-
1
-
-
0029101360
-
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
-
Olson, M. F., Ashworth, A., and Hall, A. (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269, 1270-1272
-
(1995)
Science
, vol.269
, pp. 1270-1272
-
-
Olson, M.F.1
Ashworth, A.2
Hall, A.3
-
2
-
-
0029015774
-
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
-
Hill, C. S., Wynne, J., and Treisman, R. (1995) The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81, 1159-1170
-
(1995)
Cell
, vol.81
, pp. 1159-1170
-
-
Hill, C.S.1
Wynne, J.2
Treisman, R.3
-
3
-
-
0032572557
-
Integrin-mediated signals regulated by members of the rho family of gtpases
-
DOI 10.1083/jcb.142.2.573
-
Clark, E. A., King, W. G., Brugge, J. S., Symons, M., and Hynes, R. O. (1998) Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142, 573-586 (Pubitemid 28361561)
-
(1998)
Journal of Cell Biology
, vol.142
, Issue.2
, pp. 573-586
-
-
Clark, E.A.1
King, W.G.2
Brugge, J.S.3
Symons, M.4
Hynes, R.O.5
-
4
-
-
0033543551
-
Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin
-
Fukata, M., Kuroda, S., Nakagawa, M., Kawajiri, A., Itoh, N., Shoji, I., Matsuura, Y., Yonehara, S., Fujisawa, H., Kikuchi, A., and Kaibuchi, K. (1999) Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin. J. Biol. Chem. 274, 26044-26050
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26044-26050
-
-
Fukata, M.1
Kuroda, S.2
Nakagawa, M.3
Kawajiri, A.4
Itoh, N.5
Shoji, I.6
Matsuura, Y.7
Yonehara, S.8
Fujisawa, H.9
Kikuchi, A.10
Kaibuchi, K.11
-
5
-
-
0034655467
-
Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition
-
Tanaka, T., Tatsuno, I., Uchida, D., Moroo, I., Morio, H., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Saito, Y., and Hirai, A. (2000) Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. J. Neurosci. 20, 2852-2859 (Pubitemid 30220310)
-
(2000)
Journal of Neuroscience
, vol.20
, Issue.8
, pp. 2852-2859
-
-
Tanaka, T.1
Tatsuno, I.2
Uchida, D.3
Moroo, I.4
Morio, H.5
Nakamura, S.6
Noguchi, Y.7
Yasuda, T.8
Kitagawa, M.9
Saito, Y.10
Hirai, A.11
-
6
-
-
0035914433
-
An essential role for Rac/ Cdc42 GTPases in cerebellar granule neuron survival
-
Linseman, D. A., Laessig, T., Meintzer, M. K., McClure, M., Barth, H., Aktories, K., and Heidenreich, K. A. (2001) An essential role for Rac/ Cdc42 GTPases in cerebellar granule neuron survival. J. Biol. Chem. 276, 39123-39131
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39123-39131
-
-
Linseman, D.A.1
Laessig, T.2
Meintzer, M.K.3
McClure, M.4
Barth, H.5
Aktories, K.6
Heidenreich, K.A.7
-
7
-
-
33745714459
-
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
-
Jacquier, A., Buhler, E., Schäfer, M. K., Bohl, D., Blanchard, S., Beclin, C., and Haase, G. (2006) Alsin/Rac1 signaling controls survival and growth of spinal motoneurons. Ann. Neurol. 60, 105-117
-
(2006)
Ann. Neurol.
, vol.60
, pp. 105-117
-
-
Jacquier, A.1
Buhler, E.2
Schäfer, M.K.3
Bohl, D.4
Blanchard, S.5
Beclin, C.6
Haase, G.7
-
8
-
-
33646116540
-
Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival
-
Loucks, F. A., Le, S. S., Zimmermann, A. K., Ryan, K. R., Barth, H., Aktories, K., and Linseman, D. A. (2006) Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. J. Neurochem. 97, 957-967
-
(2006)
