Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

Biochemistry

Volumn 48, Issue 29, 2009, Pages 7072-7078

  Schlenzig, Dagmar ^a   Manhart, Susanne ^a   Cinar, Yeliz ^b   Kleinschmidt, Martin ^a   Hause, Gerd ^d   Willbold, Dieter ^b,c   Funke, Susanne Aileen ^b   Schilling, Stephan ^a   Demuth, Hans Ulrich ^a  

^a PROBIODRUG AG   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATE FORMATION; AGGREGATION PROCESS; AGGREGATION PROPENSITY; ALZHEIMER'S DISEASE; AMYLOID DEPOSITS; AMYLOID PEPTIDES; AMYLOIDOGENICITY; BIOPHYSICAL PROPERTIES; DANISH DEMENTIA; DRIVING FORCES; FIBRIL MORPHOLOGY; FLUORESCENCE ASSAY; N-TERMINAL; NEURODEGENERATIVE DISEASE; PH RANGE; PH-DEPENDENT; SEED FORMATION; SHEET STRUCTURE; SHORT FIBER;

AGGLOMERATION; AMINES; GLYCOPROTEINS; HYDROPHOBICITY; MORPHOLOGY; ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING; SOLUBILITY; SPECTROSCOPIC ANALYSIS; TERNARY SYSTEMS;

PEPTIDES;

AMYLOID BETA PROTEIN; PYROGLUTAMIC ACID;

ALZHEIMER DISEASE; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; FLUORESCENCE ANALYSIS; HYDROPHOBICITY; LIGHT SCATTERING; PRIORITY JOURNAL; PROTEIN AGGREGATION; ULTRAVIOLET SPECTROSCOPY;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID; CIRCULAR DICHROISM; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; PEPTIDES; PYRROLIDONECARBOXYLIC ACID; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 67651205387     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900818a     Document Type: Article

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