Cyclin D1 is a NF-κB corepressor

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 6, 2012, Pages 1119-1131

  Rubio, María F ^a   Fernandez, Pablo N Larrosa ^a   Alvarado, Cecilia V ^a   Panelo, L C ^a   Grecco, Marina Ruiz ^a   Colo, Georgina P ^a   Martínez Noel, Giselle A ^a   Micenmacher, Sabrina M ^a   Costas, Mónica A ^a,b  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Cyclin D1; NF B; Nuclear receptor coactivator; RAC3; Transcriptional activity; Tumor development

Indexed keywords

CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RAC3 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

BINDING SITES; CELL ADHESION; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CO-REPRESSOR PROTEINS; CYCLIN D1; DNA; HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; NF-KAPPA B; PROTEIN BINDING; PROTEIN TRANSPORT; RAC GTP-BINDING PROTEINS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84860868827     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.01.009     Document Type: Article

References (50)

1. Karin M., Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 2000, 18:621-663.
2. Ghosh S., Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002, 109(Suppl.):S81-S96.
3. Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6853-6866.
4. Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., Baldwin A.S. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 1999, 19:5785-5799.
5. Hinz M., Krappmann D., Eichten A., Heder A., Scheidereit C., Strauss M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol. 1999, 19:2690-2698.
6. Werbajh S., Nojek I., Lanz R., Costas M.A. RAC-3 is a NF-kappa B coactivator. FEBS Lett. 2000, 485:195-199.
7. Sheppard K.A., Rose D.W., Haque Z.K., Kurokawa R., McInerney E., Westin S., Thanos D., Rosenfeld M.G., Glass C.K., Collins T. Transcriptional activation by NF-kappaB requires multiple coactivators. Mol. Cell. Biol. 1999, 19:6367-6378.
8. Rayet B., Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 1999, 18:6938-6947.
9. Baldwin A.S. Series introduction: the transcription factor NF-kappaB and human disease. J. Clin. Invest. 2001, 107:3-6.
10. Sun S.C., Xiao G. Deregulation of NF-kappaB and its upstream kinases in cancer. Cancer Metastasis Rev. 2003, 22:405-422.
11. Barkett M., Gilmore T.D. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6910-6924.
12. Karin M., Lin A. NF-kappaB at the crossroads of life and death. Nat. Immunol. 2002, 3:221-227.
13. Biswas D.K., Shi Q., Baily S., Strickland I., Ghosh S., Pardee A.B., Iglehart J.D. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:10137-10142.
14. Rubio M.F., Werbajh S., Cafferata E.G., Quaglino A., Colo G.P., Nojek I.M., Kordon E.C., Nahmod V.E., Costas M.A. TNF-alpha enhances estrogen-induced cell proliferation of estrogen-dependent breast tumor cells through a complex containing nuclear factor-kappa B. Oncogene 2006, 25:1367-1377.
15. Webb P., Nguyen P., Shinsako J., Anderson C., Feng W., Nguyen M.P., Chen D., Huang S.M., Subramanian S., McKinerney E., Katzenellenbogen B.S., Stallcup M.R., Kushner P.J. Estrogen receptor activation function 1 works by binding p160 coactivator proteins. Mol. Endocrinol. 1998, 12:1605-1618.
16. Klinge C.M. Estrogen receptor interaction with co-activators and co-repressors. Steroids 2000, 65:227-251.
17. Font de Mora J., Brown M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol. Cell. Biol. 2000, 20:5041-5047.
18. Glass C.K., Rosenfeld M.G. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 2000, 14:121-141.
19. Spencer T.E., Jenster G., Burcin M.M., Allis C.D., Zhou J., Mizzen C.A., McKenna N.J., Onate S.A., Tsai S.Y., Tsai M.J., O'Malley B.W. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 1997, 389:194-198.
20. Chen H., Lin R.J., Xie W., Wilpitz D., Evans R.M. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 1999, 98:675-686.
21. Wang H., Huang Z., Xia L., Feng Q., Erdjument-Bromage H., Strahl B., Briggs S., Allis C., Wong J., Tempst P., Zhang Y. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 2001, 293:853-857.
22. Arnold A., Papanikolaou A. Cyclin D1 in breast cancer pathogenesis. J. Clin. Oncol. 2005, 23:4215-4224.
23. Wang C., Li Z., Fu M., Bouras T., Pestell R.G. Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential. Cancer Treat. Res. 2004, 119:217-237.