J. Neurochem.
, vol.97
, pp. 957-967
-
-
Loucks, F.A.1
Le, S.S.2
Zimmermann, A.K.3
Ryan, K.R.4
Barth, H.5
Aktories, K.6
Linseman, D.A.7
-
9
-
-
0034832208
-
Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice
-
Igaz, P., Tóth, S., and Falus, A. (2001) Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice. Inflamm. Res. 50, 435-441 (Pubitemid 32889442)
-
(2001)
Inflammation Research
, vol.50
, Issue.9
, pp. 435-441
-
-
Igaz, P.1
Toth, S.2
Falus, A.3
-
10
-
-
0034021317
-
Cytokines and their receptors in cardiovascular diseases - Role of gp130 signalling pathway in cardiac myocyte growth and maintenance
-
DOI 10.1046/j.1365-2613.2000.00139.x
-
Yamauchi-Takihara, K., and Kishimoto, T. (2000) Cytokines and their receptors in cardiovascular diseases - role of gp130 signalling pathway in cardiac myocyte growth and maintenance. Int. J. Exp. Pathol. 81, 1-16 (Pubitemid 30171497)
-
(2000)
International Journal of Experimental Pathology
, vol.81
, Issue.1
, pp. 1-16
-
-
Yamauchi-Takihara, K.1
Kishimoto, T.2
-
11
-
-
0028923658
-
Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
-
Watson, C. J., and Miller, W. R. (1995) Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer 71, 840-844
-
(1995)
Br. J. Cancer
, vol.71
, pp. 840-844
-
-
Watson, C.J.1
Miller, W.R.2
-
12
-
-
0141590211
-
STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury
-
Kim, W. H., Hong, F., Radaeva, S., Jaruga, B., Fan, S., and Gao, B. (2003) STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G761-G768 (Pubitemid 37151238)
-
(2003)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.285
, Issue.4
-
-
Kim, W.-H.1
Hong, F.2
Radaeva, S.3
Jaruga, B.4
Fan, S.5
Gao, B.6
-
13
-
-
33845970592
-
Glucocorticoids repress bcl-X expression in lymphoid cells by recruiting STAT5B to the P4 promoter
-
DOI 10.1074/jbc.M602408200
-
Rocha-Viegas, L., Vicent, G. P., Barañao, J. L., Beato, M., and Pecci, A. (2006) Glucocorticoids repress bcl-X expression in lymphoid cells by recruiting STAT5B to the P4 promoter. J. Biol. Chem. 281, 33959-33970 (Pubitemid 46043253)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.45
, pp. 33959-33970
-
-
Rocha-Viegas, L.1
Vicent, G.P.2
Baranao, J.L.3
Beato, M.4
Pecci, A.5
-
14
-
-
0027483920
-
Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
-
DOI 10.1073/pnas.90.23.10989
-
D'Mello, S. R., Galli, C., Ciotti, T., and Calissano, P. (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. U.S.A. 90, 10989-10993 (Pubitemid 23354354)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.23
, pp. 10989-10993
-
-
D'Mello, S.R.1
Galli, C.2
Ciotti, T.3
Calissano, P.4
-
15
-
-
0011486518
-
Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro
-
Contestabile, A. (2002) Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro. Cerebellum 1, 41-55
-
(2002)
Cerebellum
, vol.1
, pp. 41-55
-
-
Contestabile, A.1
-
16
-
-
0037404665
-
Pituitary adenylate cyclase-activating polypeptide prevents C2-ceramide-induced apoptosis of cerebellar granule cells
-
DOI 10.1002/jnr.10530
-
Vaudry, D., Falluel-Morel, A., Basille, M., Pamantung, T. F., Fontaine, M., Fournier, A., Vaudry, H., and Gonzalez, B. J. (2003) Pituitary adenylate cyclase-activating polypeptide prevents C2-ceramide-induced apoptosis of cerebellar granule cells. J. Neurosci. Res. 72, 303-316 (Pubitemid 36504699)
-
(2003)
Journal of Neuroscience Research
, vol.72
, Issue.3
, pp. 303-316
-
-
Vaudry, D.1
Falluel-Morel, A.2
Basille, M.3
Pamantung, T.F.4
Fontaine, M.5
Fournier, A.6
Vaudry, H.7
Gonzalez, B.J.8
-
17
-
-
0029054398
-
Glucosylation of Rho proteins by Clostridium difficile toxin B
-
