메뉴 건너뛰기




Volumn 287, Issue 20, 2012, Pages 16835-16848

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRAL INFECTION; CEREBELLAR GRANULE NEURONS; CHROMATIN IMMUNOPRECIPITATION; CLOSTRIDIUM DIFFICILE; DNA BINDING; DOMINANT NEGATIVE; DOWN-REGULATION; GTPASE ACTIVITY; JANUS KINASE; KNOCK OUTS; NEURONAL APOPTOSIS; NEURONAL CELL; PROMOTER REGION; RHO FAMILY; ROSCOVITINE; SIGNAL TRANSDUCERS; TRANSCRIPTIONAL REPRESSION; TYROSINE PHOSPHORYLATION; WILD TYPES;

EID: 84860879228     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.302166     Document Type: Article
Times cited : (25)

References (67)
  • 1
    • 0029101360 scopus 로고
    • An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
    • Olson, M. F., Ashworth, A., and Hall, A. (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269, 1270-1272
    • (1995) Science , vol.269 , pp. 1270-1272
    • Olson, M.F.1    Ashworth, A.2    Hall, A.3
  • 2
    • 0029015774 scopus 로고
    • The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
    • Hill, C. S., Wynne, J., and Treisman, R. (1995) The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81, 1159-1170
    • (1995) Cell , vol.81 , pp. 1159-1170
    • Hill, C.S.1    Wynne, J.2    Treisman, R.3
  • 3
    • 0032572557 scopus 로고    scopus 로고
    • Integrin-mediated signals regulated by members of the rho family of gtpases
    • DOI 10.1083/jcb.142.2.573
    • Clark, E. A., King, W. G., Brugge, J. S., Symons, M., and Hynes, R. O. (1998) Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142, 573-586 (Pubitemid 28361561)
    • (1998) Journal of Cell Biology , vol.142 , Issue.2 , pp. 573-586
    • Clark, E.A.1    King, W.G.2    Brugge, J.S.3    Symons, M.4    Hynes, R.O.5
  • 5
    • 0034655467 scopus 로고    scopus 로고
    • Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition
    • Tanaka, T., Tatsuno, I., Uchida, D., Moroo, I., Morio, H., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Saito, Y., and Hirai, A. (2000) Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. J. Neurosci. 20, 2852-2859 (Pubitemid 30220310)
    • (2000) Journal of Neuroscience , vol.20 , Issue.8 , pp. 2852-2859
    • Tanaka, T.1    Tatsuno, I.2    Uchida, D.3    Moroo, I.4    Morio, H.5    Nakamura, S.6    Noguchi, Y.7    Yasuda, T.8    Kitagawa, M.9    Saito, Y.10    Hirai, A.11
  • 8
    • 33646116540 scopus 로고    scopus 로고
    • Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival
    • Loucks, F. A., Le, S. S., Zimmermann, A. K., Ryan, K. R., Barth, H., Aktories, K., and Linseman, D. A. (2006) Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. J. Neurochem. 97, 957-967
    • (2006) J. Neurochem. , vol.97 , pp. 957-967
    • Loucks, F.A.1    Le, S.S.2    Zimmermann, A.K.3    Ryan, K.R.4    Barth, H.5    Aktories, K.6    Linseman, D.A.7
  • 9
    • 0034832208 scopus 로고    scopus 로고
    • Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice
    • Igaz, P., Tóth, S., and Falus, A. (2001) Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice. Inflamm. Res. 50, 435-441 (Pubitemid 32889442)
    • (2001) Inflammation Research , vol.50 , Issue.9 , pp. 435-441
    • Igaz, P.1    Toth, S.2    Falus, A.3
  • 10
    • 0034021317 scopus 로고    scopus 로고
    • Cytokines and their receptors in cardiovascular diseases - Role of gp130 signalling pathway in cardiac myocyte growth and maintenance
    • DOI 10.1046/j.1365-2613.2000.00139.x
    • Yamauchi-Takihara, K., and Kishimoto, T. (2000) Cytokines and their receptors in cardiovascular diseases - role of gp130 signalling pathway in cardiac myocyte growth and maintenance. Int. J. Exp. Pathol. 81, 1-16 (Pubitemid 30171497)
    • (2000) International Journal of Experimental Pathology , vol.81 , Issue.1 , pp. 1-16
    • Yamauchi-Takihara, K.1    Kishimoto, T.2
  • 11
