Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids: TNF-α priming increases glucocorticoid inhibition of TNF-α-induced cytotoxicity/apoptosis

Journal of Clinical Investigation

Volumn 98, Issue 6, 1996, Pages 1409-1416

  Costas, Mónica ^a   Trapp, Thorsten ^c   Pereda, Marcelo Páez ^a   Sauer, Joachim ^c   Rupprecht, Rainer ^c   Nahmod, Víctor E ^a   Reul, Johannes M H M ^c   Holsboer, Florian ^c   Arzt, Eduardo ^a,b  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

apoptosis; cytokines; glucocorticoid receptor; glucocorticoid response element; TNF

Indexed keywords

GLUCOCORTICOID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TARGET CELL; TRANSCRIPTION REGULATION;

EID: 0029768046     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118928     Document Type: Article

References (57)

1. Besedovsky, H., A. Del Rey, E. Sorkin, and C.A. Dinarello. 1986. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science (Wash. DC). 233:652-654.
2. Sapolsky, R., C. Rivier, G. Yamamoto, P. Plotsky, and W. Vale. 1987. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science (Wash. DC). 238:22-24.
3. Snyder, D.S., and E.R. Unanue. 1982. Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J. Immunol. 129:1803-1805.
4. Gillis, S., G.R. Crabtree, and K. Smith. 1979. Glucocorticoid-induced inhibition of T-cell growth factor production. I. The effect of mitogen-induced lymphocyte proliferation. J. Immunol. 123:1624-1631.
5. Cupps, T.R., and A.S. Fauci. 1982. Corticosteroid-mediated immunoregulation in man. Immunol. Rev. 65:133-155.
6. Beutler, B., N. Krochin, I.W. Milsark, C. Luedke, and A. Cerami. 1986. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science (Wash. DC) 232:977-980.
7. Arzt, E., J. Sauer, T. Pollmächer, M. Labeur, F. Holsboer, J. Reul, and G.K. Stalla. 1994. Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin. Endocrinology. 134:672-677.
8. Salkowski, C.A., and S.N. Vogel. 1992. Lipopolysaccharide increases glucocorticoid receptor expression in marine macrophages. J. Immunol. 149:4041-4047.
9. Rakasz, E., A. Gal, J. Biró, G. Balas, and A. Falus. 1993. Modulation of glucocorticosteroid binding in human lymphoid, monocytoid and hepatoma cell lines by inflammatory cytokines interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α. Scand. J. Immunol. 37:684-689.
10. Ballard, P.L., J.D. Baxter, S.J. Higgins, G.G. Rousseau, and G.M. Tomkins. 1974. General presence of glucocorticoid receptors in mammalian tissues. Endocrinology. 94:998-1002.
11. Vamvakopoulos, N.C., and G.P. Chrousos. 1994. Hormonal regulation of human corticotropin-releasing hormone gene expression: implications for the stress response and immune/inflammatory reaction. Endocr. Rev. 15:409-420.
12. Tai, P.-K.K., M.W. Albers, H. Chang, L.E. Faber, and S.L. Schreiber. 1992. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science (Wash. DC). 256:1315-1318.
13. Ning, Y.-M., and E.R. Sánchez. 1993. Potentialion of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin. J. Biol. Chem. 268:6073-6076.
14. Hollenberg, S.M., and R.M. Evans. 1988. Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell. 55:899-906.
15. Kühnel, B., E. Buetti, and H. Diggelmann. 1986. Functional analysis of the glucocorticoid regulatory elements present in the mouse mammary tumor virus long terminal repeat. J. Mol. Biol. 190:367-378.
16. Hollenberg, S.M., C. Weinberger, E.S. Ong, G. Cerelli, A. Oro, R. Lebo, E.B. Thomson, M.G. Rosenfeld, and R.M. Evans. 1985. Primary structure and expression of a functional glucocorticoid receptor cDNA. Nature (Lond.). 318:635-641.