Just, I., Selzer, J., Wilm, M., von Eichel-Streiber, C., Mann, M., and Aktories, K. (1995) Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375, 500-503
-
(1995)
Nature
, vol.375
, pp. 500-503
-
-
Just, I.1
Selzer, J.2
Wilm, M.3
Von Eichel-Streiber, C.4
Mann, M.5
Aktories, K.6
-
18
-
-
0035448912
-
Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons
-
Li, M., Linseman, D. A., Allen, M. P., Meintzer, M. K., Wang, X., Laessig, T., Wierman, M. E., and Heidenreich, K. A. (2001) Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J. Neurosci. 21, 6544-6552 (Pubitemid 32781098)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.17
, pp. 6544-6552
-
-
Li, M.1
Linseman, D.A.2
Allen, M.P.3
Meintzer, M.K.4
Wang, X.5
Laessig, T.6
Wierman, M.E.7
Heidenreich, K.A.8
-
19
-
-
0038711502
-
Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells
-
DOI 10.1074/jbc.M304307200
-
Ahonen, T. J., Xie, J., LeBaron, M. J., Zhu, J., Nurmi, M., Alanen, K., Rui, H., and Nevalainen, M. T. (2003) Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells. J. Biol. Chem. 278, 27287-27292 (Pubitemid 36876886)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.29
, pp. 27287-27292
-
-
Ahonen, T.J.1
Xie, J.2
LeBaron, M.J.3
Zhu, J.4
Nurmi, M.5
Alanen, K.6
Rui, H.7
Nevalainen, M.T.8
-
20
-
-
42749095602
-
Structure and mode of action of clostridial glucosylating toxins: The ABCD model
-
Jank, T., and Aktories, K. (2008) Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol. 16, 222-229
-
(2008)
Trends Microbiol.
, vol.16
, pp. 222-229
-
-
Jank, T.1
Aktories, K.2
-
21
-
-
0034960254
-
STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
-
Sahni, M., Raz, R., Coffin, J. D., Levy, D., and Basilico, C. (2001) STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128, 2119-2129 (Pubitemid 32600472)
-
(2001)
Development
, vol.128
, Issue.11
, pp. 2119-2129
-
-
Sahni, M.1
Raz, R.2
Coffin, J.D.3
Levy, D.4
Basilico, C.5
-
23
-
-
1042301419
-
STAT1-induced Apoptosis Is Mediated by Caspases 2, 3, and 7
-
DOI 10.1074/jbc.M307774200
-
Sironi, J. J., and Ouchi, T. (2004) STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J. Biol. Chem. 279, 4066-4074 (Pubitemid 38198990)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.6
, pp. 4066-4074
-
-
Sironi, J.J.1
Ouchi, T.2
-
24
-
-
8544281698
-
STAT1: A modulator of chemotherapy-induced apoptosis
-
DOI 10.1158/0008-5472.CAN-04-1864
-
Thomas, M., Finnegan, C. E., Rogers, K. M., Purcell, J. W., Trimble, A., Johnston, P. G., and Boland, M. P. (2004) STAT1: a modulator of chemotherapy- induced apoptosis. Cancer Res. 64, 8357-8364 (Pubitemid 39491775)
-
(2004)
Cancer Research
, vol.64
, Issue.22
, pp. 8357-8364
-
-
Thomas, M.1
Finnegan, C.E.2
Rogers, K.M.-A.3
Purcell, J.W.4
Trimble, A.5
Johnston, P.G.6
Boland, M.P.7
-
25
-
-
34047207548
-
STAT1 activation-induced apoptosis of esophageal squamous cell carcinoma cells in vivo
-
DOI 10.1245/s10434-006-9274-7
-
Kaganoi, J., Watanabe, G., Okabe, M., Nagatani, S., Kawabe, A., Shimada, Y., Imamura, M., and Sakai, Y. (2007) STAT1 activation-induced apoptosis of esophageal squamous cell carcinoma cells in vivo. Ann. Surg. Oncol.14, 1405-1415 (Pubitemid 46536820)
-
(2007)
Annals of Surgical Oncology
, vol.14
, Issue.4
, pp. 1405-1415
-
-
Kaganoi, J.1
Watanabe, G.2
Okabe, M.3
Nagatani, S.4
Kawabe, A.5
Shimada, Y.6
Imamura, M.7
Sakai, Y.8
-
26
-
-
33847751875
-
STAT1 regulates p73-mediated Bax gene expression
-
DOI 10.1016/j.febslet.2007.02.049, PII S0014579307002116
-
Soond, S. M., Carroll, C., Townsend, P. A., Sayan, E., Melino, G., Behrmann, I., Knight, R. A., Latchman, D. S., and Stephanou, A. (2007) STAT1 regulates p73-mediated Bax gene expression. FEBS Lett. 581, 1217-1226 (Pubitemid 46385948)
