A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis

Aging Cell

Volumn 11, Issue 3, 2012, Pages 530-541

  Mazargui, Honoree ^a   Lévêque, Christian ^b,c   Bartnik, Dirk ^e   Fantini, Jacques ^e   Gouget, Tiphany ^b   Melone, Mariarosa A B ^f   Funke, Susanne A ^d   Willbold, Dieter ^c,g   Perrone, Lorena ^a,b  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c Aix Marseille University   (France)

^d FORSCHUNGSZENTRUM JÜLICH   (Germany)

^e University of Mediterranée   (France)

^f SECOND UNIVERSITY OF NAPLES   (Italy)

^g HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Aggregation; Alzheimer; Amyloid; GM1; Oxidative stress; Rafts

Indexed keywords

AMYLOID BETA PROTEIN; TYROSINE;

AGING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOIDOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INTERACTION; RAT; SYNAPTOSOME;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PEPTIDES; HUMANS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; TYROSINE;

EID: 84860881806     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2012.00814.x     Document Type: Article

References (47)

1. Ariga T, Kobayashi K, Hasegawa A, Kiso M, Ishida H, Miyatake T (2001) Characterization of high-affinity binding between gangliosides and amyloid beta-protein. Arch. Biochem. Biophys. 388, 225-230.
2. Barnham KJ, Haeffner F, Ciccotosto GD, Curtain CC, Tew D, Mavros C, Beyreuther K, Carrington D, Masters CL, Cherny RA, Cappai R, Bush AI (2004) Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. FASEB J. 18, 1427-1429.
3. Chen Y, Qin J, Chen ZW (2008) Fluorescence-topographic NSOM directly visualizes peak-valley polarities of GM1/GM3 rafts in cell membrane fluctuations. J. Lipid Res. 49, 2268-2275.
4. Di Fede G, Catania M, Morbin M, Rossi G, Suardi S, Mazzoleni G, Merlin M, Giovagnoli AR, Prioni S, Erbetta A, Falcone C, Gobbi M, Colombo L, Bastone A, Beeg M, Manzoni C, Francescucci B, Spagnoli A, Cantù L, Del Favero E, Levy E, Salmona M, Tagliavini F (2009) A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 323, 1473-1477.
5. Diarra A, Geetha T, Potter P, Babu JR (2009) Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease. Biochem. Biophys. Res. Commun. 390, 352-356.
6. Dyrks T, Dyrks E, Hartmann T, Masters C, Beyreuther K (1992) Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. J. Biol. Chem. 267, 18210-18217.
7. Dyrks T, Dyrks E, Masters CL, Beyreuther K (1993) Amyloidogenicity of rodent and human beta A4 sequences. FEBS Lett. 324, 231-236.
8. Fantini J, Yahi N (2010) Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases. Expert Rev. Mol. Med. 12, e27.
9. Fantini J, Yahi N (2011) Molecular basis for the glycosphingolipid-binding specificity of α-synuclein: key role of tyrosine 39 in membrane insertion. J. Mol. Biol. 408, 654-669.
10. Funke SA, Wang L, Birkmann E, Willbold D (2010) Single-particle detection system for Abeta aggregates: adaptation of surface-fluorescence intensity distribution analysis to laser scanning microscopy. Rejuvenation Res. 13, 202-205.
11. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
12. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K (2004) A seed for Alzheimer amyloid in the brain. J. Neurosci. 24, 4894-4902.
13. Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee JM (2009) Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc. Natl. Acad. Sci. USA 106, 20324-20329.
14. Kern A, Behl C (2009) The unsolved relationship of brain aging and late-onset Alzheimer disease. Biochim. Biophys. Acta 1790, 1124-1232.
15. Kimura N, Yanagisawa K (2007) Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains. NeuroReport 18, 1669-1673.
16. Kirkitadze MD, Bitan G, Teplow DB (2002) Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J. Neurosci. Res. 69, 567-577.
17. Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440, 352-357.
18. Lesné S, Kotilinek L, Ashe KH (2008) Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function. Neuroscience 151, 745-749.
19. Lévêque C, Boudier JA, Takahashi M, Seagar M (2000) Calcium-dependent dissociation of synaptotagmin from synaptic SNARE complexes. J. Neurochem. 74, 367-374.
20. Matsuzaki K (2011) Formation of toxic amyloid fibrils by amyloid β-protein on ganglioside clusters. Int. J. Alzheimers Dis. 2011, 956104-956110.