17. Wigler, M., R. Sweet, G.K. Sim, B. Wold, A. Pellicer, E. Lazy, T. Maniatis, S. Silverstein, and R. Axel. 1979. Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell. 16:777-785.
18. Gorman, C.M., L.F. Moffat, and B.H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
19. Trapp, T., R. Rupprecht, M. Castrén, J.M.H.M. Reul, and F. Holsboer. 1994. Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS. Neuron. 13:1457-1462.
20. Rupprecht, R., J.L. Arriza, D. Spengler, J.M.H.M. Reul, R.M. Evans, F. Holsboer, and K. Damm. 1993. Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor. Mol. Endocrinol. 7:597-603.
21. Arriza, J.L., R.B. Simerly, L.W. Swanson, and R.M. Evans. 1988. The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Neuron. 1:887-900.
22. Herbomel, P., B. Bourachot, and M. Yaniv. 1984. Two distinct enhancers with different cell specificities coexist in the regulatory region of polioma. Cell. 39:653-662.
23. Arzt, E., G. Stelzer, U. Renner, M. Lange, O.A. Müller, and G.K. Stalla. 1992. Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures. J Clin. Invest. 90:1944-1951.
24. Costas, M., D. Mella, M. Criscuolo, A. Díaz, S. Finkielman, V.E. Nahmod, and E. Arzt. 1993. Superinduction of mitogen-stimulated interferon-γ production and other lymphokines by Sendai virus. J. Interferon Res. 13:407-412.
25. Sgonc, R., G. Boeck, H. Dietrich, J. Gruber, H. Recbeis, and G. Wick. 1994. Simultaneous determination of cell surface antigens and apoptosis. TIG (Trends Genet). 10:41-42.
26. Reul, J.M.H.M., I. Stec, G.J. Wiegers, M.S. Labeur, A.C.E. Linthorst, E. Arzt, and F. Holsboer. 1994. Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats. J. Clin. Invest. 93:2600-2607.
27. Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
28. Cidlowski, J.A., and N.B. Cidlowski. 1982. Glucocorticoid receptors and the cell cycle: evidence that the accumulation of glucocorticoid receptors during the S phase of the cycle is dependent on ribonucleic acid and protein synthesis. Endocrinology. 110:1653-1662.
29. Kull, F.C., Jr. 1988. Reduction in tumor necrosis factor receptor affinity and cytotoxicity by glucocorticoids. Biochem. Biophys. Res. Commun. 153:402-409.
30. Pagliacci, M.C., G. Migliorati, M. Smacchia, F. Grignani, C. Riccardi, and I. Nicoletti. 1993. Cellular stress and glucocorticoid hormones protect L-929 mouse fibroblasts from tumor necrosis factor alpha cytotoxicity. J. Endocrinol. Invest. 16:591-599.
31. Reid, T., P. Louie, and R. A. Heller. 1995. Mechanisms of tumor necrosis factor cytotoxicity and the cytotoxic signals transduced by the p75-tumor necrosis factor receptor. Circ. Shock. 44:84-90.
32. Boldin, M.P., I.L. Mett, E.E. Varfolomeev, I. Chumakov, Y. Shemer-Avni, J.H. Camonis, and D. Wallach. 1995. Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects. J. Biol. Chem. 270:387-391.
33. Nagata, S., and P. Golstein. 1995. The Fas death factor. Science (Wash. DC). 267:1449-1455.
34. Tartaglia, L.A., T.M. Ayres, G.H.W. Wong, and D.V. Goeddel. 1993. A novel domain within the 55 kD TNF receptor signals cell death. Cell. 74:845-853.
35. Vacca, A., M.P. Felli, A.R. Farina, S. Martinotti, M. Maroder, I. Screpanti, D. Meco, E. Petrangeli, L. Frati, and A. Gulino. 1992. Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements. J. Exp. Med. 175:637-646.
36. Lucibello, F.C., E.P. Slater, K.U. Jooss, M. Beato, and R. Müller. 1990. Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB. EMBO (Eur. Mol. Biol. Organ.) J. 9:2827-2834.
37. Diamond, M.I., J.N. Miner, S.K. Yoshinaga, and K.R. Yamamoto. 1990. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science (Wash. DC). 249:1266-1272.