-
(2007)
FEBS Letters
, vol.581
, Issue.6
, pp. 1217-1226
-
-
Soond, S.M.1
Carroll, C.2
Townsend, P.A.3
Sayan, E.4
Melino, G.5
Behrmann, I.6
Knight, R.A.7
Latchman, D.S.8
Stephanou, A.9
-
27
-
-
0036844219
-
STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury
-
Takagi, Y., Harada, J., Chiarugi, A., and Moskowitz, M. A. (2002) STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury. J. Cereb. Blood Flow Metab. 22, 1311-1318 (Pubitemid 35285088)
-
(2002)
Journal of Cerebral Blood Flow and Metabolism
, vol.22
, Issue.11
, pp. 1311-1318
-
-
Takagi, Y.1
Harada, J.2
Chiarugi, A.3
Moskowitz, M.A.4
-
29
-
-
2342445635
-
The JAK/STAT signaling pathway
-
DOI 10.1242/jcs.00963
-
Rawlings, J. S., Rosler, K. M., and Harrison, D. A. (2004) The JAK/STAT signaling pathway. J. Cell Sci. 117, 1281-1283 (Pubitemid 38559804)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.8
, pp. 1281-1283
-
-
Rawlings, J.S.1
Rosler, K.M.2
Harrison, D.A.3
-
30
-
-
77952604395
-
Tyk2/STAT3 signaling mediates β-amyloid- induced neuronal cell death: Implications in Alzheimer's disease
-
Wan, J., Fu, A. K., Ip, F. C., Ng, H. K., Hugon, J., Page, G., Wang, J. H., Lai, K. O., Wu, Z., and Ip, N. Y. (2010) Tyk2/STAT3 signaling mediates β-amyloid- induced neuronal cell death: implications in Alzheimer's disease. J. Neurosci. 30, 6873-6881
-
(2010)
J. Neurosci.
, vol.30
, pp. 6873-6881
-
-
Wan, J.1
Fu, A.K.2
Ip, F.C.3
Ng, H.K.4
Hugon, J.5
Page, G.6
Wang, J.H.7
Lai, K.O.8
Wu, Z.9
Ip, N.Y.10
-
31
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich, M. A., Sun, J., Cantor, A., Turkson, J., Jove, R., and Sebti, S. M. (2003) Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63, 1270-1279 (Pubitemid 36348705)
-
(2003)
Cancer Research
, vol.63
, Issue.6
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
32
-
-
35348850681
-
Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53
-
DOI 10.1038/sj.onc.1210492, PII 1210492
-
Chipoy, C., Brounais, B., Trichet, V., Battaglia, S., Berreur, M., Oliver, L., Juin, P., Rédini, F., Heymann, D., and Blanchard, F. (2007) Sensitization of osteosarcoma cells to apoptosis by on costat in M depends on STAT5 and p53. Oncogene 26, 6653-6664 (Pubitemid 47573687)
-
(2007)
Oncogene
, vol.26
, Issue.46
, pp. 6653-6664
-
-
Chipoy, C.1
Brounais, B.2
Trichet, V.3
Battaglia, S.4
Berreur, M.5
Oliver, L.6
Juin, P.7
Redini, F.8
Heymann, D.9
Blanchard, F.10
-
33
-
-
11144241637
-
Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification
-
DOI 10.1074/jbc.M408464200
-
Nelson, E. A., Walker, S. R., Alvarez, J. V., and Frank, D. A. (2004) Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J. Biol. Chem. 279, 54724-54730 (Pubitemid 40053217)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.52
, pp. 54724-54730
-
-
Nelson, E.A.1
Walker, S.R.2
Alvarez, J.V.3
Frank, D.A.4
-
34
-
-
0037163109
-
Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the β-casein gene promoter in mammary cells
-
DOI 10.1074/jbc.M200156200
-
Chughtai, N., Schimchowitsch, S., Lebrun, J. J., and Ali, S. (2002) Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the β-casein gene promoter in mammary cells. J. Biol. Chem. 277, 31107-31114 (Pubitemid 34970816)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.34
, pp. 31107-31114
-
-
Chughtai, N.1
Schimchowitsch, S.2
Lebrun, J.-J.3
Ali, S.4
-
35
-
-
0345276476
-
LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain
-
DOI 10.1016/j.bbrc.2003.10.126
-
