Structural determinants of affinity enhancement between GoLoco motifs and G-protein α subunit mutants

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3351-3358

  Bosch, Dustin E ^a   Kimple, Adam J ^a   Sammond, Deanne W ^a   Muller, Robin E ^a   Miley, Michael J ^a   Machius, Mischa ^a   Kuhlman, Brian ^a   Willard, Francis S ^a   Siderovski, David P ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC-CELLS; BINDING AFFINITIES; BINDING ENTHALPIES; FLUORESCENCE POLARIZATION; G PROTEIN; HYDROPHOBIC SURFACES; ISOTHERMAL TITRATION CALORIMETRY; MONTE CARLO SIMULATION; PEPTIDE BINDING; POINT MUTATIONS; PROTEIN DESIGN; RATE OF DISSOCIATION; SIDE CHAINS; STRUCTURAL DETERMINANTS; STRUCTURE-BASED; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; CELL PROLIFERATION; COMPLEXATION; COMPUTER SIMULATION; HYDROPHOBICITY; MONTE CARLO METHODS; PEPTIDES; SURFACE CHEMISTRY;

CRYSTAL STRUCTURE;

CELL PROTEIN; GOLOCO MOTIF PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; UNCLASSIFIED DRUG; PEPTIDE;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION; ENTHALPY; ENTROPY; FLUORESCENCE POLARIZATION; GAIN OF FUNCTION MUTATION; GENE MUTATION; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MONTE CARLO METHOD; MUTATIONAL ANALYSIS; POINT MUTATION; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; SYNTHESIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 79952801398     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.190496     Document Type: Article

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