An Essential Role for Rac/Cdc42 GTPases in Cerebellar Granule Neuron Survival

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 39123-39131

  Linseman, Daniel A ^a,c   Laessig, Tracey ^a   Meintzer, Mary Kay ^a   McClure, Maria ^a   Barth, Holger ^b   Aktories, Klaus ^b   Heidenreich, Kim A ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; MOLECULES;

GRANULE NEURONS;

ENZYMES;

ACTIN; CASPASE 3; CLOSTRIDIUM DIFFICILE TOXIN B; F ACTIN; GLYCOGEN SYNTHASE KINASE 3BETA; GUANOSINE TRIPHOSPHATASE; IMIDAZOLE DERIVATIVE; INHIBITOR OF APOPTOSIS PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; PROTEIN CDC42; PROTEIN KINASE B; PYRIDINE DERIVATIVE; RAC PROTEIN; RHO FACTOR; AKT1 PROTEIN, RAT; BACTERIAL PROTEIN; BACTERIAL TOXIN; CASP3 PROTEIN, RAT; CASPASE; GLYCOGEN SYNTHASE KINASE; GLYCOGEN SYNTHASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; ONCOPROTEIN; POTASSIUM; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN SERINE THREONINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL SURVIVAL; CEREBELLUM; CLOSTRIDIUM SORDELLII; CONTROLLED STUDY; CYTOSKELETON; DEPOLARIZATION; ENZYME ACTIVATION; ENZYME INHIBITION; GRANULE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ADENOVIRUS; ANIMAL; CELL CULTURE; CELL NUCLEUS; CULTURE MEDIUM; CYTOLOGY; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING;

ANIMALIA; CLOSTRIDIUM; CLOSTRIDIUM BOTULINUM; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM SORDELLII; JANUS;

ACTINS; ADENOVIRIDAE; ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASPASE 3; CASPASES; CDC42 GTP-BINDING PROTEIN; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; CYTOSKELETON; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POTASSIUM; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-JUN; RAC GTP-BINDING PROTEINS; RATS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0035914433     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103959200     Document Type: Article

References (57)