Rigacci, S., Talini, D., and Berti, A. (2003) LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain. Biochem. Biophys. Res. Commun. 312, 360-366 (Pubitemid 37445181)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.312
, Issue.2
, pp. 360-366
-
-
Rigacci, S.1
Talini, D.2
Berti, A.3
-
36
-
-
0037818425
-
Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia
-
DOI 10.1182/blood-2002-06-1890
-
Faderl, S., Harris, D., Van, Q., Kantarjian, H. M., Talpaz, M., and Estrov, Z. (2003) Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia. Blood 102, 630-637 (Pubitemid 36841985)
-
(2003)
Blood
, vol.102
, Issue.2
, pp. 630-637
-
-
Faderl, S.1
Harris, D.2
Van, Q.3
Kantarjian, H.M.4
Talpaz, M.5
Estrov, Z.6
-
37
-
-
0029838670
-
Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes
-
Rosen, R. L., Winestock, K. D., Chen, G., Liu, X., Hennighausen, L., and Finbloom, D. S. (1996) Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes. Blood 88, 1206-1214 (Pubitemid 26276795)
-
(1996)
Blood
, vol.88
, Issue.4
, pp. 1206-1214
-
-
Rosen, R.L.1
Winestock, K.D.2
Chen, G.3
Liu, X.4
Hennighausen, L.5
Finbloom, D.S.6
-
38
-
-
0031001282
-
Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters
-
al-Shami, A., Bourgoin, S. G., and Naccache, P. H. (1997) Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters. Blood 89, 1035-1044 (Pubitemid 27121298)
-
(1997)
Blood
, vol.89
, Issue.3
, pp. 1035-1044
-
-
Al-Shami, A.1
Bourgoin, S.G.2
Naccache, P.H.3
-
39
-
-
0342723739
-
Insulin selectively activates STAT5b, but not STAT5a, via a JAK2- independent signalling pathway in Kym-1 rhabdomyosarcoma cells
-
DOI 10.1016/S0014-5793(99)01689-0, PII S0014579399016890
-
Storz, P., Döppler, H., Pfizenmaier, K., and Müller, G. (1999) Insulin selectively activates STAT5b, but not STAT5a, via a JAK2-independent signalling pathway in Kym-1 rhabdomyosarcoma cells. FEBS Lett. 464, 159-163 (Pubitemid 30017934)
-
(1999)
FEBS Letters
, vol.464
, Issue.3
, pp. 159-163
-
-
Storz, P.1
Doppler, H.2
Pfizenmaier, K.3
Muller, G.4
-
40
-
-
0032831735
-
Stat5a and Stat5b: Fraternal twins of signal transduction and transcriptional activation
-
DOI 10.1016/S1359-6101(99)00011-8, PII S1359610199000118
-
Grimley, P. M., Dong, F., and Rui, H. (1999) Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation. Cytokine Growth Factor Rev. 10, 131-157 (Pubitemid 29446377)
-
(1999)
Cytokine and Growth Factor Reviews
, vol.10
, Issue.2
, pp. 131-157
-
-
Grimley, P.M.1
Dong, F.2
Rui, H.3
-
41
-
-
0034702266
-
Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines
-
Edamatsu, H., Gau, C. L., Nemoto, T., Guo, L., and Tamanoi, F. (2000) Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene 19, 3059-3068 (Pubitemid 30438462)
-
(2000)
Oncogene
, vol.19
, Issue.27
, pp. 3059-3068
-
-
Edamatsu, H.1
Gau, C.-L.2
Nemoto, T.3
Guo, L.4
Tamanoi, F.5
-
42
-
-
0029826282
-
Naturally occurring dominant negative variants of Stat5
-
Wang, D., Stravopodis, D., Teglund, S., Kitazawa, J., and Ihle, J. N. (1996) Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol. 16, 6141-6148 (Pubitemid 26360974)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.11
, pp. 6141-6148
-
-
Wang, D.1
Stravopodis, D.2
Teglund, S.3
Kitazawa, J.4
Ihle, J.N.5
-
43
-
-
17144427278
-
Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors
-
DOI 10.1074/jbc.M407326200
-
Moucadel, V., and Constantinescu, S. N. (2005) Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors. J. Biol. Chem. 280, 13364-13373 (Pubitemid 40517223)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13364-13373
-
-
Moucadel, V.1
Constantinescu, S.N.2
-
44
-
-
0027130238
-
Bcl-2/Bax - A rheostat that regulates an anti-oxidant pathway and cell death
