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Volumn 10, Issue , 2009, Pages

Oxidative stress promotes autophagic cell death in human neuroblastoma cells with ectopic transfer of mitochondrial PPP2R2B (Bβ2)

Author keywords

[No Author keywords available]

Indexed keywords

HOLOENZYME; HYDROGEN PEROXIDE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN PPP2R2B; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG; NERVE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2R2B PROTEIN, HUMAN;

EID: 75449084767     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-10-91     Document Type: Article
Times cited : (21)

References (36)
  • 1
    • 0025881195 scopus 로고
    • Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform
    • 10.1021/bi00229a001, 1849734
    • Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA. Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. Biochemistry 1991, 30(15):3589-3597. 10.1021/bi00229a001, 1849734.
    • (1991) Biochemistry , vol.30 , Issue.15 , pp. 3589-3597
    • Mayer, R.E.1    Hendrix, P.2    Cron, P.3    Matthies, R.4    Stone, S.R.5    Goris, J.6    Merlevede, W.7    Hofsteenge, J.8    Hemmings, B.A.9
  • 2
    • 0033153258 scopus 로고    scopus 로고
    • Brain protein serine/threonine phosphatases
    • 10.1016/S0959-4388(99)80049-X, 10395578
    • Price NE, Mumby MC. Brain protein serine/threonine phosphatases. Curr Opin Neurobiol 1999, 9(3):336-342. 10.1016/S0959-4388(99)80049-X, 10395578.
    • (1999) Curr Opin Neurobiol , vol.9 , Issue.3 , pp. 336-342
    • Price, N.E.1    Mumby, M.C.2
  • 3
    • 0036830613 scopus 로고    scopus 로고
    • Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade
    • 10.1074/jbc.M203767200, 12191994
    • Strack S. Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade. J Biol Chem 2002, 277(44):41525-41532. 10.1074/jbc.M203767200, 12191994.
    • (2002) J Biol Chem , vol.277 , Issue.44 , pp. 41525-41532
    • Strack, S.1
  • 4
    • 0030684714 scopus 로고    scopus 로고
    • Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments
    • 10.1016/S0169-328X(97)00117-4, 9387859
    • Strack S, Westphal RS, Colbran RJ, Ebner FF, Wadzinski BE. Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments. Brain Res Mol Brain Res 1997, 49(1-2):15-28. 10.1016/S0169-328X(97)00117-4, 9387859.
    • (1997) Brain Res Mol Brain Res , vol.49 , Issue.1-2 , pp. 15-28
    • Strack, S.1    Westphal, R.S.2    Colbran, R.J.3    Ebner, F.F.4    Wadzinski, B.E.5
  • 5
    • 0032536810 scopus 로고    scopus 로고
    • Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits
    • 10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3, 9514514
    • Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE. Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. J Comp Neurol 1998, 392(4):515-527. 10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3, 9514514.
    • (1998) J Comp Neurol , vol.392 , Issue.4 , pp. 515-527
    • Strack, S.1    Zaucha, J.A.2    Ebner, F.F.3    Colbran, R.J.4    Wadzinski, B.E.5
  • 6
    • 0032703317 scopus 로고    scopus 로고
    • Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A
    • 10.1016/S0014-5793(99)01377-0, 10556517
    • Strack S, Chang D, Zaucha JA, Colbran RJ, Wadzinski BE. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS Lett 1999, 460(3):462-466. 10.1016/S0014-5793(99)01377-0, 10556517.
    • (1999) FEBS Lett , vol.460 , Issue.3 , pp. 462-466
    • Strack, S.1    Chang, D.2    Zaucha, J.A.3    Colbran, R.J.4    Wadzinski, B.E.5
  • 7
    • 0029834655 scopus 로고    scopus 로고
    • The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm
    • 10.1074/jbc.271.36.22081, 8703017
    • McCright B, Rivers AM, Audlin S, Virshup DM. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem 1996, 271(36):22081-22089. 10.1074/jbc.271.36.22081, 8703017.
    • (1996) J Biol Chem , vol.271 , Issue.36 , pp. 22081-22089
