In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization

Osteoporosis International

Volumn 21, Issue 4, 2010, Pages 667-677

  Boivin, G ^a,b   Farlay, D ^a,b   Khebbab, M T ^a,b   Jaurand, X ^b   Delmas, P D ^a   Meunier, P J ^a  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ DE LYON   (France)

Author keywords

Bone mineralization; Postmenopausal osteoporosis; Quantitative microradiography; Strontium ranelate; X ray cartography; X ray microanalysis

Indexed keywords

CALCIUM; PHOSPHORUS; PLACEBO; STRONTIUM RANELATE;

ARTICLE; BONE BIOPSY; BONE MINERAL; BONE MINERALIZATION; CANCELLOUS BONE; CORTICAL BONE; DRUG BLOOD LEVEL; DRUG BONE LEVEL; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG SAFETY; DRUG UPTAKE; FEMALE; HUMAN; HUMAN TISSUE; MICRORADIOGRAPHY; OSSIFICATION; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TREATMENT DURATION; X RAY MICROANALYSIS;

AGED; BIOPSY; BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CALCIFICATION, PHYSIOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTRON PROBE MICROANALYSIS; FEMALE; HUMANS; ILIUM; MICRORADIOGRAPHY; MIDDLE AGED; ORGANOMETALLIC COMPOUNDS; OSTEOPOROSIS, POSTMENOPAUSAL; THIOPHENES;

EID: 77950940515     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-009-1005-z     Document Type: Article

References (41)

