Differences in the enzymatic efficiency of human and bony fish AID are mediated by a single residue in the C terminus modulating single-stranded DNA binding

FASEB Journal

Volumn 26, Issue 4, 2012, Pages 1517-1525

  Dancyger, Alex M ^a   King, Justin J ^a   Quinlan, Matthew J ^a   Fifield, Heather ^a   Tucker, Stephanie ^a   Saunders, Holly L ^b   Berru, Maribel ^c   Magor, Bradley G ^b   Martin, Alberto ^c   Larijani, Mani ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Antibody diversification; DNA mutating enzymes; Mechanisms of enzyme thermosensitivity

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; AMINO ACID; SINGLE STRANDED DNA;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CATFISH; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; SPECIES DIFFERENCE; STRUCTURE ANALYSIS; TEMPERATURE DEPENDENCE; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CYTIDINE DEAMINASE; DNA, SINGLE-STRANDED; HUMANS; ICTALURIDAE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; ZEBRAFISH;

DANIO RERIO; OSTEICHTHYES;

EID: 84860914465     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-198135     Document Type: Article

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