    • McCright, B.1    Rivers, A.M.2    Audlin, S.3    Virshup, D.M.4
  • 8
    • 0034009389 scopus 로고    scopus 로고
    • Protein phosphatase 2A: a panoply of enzymes
    • 10.1016/S0955-0674(99)00074-5, 10712915
    • Virshup DM. Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol 2000, 12(2):180-185. 10.1016/S0955-0674(99)00074-5, 10712915.
    • (2000) Curr Opin Cell Biol , vol.12 , Issue.2 , pp. 180-185
    • Virshup, D.M.1
  • 9
    • 0031741865 scopus 로고    scopus 로고
    • Physical and functional interactions between type I transforming growth factor beta receptors and B alpha, a WD-40 repeat subunit of phosphatase 2A
    • 109244, 9774674
    • Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R. Physical and functional interactions between type I transforming growth factor beta receptors and B alpha, a WD-40 repeat subunit of phosphatase 2A. Mol Cell Biol 1998, 18(11):6595-6604. 109244, 9774674.
    • (1998) Mol Cell Biol , vol.18 , Issue.11 , pp. 6595-6604
    • Griswold-Prenner, I.1    Kamibayashi, C.2    Maruoka, E.M.3    Mumby, M.C.4    Derynck, R.5
  • 10
    • 1842510667 scopus 로고    scopus 로고
    • Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology
    • Sontag E, Luangpirom A, Hladik C, Mudrak I, Ogris E, Speciale S, White CL. Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 2004, 63(4):287-301.
    • (2004) J Neuropathol Exp Neurol , vol.63 , Issue.4 , pp. 287-301
    • Sontag, E.1    Luangpirom, A.2    Hladik, C.3    Mudrak, I.4    Ogris, E.5    Speciale, S.6    White, C.L.7
  • 11
    • 0035503214 scopus 로고    scopus 로고
    • SCA12: an unusual mutation leads to an unusual spinocerebellar ataxia
    • 10.1016/S0361-9230(01)00596-2, 11719278
    • Holmes SE, Hearn EO, Ross CA, Margolis RL. SCA12: an unusual mutation leads to an unusual spinocerebellar ataxia. Brain Res Bull 2001, 56(3-4):397-403. 10.1016/S0361-9230(01)00596-2, 11719278.
    • (2001) Brain Res Bull , vol.56 , Issue.3-4 , pp. 397-403
    • Holmes, S.E.1    Hearn, E.O.2    Ross, C.A.3    Margolis, R.L.4
  • 12
    • 0344962346 scopus 로고    scopus 로고
    • Why is SCA12 different from other SCAs?
    • 10.1159/000072854, 14526180
    • Holmes SE, O'Hearn E, Margolis RL. Why is SCA12 different from other SCAs?. Cytogenet Genome Res 2003, 100(1-4):189-197. 10.1159/000072854, 14526180.
    • (2003) Cytogenet Genome Res , vol.100 , Issue.1-4 , pp. 189-197
    • Holmes, S.E.1    O'Hearn, E.2    Margolis, R.L.3
  • 13
    • 0002069827 scopus 로고    scopus 로고
    • Spinocerebellar ataxia type 12 (SCA12): additional evidence for a causative role of the CAG repeat expansion in PPP2R2B
    • HolmesE SEFH, O'Hearn E, et al. Spinocerebellar ataxia type 12 (SCA12): additional evidence for a causative role of the CAG repeat expansion in PPP2R2B. Abstract Am J Hum Genet 2000, 67:1074.
    • (2000) Abstract Am J Hum Genet , vol.67 , pp. 1074
    • HolmesE, S.E.F.H.1    O'Hearn, E.2
  • 15
    • 0032978487 scopus 로고    scopus 로고
    • Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55
    • 25403, 10359611
    • Turowski P, Myles T, Hemmings BA, Fernandez A, Lamb NJ. Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55. Mol Biol Cell 1999, 10(6):1997-2015. 25403, 10359611.
    • (1999) Mol Biol Cell , vol.10 , Issue.6 , pp. 1997-2015
    • Turowski, P.1    Myles, T.2    Hemmings, B.A.3    Fernandez, A.4    Lamb, N.J.5
  • 16
    • 0028142259 scopus 로고
    • Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2
    • Mayer-Jaekel RE, Ohkura H, Ferrigno P, Andjelkovic N, Shiomi K, Uemura T, Glover DM, Hemmings BA. Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. J Cell Sci 1994, 107(Pt 9):2609-2616.
    • (1994) J Cell Sci , vol.107 , Issue.PART. 9 , pp. 2609-2616
    • Mayer-Jaekel, R.E.1    Ohkura, H.2    Ferrigno, P.3    Andjelkovic, N.4    Shiomi, K.5    Uemura, T.6    Glover, D.M.7    Hemmings, B.A.8
  • 17
    • 0027772552 scopus 로고
