Treatment of chronic leg ulcers with topical activated protein C

Archives of Dermatology

Volumn 144, Issue 11, 2008, Pages 1479-1483

  Whitmont, Kaley ^a,b   Reid, Ian ^b   Tritton, Sara ^a,b   March, Lyn ^a   Xue, Meilang ^a   Lee, Michael ^b   Fulcher, Greg ^b   Sambrook, Phil ^a   Slobedman, Eric ^c   Cooper, Alan ^b   Jackson, Chris ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c Symbion Health Laverty Pathology   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANTIBIOTIC AGENT;

AGED; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; HISTOPATHOLOGY; HUMAN; LEG ULCER; MALE; PRIORITY JOURNAL; SKIN BIOPSY; SKIN INJURY; TREATMENT RESPONSE; WOUND; WOUND DRESSING;

ADMINISTRATION, TOPICAL; AGED; BIOPSY, NEEDLE; CHRONIC DISEASE; DEBRIDEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; LEG ULCER; MALE; PROTEIN C; RISK ASSESSMENT; SAMPLING STUDIES; SEVERITY OF ILLNESS INDEX; SKIN CARE; TREATMENT OUTCOME; WOUND HEALING;

EID: 47949100730     PISSN: 0003987X     EISSN: 15383652     Source Type: Journal    
DOI: 10.1001/archderm.144.11.1479     Document Type: Article

References (10)

1. Martin P, Leibovich SJ. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15(11):599-607.
2. Nguyen M, Arkell J, Jackson CJ. Activated protein C directly activates human endothelial gelatinase A. J Biol Chem. 2000;275(13):9095-9098.
3. Jackson CJ, Xue M, Thompson P, et al. Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair Regen. 2005;13(3):284-294.
4. Esmon CT. Crosstalk between inflammation and thrombosis. Maturitas. 2004;47(4):305-314.
5. Xue M, Campbell D, Sambrook PN, Fukudome K, Jackson CJ. Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C. J Invest Dermatol. 2005;125(6):1279-1285.
6. Xue M, Campbell D, Jackson CJ. Protein C is an autocrine growth factor for human skin keratinocytes. J Biol Chem. 2007;282(18):13610-13616.
7. Griffin JH, Zlokovic B, Fernandez JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002;39(3):197-205.
8. Mann HJ. Recombinant human activated protein C in severe sepsis. Am J Health Syst Pharm. 2002;59(suppl 1):S19-S23.
9. Martí-Carvajal A, Salanti G, Cardona AF. Human recombinant activated protein C for severe sepsis. Cochrane Database Syst Rev. 2007;18(3):CD004388.
10. Xue M, Thompson P, Kelso I, Jackson C. Activated protein C stimulates proliferation, migration and wound closure, inhibits apoptosis and upregulates MMP-2 activity in cultured human keratinocytes. Exp Cell Res. 2004;299(1):119-127.