Insulin inhibits Aβ fibrillogenesis through a decrease of the GM1 ganglioside-rich microdomain in neuronal membranes

Journal of Neurochemistry

Volumn 113, Issue 3, 2010, Pages 628-636

  Yamamoto, Naoki ^a   Taniura, Hideo ^a   Suzuki, Kenji ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

Alzheimaer's disease; Amyloid beta protein; GM1 ganglioside; Insulin; Type 2 diabetes

Indexed keywords

AMYLOID BETA PROTEIN; GANGLIOSIDE GM1; INSULIN; NERVE GROWTH FACTOR; 2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; ACTIN; ANTIDIABETIC AGENT; CHLOROQUINE; CYCLOHEXIMIDE; FLUORESCENT DYE; LIPOSOME; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SYNTHESIS INHIBITOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HORMONE ACTION; NERVE CELL CULTURE; NERVE CELL MEMBRANE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE; CELL STRAIN; DRUG ANTAGONISM; DRUG EFFECT; HOMEOSTASIS; METABOLISM; NERVE CELL; NEUROFIBRILLARY TANGLE; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

RATTUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; AMYLOID BETA-PROTEIN; ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; CHLOROQUINE; CYCLOHEXIMIDE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT DYES; G(M1) GANGLIOSIDE; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN; LIPOSOMES; MORPHOLINES; NEUROFIBRILLARY TANGLES; NEURONS; PC12 CELLS; PROTEIN SYNTHESIS INHIBITORS; RATS;

EID: 77950650360     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06620.x     Document Type: Article

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