-
Korsmeyer, S. J., Shutter, J. R., Veis, D. J., Merry, D. E., and Oltvai, Z. N. (1993) Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin. Cancer Biol. 4, 327-332 (Pubitemid 2028596)
-
(1993)
Seminars in Cancer Biology
, vol.4
, Issue.6
, pp. 327-332
-
-
Korsmeyer, S.J.1
Shutter, J.R.2
Veis, D.J.3
Merry, D.E.4
Oltvai, Z.N.5
-
45
-
-
1842682003
-
Survival of Developing Motor Neurons Mediated by Rho GTPase Signaling Pathway through Rho-Kinase
-
DOI 10.1523/JNEUROSCI.0295-04.2004
-
Kobayashi, K., Takahashi, M., Matsushita, N., Miyazaki, J., Koike, M., Yaginuma, H., Osumi, N., Kaibuchi, K., and Kobayashi, K. (2004) Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J. Neurosci. 24, 3480-3488 (Pubitemid 38481104)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.14
, pp. 3480-3488
-
-
Kobayashi, K.1
Takahashi, M.2
Matsushita, N.3
Miyazaki, J.-I.4
Koike, M.5
Yaginuma, H.6
Osumi, N.7
Kaibuchi, K.8
Kobayashi, K.9
-
46
-
-
14244264186
-
A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by alsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death
-
DOI 10.1074/jbc.M410508200
-
Kanekura, K., Hashimoto, Y., Kita, Y., Sasabe, J., Aiso, S., Nishimoto, I., and Matsuoka, M. (2005) A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by Als in LF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. J. Biol. Chem. 280, 4532-4543 (Pubitemid 40288621)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.6
, pp. 4532-4543
-
-
Kanekura, K.1
Hashimoto, Y.2
Kita, Y.3
Sasabe, J.4
Aiso, S.5
Nishimoto, I.6
Matsuoka, M.7
-
47
-
-
34247342131
-
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons
-
Cheung, Z. H., Chin, W. H., Chen, Y., Ng, Y. P., and Ip, N. Y. (2007) Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol. 5, e63
-
(2007)
PLoS Biol.
, vol.5
-
-
Cheung, Z.H.1
Chin, W.H.2
Chen, Y.3
Ng, Y.P.4
Ip, N.Y.5
-
48
-
-
77956194466
-
Interferon- γ produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells
-
Mäkelä, J., Koivuniemi, R., Korhonen, L., and Lindholm, D. (2010) Interferon- γ produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells. PLoS One 5, e11091
-
(2010)
PLoS One
, vol.5
-
-
Mäkelä, J.1
Koivuniemi, R.2
Korhonen, L.3
Lindholm, D.4
-
49
-
-
78649723354
-
Glial fibrillary tangles and JAK/ STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy
-
Colodner, K. J., and Feany, M. B. (2010) Glial fibrillary tangles and JAK/ STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J. Neurosci. 30, 16102-16113
-
(2010)
J. Neurosci.
, vol.30
, pp. 16102-16113
-
-
Colodner, K.J.1
Feany, M.B.2
-
50
-
-
33751260100
-
EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-γ: Role of JAK/STAT1 signaling and implications for HIV-associated dementia
-
DOI 10.1016/j.brainres.2006.09.057, PII S000689930602779X
-
Giunta, B., Obregon, D., Hou, H., Zeng, J., Sun, N., Nikolic, V., Ehrhart, J., Shytle, D., Fernandez, F., and Tan, J. (2006) EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-γ: role of JAK/STAT1 signaling and implications for HIV-associated dementia. Brain Res. 1123, 216-225 (Pubitemid 44794387)
-
(2006)
Brain Research
, vol.1123
, Issue.1
, pp. 216-225
-
-
Giunta, B.1
Obregon, D.2
Hou, H.3
Zeng, J.4
Sun, N.5
Nikolic, V.6
Ehrhart, J.7
Shytle, D.8
Fernandez, F.9
Tan, J.10
-
51
-
-
78650006986
-
Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAKSTAT signaling and down-regulation of PI3K/Akt pathway
-
Dedoni, S., Olianas, M. C., and Onali, P. (2010) Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAKSTAT signaling and down-regulation of PI3K/Akt pathway. J. Neurochem. 115, 1421-1433
-
(2010)
