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Volumn 8, Issue 2, 2009, Pages 128-139

A free radical-generating system induces the cholesterol biosynthesis pathway: A role in Alzheimer's disease

Author keywords

Alzheimer's disease; Cell injury; Cholesterol; Genetic association; HMGCR; Neurodegeneration; Oxidative stress

Indexed keywords

CHOLESTEROL; FREE RADICAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; XANTHINE; XANTHINE OXIDASE;

EID: 63549095100     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2009.00457.x     Document Type: Article
Times cited : (38)

References (62)
  • 2
    • 13444274645 scopus 로고    scopus 로고
    • Iron dysregulation and Parkinson's disease
    • Andersen JK (2004) Iron dysregulation and Parkinson's disease. J. Alzheimers. Dis. 6, S47-S52.
    • (2004) J. Alzheimers. Dis. , vol.6
    • Andersen, J.K.1
  • 3
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
    • Anon
    • Anon. (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol. Aging. 18, S1-S2.
    • (1997) Neurobiol. Aging , vol.18
  • 5
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat Soc. Series B. 57, 289-300.
    • (1995) J. R. Stat Soc. Series B. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 6
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database. Nat. Genet. 39, 17-23.
    • (2007) Nat. Genet. , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 7
    • 2442557294 scopus 로고    scopus 로고
    • Brain cholesterol: Long secret life behind a barrier
    • Bjorkhem I, Meaney S (2004) Brain cholesterol: Long secret life behind a barrier. Arterioscler Thromb. Vasc Biol. 24, 806-815.
    • (2004) Arterioscler Thromb. Vasc Biol. , vol.24 , pp. 806-815
    • Bjorkhem, I.1    Meaney, S.2
  • 8
    • 1242341923 scopus 로고    scopus 로고
    • Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    • Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW (2004) Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc. Natl. Acad. Sci. USA 101, 2173-2178.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2173-2178
    • Blalock, E.M.1    Geddes, J.W.2    Chen, K.C.3    Porter, N.M.4    Markesbery, W.R.5    Landfield, P.W.6
  • 9
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 10
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 19, 185-193.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 11
    • 4344571581 scopus 로고    scopus 로고
    • Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
    • Breitling R, Armengaud P, Amtmann A, Herzyk P (2004) Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett. 573, 83-92.
    • (2004) FEBS Lett. , vol.573 , pp. 83-92
    • Breitling, R.1    Armengaud, P.2    Amtmann, A.3    Herzyk, P.4
  • 13
    • 0037386086 scopus 로고    scopus 로고
    • The metallobiology of Alzheimer's disease
    • Bush AI (2003) The metallobiology of Alzheimer's disease. Trends Neurosci. 26, 207-214.
    • (2003) Trends Neurosci. , vol.26 , pp. 207-214
    • Bush, A.I.1
  • 14
    • 0036905921 scopus 로고    scopus 로고
    • Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimer's disease brain. A review
    • Butterfield DA (2002) Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic Res. 36, 1307-1313.
    • (2002) Free Radic Res. , vol.36 , pp. 1307-1313
    • Butterfield, D.A.1
  • 15
    • 34548588380 scopus 로고    scopus 로고
    • Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: Insights into the progression of this dementing disorder
    • Butterfield DA, Sultana R (2007) Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: Insights into the progression of this dementing disorder. J. Alzheimers. Dis. 12, 61-72.
