Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

Journal of Clinical Investigation

Volumn 108, Issue 5, 2001, Pages 703-708

  Aucouturier, Pierre ^a,b   Geissmann, Frédéric ^a   Damotte, Diane ^a   Saborio, Gabriela P ^c   Meeker, Harry C ^d   Kascsak, Regina ^d   Kascsak, Richard ^d   Carp, Richard I ^d   Wisniewski, Thomas ^b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

^d NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; DENDRITIC CELL; DISEASE TRANSMISSION; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; SCRAPIE; SPLEEN CELL;

ADOPTIVE TRANSFER; ANIMALS; DENDRITIC CELLS; GENES, RAG-1; INTEGRIN ALPHAXBETA2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PRIONS; PRPSC PROTEINS; SCRAPIE; SPLEEN;

EID: 0034798246     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200113155     Document Type: Article

References (24)

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18. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins
19. B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice
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22. Pathogenesis of mouse scrapie: Distribution of agent in the pulp and stroma of infected spleens
23. PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice
24. Sites of priori protein accumulation in scrapie-infected mouse spleen revealed by immune-electron microscopy