The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress

Biochemical Journal

Volumn 444, Issue 2, 2012, Pages 239-247

  Yan, Ling ^a   Guo, Shuangli ^a   Brault, Marie ^a   Harmon, Jamie ^b   Robertson, R Paul ^b   Hamid, Rizwan ^a   Stein, Roland ^a   Yang, Elizabeth ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

B55 regulatory subunit; Diabetes; Forkhead box O1 (FOXO1); Oxidative stress; Pancreatic cell; Protein phosphatase 2A (PP2A)

Indexed keywords

B55ALPHA ENZYME; HOLOENZYME; PHOSPHOPROTEIN PHOSPHATASE 2A; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL DEATH; CONTROLLED STUDY; CROSS LINKING; ENZYME ISOLATION; ENZYME STRUCTURE; GENE SILENCING; HYPERGLYCEMIA; IN VIVO CULTURE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RAT;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HEK293 CELLS; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; ISOENZYMES; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; UP-REGULATION;

ANIMALIA;

EID: 84860873833     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111606     Document Type: Article

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