Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction

Annals of the New York Academy of Sciences

Volumn 1117, Issue , 2007, Pages 138-142

  Celil Aydemir, Ayse B ^a   Lee, Stephenie ^a   Dae, Won Kim ^b   Gardner, Thomas R ^a   Prince, Daniel ^a   Jae, Mok Ahn ^c   Lee, Francis Young In ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c Hallym University   (South Korea)

Author keywords

Cox2; Fluid shear stress; NFAT

Indexed keywords

CALCINEURIN; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN FUNCTION; SHEAR STRESS; SIGNAL TRANSDUCTION;

EID: 36549025436     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1402.004     Document Type: Conference Paper

References (8)

1. HUGHES-FULFORD, M. 2004. Signal transduction and mechanical stress. Sci. STKE. 249: re12.
2. DONAHUE, T.L., T.R. HAUT, C.E. YELLOWLEY, et al. 2003. Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport. J. Biomech. 36: 1363-1371.
3. YOU, J., G.C. REILLY, X. ZHEN, et al. 2001. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J. Biol. Chem. 276: 133365-133371.
4. IQBAL, J. & M. ZAIDI. 2005. Molecular recognition of mechanotransduction. Bioch. Biophys. Res. Commun. 328: 751-755.
5. IM, S.H. & A. RAO. 2004. Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling. Mol. Cells 18: 1-9.
6. HUNG, C.T., S.R. POLLACK, T.M. REILLY & C.T. BRIGHTON. 1995. Real-time calcium response of cultured bone cells to fluid flow. Calcif. Tissue Intl. 60: 48-53.
7. FRANGOS, J.A., L.V. MCINTIRE & S.G. ESKIN. 1988. Shear stress induced stimulation of mammalian cell metabolism. Biotech. Bioeng. 32: 1053-1060.
8. RIDDLE, R.C., A.F. TAYLOR, D.C. GENETOS & H.J. DONAHUE. 2006. MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am. J. Physiol. Cell Physiol. 290: C776-C784.