Cutting Edge: Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune Encephalomyelitis

Journal of Immunology

Volumn 180, Issue 10, 2008, Pages 6457-6461

  Bailey Bucktrout, Samantha L ^a   Caulkins, Sarah C ^a   Goings, Gwendolyn ^a   Fischer, Jens A A ^b   Dzionek, Andrzej ^b   Miller, Stephen D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b MILTENYI BIOTEC GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; MOUSE; MULTIPLE SCLEROSIS; MYELOID DENDRITIC CELL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; RECURRENT DISEASE; T LYMPHOCYTE ACTIVATION; ANIMAL; CENTRAL NERVOUS SYSTEM; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MICE; T-LYMPHOCYTE SUBSETS;

EID: 45549095991     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.10.6457     Document Type: Article

References (24)

1. Hohlfeld, R., and H. Wekerle. 2004. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc. Natl Acad. Sci. USA 101 (Suppl. 2): 14599-14606.
2. Langrish, C. L., Y. Chen, W. M. Blumenschein, J. Mattson, B. Basham, J. D. Sedgwick, T. McClanahan, R. A. Kastelein, and D. J. Cua. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201: 233-240.
3. Veldhoen, M., R. J. Hocking, R. A. Flavell, and B. Stockinger. 2006. Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7: 1151-1156.
4. Vanderlugt, C. L., and S. D. Miller. 2002. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat. Rev. Immunol 2: 85-95.
5. McMahon, E. J., S. L. Bailey, C. V. Castenada, H. Waldner, and S. D. Miller. 2005. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 11:335-339.
6. H-17 cells in relapsing EAE. Nat. Immunol. 8: 172-180.
7. Lande, R., J. Gregorio, V. Facchinetti, B. Chatterjee, Y. H. Wang, B. Homey, W. Cao, Y. H. Wang, B. Su, F. O. Nestle, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449: 564-569.
8. Means, T. K., E. Larz, F. Hayashi, M. R. Murali, D. T. Golenbock, and A. D. Luster. 2005. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115: 407-417.
9. Pashenkov, M., Y. M. Huang, V. Kosrulas, M. Haglund, M. Soderstrom, and H. Link. 2001. Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 124: 480-492.
10. Gottenberg, J. E., N. Cagnard, C. Lucchesi, F. Letourneur, S. Mistou, T. Lazure, S. Jacques, N. Ba, M. Irtah, C. Lepajolec, et al. 2006. Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome. Proc. Natl. Acad. Sci. USA 103: 2770-2775.
11. Blanco, P., A. K. Palucka, M. Gill, V. Pascual, and J. Banchereau. 2001. Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus. Science 294: 1540-1543.
12. Munn, D. H., M. D. Sharma, D. Hou, B. Baban, J. R. Lee, S. J. Antonia, J. L. Messina, P. Chandler, P. A. Koni, and A. L. Mellor. 2004. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J. Clin. Invest. 114: 280-290.
13. Tompkins, S. M., J. Padilla, M. C. Dal Canto, J. P. Ting, L. Van Kaer, and S. D. Miller. 2002. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J. Immunol. 168: 4173-4183.
14. Asselin-Paturel, C., G. Brizard, J. J. Pin, F. Briere, and G. Trinchieri. 2003. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol. 171: 6466-6477.
15. Krug, A., A. R. French, W. Barchet, J. A. Fischer, A. Dzionek, J. T. Pingel, M. M. Orihuela, S. Akira, W. M. Yokoyama, and M. Colonna. 2004. TLR9-depen-dent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21: 107-119.
16. +, T cells by plasmacytoid dendritic cells. J. Exp. Med. 204: 1923-1933.
17. Kawakami, N., S. Lassmann, Z. Li, F. Odoardi, T. Ritter, T. Ziemssen, W. E. Klinkert, J. W. Ellwart, M. Bradl, K. Krivacic, et al. 2004. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J. Exp. Med. 199:185-197.
18. + dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 100: 383-390.
19. Ochando, J. C., C. Homma, Y. Yang, A. Hidalgo, A. Garin, F. Tacke, V. Angeli, Y. Li, P. Boros, Y. Ding, et al. 2006. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat. Immunol. 7: 652-662.
20. Mellor, A. L., and D. H. Munn. 2004. IDO expression by dendritic cells: tolerance and tryptophan embolism. Nat. Rev. Immunol. 4: 762-774.
21. Meyers, J. A., A. J. Mangini, T. Nagai, C. F. Roff, D. Sehy, G. A. van Seventer, and J. M. van Seventer. 2006. Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-γ and IL-17 secretion by activated human PBMC. Cytokine 35: 235-246.
22. Barchet, W., M. Cella, and M. Colonna. 2005. Plasmacytoid dendritic cells-virus experts of innate immunity. Semin. Immunol. 17: 253-261.
23. Rudick, R. A., R. M. Ransohoff, J. C. Lee, R. Peppier, M. Yu, P. M. Mathisen, and V. K. Tuohy. 1998. In vivo effects of interferon β-1a on immunosuppressive cytokines in multiple sclerosis. Neurology 50: 1294-1300.
24. Tuohy, V. K., M. Yu, L. Tin, P. M. Mathisen, J. M. Johnson, and J. A. Kawczak. 2000. Modulation of the IL-10/IL-12 cytokine circuit by interferon-β inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis. J. Neuroimmunol. 111: 55-63.