    • The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation
    • 10.1016/0092-8674(93)90533-V, 8252625
    • Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, Mumby M. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell 1993, 75(5):887-897. 10.1016/0092-8674(93)90533-V, 8252625.
    • (1993) Cell , vol.75 , Issue.5 , pp. 887-897
    • Sontag, E.1    Fedorov, S.2    Kamibayashi, C.3    Robbins, D.4    Cobb, M.5    Mumby, M.6
  • 18
    • 27744512550 scopus 로고    scopus 로고
    • Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
    • 10.1074/jbc.M506986200, 16129692
    • Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem 2005, 280(43):36029-36036. 10.1074/jbc.M506986200, 16129692.
    • (2005) J Biol Chem , vol.280 , Issue.43 , pp. 36029-36036
    • Van Kanegan, M.J.1    Adams, D.G.2    Wadzinski, B.E.3    Strack, S.4
  • 19
    • 0043092070 scopus 로고    scopus 로고
    • A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis
    • 10.1074/jbc.M302832200, 12716901
    • Dagda RK, Zaucha JA, Wadzinski BE, Strack S. A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis. J Biol Chem 2003, 278(27):24976-24985. 10.1074/jbc.M302832200, 12716901.
    • (2003) J Biol Chem , vol.278 , Issue.27 , pp. 24976-24985
    • Dagda, R.K.1    Zaucha, J.A.2    Wadzinski, B.E.3    Strack, S.4
  • 20
    • 0034757817 scopus 로고    scopus 로고
    • The SCA12 mutation as a rare cause of spinocerebellar ataxia
    • 10.1001/archneur.58.11.1833, 11708992
    • Cholfin JA, Sobrido MJ, Perlman S, Pulst SM, Geschwind DH. The SCA12 mutation as a rare cause of spinocerebellar ataxia. Arch Neurol 2001, 58(11):1833-1835. 10.1001/archneur.58.11.1833, 11708992.
    • (2001) Arch Neurol , vol.58 , Issue.11 , pp. 1833-1835
    • Cholfin, J.A.1    Sobrido, M.J.2    Perlman, S.3    Pulst, S.M.4    Geschwind, D.H.5
  • 21
    • 60249095382 scopus 로고    scopus 로고
    • The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission
    • 10.1074/jbc.M800989200, 2605997, 18940801
    • Dagda RK, Merrill RA, Cribbs JT, Chen Y, Hell J, Usachev YM, Strack S. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. J Biol Chem 2008, 283(52):36241-36248. 10.1074/jbc.M800989200, 2605997, 18940801.
    • (2008) J Biol Chem , vol.283 , Issue.52 , pp. 36241-36248
    • Dagda, R.K.1    Merrill, R.A.2    Cribbs, J.T.3    Chen, Y.4    Hell, J.5    Usachev, Y.M.6    Strack, S.7
  • 22
    • 33745866310 scopus 로고    scopus 로고
    • Autophagic stress in neuronal injury and disease
    • 10.1097/01.jnen.0000229233.75253.be, 1885377, 16772866
    • Chu CT. Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol 2006, 65(5):423-432. 10.1097/01.jnen.0000229233.75253.be, 1885377, 16772866.
    • (2006) J Neuropathol Exp Neurol , vol.65 , Issue.5 , pp. 423-432
    • Chu, C.T.1
  • 23
    • 50249168137 scopus 로고    scopus 로고
    • Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease
    • 2574804, 18594198
    • Dagda RK, Zhu J, Kulich SM, Chu CT. Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy 2008, 4(6):770-782. 2574804, 18594198.
    • (2008) Autophagy , vol.4 , Issue.6 , pp. 770-782
    • Dagda, R.K.1    Zhu, J.2    Kulich, S.M.3    Chu, C.T.4
  • 24
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • 10.1093/emboj/19.21.5720, 305793, 11060023
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000, 19(21):5720-5728. 10.1093/emboj/19.21.5720, 305793, 11060023.
    • (2000) EMBO J , vol.19 , Issue.21 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6    Kominami, E.7    Ohsumi, Y.8    Yoshimori, T.9
  • 26
    • 0005677775 scopus 로고
    • 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • Seglen PO, Gordon PB. 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proceedings of the National Academy of Sciences USA 1892, 79(6):1889-1982.
    • (1892) Proceedings of the National Academy of Sciences USA , vol.79 , Issue.6 , pp. 1889-1982