1. Meunier PJ, Slosman DO, Delmas PD, Sebert JL, Brandi ML, Albanese C, Lorenc R, Pors Nielsen S, De Vernejoul MC, Roces A, Reginster JY (2002) Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis - a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 87:2060-2066 (Pubitemid 34521489)
2. Meunier PJ, Roux C, Seemar E, Ortolani S, Badurski JE, Spector TM, Cannata J, Balogh A, Lemmel EM, Pors Nielsen S, Rizzoli R, Genant HK, Reginster JY (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350:459-468 (Pubitemid 38133766)
3. Reginster JY, Seeman E, De Vernejoul C, Adami S, Compston J, Phenekos C, Devogelaer JP, Diaz Curiel M, Sawicki A, Goemaere S, Sorensen OH, Felsenberg D, Meunier PJ (2005) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816-2822 (Pubitemid 40686329)
4. Barbara A, Delannoy P, Denis BG, Marie PJ (2004) Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells. Metabolism 53:532-537 (Pubitemid 38419200)
5. Baron R, Tsouderos Y (2002) In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 450:11-17
6. Bonnelye E, Chabadel A, Saltel F, Jurdic P (2008) Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 42:129-138 (Pubitemid 350297175)
7. Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ (1996) The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 18:517-523 (Pubitemid 26257871)
8. MariePJ,HottM,ModrowskiD,DePC,GuillemainJ,DeloffreP,TsouderosY(1993) Anuncouplingagentcontainingstrontiumpreventsbonelossbydepressingboneresorptiona ndmaintainingboneformationinestrogen-deficientrats.JBoneMinerRes8: 607-615(Pubitemid23127921)
9. Takahashi N, Sasaki T, Tsouderos Y, Suda T (2003) S12911-2 inhibits osteoclastic bone resorption in vitro. J Bone Miner Res 18:1082-1087 (Pubitemid 37294946)
10. Zhu LL, Zaidi S, Peng Y, Zhou H, Moonga BS, Blesius A, Dupin-Roger I, Zaidi M, Sun L (2007) Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochem Biophys Res Commun 355:307-311 (Pubitemid 46282628)
11. Ammann P, Shen V, Robin B, Mauras Y, Bonjour JP, Rizzoli R (2004) Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J Bone Miner Res 19:2012-2020 (Pubitemid 41103416)
12. Ammann P, Badoud I, Barraud S, Dayer R, Rizzoli R (2007) Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength. J Bone Miner Res 22:1419-1425 (Pubitemid 351339686)
13. Bain SD, Jerome C, Shen V, Dupin-Roger I, Ammann P (2008) Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants. Osteoporos Int doi:10.1007/s00198-008-0815-8.
14. Marie PJ (2003) Optimizing bone metabolism in osteoporosis: insight into the pharmacologic profile of strontium ranelate. Osteoporos Int 14:S9-S12
15. BoivinG,DeloffreP,PerratB,PanczerG,BoudeulleM,MaurasY,AllainP,TsouderosY, MeunierPJ(1996) Strontiumdistributionandinteractionswithbonemineralinmonkeyiliacboneafterstron tiumsalt(S12911)administration.JBoneMinerRes11:1302-1311(Pubitemid26282531)
16. Cazalbou S, Combes C, Rey C (2002) S12911 treatment maintains bone mineral crystal characteristics. J Bone Miner Res 17:S376-S377
17. Farlay D, Boivin G, Panczer G, Lalande A, Meunier PJ (2005) Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degrees of mineralisation of bone. J Bone Miner Res 20: 1569-1578 (Pubitemid 41243546)
18. LeGeros RZ, Lin S, LeGeros JP, Cazalbou S, Combes C, Dupin Roger I, Rey C (2004) Strontium ranelate treatment preserves bone crystal characteristics and bone mineral reactivity. Osteoporos Int 15:S116-S117
19. BoivinG,MeunierPJ(2002) Changesinboneremodelingrateinfluencethedegreeofmineralizationofbone. ConnectTissueRes43:535-537(Pubitemid34777975)
20. Boivin G, Meunier PJ (2002) Effects of bisphosphonates on matrix mineralization. J Musculoskelet Neuronal Interact 2:538-543
21. Boivin G, Meunier PJ (2002) The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif Tissue Int 70:503-511 (Pubitemid 36929589)
22. Boivin G, Meunier PJ (2003) The mineralization of bone tissue: a forgotten dimension in osteoporosis research. Osteoporos Int 14: S19-S24
23. Boivin G, Meunier PJ (2003) Methodological considerations in measurement of bone mineral content. Osteoporos Int 14 (Suppl 5):S22-S27
24. Boivin G, Bala Y, Doublier A, Farlay D, Ste-Marie LG, Meunier PJ, Delmas PD (2008) The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients. Bone 43:532-538
25. Meunier PJ, Boivin G (1997) Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications. Bone 21:373-377
26. Arlot M, Meunier PJ, Boivin G, Haddock L, Tamayo J, Correa-Rotter R, Jasqui S, Donley DW, Dalsky GP, Martin JS, Eriksen EF (2005) Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters. J Bone Miner Res 20:1244-1253 (Pubitemid 40863814)
27. Misof BM, Roschger P, Cosman F, Kurland ES, Tesch W, Messmer P, Dempster DW, Nieves J, Shane E, Fratzl P, Klaushofer K, Bilezikian J, Lindsay R (2003) Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab 88:1150-1156 (Pubitemid 36337769)
28. Boivin G, Lips P, Ott SM, Harper KD, Sarkar S, Pinette KV, Meunier PJ (2003) Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab 88:4199-4205 (Pubitemid 37153720)
29. Boivin G, Vedi S, Purdie DW, Compston JE, Meunier PJ (2005) Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women. Bone 36:562-567 (Pubitemid 40403855)
30. Boivin GY, Chavassieux PM, Santora AC, Yates J, Meunier PJ (2000) Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone 27:687-694
31. Arlot ME, Jiang Y, Genant HK, Zhao J, Burt-Pichat B, Roux JP, Delmas PD, Meunier PJ (2008) Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res 23:215-222 (Pubitemid 351160035)
32. Boivin G, Meunier PJ (1993) Histomorphometric methods applied to bone. In: Grupe G, Garland AN (eds) Histology of ancient human bone. Springer, Berlin, pp 137-156
33. Basle MF, Mauras Y, Audran M, Clochon P, Rebel A, Allain P (1990) Concentration of bone elements in osteoporosis. J Bone Miner Res 5:41-47
34. Pors Nielsen S (2004) The biological role of strontium. Bone 35:583-588
35. StaubJF,FoosE,CourtinB,JochemsenR,PeraultStaubAM(2003) AnonlinearcompartmentalmodelofSrmetabolism.II. ItsphysiologicalrelevanceforCametabolism.AmJPhysiolRegulIntegrCompPhysiol284: R835-R852(Pubitemid36342818)
36. StaubJF,FoosE,CourtinB,JochemsenR,PeraultStaubAM(2003) AnonlinearcompartmentalmodelofSrmetabolism.I.Non-steady- statekineticsandmodelbuilding.AmJPhysiolRegulIntegrCompPhysiol284: R819-R834(Pubitemid36342817)
37. Dahl SG, Allain P, Marie PJ, Mauras Y, Boivin G, Ammann P, Tsouderos Y, Delmas PD, Christiansen C (2001) Incorporation and distribution of strontium in bone. Bone 28:446-453
38. Marie PJ, Ammann P, Boivin G, Rey C (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69:121-129 (Pubitemid 32912229)
39. LeGeros RZ, Lin S,Mijares D, LeGeros JP (2003) Strontium ranelate treatment preserves bone crystal characteristics and dissolution properties of bone apatite. J Bone Miner Res 18 (Suppl 2):276
40. Parfitt AM (2002) Misconceptions (2): turnover is always higher in cancellous than in cortical bone. Bone 30:807-809
41. Boivin G, Meunier PJ (2004) Inter-individual heterogeneity index of mineralization is an important determinant of the quality of bone. J Bone Miner Res 19 (suppl 1):S114