A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus

European Journal of Neuroscience

Volumn 10, Issue 12, 1998, Pages 3898-3902

  Pankratov, Yuri ^a   Castro, Enrique ^b   Miras Portugal, Maria Teresa ^b   Krishtal, Oleg ^b  

^a BOGOMOLETZ INSTITUTE OF PHYSIOLOGY   (Ukraine)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

ATP gated channel; Hippocampus; P2X purinoceptor; Synaptic transmission

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ADENOSINE TRIPHOSPHATE; PURINE P2X RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ADENOSINE TRIPHOSPHATE; ANIMALS; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; HIPPOCAMPUS; NEURONS; ORGAN CULTURE TECHNIQUES; PLATELET AGGREGATION INHIBITORS; PYRIDOXAL PHOSPHATE; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; STIMULATION, CHEMICAL;

EID: 0032465105     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00419.x     Document Type: Article

References (22)

1. Balachandran, C. & Bennett, M.R. (1996) ATP-activated cationic and anionic conductances in cultured rat hippocampal neurons. Neurosci. Lett., 204, 73-76.
2. Balcar, V.J., Li, Y., Killinger, S. & Bennett, M.R. (1995) Autoradiography of P2x ATP receptors in the rat brain. Br. J. Pharmacol., 115, 302-306.
3. 3H]alpha,beta-methylene ATP binding sites in rat brain and spinal cord. Neuroreport, 5, 1601-1604.
4. Buell, G., Lewis, C., Collo, G., North, R.A. & Suprenant, A. (1996) An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J., 15, 55-62.
5. Collo, G., North, R.A., Kawashima, E., Merlo-Pich, E., Neidhart, S., Surprenant, A. & Buell, G. (1996) Cloning of P2X5 and P2X6 receptors and the distributions and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16, 2495-2507.
6. Edwards, F.A., Gibb, A.J. & Colquhoun, D. (1992) ATP receptor-mediated currents in the central nervous system. Nature, 359, 144-147.
7. Edwards, F.A., Robertson, S.J. & Gibb, A.J. (1997) Properties of ATP receptor-mediated synaptic transmission in the rat medial habenula. Neuropharmacology, 36, 1253-1268.
8. Hamann, M. & Attwell, D. (1996) Non-synaptic release of ATP by electrical stimulation in slices of rat hippocampus, cerebellum and habenula. Eur. J. Neurosci., 8, 1510-1515.
9. Illes, P., Nieber, K. & Norenberg, W. (1996) Electrophysiological effects of ATP on brain neurones. J. Auton. Pharmacol., 16, 407-411.
10. Inoue, K., Nakazawa, K., Fujimori, K., Watano, T. & Takanaka, A. (1992) Extracellular adenosine 5′-triphosphate-evoked glutamate release in cultured hippocampal neurons. Neurosci. Lett., 134, 215-218.
11. Kidd, E.J., Grahames, C.B., Simon, J., Michel, A.D., Barnard, E.A. & Humphrey, P.P. (1995) Localization of P2X purinoceptor transcripts in the rat nervous system. Mol. Pharmacol., 48, 569-573.
12. Lambrecht, G., Friebe, T., Grimm, U., Windscheif, U., Bungardt, E., Hildebrandt, C., Baumert, H.G., Spatz-Kumbel, G. & Mutschler, E. (1992) PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur. J. Pharmacol., 217, 217-219.
13. Le, K.T., Villeneuve, P., Ramjaun, A.R., McPherson, P.S., Beaudet, A. & Seguela, P. (1998) Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors. Neuroscience, 83, 177-190.
14. 3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature, 377, 432-435.
15. 2+ potentiates excitatory action of ATP on mammalian neurons. Proc. Natl. Acad. Sci. USA, 90, 8264-8267.
16. Motin, L. & Bennett, M.R. (1995) Effect of P2-purinoceptor antagonists on glutamatergic transmission in the rat hippocampus. Br. J. Pharmacol., 115, 1276-1280.
17. Nieber, K., Poelchen, W. & Illes, P. (1997) Role of ATP in fast excitatory synaptic potentials in locus coeruleus neurones of the rat. Br. J. Pharmacol., 122, 423-431.
18. Simon, J., Kidd, E.J., Smith, F.M., Chessel, I.P., Murrel-Lagnado, R., Humphrey, P.P.A. & Barnard, E.A. (1997) Localization and functional expression of splice variants of the P2X2 receptor. Mol. Pharmacol., 52, 237-248.
19. Soto, F., Garcia-Guzman, M., Gomez-Hernandez, J.M., Hollmann, M., Karschin, C. & Stuehmer, W. (1996) P2X4: An ATP-activated ionotropic receptor cloned from rat brain. Proc. Natl Acad. Sci. USA, 93, 3684-3688.
20. Soto, F., García-Guzmán, M. & Stuhmer, W. (1997) Cloned ligand-gated channels activated by extracellular ATP (P2X receptors). J. Membrane Biol., 160, 91-100.
21. Wieraszko, A., Goldsmith, G. & Seyfried, T.N. (1989) Stimulation-dependent release of adenosine triphosphate from hippocampal slices. Brain Res., 485, 244-250.
22. Zimmermann, H. (1994) Signalling via ATP in the nervous system. Trends Neurosci., 17, 420-426.