J. Neurochem.
, vol.115
, pp. 1421-1433
-
-
Dedoni, S.1
Olianas, M.C.2
Onali, P.3
-
52
-
-
33646928625
-
STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I
-
DOI 10.1016/j.bcp.2006.04.001, PII S0006295206002152
-
Graness, A., Poli, V., and Goppelt-Struebe, M. (2006) STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I. Biochem. Pharmacol. 72, 32-41 (Pubitemid 43795344)
-
(2006)
Biochemical Pharmacology
, vol.72
, Issue.1
, pp. 32-41
-
-
Graness, A.1
Poli, V.2
Goppelt-Struebe, M.3
-
53
-
-
40949134551
-
Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin
-
DOI 10.1038/cdd.2008.1, PII CDD20081, The biology of Hypoxia-inducible factors
-
Byts, N., Samoylenko, A., Fasshauer, T., Ivanisevic, M., Hennighausen, L., Ehrenreich, H., and Sirén, A. L. (2008) Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin. Cell Death Differ. 15, 783-792 (Pubitemid 351405083)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.4
, pp. 783-792
-
-
Byts, N.1
Samoylenko, A.2
Fasshauer, T.3
Ivanisevic, M.4
Hennighausen, L.5
Ehrenreich, H.6
Siren, A.-L.7
-
54
-
-
0347626096
-
Roscovitine Inhibits STAT5 Activity and Induces Apoptosis in the Human Leukemia Virus Type 1-Transformed Cell Line MT-2
-
Mohapatra, S., Chu, B., Wei, S., Djeu, J., Epling-Burnette, P. K., Loughran, T., Jove, R., and Pledger, W. J. (2003) Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res. 63, 8523-8530 (Pubitemid 37549511)
-
(2003)
Cancer Research
, vol.63
, Issue.23
, pp. 8523-8530
-
-
Mohapatra, S.1
Chu, B.2
Wei, S.3
Djeu, J.4
Epling-Burnette, P.K.5
Loughran, T.6
Jove, R.7
Pledger, W.J.8
-
55
-
-
33646834778
-
Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways
-
DOI 10.1074/jbc.M510943200
-
Um, M., and Lodish, H. F. (2006) Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. J. Biol. Chem. 281, 5648-5656 (Pubitemid 43847662)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.9
, pp. 5648-5656
-
-
Um, M.1
Lodish, H.F.2
-
56
-
-
79951581677
-
Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway
-
Choi, J. K., Kim, K. H., Park, H., Park, S. R., and Choi, B. H. (2011) Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway. Apoptosis 16, 127-134
-
(2011)
Apoptosis
, vol.16
, pp. 127-134
-
-
Choi, J.K.1
Kim, K.H.2
Park, H.3
Park, S.R.4
Choi, B.H.5
-
57
-
-
0032526629
-
Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway
-
Bingisser, R. M., Tilbrook, P. A., Holt, P. G., and Kees, U. R. (1998) Macrophage- derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J. Immunol. 160, 5729-5734 (Pubitemid 28298028)
-
(1998)
Journal of Immunology
, vol.160
, Issue.12
, pp. 5729-5734
-
-
Bingisser, R.M.1
Tilbrook, P.A.2
Holt, P.G.3
Kees, U.R.4
-
58
-
-
77951673112
-
JAK3/STAT5/6 pathway alterations are associated with immune deviation in CD8 T cells in renal cell carcinoma patients
-
Cavalcanti, E., Gigante, M., Mancini, V., Battaglia, M., Ditonno, P., Capobianco, C., Cincione, R. I., Selvaggi, F. P., Herr, W., Storkus, W. J., Gesualdo, L., and Ranieri, E. (2010) JAK3/STAT5/6 pathway alterations are associated with immune deviation in CD8 T cells in renal cell carcinoma patients. J. Biomed. Biotechnol. 2010, 935764
-
(2010)
