Independent receptors for diadenosine pentaphosphate and ATP in rat midbrain single synaptic terminals

European Journal of Neuroscience

Volumn 14, Issue 6, 2001, Pages 918-926

  Diaz Hernandez M ^a   Pintor, J ^a   Castro, E ^a   Miras Portugal, M T ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

ATP; Calcium voltage channels; Diadenosine polyphosphates; Microfluorimetry; Synaptosomes

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; DIADENOSINE PENTAPHOSPHATE; DINUCLEOTIDE; FURA 2 ACETOXYMETHYL ESTER; IONOTROPIC RECEPTOR; POTASSIUM ION; PURINE P2X RECEPTOR; RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CHANNEL GATING; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; MALE; MESENCEPHALON; MICROFLUOROMETRY; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; RAT; SYNAPSE;

ANIMALS; CALCIUM; COLORING AGENTS; DINUCLEOSIDE PHOSPHATES; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; MESENCEPHALON; PRESYNAPTIC TERMINALS; PYRIDOXAL PHOSPHATE; RATS; RATS, WISTAR; RECEPTORS, DRUG; RECEPTORS, PURINERGIC P2; SYNAPTOPHYSIN;

EID: 0035783453     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01703.x     Document Type: Article

References (46)

1. Boehm, S. (1994) Noradrenaline release from rat sympathetic neurons evoked by P2-purinoceptor activation. Naunyn-Schmiedeberg's Arch. Pharmacol., 350, 454-460.
2. Burgstahler, B. & Grafe, P. (2001) Diadenosine pentaphosphate is more potent than ATP at P2X receptors in isolated rat vagus nerve. Neuroreport, 12, 679-682.
3. Carbone, E. & Swandulla, D. (1989) Neuronal calcium channel: Kinetics, blockade and modulation. Pro. Biophys. Mol. Biol., 54, 31-58.
4. Cho, K.O., Hunt, C.A. & Kennedy, M.B. (1992) The rat brain post-synaptic density fraction contains a homologue of the Drosophila discs large tumor suppressor protein. Neuron, 9, 929-942.
5. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16, 2495-2507.
6. 3 subunits. Neurosci. Lett., 301, 159-162.
7. Díaz-Hernández, M., Pintor, J. & Miras-Portugal, M.T. (2000) Modulation of the dinucleotide receptor present in rat midbrain synaptosomes by adenosine and ATP. Br. J. Pharmacol., 130, 434-440.
8. Dunkley, P.R., Jarvie, P.E., Heath, J.W., Kidd, G.J.E. & Rostas, J.A.P. (1986) A rapid method for isolation of synaptosomes on percoll gradients. Brain Res., 372, 115-129.
9. Edwards, F.A., Gibb, A.J. & Colquhoun, D. (1992) ATP receptor-mediated synaptic currents in the central nervous system. Nature, 359, 144-147.
10. Evans, R.J., Derkach, V. & Supernant, A. (1992) ATP mediates fast synaptic transmission in mammalian neurons. Nature, 357, 503-505.
11. Giraldez, L., Diaz-Hernández, M., Gomez-Villafuertes, R., Pintor, J., Castro, E. & Miras-Portugal, M.T. (2001) ATP and diadenosine polyphosphate receptors in rat basal ganglia aminergic terminals. J. Neurosci. Res., 64, 174-182.
12. Gómez-Villafuertes, R., Gualix, J. & Miras-Portugal, M.T. (2001) Single GABAergic synaptic terminals from rat midbrain exhibit functional P2X and dinucleotide receptor, able to induce GABA secretion. J. Neurochem., 77, 84-93.
13. Grynkiewicz, G., Poenie, M. & Tsien, R.Y. (1985) A new generation of fluorescent calcium indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
14. Gu, J.G. & MacDermott, A.B. (1997) Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature, 389, 749-753.
15. Hoyle, C.H.V., Pintor, J., Gualix, J. & Miras-Portugal, M.T. (1997) Antagonism of P2X receptors in guinea-pig vas deferens by diinosine pentaphosphate. Eur. J. Pharmacol., 333, R1-R2.
16. 2B receptor stimulation and other signals couple to Gs proteins in type1 cerebellar astrocytes. Glia, 2, 119-129.
17. Khakh, B.S. & Henderson, G. (2000) Modulation of fast synaptic transmission by presynaptic ligand-gated ion channels. J. Autonom. Nerv. Sys., 81, 110-121.
18. 1 receptors. Br. J. Pharmacol., 128, 981-988.