    • 0028923658 scopus 로고
    • Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
    • Watson, C. J., and Miller, W. R. (1995) Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer 71, 840-844
    • (1995) Br. J. Cancer , vol.71 , pp. 840-844
    • Watson, C.J.1    Miller, W.R.2
  • 13
    • 33845970592 scopus 로고    scopus 로고
    • Glucocorticoids repress bcl-X expression in lymphoid cells by recruiting STAT5B to the P4 promoter
    • DOI 10.1074/jbc.M602408200
    • Rocha-Viegas, L., Vicent, G. P., Barañao, J. L., Beato, M., and Pecci, A. (2006) Glucocorticoids repress bcl-X expression in lymphoid cells by recruiting STAT5B to the P4 promoter. J. Biol. Chem. 281, 33959-33970 (Pubitemid 46043253)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.45 , pp. 33959-33970
    • Rocha-Viegas, L.1    Vicent, G.P.2    Baranao, J.L.3    Beato, M.4    Pecci, A.5
  • 15
    • 0011486518 scopus 로고    scopus 로고
    • Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro
    • Contestabile, A. (2002) Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro. Cerebellum 1, 41-55
    • (2002) Cerebellum , vol.1 , pp. 41-55
    • Contestabile, A.1
  • 18
    • 0035448912 scopus 로고    scopus 로고
    • Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons
    • Li, M., Linseman, D. A., Allen, M. P., Meintzer, M. K., Wang, X., Laessig, T., Wierman, M. E., and Heidenreich, K. A. (2001) Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J. Neurosci. 21, 6544-6552 (Pubitemid 32781098)
    • (2001) Journal of Neuroscience , vol.21 , Issue.17 , pp. 6544-6552
    • Li, M.1    Linseman, D.A.2    Allen, M.P.3    Meintzer, M.K.4    Wang, X.5    Laessig, T.6    Wierman, M.E.7    Heidenreich, K.A.8
  • 20
    • 42749095602 scopus 로고    scopus 로고
    • Structure and mode of action of clostridial glucosylating toxins: The ABCD model
    • Jank, T., and Aktories, K. (2008) Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol. 16, 222-229
    • (2008) Trends Microbiol. , vol.16 , pp. 222-229
    • Jank, T.1    Aktories, K.2
  • 21
    • 0034960254 scopus 로고    scopus 로고
    • STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
    • Sahni, M., Raz, R., Coffin, J. D., Levy, D., and Basilico, C. (2001) STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128, 2119-2129 (Pubitemid 32600472)
    • (2001) Development , vol.128 , Issue.11 , pp. 2119-2129
    • Sahni, M.1    Raz, R.2    Coffin, J.D.3    Levy, D.4    Basilico, C.5
  • 23
    • 1042301419 scopus 로고    scopus 로고
    • STAT1-induced Apoptosis Is Mediated by Caspases 2, 3, and 7
    • DOI 10.1074/jbc.M307774200
    • Sironi, J. J., and Ouchi, T. (2004) STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J. Biol. Chem. 279, 4066-4074 (Pubitemid 38198990)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.6 , pp. 4066-4074
    • Sironi, J.J.1    Ouchi, T.2
  • 28
    • 0344142396 scopus 로고    scopus 로고
    • Emerging roles of caspase-3 in apoptosis
    • Porter, A. G., and Jänicke, R. U. (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6, 99-104 (Pubitemid 29082297)
    • (1999) Cell Death and Differentiation , vol.6 , Issue.2 , pp. 99-104
    • Porter, A.G.1    Janicke, R.U.2
  • 30
    • 77952604395 scopus 로고    scopus 로고
    • Tyk2/STAT3 signaling mediates β-amyloid- induced neuronal cell death: Implications in Alzheimer's disease
    • Wan, J., Fu, A. K., Ip, F. C., Ng, H. K., Hugon, J., Page, G., Wang, J. H., Lai, K. O., Wu, Z., and Ip, N. Y. (2010) Tyk2/STAT3 signaling mediates β-amyloid- induced neuronal cell death: implications in Alzheimer's disease. J. Neurosci. 30, 6873-6881
    • (2010) J. Neurosci. , vol.30 , pp. 6873-6881
    • Wan, J.1    Fu, A.K.2    Ip, F.C.3    Ng, H.K.4    Hugon, J.5    Page, G.6    Wang, J.H.7    Lai, K.O.8    Wu, Z.9    Ip, N.Y.10
  • 31
