A P-loop mutation in Gα subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis

PLoS Pathogens

Volumn 8, Issue 2, 2012, Pages

  Bosch, Dustin E ^a   Willard, Francis S ^a,e   Ramanujam, Ravikrishna ^b,c   Kimple, Adam J ^a   Willard, Melinda D ^a,e   Naqvi, Naweed I ^b,c,d   Siderovski, David P ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Temasek Life Sciences Laboratory   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM DERIVATIVE; ALUMINUM TETRAFLUORIDE; ARGININE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; KB 1753; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MUTANT PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING MOTIF; FUNGAL STRAIN; FUNGUS; GENE LOCUS; GENE MUTATION; HYDROLYSIS; INTRACELLULAR SIGNALING; NONHUMAN; PATHOGENESIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; HORDEUM; MAGNAPORTHE; METABOLISM; MICROBIOLOGY; MYCOSIS; PATHOGENICITY; PHYSIOLOGY; PLANT DISEASE; PLANT LEAF; POINT MUTATION; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

FUNGI; MAGNAPORTHE GRISEA; MAGNAPORTHE ORYZAE; THESPESIA GRANDIFLORA;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GTP-BINDING PROTEIN ALPHA SUBUNITS; HORDEUM; MAGNAPORTHE; MODELS, MOLECULAR; MUTANT PROTEINS; MYCOSES; PLANT DISEASES; PLANT LEAVES; POINT MUTATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 84860907660     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002553     Document Type: Article

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