Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAK-STAT signaling and down-regulation of PI3K/Akt pathway

Journal of Neurochemistry

Volumn 115, Issue 6, 2010, Pages 1421-1433

  Dedoni, Simona ^a   Olianas, Maria C ^a   Onali, Pierluigi ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

apoptosis; human neuroblastoma cells; JAK STAT signaling; PI3K Akt pathway; PKR; type I interferons

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CASPASE 3; CYTOCHROME C; INSULIN RECEPTOR SUBSTRATE 1; JANUS KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL STRAIN; CELL STRAIN SH SY5Y; CELL VIABILITY; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME RELEASE; GENE ACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; INTERFERON-BETA; JANUS KINASES; MICE; NEUROBLASTOMA; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

EID: 78650006986     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.07046.x     Document Type: Article

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