Single-particle detection system for aβ aggregates: Adaptation of surface-fluorescence intensity distribution analysis to laser scanning microscopy

Rejuvenation Research

Volumn 13, Issue 2-3, 2010, Pages 206-209

  Funke, Susanne Aileen ^a   Wang, Lei ^a   Birkmann, Eva ^a,b   Willbold, Dieter ^a,b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ANALYTIC METHOD; ARTICLE; BODY FLUID; HUMAN; LASER MICROSCOPY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DETERMINATION; SURFACE FLUORESCENCE INTENSITY DISTRIBUTION ANALYSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BODY FLUIDS; CHEMICAL PRECIPITATION; EARLY DIAGNOSIS; HUMANS; IMAGE ENHANCEMENT; MICROSCOPY, CONFOCAL; SENILE PLAQUES; SPECTROMETRY, FLUORESCENCE;

EID: 77952345825     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2009.0925     Document Type: Article

References (10)

1. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alz-heimers & Dementia 2007;3:186-191.
2. Hardy JA, Higgins GA. Alzheimer's disease: The amyloid cascade hypothesis. Science 1992;256:184-185.
3. Haass C, Selkoe DJ. Soluble protein oligomers in neurode-generation: Lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007;8:101-112.
4. Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C, McCormack R, Wolfert R, Selkoe DJ, Lieberburg I, Schenk D. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 1992;359:325-327.
5. Birkmann E, Henke F, Weinmann N, Dumpitak C, Groschup M, Funke A, Willbold D, Riesner D. Counting of single prion particles bound to a capture-antibody surface (surface-FIDA). Vet Microbiol 2007;123:294-304.
6. Funke SA, BirkmannE,HenkeF, GörtzP,Lange-Asschenfeldt C, Riesner D, Willbold D. Single particle detection of Abeta aggregates associated with Alzheimer's disease. Biochem Biophys Res Commun 2007;364:902-907.
7. Funke SA, Birkmann E, Henke F, Görtz P, Lange-Asschen-feldt C, Riesner D, Willbold D. An ultrasensitive assay for diagnosis of Alzheimer's disease. Rejuvenation Res 2008;11: 315-318.
8. Eigen M and Rigler R. Sorting single molecules: application to diagnostics and evolutionary biotechnology. Proc Natl Acad Sci USA 1994;91:5740-5747.
9. Kask P, Palo K, Ullmann D, Gall K. Fluorescence-intensity distribution analysis and its application in biomolecular detection technology. Proc Natl Acad Sci USA 1999;96: 13756-13761.
10. Henkel AW, Dittrich PS, Groemer TW, Lemke EA, Klingauf J, Klafki HW, Lewczuk P, Esselmann H, Schwille P, Korn-huber J, Wiltfang J. Immune complexes of auto-antibodies against Abeta 1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients. Mol Psychiatry 2007; 12: 601-610.