M., Woloszczuk W., Peterlik P., and Tragl KH. The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism. Exp. Gerontol. 38 (2003) 1119-1127
46. Rauner M., Sipos W., and Pietschmann P. Osteoimmunology. Int. Arch. Allergy Immunol. 143 (2007) 31-48
47. Rissanen J.P., Suominen M.I., Oksala R., Ravanti L., Kallio P.J., and Halleen J.M. The ratio of osteoclast activity/osteoclast number (CTX/TRAP 5b) is a useful parameter in experimental rat models of osteoporosis. J. Bone Miner. Res. 21 (2006) S233
48. Russo C.R., Lauretani F., Bandinelli S., Bartali B., Di Iorio A., Volpato S., Guralnik J.M., Harris T., and Ferrucci L. Aging bone in men and women: beyond changes in bone mineral density. Osteoporos Int. 14 (2003) 531-538
49. Salminen-Mankonen HJ., Morko J., and Vuorio E. Role of cathepsin K in normal joints and in the development of arthritis. Curr. Drug Targets 8 2 (2007) 315-323
50. Scarpace P., and Zhang Y. Elevated leptin: consequences or cause of obesity? Frontiers in Bioscience 12 (2007) 3531-3544
51. Schondorf T., Maiworm A., Emmison N., Forst T., and Pfutzner A. Biological background and role of adiponectin as marker for insulin resistance and cardiovascular diseases. Clin. Lab. 51 (2005) 489-494
52. Szulc P., Garnero P., Munoz F., Marchand F., and Delmas P.D. Cross-sectional evaluation of bone metabolism in men. J. Bone Miner. Res. 16 (2001) 1642-1650
53. Tepel C., Bromme D., Herzog V., and Brix K. Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. J. Cell. Sci. 113 Pt 24 (2000) 4487-4498
54. Trayhurn P., Bing Chen., and Wood IS. Adipose tissue and adipokines - energy regulation from the human perspective. J. Nutr. 136 (2006) 1935S-1939S
55. Trippel S.B. Potential role of insulin like growth factors in fracture healing. Clin. Orthop. Relat. Res. 355 (1998) S301-S313
56. Troen B.R. Molecular mechanisms underlying osteoclast formation and activation. Exp. Gerontol. 38 (2003) 605-614
57. Tsai K.S., Pan W.H., Hsu S.H., Cheng W.C., Chen C.K., Chieng P.U., Yang R.S., and Twu S.T. Sexual differences in bone markers and bone mineral density of normal Chinese. Calcif. Tissue Int. 59 (1996) 454-460
58. Vanderschueren D., Gevers G., Raymaekers G., Devos P., and Dequeker J. Sex- and age-related changes in bone and serum osteocalcin. Calcif. Tissue Int. 46 (1990) 179-182
59. Vanderschueren D., Van Herck E., Suiker AM., Visser WJ., Schot LPC., and Bouillon R. Bone and mineral metabolism in aged male rats: Short and long term effects of androgen deficiency. Endocrinology 130 (1992) 2906-2916
60. Wang L., Banu J., McMahan C.A., and Kalu D.N. Male rodent model of age-related bone loss in men. Bone 29 (2001) 141-148
61. Willheim M., Thien R., Schrattbauer K., Bajna E., Holub M., Gruber R., Baier K., Pietschmann P., Reinisch W., Scheiner O., and Peterlik M. Regulatory effects of 1α,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. J. Clin. Endocrinol. Metabol. 84 (1999) 3739-3744
62. Xiao Y., Junfeng H., Tianhong L., Lu W., Shulin C., Yu Z., Xiaohua L., Weixia J., Sheng Z., Yanyun G., Guo L., and Min L. Cathepsin K in adipocyte differentiation and its potential role in the pathogenesis of obesity. J. Clin. Endocrinol. Metab. 91 (2006) 4520-4527
63. Yamaguchi N., Kukita T., Li Y., Argueta J.G.M., Saito T., Hanazawa S., and Yamashita Y. Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans. FEMS Immunol. Med. Microbiol. 49 (2007) 28-34