    • Seglen, P.O.1    Gordon, P.B.2
  • 28
    • 0033788787 scopus 로고    scopus 로고
    • Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and Parkinsonism linked to chromosome 17 mutations
    • 10.1046/j.1471-4159.2000.0752155.x, 11032905
    • Goedert M, Satumtira S, Jakes R, Smith MJ, Kamibayashi C, White CL, Sontag E. Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and Parkinsonism linked to chromosome 17 mutations. J Neurochem 2000, 75(5):2155-2162. 10.1046/j.1471-4159.2000.0752155.x, 11032905.
    • (2000) J Neurochem , vol.75 , Issue.5 , pp. 2155-2162
    • Goedert, M.1    Satumtira, S.2    Jakes, R.3    Smith, M.J.4    Kamibayashi, C.5    White, C.L.6    Sontag, E.7
  • 29
    • 1642289188 scopus 로고    scopus 로고
    • Role of tau protein in both physiological and pathological conditions
    • 10.1152/physrev.00024.2003, 15044677
    • Avila J, Lucas JJ, Perez MAR, Hernandez F. Role of tau protein in both physiological and pathological conditions. Physiol Rev 2004, 84(2):361-384. 10.1152/physrev.00024.2003, 15044677.
    • (2004) Physiol Rev , vol.84 , Issue.2 , pp. 361-384
    • Avila, J.1    Lucas, J.J.2    Perez, M.A.R.3    Hernandez, F.4
  • 30
    • 33745088678 scopus 로고    scopus 로고
    • Molecular pathogenesis of spinocerebellar ataxias
    • 10.1093/brain/awl081, 16613893
    • Duenas AM, Goold R, Giunti P. Molecular pathogenesis of spinocerebellar ataxias. Brain 2006, 129(Pt 6):1357-1370. 10.1093/brain/awl081, 16613893.
    • (2006) Brain , vol.129 , Issue.PART. 6 , pp. 1357-1370
    • Duenas, A.M.1    Goold, R.2    Giunti, P.3
  • 31
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: their role in cell survival and cell death
    • 10.1038/sj.cdd.4401751, 16247498
    • Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005, 12(Suppl 2):1509-1518. 10.1038/sj.cdd.4401751, 16247498.
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 33
    • 0035503214 scopus 로고    scopus 로고
    • SCA12: an unusual mutation leads to an unusual spinocerebellar ataxia
    • 10.1016/S0361-9230(01)00596-2, 11719278
    • Holmes S, Hearn E, Ross C, Margolis R. SCA12: an unusual mutation leads to an unusual spinocerebellar ataxia. Brain Res Bull 2001, 56(3):397-403. 10.1016/S0361-9230(01)00596-2, 11719278.
    • (2001) Brain Res Bull , vol.56 , Issue.3 , pp. 397-403
    • Holmes, S.1    Hearn, E.2    Ross, C.3    Margolis, R.4
  • 34
    • 41549114279 scopus 로고    scopus 로고
    • The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
    • 10.1093/brain/awm318, 18187492
    • Pan T, Kondo S, Le W, Jankovic J. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 2008, 131(8):1969-1978. 10.1093/brain/awm318, 18187492.
    • (2008) Brain , vol.131 , Issue.8 , pp. 1969-1978
    • Pan, T.1    Kondo, S.2    Le, W.3    Jankovic, J.4
  • 35
    • 9144223779 scopus 로고    scopus 로고
    • Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival
    • 10.1074/jbc.M408015200, 15364932
    • Strack S, Cribbs JT, Gomez L. Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival. J Biol Chem 2004, 279(46):47732-47739. 10.1074/jbc.M408015200, 15364932.
    • (2004) J Biol Chem , vol.279 , Issue.46 , pp. 47732-47739
    • Strack, S.1    Cribbs, J.T.2    Gomez, L.3
  • 36
    • 44949099249 scopus 로고    scopus 로고
    • A protein phosphatase 2A (PP2A) inhibition assay using a recombinant enzyme for rapid detection of microcystins
    • 10.1016/j.toxicon.2008.03.003, 18430448
    • Ikehara T, Imamura S, Oshiro N, Ikehara S, Shinjo F, Yasumoto T. A protein phosphatase 2A (PP2A) inhibition assay using a recombinant enzyme for rapid detection of microcystins. Toxicon 2008, 51(8):1368-1373. 10.1016/j.toxicon.2008.03.003, 18430448.
    • (2008) Toxicon , vol.51 , Issue.8 , pp. 1368-1373
    • Ikehara, T.1    Imamura, S.2    Oshiro, N.3    Ikehara, S.4    Shinjo, F.5    Yasumoto, T.6


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