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich, M. A., Sun, J., Cantor, A., Turkson, J., Jove, R., and Sebti, S. M. (2003) Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63, 1270-1279 (Pubitemid 36348705)
    • (2003) Cancer Research , vol.63 , Issue.6 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 32
    • 35348850681 scopus 로고    scopus 로고
    • Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53
    • DOI 10.1038/sj.onc.1210492, PII 1210492
    • Chipoy, C., Brounais, B., Trichet, V., Battaglia, S., Berreur, M., Oliver, L., Juin, P., Rédini, F., Heymann, D., and Blanchard, F. (2007) Sensitization of osteosarcoma cells to apoptosis by on costat in M depends on STAT5 and p53. Oncogene 26, 6653-6664 (Pubitemid 47573687)
    • (2007) Oncogene , vol.26 , Issue.46 , pp. 6653-6664
    • Chipoy, C.1    Brounais, B.2    Trichet, V.3    Battaglia, S.4    Berreur, M.5    Oliver, L.6    Juin, P.7    Redini, F.8    Heymann, D.9    Blanchard, F.10
  • 33
    • 11144241637 scopus 로고    scopus 로고
    • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification
    • DOI 10.1074/jbc.M408464200
    • Nelson, E. A., Walker, S. R., Alvarez, J. V., and Frank, D. A. (2004) Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J. Biol. Chem. 279, 54724-54730 (Pubitemid 40053217)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.52 , pp. 54724-54730
    • Nelson, E.A.1    Walker, S.R.2    Alvarez, J.V.3    Frank, D.A.4
  • 34
    • 0037163109 scopus 로고    scopus 로고
    • Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the β-casein gene promoter in mammary cells
    • DOI 10.1074/jbc.M200156200
    • Chughtai, N., Schimchowitsch, S., Lebrun, J. J., and Ali, S. (2002) Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the β-casein gene promoter in mammary cells. J. Biol. Chem. 277, 31107-31114 (Pubitemid 34970816)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.34 , pp. 31107-31114
    • Chughtai, N.1    Schimchowitsch, S.2    Lebrun, J.-J.3    Ali, S.4
  • 35
    • 0345276476 scopus 로고    scopus 로고
    • LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain
    • DOI 10.1016/j.bbrc.2003.10.126
    • Rigacci, S., Talini, D., and Berti, A. (2003) LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain. Biochem. Biophys. Res. Commun. 312, 360-366 (Pubitemid 37445181)
    • (2003) Biochemical and Biophysical Research Communications , vol.312 , Issue.2 , pp. 360-366
    • Rigacci, S.1    Talini, D.2    Berti, A.3
  • 36
    • 0037818425 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia
    • DOI 10.1182/blood-2002-06-1890
    • Faderl, S., Harris, D., Van, Q., Kantarjian, H. M., Talpaz, M., and Estrov, Z. (2003) Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia. Blood 102, 630-637 (Pubitemid 36841985)
    • (2003) Blood , vol.102 , Issue.2 , pp. 630-637
    • Faderl, S.1    Harris, D.2    Van, Q.3    Kantarjian, H.M.4    Talpaz, M.5    Estrov, Z.6
  • 37
    • 0029838670 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes
    • Rosen, R. L., Winestock, K. D., Chen, G., Liu, X., Hennighausen, L., and Finbloom, D. S. (1996) Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes. Blood 88, 1206-1214 (Pubitemid 26276795)
    • (1996) Blood , vol.88 , Issue.4 , pp. 1206-1214
    • Rosen, R.L.1    Winestock, K.D.2    Chen, G.3    Liu, X.4    Hennighausen, L.5    Finbloom, D.S.6
  • 38
    • 0031001282 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters
    • al-Shami, A., Bourgoin, S. G., and Naccache, P. H. (1997) Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters. Blood 89, 1035-1044 (Pubitemid 27121298)
    • (1997) Blood , vol.89 , Issue.3 , pp. 1035-1044
    • Al-Shami, A.1    Bourgoin, S.G.2    Naccache, P.H.3
  • 39
    • 0342723739 scopus 로고    scopus 로고