24. Horstmann S., Ferrari S., Klempnauer K.H. Regulation of B-Myb activity by cyclin D1. Oncogene 2000, 19:298-306.
25. Inoue K., Sherr C.J. Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Mol. Cell. Biol. 1998, 18:1590-1600.
26. Zwijsen R.M., Buckle R.S., Hijmans E.M., Loomans C.J., Bernards R. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev. 1998, 12:3488-3498.
27. Knudsen K.E., Cavenee W.K., Arden K.C. D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res. 1999, 59:2297-2301.
28. Petre C.E., Wetherill Y.B., Danielsen M., Knudsen K.E. Cyclin D1: mechanism and consequence of androgen receptor co-repressor activity. J. Biol. Chem. 2002, 277:2207-2215.
29. Lin H.M., Zhao L., Cheng S.Y. Cyclin D1 is a ligand-independent co-repressor for thyroid hormone receptors. J. Biol. Chem. 2002, 277:28733-28741.
30. Sakamaki T., Casimiro M.C., Ju X., Quong A.A., Katiyar S., Liu M., Jiao X., Li A., Zhang X., Lu Y., Wang C., Byers S., Nicholson R., Link T., Shemluck M., Yang J., Fricke S.T., Novikoff P.M., Papanikolaou A., Arnold A., Albanese C., Pestell R. Cyclin D1 determines mitochondrial function in vivo. Mol. Cell. Biol. 2006, 26:5449-5469.
31. Ito C.Y., Kazantsev A.G., Baldwin A.S. Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha. Nucleic Acids Res. 1994, 22:3787-3792.
32. Beg A.A., Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996, 274:782-784.
33. Costas M., Trapp T., Pereda M.P., Sauer J., Rupprecht R., Nahmod V.E., Reul J.M., Holsboer F., Arzt E. Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis. J. Clin. Invest. 1996, 98:1409-1416.
34. Chen H., Lin R.J., Schiltz R.L., Chakravarti D., Nash A., Nagy L., Privalsky M.L., Nakatani Y., Evans R.M. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 1997, 90:569-580.
35. Hulit J., Wang C., Li Z., Albanese C., Rao M., Di Vizio D., Shah S., Byers S.W., Mahmood R., Augenlicht L.H., Russell R., Pestell R.G. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol. Cell. Biol. 2004, 24:7598-7611.
36. Buckley M.F., Sweeney K.J., Hamilton J.A., Sini R.L., Manning D.L., Nicholson R.I., deFazio A., Watts C.K., Musgrove E.A., Sutherland R.L. Expression and amplification of cyclin genes in human breast cancer. Oncogene 1993, 8:2127-2133.
37. J.P. Lydon and B.W. O'Malley, Minireview: steroid receptor coactivator-3: a multifarious coregulator in mammary gland metastasis, Endocrinology.
38. Anzick S.L., Kononen J., Walker R.L., Azorsa D.O., Tanner M.M., Guan X.Y., Sauter G., Kallioniemi O.P., Trent J.M., Meltzer P.S. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 1997, 277:965-968.
39. Hinds P.W., Dowdy S.F., Eaton E.N., Arnold A., Weinberg R.A. Function of a human cyclin gene as an oncogene. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:709-713.
40. Baldin V., Lukas J., Marcote M.J., Pagano M., Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 1993, 7:812-821.
41. Sherr C.J. Cancer cell cycles. Science 1996, 274:1672-1677.
42. Louie M.C., Revenko A.S., Zou J.X., Yao J., Chen H.W. Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol. Cell. Biol. 2006, 26:3810-3823.
43. Chen F., Castranova V., Shi X. New insights into the role of nuclear factor-kappaB in cell growth regulation. Am. J. Pathol. 2001, 159:387-397.
44. Chen L.F., Mu Y., Greene W.C. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 2002, 21:6539-6548.
45. Biswas D.K., Dai S.C., Cruz A., Weiser B., Graner E., Pardee A.B. The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:10386-10391.
46. Cao Y., Bonizzi G., Seagroves T.N., Greten F.R., Johnson R., Schmidt E.V., Karin M. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 2001, 107:763-775.
47. Bautista S., Valles H., Walker R.L., Anzick S., Zeillinger R., Meltzer P., Theillet C. In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Clin. Cancer Res. 1998, 4:2925-2929.
48. Sakakura C., Hagiwara A., Yasuoka R., Fujita Y., Nakanishi M., Masuda K., Kimura A., Nakamura Y., Inazawa J., Abe T., Yamagishi H. Amplification and over-expression of the AIB1 nuclear receptor co-activator gene in primary gastric cancers. Int. J. Cancer 2000, 89:217-223.
49. Ghadimi B.M., Schrock E., Walker R.L., Wangsa D., Jauho A., Meltzer P.S., Ried T. Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Am. J. Pathol. 1999, 154:525-536.
50. Nakshatri H., Bhat-Nakshatri P., Martin D.A., Goulet R.J., Sledge G.W. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 1997, 17:3629-3639.