38. Jonat, G., H.J. Rahmsdorf, K.-K. Park, A.C.B. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell. 62:1189-1204.
39. Yang-Yen, H.F., J.C. Chambard, Y.L. Sun, T. Smeal, T.J. Schimdt, J. Drouin, and M. Karin. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 62:1205-1215.
40. Ray, A., and K.E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA. 91:752-756.
41. Scheinman, R.I., A. Gualberto, C.M. Jewell, J.A. Cidlowski, and A.S. Baldwin, Jr. 1995. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol. Cell. Biol. 15:943-953.
42. Caldenhoven, E., J. Liden, S. Wissink, A. Van de Stolpe, J. Raaijmakers, L. Koenderman, S. Okret, J.-A. Gustafsson, and P.T. Van der Saag. 1995. Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol. Endocrinol. 9:401-412.
43. Scheinman, R.I., P.C. Cogswell, A.K. Lofquist, and A.S. Baldwin, Jr. 1995. Role of transcriptional activation of IκB in mediation of immunosuppression by glucocorticoids. Science (Wash. DC). 270:283-286.
44. Auphan, N., J.A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NFκB activity through induction of IκB synthesis. Science (Wash. DC). 270:286-290.
45. Barbara, J.A.J., W.B. Smith, J.R. Gamble, X. Van Ostade, P. Vandenabeele, J. Tavernier, W. Fiers, M.A. Vadas, and A.F. Lopez. 1994. Dissociation of TNF-α cytotoxic and proinflammatory activities by p55 receptor and p75 receptor-selective TNF-α mutants. EMBO (Eur. Mol. Biol. Organ.) J. 13:843-850.
46. Clement, M.-V., and I. Stamenkovic. 1994. Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions. J. Exp. Med. 180: 557-567.
47. Beutler, B., and A. Cerami. 1986. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature (Lond.). 320:584-588.
48. Beutler, B., I.W. Milsark, and A.C. Cerami. 1985. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science (Wash. DC). 229:869-871.
49. Tracey, K.J., B. Beutler, S.F. Lowry, J. Merryweather, S. Wolpe, I.W. Milsark, R.J. Hariri, TJ. Fahey III, A. Zentella, J.D. Albert, et al. 1986. Shock and tissue injury induced by recombinant human cachectin. Science (Wash. DC). 234:470-474.
50. Van Zee, K.J., S.A. Stackpole, W.J. Montegut, M.A. Rogy, S.E. Calvano, K.C. Hsu, M. Chao, C.L. Meschter, H. Loetscher, D. Stüber, et al. 1994. A human tumor necrosis factor (TNF) α mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon. J. Exp. Med. 179:1185-1191.
51. Okusawa, S., J.A. Gelfand, T. Ikejima, R.J. Connolly, and C.A. Dinarello. 1988. Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J. Clin. Invest. 81:1162-1172.
52. Matsuura, M., M. Kiso, A. Hasegawa, and M. Nakano. 1994. Multistep regulation mechanisms for tolerance induction to lipopolysaccharide lethality in the tumor necrosis factor-α mediated pathway. Eur. J. Biochem. 221:335-341.
53. Szabó, C., C. Thiemermann, C.-C. Wu, M. Perretti, and J.R. Vane. 1994. Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proc. Natl. Acad. Sci. USA. 91: 271-275.
54. Evans, G.E., and S.H. Zuckerman. 1991. Glucocorticoid-dependent and -independent mechanisms involved in lipopolysaccharide tolerance. Eur. J. Immunol. 21:1973-1979.
55. Hinshaw, L.B., B.K. Beller-Todd, and L.T. Archer. 1982. Current management of the septic shock patient: experimental bases for treatment. Circ. Shock. 9:545-553.
56. Parant, M., C. Le Contel, F. Parant, and L. Chedid. 1991. Influence of endogenous glucocorticoid on endotoxin-induced production of circulating TNF-α. Lymphokine Cytokine Res. 10:265-271.
57. Munck, A., P.M. Guyre, and N.J. Holbrook. 1984. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrinol. Rev. 5:25-44.