1. Nobes, C. D., and Hall, A. (1995) Cell 81, 53-62
2. Olson, M. F., Ashworth, A., and Hall, A. (1995) Science 269, 1270-1272
3. Hill, C. S., Wynne, J., and Treisman, R. (1995) Cell 81, 1159-1170
4. Clark, E. A., King, W. G., Brugge, J. S., Symons, M., and Hynes, R. O. (1998) J. Cell Biol. 142, 573-586
5. Fukata, M., Kuroda, S., Nakagawa, M., Kawajiri, A., Itoh, N., Shoji, I., Matsuura, Y., Yonehara, S., Fujisawa, H., Kikuchi, A., and Kaibuchi, K. (1999) J. Biol. Chem. 274, 26044-26050
6. Gomez, J., Martinez, C., Giry, M., Garcia, A., and Rebollo, A. (1997) Eur. J. Immunol. 27, 2793-2799
7. Fiorentini, C., Matarrese, P., Straface, E., Falzano, L., Fabbri, A., Donelli, G., Cossarizza, A., Boquet, P., and Malorni, W. (1998) Exp. Cell Res. 242, 341-350
8. Fiorentini, C., Fabbri, A., Matarrese, P., Falzano, L., Boquet, P., and Malorni, W. (1997) Biochem. Biophys. Res. Commun. 241, 341-346
9. Boehm, J. E., Chaika, O. V., and Lewis, R. E. (1999) J. Biol. Chem. 274, 28632-28636
10. Joneson, T., and Bar-Sagi, D. (1999) Mol. Cell. Biol. 19, 5892-5901
11. Nishida, K., Kaziro, Y., and Satoh, T. (1999) Oncogene 18, 407-415
12. Embade, N., Valerón, P. F., Aznar, S., López-Collazo, E., and Lacal, J. C. (2000) Mol. Biol. Cell 11, 4347-4358
13. Subauste, M. C., Von Herrath, M., Benard, V., Chamberlain, C. E., Chuang, T.-H., Chu, K., Bokoch, G. M., and Hahn, K. M. (2000) J. Biol. Chem. 275, 9725-9733
14. Bazenet, C. E., Mota, M. A., and Rubin, L. L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3984-3989
15. Kanamoto, T., Mota, M., Takeda, K., Rubin, L. L., Miyazono, K., Ichijo, H., and Bazenet, C. E. (2000) Mol. Cell. Biol. 20, 196-204
16. Tanaka, T., Tatsuno, I., Uchida, D., Moroo, I., Morio, H., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Saito, Y., and Hirai, A. (2000) J. Neurosci. 20, 2852-2859
17. Garcia-Roman, N., Alvarez, A. M., Toro, M. J., Montes, A., and Lorenzo, M. J. (2001) Mol. Cell. Neurosci. 17, 329-341
18. Busch, C., and Aktories, K. (2000) Curr. Opin. Struct. Biol. 10, 528-535
19. D'Mello, S. R., Galli, C., Ciotti, T., and Calissano, P. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10989-10993
20. Galli, C., Meucci, O., Scorziello, A., Werge, T. M., Calissano, P., and Schettini, G. (1995) J. Neurosci. 15, 1172-1179
21. Von Eichel-Streiber, C., Harperath, U., Bosse, D., and Hadding, U. (1987) Microb. Pathog. 2, 307-318
22. Just, I., Selzer, J., Hofmann, F., Green, G. A., and Aktories, K. (1996) J. Biol. Chem. 271, 10149-10153
23. Aktories, K., Bärmann, M., Ohishi, I., Tsuyama, S., Jakobs, K. H., and Habermann, E. (1986) Nature 322, 390-392
24. Barth, H., Hofmann, F., Olenik, C., Just, I., and Aktories, K. (1998) Infect. Immun. 66, 1364-1369
25. Li, M., Wang, X., Meintzer, M. K., Laessig, T., Birnbaum, M. J., and Heidenreich, K. A. (2000) Mol. Cell. Biol. 20, 9356-9363
26. Just, I., Selzer, J., Wilm, M., Von Eichel-Streiber, C., Mann, M., and Aktories, K. (1995) Nature 375, 500-503
27. Nunez, G., Benedict, M. A., Hu, Y., and Inohara, N. (1998) Oncogene 17, 3237-3245
28. Kumar, S. (1997) Int. J. Biochem. Cell Biol. 29, 393-396
29. Porter, A. G., and Janicke, R. U. (1999) Cell Death Differ. 6, 99-104
30. Eldadah, B. A., Ren, R. F., and Faden, A. I. (2000) J. Neurosci. 20, 179-186
31. Garcia-Calvo, M., Peterson, E. P., Leiting, B., Ruel, R., Nicholson, D. W., and Thornberry, N. A. (1998) J. Biol. Chem. 273, 32608-32613
32. Watson, A., Eilers, A., Lallemand, D., Kyriakis, J., Rubin, L. L., and Ham, J. (1998) J. Neurosci. 18, 751-762
33. Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J., and Dedhar, S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11211-11216
34. Downward, J. (1998) Curr. Opin. Cell Biol. 10, 262-267
35. Hetman, M., Cavanaugh, J. E., Kimelrnan, D., and Xia, Z. (2000) J. Neurosci. 20, 2567-2574
36. Shaw, M., Cohen, P., and Alessi, D. R. (1997) FEBS Lett. 416, 307-311
37. Popoff, M. R., Chaves-Olarte, E., Lemichez, E., Von Eichel-Streiber, C., Thelestam, M., Chardin, P., Cussac, D., Antonny, B., Chavrier, P., Flatau, G., Giry, M., Gunzburg, J., and Boquet, P. (1996) J. Biol. Chem. 271, 10217-10224
38. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., and Narumiya, S. (1997) Nature 389, 990-994
39. Coffey, E. T., Hongisto, V., Dickens, M., Davis, R. J., and Courtney, M. J. (2000) J. Neurosci. 20, 7602-7613
40. Harada, J., and Sugimoto, M. (1999) Jpn. J. Pharmacol. 79, 369-378
41. Zawada, W. M., Meintzer, M. K., Rao, P., Marotti, J., Wang, X., Esplen, J. E., Clarkson, E. D., Freed, C. R., and Heidenreich, K. A. (2001) Brain Res. 891, 185-196
42. Wadsworth, S. A., Cavender, D. E., Beers, S. A., Lalan, P., Schafer, P. H., Malloy, E. A., Wu, W., Fahmy, B., Olini, G. C., Davis, J. E., Pellegrino-Gensey, J. L., Wachter, M. P., and Siekierka, J. J. (1999) J. Pharmacol. Exp. Ther. 291, 680-687
43. Mao, Z., Bonni, A., Xia, F., Nadal-Vicens, M., and Greenberg, M. E. (1999) Science 286, 785-790
44. Miller, T. M., Tansey, M. G., Johnson, E. M., Jr., and Creedon, D. J. (1997) J. Biol. Chem. 272, 9487-9453
45. Carpenter, C. L. (1996) Cell Dev. Biol. 7, 691-697
46. Ren, X.-D., and Schwartz, M. A. (1998) Curr. Opin. Genet. Dev. 8, 63-67
47. Djouder, N., Schmidt, G., Frings, M., Cavalié, A., Thelen, M., and Aktories, K. (2001) J. Immunol. 166, 1627-1634
48. Iimura, O., Vrtovsnik, F., Terzi, F., and Friedlander, G. (1997) Kidney Int. 52, 962-972
49. Suria, H., Chau, L. A., Negrou, E., Kelvin, D. J., and Madrenas, J. (1999) Life Sci. 65, 2697-2707
50. Yamazaki, Y., Tsuruga, M., Zhou, D., Fujita, Y., Shang, X., Dang, Y., Kawasaki, K., and Oka, S. (2000) Exp. Cell Res. 259, 64-78
51. Fiorentini, C., Fabbri, A., Falzano, L., Fattorossi, A., Matarrese, P., Rivabene, R., and Donelli, G. (1998) Infect. Immun. 66, 2660-2665
52. Schurmann, A., Mooney, A. F., Sanders, L. C., Sells, M. A., Wang, H. G., Reed, J. C., and Bokoch, G. M. (2000) Mol. Cell. Biol. 20, 453-461
53. Eilers, A., Whitfield, J., Babij, C., Rubin, L. L., and Ham, J. (1998) J. Neurosci. 18, 1713-1724
54. Coso, O. A., Chiariello, M., Yu, J. C., Teramoto, H., Crespo, P., Xu, N., Miki, T., and Gutkind, J. S. (1995) Cell 81, 1137-1146
55. Minden, A., Lin, A., Claret, F. X., Abo, A., and Karin, M. (1995) Cell 81, 1147-1157
56. Davis, W., Stephens, L. R., Hawkins, P. T., and Saklatvala, J. (1999) Biochem. J. 338, 387-392
57. Meyer, D., Liu, A., and Margolis, B. (1999) J. Biol. Chem. 274, 35113-35118