    • Insulin selectively activates STAT5b, but not STAT5a, via a JAK2- independent signalling pathway in Kym-1 rhabdomyosarcoma cells
    • DOI 10.1016/S0014-5793(99)01689-0, PII S0014579399016890
    • Storz, P., Döppler, H., Pfizenmaier, K., and Müller, G. (1999) Insulin selectively activates STAT5b, but not STAT5a, via a JAK2-independent signalling pathway in Kym-1 rhabdomyosarcoma cells. FEBS Lett. 464, 159-163 (Pubitemid 30017934)
    • (1999) FEBS Letters , vol.464 , Issue.3 , pp. 159-163
    • Storz, P.1    Doppler, H.2    Pfizenmaier, K.3    Muller, G.4
  • 40
    • 0032831735 scopus 로고    scopus 로고
    • Stat5a and Stat5b: Fraternal twins of signal transduction and transcriptional activation
    • DOI 10.1016/S1359-6101(99)00011-8, PII S1359610199000118
    • Grimley, P. M., Dong, F., and Rui, H. (1999) Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation. Cytokine Growth Factor Rev. 10, 131-157 (Pubitemid 29446377)
    • (1999) Cytokine and Growth Factor Reviews , vol.10 , Issue.2 , pp. 131-157
    • Grimley, P.M.1    Dong, F.2    Rui, H.3
  • 41
    • 0034702266 scopus 로고    scopus 로고
    • Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines
    • Edamatsu, H., Gau, C. L., Nemoto, T., Guo, L., and Tamanoi, F. (2000) Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene 19, 3059-3068 (Pubitemid 30438462)
    • (2000) Oncogene , vol.19 , Issue.27 , pp. 3059-3068
    • Edamatsu, H.1    Gau, C.-L.2    Nemoto, T.3    Guo, L.4    Tamanoi, F.5
  • 43
    • 17144427278 scopus 로고    scopus 로고
    • Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors
    • DOI 10.1074/jbc.M407326200
    • Moucadel, V., and Constantinescu, S. N. (2005) Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors. J. Biol. Chem. 280, 13364-13373 (Pubitemid 40517223)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.14 , pp. 13364-13373
    • Moucadel, V.1    Constantinescu, S.N.2
  • 46
    • 14244264186 scopus 로고    scopus 로고
    • A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by alsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death
    • DOI 10.1074/jbc.M410508200
    • Kanekura, K., Hashimoto, Y., Kita, Y., Sasabe, J., Aiso, S., Nishimoto, I., and Matsuoka, M. (2005) A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by Als in LF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. J. Biol. Chem. 280, 4532-4543 (Pubitemid 40288621)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.6 , pp. 4532-4543
    • Kanekura, K.1    Hashimoto, Y.2    Kita, Y.3    Sasabe, J.4    Aiso, S.5    Nishimoto, I.6    Matsuoka, M.7
  • 47
    • 34247342131 scopus 로고    scopus 로고
    • Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons
    • Cheung, Z. H., Chin, W. H., Chen, Y., Ng, Y. P., and Ip, N. Y. (2007) Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol. 5, e63
    • (2007) PLoS Biol. , vol.5
    • Cheung, Z.H.1    Chin, W.H.2    Chen, Y.3    Ng, Y.P.4    Ip, N.Y.5
  • 48
    • 77956194466 scopus 로고    scopus 로고
    • Interferon- γ produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells
    • Mäkelä, J., Koivuniemi, R., Korhonen, L., and Lindholm, D. (2010) Interferon- γ produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells. PLoS One 5, e11091
    • (2010) PLoS One , vol.5
    • Mäkelä, J.1    Koivuniemi, R.2    Korhonen, L.3    Lindholm, D.4
  • 49
    • 78649723354 scopus 로고    scopus 로고
    • Glial fibrillary tangles and JAK/ STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy
    • Colodner, K. J., and Feany, M. B. (2010) Glial fibrillary tangles and JAK/ STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J. Neurosci. 30, 16102-16113
    • (2010) J. Neurosci. , vol.30 , pp. 16102-16113
    • Colodner, K.J.1    Feany, M.B.2
  • 50
    • 33751260100 scopus 로고    scopus 로고
    • EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-γ: Role of JAK/STAT1 signaling and implications for HIV-associated dementia
    • DOI 10.1016/j.brainres.2006.09.057, PII S000689930602779X
    • Giunta, B., Obregon, D., Hou, H., Zeng, J., Sun, N., Nikolic, V., Ehrhart, J., Shytle, D., Fernandez, F., and Tan, J. (2006) EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-γ: role of JAK/STAT1 signaling and implications for HIV-associated dementia. Brain Res. 1123, 216-225 (Pubitemid 44794387)
    • (2006) Brain Research , vol.1123 , Issue.1 , pp. 216-225
    • Giunta, B.1    Obregon, D.2    Hou, H.3    Zeng, J.4    Sun, N.5    Nikolic, V.6    Ehrhart, J.7    Shytle, D.8    Fernandez, F.9    Tan, J.10
  • 51
    • 78650006986 scopus 로고    scopus 로고
    • Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAKSTAT signaling and down-regulation of PI3K/Akt pathway
    • Dedoni, S., Olianas, M. C., and Onali, P. (2010) Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAKSTAT signaling and down-regulation of PI3K/Akt pathway. J. Neurochem. 115, 1421-1433
    • (2010) J. Neurochem. , vol.115 , pp. 1421-1433
    • Dedoni, S.1    Olianas, M.C.2    Onali, P.3
  • 52
    • 33646928625 scopus 로고    scopus 로고
    • STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I
    • DOI 10.1016/j.bcp.2006.04.001, PII S0006295206002152
    • Graness, A., Poli, V., and Goppelt-Struebe, M. (2006) STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I. Biochem. Pharmacol. 72, 32-41 (Pubitemid 43795344)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.1 , pp. 32-41
    • Graness, A.1    Poli, V.2    Goppelt-Struebe, M.3
  • 53
    • 40949134551 scopus 로고    scopus 로고
    • Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin
    • DOI 10.1038/cdd.2008.1, PII CDD20081, The biology of Hypoxia-inducible factors
    • Byts, N., Samoylenko, A., Fasshauer, T., Ivanisevic, M., Hennighausen, L., Ehrenreich, H., and Sirén, A. L. (2008) Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin. Cell Death Differ. 15, 783-792 (Pubitemid 351405083)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.4 , pp. 783-792
    • Byts, N.1    Samoylenko, A.2    Fasshauer, T.3    Ivanisevic, M.4    Hennighausen, L.5    Ehrenreich, H.6    Siren, A.-L.7
  • 54
    • 0347626096 scopus 로고    scopus 로고
    • Roscovitine Inhibits STAT5 Activity and Induces Apoptosis in the Human Leukemia Virus Type 1-Transformed Cell Line MT-2
    • Mohapatra, S., Chu, B., Wei, S., Djeu, J., Epling-Burnette, P. K., Loughran, T., Jove, R., and Pledger, W. J. (2003) Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res. 63, 8523-8530 (Pubitemid 37549511)
    • (2003) Cancer Research , vol.63 , Issue.23 , pp. 8523-8530
    • Mohapatra, S.1    Chu, B.2    Wei, S.3    Djeu, J.4    Epling-Burnette, P.K.5    Loughran, T.6    Jove, R.7    Pledger, W.J.8
  • 55
    • 33646834778 scopus 로고    scopus 로고
    • Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways
    • DOI 10.1074/jbc.M510943200
    • Um, M., and Lodish, H. F. (2006) Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. J. Biol. Chem. 281, 5648-5656 (Pubitemid 43847662)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.9 , pp. 5648-5656
    • Um, M.1    Lodish, H.F.2
  • 56
    • 79951581677 scopus 로고    scopus 로고
    • Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway
    • Choi, J. K., Kim, K. H., Park, H., Park, S. R., and Choi, B. H. (2011) Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway. Apoptosis 16, 127-134
    • (2011) Apoptosis , vol.16 , pp. 127-134
    • Choi, J.K.1    Kim, K.H.2    Park, H.3    Park, S.R.4    Choi, B.H.5
  • 57
    • 0032526629 scopus 로고    scopus 로고
    • Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway
    • Bingisser, R. M., Tilbrook, P. A., Holt, P. G., and Kees, U. R. (1998) Macrophage- derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J. Immunol. 160, 5729-5734 (Pubitemid 28298028)
    • (1998) Journal of Immunology , vol.160 , Issue.12 , pp. 5729-5734
    • Bingisser, R.M.1    Tilbrook, P.A.2    Holt, P.G.3    Kees, U.R.4
  • 60
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • Krebs, D. L., and Hilton, D. J. (2001) SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19, 378-387 (Pubitemid 32900080)
    • (2001) Stem Cells , vol.19 , Issue.5 , pp. 378-387
    • Krebs, D.L.1    Hilton, D.J.2
  • 61
    • 0036480027 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling (SOCS): Inhibitors of the JAK/STAT pathway
    • Cooney, R. N. (2002) Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway. Shock 17, 83-90
    • (2002) Shock , vol.17 , pp. 83-90
    • Cooney, R.N.1
  • 62
    • 0034705453 scopus 로고    scopus 로고
    • The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
    • Terstegen, L., Gatsios, P., Bode, J. G., Schaper, F., Heinrich, P. C., and Graeve, L. (2000) The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. J. Biol. Chem. 275, 18810 -18817
    • (2000) J. Biol. Chem. , vol.275 , pp. 18810-18817
    • Terstegen, L.1    Gatsios, P.2    Bode, J.G.3    Schaper, F.4    Heinrich, P.C.5    Graeve, L.6
  • 63
    • 67650561174 scopus 로고    scopus 로고
    • Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/ enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells
    • Borland, G., Bird, R. J., Palmer, T. M., and Yarwood, S. J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/ enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. J. Biol. Chem. 284, 17391-17403
    • (2009) J. Biol. Chem. , vol.284 , pp. 17391-17403
    • Borland, G.1    Bird, R.J.2    Palmer, T.M.3    Yarwood, S.J.4
  • 64
    • 0027282044 scopus 로고
    • bcl-x, A bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
    • DOI 10.1016/0092-8674(93)90508-N
    • Boise, L. H., González-García, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nuñez, G., and Thompson, C. B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608 (Pubitemid 23259741)
    • (1993) Cell , vol.74 , Issue.4 , pp. 597-608
    • Boise, L.H.1    Gonzalez-Garcia, M.2    Postema, C.E.3    Ding, L.4    Lindsten, T.5    Turka, L.A.6    Mao, X.7    Nunez, G.8    Thompson, C.B.9
  • 65
    • 0033534562 scopus 로고    scopus 로고
    • Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling
    • Zhu, M., John, S., Berg, M., and Leonard, W. J. (1999) Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling. Cell 96, 121-130
    • (1999) Cell , vol.96 , pp. 121-130
    • Zhu, M.1    John, S.2    Berg, M.3    Leonard, W.J.4
  • 66
    • 50349092265 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type 1 Tax modulates interferon-α signal transduction through competitive usage of the coactivator CBP/p300
    • Zhang, J., Yamada, O., Kawagishi, K., Araki, H., Yamaoka, S., Hattori, T., and Shimotohno, K. (2008) Human T-cell leukemia virus type 1 Tax modulates interferon-α signal transduction through competitive usage of the coactivator CBP/p300. Virology 379, 306-313
    • (2008) Virology , vol.379 , pp. 306-313
    • Zhang, J.1    Yamada, O.2    Kawagishi, K.3    Araki, H.4    Yamaoka, S.5    Hattori, T.6    Shimotohno, K.7
  • 67
    • 60849088258 scopus 로고    scopus 로고
    • STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes
    • Xu, J., Chen, S., Chen, H., Xiao, Q., Hsu, C. Y., Michael, D., and Bao, J. (2009) STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J. Neurosci. 29, 2022-2026
    • (2009) J. Neurosci. , vol.29 , pp. 2022-2026
    • Xu, J.1    Chen, S.2    Chen, H.3    Xiao, Q.4    Hsu, C.Y.5    Michael, D.6    Bao, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.