J. Biomed. Biotechnol.
, vol.2010
, pp. 935764
-
-
Cavalcanti, E.1
Gigante, M.2
Mancini, V.3
Battaglia, M.4
Ditonno, P.5
Capobianco, C.6
Cincione, R.I.7
Selvaggi, F.P.8
Herr, W.9
Storkus, W.J.10
Gesualdo, L.11
Ranieri, E.12
-
59
-
-
78049398753
-
CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation
-
Martín, P., Gómez, M., Lamana, A., Cruz-Adalia, A., Ramírez-Huesca, M., Ursa, M. A., Yáñez-Mo, M., and Sánchez-Madrid, F. (2010) CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation. Mol. Cell Biol. 30, 4877-4889
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 4877-4889
-
-
Martín, P.1
Gómez, M.2
Lamana, A.3
Cruz-Adalia, A.4
Ramírez-Huesca, M.5
Ursa, M.A.6
Yáñez-Mo, M.7
Sánchez- Madrid, F.8
-
60
-
-
0034801684
-
SOCS proteins: Negative regulators of cytokine signaling
-
Krebs, D. L., and Hilton, D. J. (2001) SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19, 378-387 (Pubitemid 32900080)
-
(2001)
Stem Cells
, vol.19
, Issue.5
, pp. 378-387
-
-
Krebs, D.L.1
Hilton, D.J.2
-
61
-
-
0036480027
-
Suppressors of cytokine signaling (SOCS): Inhibitors of the JAK/STAT pathway
-
Cooney, R. N. (2002) Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway. Shock 17, 83-90
-
(2002)
Shock
, vol.17
, pp. 83-90
-
-
Cooney, R.N.1
-
62
-
-
0034705453
-
The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
-
Terstegen, L., Gatsios, P., Bode, J. G., Schaper, F., Heinrich, P. C., and Graeve, L. (2000) The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. J. Biol. Chem. 275, 18810 -18817
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18810-18817
-
-
Terstegen, L.1
Gatsios, P.2
Bode, J.G.3
Schaper, F.4
Heinrich, P.C.5
Graeve, L.6
-
63
-
-
67650561174
-
Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/ enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells
-
Borland, G., Bird, R. J., Palmer, T. M., and Yarwood, S. J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/ enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. J. Biol. Chem. 284, 17391-17403
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 17391-17403
-
-
Borland, G.1
Bird, R.J.2
Palmer, T.M.3
Yarwood, S.J.4
-
64
-
-
0027282044
-
bcl-x, A bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
-
DOI 10.1016/0092-8674(93)90508-N
-
Boise, L. H., González-García, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nuñez, G., and Thompson, C. B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608 (Pubitemid 23259741)
-
(1993)
Cell
, vol.74
, Issue.4
, pp. 597-608
-
-
Boise, L.H.1
Gonzalez-Garcia, M.2
Postema, C.E.3
Ding, L.4
Lindsten, T.5
Turka, L.A.6
Mao, X.7
Nunez, G.8
Thompson, C.B.9
-
65
-
-
0033534562
-
Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling
-
Zhu, M., John, S., Berg, M., and Leonard, W. J. (1999) Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling. Cell 96, 121-130
-
(1999)
Cell
, vol.96
, pp. 121-130
-
-
Zhu, M.1
John, S.2
Berg, M.3
Leonard, W.J.4
-
66
-
-
50349092265
-
Human T-cell leukemia virus type 1 Tax modulates interferon-α signal transduction through competitive usage of the coactivator CBP/p300
-
Zhang, J., Yamada, O., Kawagishi, K., Araki, H., Yamaoka, S., Hattori, T., and Shimotohno, K. (2008) Human T-cell leukemia virus type 1 Tax modulates interferon-α signal transduction through competitive usage of the coactivator CBP/p300. Virology 379, 306-313
-
(2008)
Virology
, vol.379
, pp. 306-313
-
-
Zhang, J.1
Yamada, O.2
Kawagishi, K.3
Araki, H.4
Yamaoka, S.5
Hattori, T.6
Shimotohno, K.7
-
67
-
-
60849088258
-
STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes
-
Xu, J., Chen, S., Chen, H., Xiao, Q., Hsu, C. Y., Michael, D., and Bao, J. (2009) STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J. Neurosci. 29, 2022-2026
-
(2009)
J. Neurosci.
, vol.29
, pp. 2022-2026
-
-
Xu, J.1
Chen, S.2
Chen, H.3
Xiao, Q.4
Hsu, C.Y.5
Michael, D.6
Bao, J.7
|