19. Klishin, A., Lozoyova, N., Pintor, J., Miras-Portugal, M.T. & Krishtal, O.A. (1998) Possible functional role of diadenosine polyphosphates: Negative feedback for excitation in hippocampus. Neuroscience, 58, 235-236.
20. Lehman-Horn, F. & Jurkat-Rott, K. (1999) Voltage-gated ion channels and hereditary disease. Pharmacol. Rev., 79, 1317-1372.
21. Lev-Ram, V., Miyakawa, H., Lasser-Ross, N. & Ross, W.N. (1992) Calcium transient in cerebellar Purkinje neurons evoked by intracellular stimulation. J. Neurophysiol., 68, 1167-1177.
22. 2+ signals mediated by P2X-type purinoceptors in cultured cerebellar Purkinje cells. J. Neurosci., 18, 1704-1712.
23. McGehee, D.S. & Role, L.W. (1996) Neurobiology: Memories of nicotine. Nature, 383, 670-671.
24. Miras-Portugal, M.T., Gualix, J., Mateo, J., Díaz-Hernández, M., Gómez-Villafuertes, R., Castro, E. & Pintor, J. (1999) Diadenosine polyphosphates, extracellular function and catabolism. Prog. Brain Res., 120, 397-409.
25. Miras-Portugal, M.T., Gualix, J. & Pintor, J. (1998) The neurotransmitter role of diadenosine polyphosphates. FEBS Lett., 430, 78-82.
26. Nordmann, J.J., Dayanithi, G. & Lemos, J.R. (1987) Isolated neurosecretory nerve endings as a tool for studying the mechanism of stimulus-secretion coupling. Biosci. Report, 7, 411-426.
27. North, R.A. & Surprenant, A. (2000) Pharmacology of cloned P2X receptors. Annu. Rev. Pharmacol. Toxicol., 40, 563-580.
28. Pintor, J., Díaz-Hernández, M., Gualix, J., Gómez-Villafuertes, R., Hernando, F. & Miras-Portugal, M.T. (2000) Diadenosine polyphosphate receptors from rat and guinea-pig brain to human nervous system. Pharmacol. Ther., 87, 103-115.
29. Pintor, J., Gualix, J. & Miras-Portugal, M.T. (1997a) Diinosine polyphosphates, a group of dinucleotides with antagonistic effects on diadenosine polyphosphate receptor. Mol. Pharmacol., 51, 277-284.
30. 1 purinoceptors. Br. J. Pharmacol., 119, 1006-1012.
31. Pintor, J. & Miras-Portugal, M.T. (1995) A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat midbrain synaptosomes. Br. J. Pharmacol., 115, 895-902.
32. 2+ transients in guinea-pig brain via receptors distinct from those for ATP. J. Physiol. (Lond.), 504, 327-335.
33. 2+ influx distinct from ATP-mediated influx. J. Neurosci. Res., 44, 478-489.
34. Poenie, M. (1990) Alteration of intracellular fura-2 fluorescence by viscosity: A simple correction. Cell Calcium, 11, 85-91.
35. Salter, M.W., De-Koninck, Y. & Henry, J.L. (1993) Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn. Prog. Neurobiol., 41, 125-156.
36. 1-purinoceptor. Br. J. Pharmacol., 118, 167-173.
37. Varadi, G., Mori, Y., Mikala, G. & Schwartz, A. (1995) Molecular determinants of Ca2+ channel function and drug action. Trends Pharmacol. Sci., 16, 43-49.
38. 2+ dependent regulation of presynaptic stimulus secretion coupling. J. Neurochem., 53, 1188-1194.
39. 2+ channels in cultured rat neocortical neurons. Neuroscience, 93, 491-496.
40. Webb, T.E., Feolde, E., Vigne, P., Neary, J.T., Runberg, A., Frelin, C. & Barnard, E.A. (1996a) The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase. Br. J. Pharmacol., 119, 1385-1392.
41. 3 activated preferentially by nucleoside diphosphates. Mol. Pharmacol., 50, 258-265.
42. Wiedenmann, B. & Franke, W.W. (1985) Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell, 41, 1017-1028.
43. Wildman, S.S., Brown, S.G., King, B.F. & Burnstock, G. (1999) Selectivity of diadenosine polyphosphates for rat P2X receptors subunits. Eur. J. Pharmacol., 367, 119-123.
44. Zhang, Y.X., Yamashita, H., Ohshita, T., Sawamoto, N. & Nakamura, S. (1996) ATP induces release of newly synthesized dopamine in the rat striatum. Neurochem. Int., 28, 395-400.
45. Ziganshin, A.U., Hoyle, C.H.V., Bo, X., Lambrech, G., Mutscher, E., Baumert, H.G. & Burnstock, G. (1993) PPADS selective antagonizes P2X purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol., 110, 1491-1495.
46. Zimmermann, H. (1994) Signalling via ATP in the nervous system. Trends Neurosci., 17, 420-426.