    • (2007) J. Alzheimers. Dis. , vol.12 , pp. 61-72
    • Butterfield, D.A.1    Sultana, R.2
  • 17
    • 33845286140 scopus 로고    scopus 로고
    • Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
    • Carter CJ (2007) Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis. Neurochem. Int. 50, 12-38.
    • (2007) Neurochem. Int. , vol.50 , pp. 12-38
    • Carter, C.J.1
  • 18
    • 33644953299 scopus 로고    scopus 로고
    • Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme
    • Chinopoulos C, Adam-Vizi V (2006) Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J. 273, 433-450.
    • (2006) FEBS J. , vol.273 , pp. 433-450
    • Chinopoulos, C.1    Adam-Vizi, V.2
  • 20
    • 33947258832 scopus 로고    scopus 로고
    • Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies
    • Elliott DA, Kim WS, Jans DA, Garner B (2007) Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neurosci. Lett. 416, 206-210.
    • (2007) Neurosci. Lett. , vol.416 , pp. 206-210
    • Elliott, D.A.1    Kim, W.S.2    Jans, D.A.3    Garner, B.4
  • 21
    • 33947225731 scopus 로고    scopus 로고
    • Hydrogen peroxide mediates damage by xanthine and xanthine oxidase in cerebellar granule neuronal cultures
    • Fatokun AA, Stone TW, Smith RA (2007) Hydrogen peroxide mediates damage by xanthine and xanthine oxidase in cerebellar granule neuronal cultures. Neurosci. Lett. 416, 34-38.
    • (2007) Neurosci. Lett. , vol.416 , pp. 34-38
    • Fatokun, A.A.1    Stone, T.W.2    Smith, R.A.3
  • 23
    • 0028987937 scopus 로고
    • Calcium signaling in neurons: Molecular mechanisms and cellular consequences
    • Ghosh A, Greenberg ME (1995) Calcium signaling in neurons: Molecular mechanisms and cellular consequences. Science (New York, N.Y.) 268, 239-247.
    • (1995) Science (New York, N.Y.) , vol.268 , pp. 239-247
    • Ghosh, A.1    Greenberg, M.E.2
  • 24
    • 13644268560 scopus 로고    scopus 로고
    • Oxidative stress in Alzheimer's disease
    • Gibson GE, Huang HM (2005) Oxidative stress in Alzheimer's disease. Neurobiol. Aging. 26, 575-578.
    • (2005) Neurobiol. Aging , vol.26 , pp. 575-578
    • Gibson, G.E.1    Huang, H.M.2
  • 26
    • 0036141225 scopus 로고    scopus 로고
    • XOD-catalyzed ROS generation mobilizes calcium from intracellular stores in mouse pancreatic acinar cells
    • Gonzalez A, Schmid A, Salido GM, Camello PJ, Pariente JA (2002) XOD-catalyzed ROS generation mobilizes calcium from intracellular stores in mouse pancreatic acinar cells. Cell Signal. 14, 153-159.
    • (2002) Cell Signal. , vol.14 , pp. 153-159
    • Gonzalez, A.1    Schmid, A.2    Salido, G.M.3    Camello, P.J.4    Pariente, J.A.5
  • 27
    • 0037427474 scopus 로고    scopus 로고
    • Calcium signaling and apoptosis
    • Hajnoczky G, Davies E, Madesh M (2003) Calcium signaling and apoptosis. Biochem. Biophys. Res. Commun. 304, 445-454.
    • (2003) Res. Commun. , vol.304 , pp. 445-454
    • Hajnoczky, G.1    Davies, E.2    Madesh, M.3
  • 28
    • 0024595042 scopus 로고
    • Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
    • Hansen MB, Nielsen SE, Berg K (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/ cell kill. J. Immunol. Methods 119, 203-210.
    • (1989) J. Immunol. Methods , vol.119 , pp. 203-210
    • Hansen, M.B.1    Nielsen, S.E.2    Berg, K.3
  • 30
    • 0032617027 scopus 로고    scopus 로고
    • Cellular response to cancer chemopreventive agents: Contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress
    • Hayes JD, Ellis EM, Neal GE, Harrison DJ, Manson MM (1999) Cellular response to cancer chemopreventive agents: Contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress. Biochem. Soc. Symp. 64, 141-168.
    • (1999) Biochem. Soc. Symp. , vol.64 , pp. 141-168
    • Hayes, J.D.1    Ellis, E.M.2    Neal, G.E.3    Harrison, D.J.4    Manson, M.M.5
  • 31
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO (2000) The biochemistry of apoptosis. Nature 407, 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 32
    • 0027971798 scopus 로고
    • Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: Longitudinal apolipoprotein E genotype effects
    • Jarvik GP, Austin MA, Fabsitz RR, Auwerx J, Reed T, Christian JC, Deeb S (1994) Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects. Genet. Epidemiol. 11, 375-384.
    • (1994) Genet. Epidemiol. , vol.11 , pp. 375-384
    • Jarvik, G.P.1    Austin, M.A.2    Fabsitz, R.R.3    Auwerx, J.4    Reed, T.5    Christian, J.C.6    Deeb, S.7
  • 34
    • 0035900217 scopus 로고    scopus 로고
    • The levels of soluble amyloid beta in different high density lipoprotein subfractions distinguish Alzheimer's and normal aging cerebrospinal fluid: Implication for brain cholesterol pathology?
    • Koudinov AR, Berezov TT, Koudinova NV (2001) The levels of soluble amyloid beta in different high density lipoprotein subfractions distinguish Alzheimer's and normal aging cerebrospinal fluid: implication for brain cholesterol pathology? Neurosci. Lett. 314, 115-118.
    • (2001) Neurosci. Lett. , vol.314 , pp. 115-118
    • Koudinov, A.R.1    Berezov, T.T.2    Koudinova, N.V.3
  • 35
    • 33749045445 scopus 로고    scopus 로고
    • Amyloid excess in Alzheimer's disease: What is cholesterol to be blamed for?
    • Ledesma MD, Dotti CG (2006) Amyloid excess in Alzheimer's disease: What is cholesterol to be blamed for? FEBS Lett. 580, 5525-5532.
    • (2006) FEBS Lett. , vol.580 , pp. 5525-5532
    • Ledesma, M.D.1    Dotti, C.G.2
  • 37
    • 39449093070 scopus 로고    scopus 로고
    • Caspase activation cascades in apoptosis
    • Logue SE, Martin SJ (2008) Caspase activation cascades in apoptosis. Biochem. Soc. Trans. 36, 1-9.
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 1-9
    • Logue, S.E.1    Martin, S.J.2
  • 38
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lutjohann D, Breuer O, Ahlborg G, Nennesmo I, Siden A, Diczfalusy U, Bjorkhem I (1996) Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA 93, 9799-9804.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9799-9804
    • Lutjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Siden, A.5    Diczfalusy, U.6    Bjorkhem, I.7
  • 39
    • 36248949141 scopus 로고    scopus 로고
    • The endoplasmic reticulum and the unfolded protein response
    • Malhotra JD, Kaufman RJ (2007) The endoplasmic reticulum and the unfolded protein response. Semin. Cell Dev. Biol. 18, 716-731.
    • (2007) Semin. Cell Dev. Biol. , vol.18 , pp. 716-731
    • Malhotra, J.D.1    Kaufman, R.J.2
  • 40
    • 0042847291 scopus 로고    scopus 로고
    • Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: Oxidative stress, caspases, and the JNK pathway
    • Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A (2003) Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: Oxidative stress, caspases, and the JNK pathway. J. Biol. Chem. 278, 28294-28302.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28294-28302
    • Marques, C.A.1    Keil, U.2    Bonert, A.3    Steiner, B.4    Haass, C.5    Muller, W.E.6    Eckert, A.7
  • 42
    • 0021271971 scopus 로고
    • Clinical Diagnosis of Alzheimer's Disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical Diagnosis of Alzheimer's Disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 43