21. Nygaard HB, Strittmatter SM (2009) Cellular prion protein mediates the toxicity of beta-amyloid oligomers: implications for Alzheimer disease. Arch. Neurol. 66, 1325-1328.
22. Origlia N, Arancio O, Domenici L, Yan SS (2009) MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE. Expert Rev. Neurother. 9, 1635-1645.
23. Permanne B, Adessi C, Saborio GP, Fraga S, Frossard MJ, Van Dorpe J, Dewachter I, Banks WA, Van Leuven F, Soto C (2002) Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J. 16, 860-862.
24. Perrone L, Paladino S, Mazzone M, Nitsch L, Gulisano M, Zurzolo C (2005) Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signaling. Biochem J. 385, 233-241.
25. Perrone L, Peluso G, Melone MA (2008) RAGE recycles at the plasma membrane in S100B secretory vesicles and promotes Schwann cells morphological changes. J. Cell. Physiol. 217, 60-71.
26. Perrone L, Devi TS, Hosoya KC, Terasaki T, Singh LP (2009) Thioredoxin Interacting Protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. J. Cell. Physiol. 221, 262-272.
27. Perrone L, Devi TS, Hosoya KC, Terasaki T, Singh LP (2010a) Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy. Cell Death Dis. 1, e65.
28. Perrone L, Mothes E, Vignes M, Mockel A, Figueroa C, Miquel MC, Maddelein ML, Faller P (2010b) Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity. ChemBioChem 11, 110-118.
29. Radde R, Duma C, Goedert M, Jucker M (2008) The value of incomplete mouse models of Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging 35, S70-S74.
30. Recuero M, Vicente MC, Martínez-García A, Ramos MC, Carmona-Saez P, Sastre I, Aldudo J, Vilella E, Frank A, Bullido MJ, Valdivieso F (2009) A free radical-generating system induces the cholesterol biosynthesis pathway: a role in Alzheimer's disease. Aging Cell 8, 128-139.
31. Saavedra L, Mohamed A, Ma V, Kar S, de Chaves EP (2007) Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E. J. Biol. Chem. 282, 35722-35732.
32. Sbai O, Devi TS, Melone MA, Feron F, Khrestchatisky M, Singh LP, Perrone L (2010) RAGE-TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion. J. Cell Sci. 123, 4332-4339.
33. Schlenzig D, Manhart S, Cinar Y, Kleinschmidt M, Hause G, Willbold D, Funke SA, Schilling S, Demuth HU (2009) Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides. Biochemistry 48, 7072-7078.
34. Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
35. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 14, 837-842.
36. Simons K, Gerl MJ (2010) Revitalizing membrane rafts: new tools and insights. Nat. Rev. Mol. Cell Biol. 11, 688-699.
37. Smith DP, Ciccotosto GD, Tew DJ, Fodero-Tavoletti MT, Johanssen T, Masters CL, Barnham KJ, Cappai R (2007) Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide. Biochemistry 46, 2881-2891.
38. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS (2009) RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc. Natl. Acad. Sci. USA 106, 20021-20026.
39. Taneja V, Maddelein ML, Talarek N, Saupe SJ, Liebman SW (2007) A non-Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast. Mol. Cell 27, 67-77.
40. Thathiah A, De Strooper B (2009) G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. Sci. Signal. 2, re8.
41. Williamson R, Usardi A, Hanger DP, Anderton BH (2008) Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism. FASEB J. 22, 1552-1559.
42. Wood WG, Schroeder F, Igbavboa U, Avdulov NA, Chochina SV (2002) Brain membrane cholesterol domains, aging and amyloid beta-peptides. Neurobiol. Aging 23, 685-694.
43. Yahi N, Aulas A, Fantini J (2010) How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40). PLoS ONE 5, e9079.
44. Yamamoto N, Igbabvoa U, Shimada Y, Ohno-Iwashita Y, Kobayashi M, Wood WG, Fujita SC, Yanagisawa K (2004) Accelerated Abeta aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain. FEBS Lett. 569, 135-139.
45. Yamamoto N, Matsubara T, Sato T, Yanagisawa K (2008) Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis. Biochim. Biophys. Acta 1778, 2717-2726.
46. Yamamoto N, Taniura H, Suzuki K (2010) Insulin inhibits Abeta fibrillogenesis through a decrease of the GM1 ganglioside-rich microdomain in neuronal membranes. J. Neurochem. 113, 628-636.
47. Ye L, Morgenstern JL, Gee AD, Hong G, Brown J, Lockhart A (2005) Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils. J. Biol. Chem. 280, 23599-23604.