    • 33746269416 scopus 로고    scopus 로고
    • Role of oxidative stress on beta-amyloid neurotoxicity elicited during impairment of energy metabolism in the hippocampus: Protection by antioxidants
    • Montiel T, Quiroz-Baez R, Massieu L, Arias C (2006) Role of oxidative stress on beta-amyloid neurotoxicity elicited during impairment of energy metabolism in the hippocampus: Protection by antioxidants. Exp. Neurol. 200, 496-508.
    • (2006) Exp. Neurol. , vol.200 , pp. 496-508
    • Montiel, T.1    Quiroz-Baez, R.2    Massieu, L.3    Arias, C.4
  • 50
    • 0043037253 scopus 로고    scopus 로고
    • Endoplasmic reticulum: A primary target in various acute disorders and degenerative diseases of the brain
    • Paschen W (2003) Endoplasmic reticulum: A primary target in various acute disorders and degenerative diseases of the brain. Cell Calcium. 34, 365-383.
    • (2003) Cell Calcium. , vol.34 , pp. 365-383
    • Paschen, W.1
  • 51
    • 0037710127 scopus 로고    scopus 로고
    • Cholesterol homeostasis and function in neurons of the central nervous system
    • Pfrieger FW (2003a) Cholesterol homeostasis and function in neurons of the central nervous system. Cell. Mol. Life Sci. 60, 1158-1171.
    • (2003) Cell. Mol. Life Sci. , vol.60 , pp. 1158-1171
    • Pfrieger, F.W.1
  • 52
    • 0037230328 scopus 로고    scopus 로고
    • Outsourcing in the brain: Do neurons depend on cholesterol delivery by astrocytes?
    • Pfrieger FW (2003b) Outsourcing in the brain: Do neurons depend on cholesterol delivery by astrocytes? Bioessays. 25, 72-78.
    • (2003) Bioessays. , vol.25 , pp. 72-78
    • Pfrieger, F.W.1
  • 55
    • 0032926539 scopus 로고    scopus 로고
    • Apolipoprotein E genetic variation and Alzheimer's disease: A meta-analysis
    • Rubinsztein DC, Easton DF (1999) Apolipoprotein E genetic variation and Alzheimer's disease: A meta-analysis. Dement. Geriatr. Cogn. Disord. 10, 199-209.
    • (1999) Dement. Geriatr. Cogn. Disord. , vol.10 , pp. 199-209
    • Rubinsztein, D.C.1    Easton, D.F.2
  • 56
    • 0036710399 scopus 로고    scopus 로고
    • Importance of individuality in oxidative stress and aging
    • Stadtman ER (2002) Importance of individuality in oxidative stress and aging. Free Radic Biol. Med. 33, 597-604.
    • (2002) Free Radic Biol. Med. , vol.33 , pp. 597-604
    • Stadtman, E.R.1
  • 58
    • 0032529710 scopus 로고    scopus 로고
    • Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress
    • White AR, Zheng H, Galatis D, Maher F, Hesse L, Multhaup G, Beyreuther K, Masters CL, Cappai R (1998) Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. J. Neurosci. 18, 6207-6217.
    • (1998) J. Neurosci. , vol.18 , pp. 6207-6217
    • White, A.R.1    Zheng, H.2    Galatis, D.3    Maher, F.4    Hesse, L.5    Multhaup, G.6    Beyreuther, K.7    Masters, C.L.8    Cappai, R.9
  • 59
    • 0028694808 scopus 로고
    • Special report: DSM-IV: Overview and examination of major changes
    • WiOson HS, Skodol A (1994) Special report: DSM-IV: overview and examination of major changes. Arch. Psychiatr. Nurs. 8, 340-347.
    • (1994) Arch. Psychiatr. Nurs. , vol.8 , pp. 340-347
    • Wilson, H.S.1    Skodol, A.2
  • 61
    • 0035826795 scopus 로고    scopus 로고
    • A fluid connection: Cholesterol and Abeta
    • Wolozin B (2001) A fluid connection: Cholesterol and Abeta. Proc. Natl. Acad. Sci. USA 98, 5371-5373.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5371-5373
    • Wolozin, B.1


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