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Volumn 14, Issue 3, 2012, Pages 393-399

ETS rearrangements in prostate cancer

Author keywords

ETS; gene fusion; next generation sequencing; prostate cancer; TMPRSS2:ERG; translocation

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR TMPRSS2; UNCLASSIFIED DRUG;

EID: 84860842223     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2011.145     Document Type: Review
Times cited : (20)

References (80)
  • 3
    • 33750339350 scopus 로고    scopus 로고
    • Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer
    • DOI 10.1038/labinvest.3700477, PII 3700477
    • Rubin MA, Chinnaiyan AM. Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer. Lab Invest 2006; 86: 1099-1102. (Pubitemid 44624146)
    • (2006) Laboratory Investigation , vol.86 , Issue.11 , pp. 1099-1102
    • Rubin, M.A.1    Chinnaiyan, A.M.2
  • 5
    • 33645750799 scopus 로고    scopus 로고
    • Tmprss2:ETV4 gene fusions define a third molecular subtype of prostate cancer
    • Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D et al. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res 2006; 66: 3396-3400.
    • (2006) Cancer Res. , vol.66 , pp. 3396-3400
    • Tomlins, S.A.1    Mehra, R.2    Rhodes, D.R.3    Smith, L.R.4    Roulston, D.5
  • 7
    • 66149150235 scopus 로고    scopus 로고
    • SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer
    • Rickman DS, Pflueger D, Moss B, VanDoren VE, Chen CX et al. SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer. Cancer Res 2009; 69: 2734-2738.
    • (2009) Cancer Res. , vol.69 , pp. 2734-2738
    • Rickman, D.S.1    Pflueger, D.2    Moss, B.3    VanDoren, V.E.4    Chen, C.X.5
  • 8
    • 77955660663 scopus 로고    scopus 로고
    • Diverse somatic mutation patterns and pathway alterations in human cancers
    • Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 2010; 466: 869-873.
    • (2010) Nature , vol.466 , pp. 869-873
    • Kan, Z.1    Jaiswal, B.S.2    Stinson, J.3    Janakiraman, V.4    Bhatt, D.5
  • 9
    • 77950518687 scopus 로고    scopus 로고
    • Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort
    • Esgueva R, Perner S, J LaFargue C, Scheble V, Stephan C et al. Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. Mod Pathol 2010; 23: 539-546.
    • (2010) Mod. Pathol. , vol.23 , pp. 539-546
    • Esgueva, R.1    Perner, S.2    J LaFargue, C.3    Scheble, V.4    Stephan, C.5
  • 10
    • 54749111457 scopus 로고    scopus 로고
    • A fluorescence in situ hybridization screen for E26 transformation- specific aberrations: Identification of DDX5-ETV4 fusion protein in prostate cancer
    • Han B, Mehra R, Dhanasekaran SM, Yu J, Menon A et al. A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: Identification of DDX5-ETV4 fusion protein in prostate cancer. Cancer Res 2008; 68: 7629-7637.
    • (2008) Cancer Res. , vol.68 , pp. 7629-7637
    • Han, B.1    Mehra, R.2    Dhanasekaran, S.M.3    Yu, J.4    Menon, A.5
  • 12
    • 67650489112 scopus 로고    scopus 로고
    • N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer
    • Pflueger D, Rickman DS, Sboner A, Perner S, LaFargue CJ et al. N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer. Neoplasia 2009; 11: 804-811.
    • (2009) Neoplasia , vol.11 , pp. 804-811
    • Pflueger, D.1    Rickman, D.S.2    Sboner, A.3    Perner, S.4    LaFargue, C.J.5
  • 13
    • 77954526989 scopus 로고    scopus 로고
    • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
    • Palanisamy N, Ateeq B, Kalyana-Sundaram S, Pflueger D, Ramnarayanan K et al. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat Med 2010; 16: 793-798.
    • (2010) Nat. Med. , vol.16 , pp. 793-798
    • Palanisamy, N.1    Ateeq, B.2    Kalyana-Sundaram, S.3    Pflueger, D.4    Ramnarayanan, K.5
  • 16
    • 50349093250 scopus 로고    scopus 로고
    • Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications
    • Mosquera JM, Perner S, Genega EM, Sanda M, Hofer MD et al. Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications. Clin Cancer Res 2008; 14: 3380-3385.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3380-3385
    • Mosquera, J.M.1    Perner, S.2    Genega, E.M.3    Sanda, M.4    Hofer, M.D.5
  • 19
    • 33749870551 scopus 로고    scopus 로고
    • TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions
    • DOI 10.1593/neo.06427
    • Cerveira N, Ribeiro FR, Peixoto A, Costa V, Henrique R et al. TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia 2006; 8: 826-832. (Pubitemid 44564838)
    • (2006) Neoplasia , vol.8 , Issue.10 , pp. 826-832
    • Cerveira, N.1    Ribeiro, F.R.2    Peixoto, A.3    Costa, V.4    Henrique, R.5    Jeronimo, C.6    Teixeira, M.R.7
  • 20
    • 77954997528 scopus 로고    scopus 로고
    • Antibody-based detection of ERG rearrangement-positive prostate cancer
    • Park K, Tomlins SA, Mudaliar KM, Chiu YL, Esgueva R et al. Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia 2010; 12: 590-598.
    • (2010) Neoplasia , vol.12 , pp. 590-598
    • Park, K.1    Tomlins, S.A.2    Mudaliar, K.M.3    Chiu, Y.L.4    Esgueva, R.5
  • 21
    • 33646428393 scopus 로고    scopus 로고
    • ETS-TMPRSS2 fusion gene products in prostate cancer
    • Ahlers CM, Figg WD. ETS-TMPRSS2 fusion gene products in prostate cancer. Cancer Biol Ther 2006; 5: 254-255.
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 254-255
    • Ahlers, C.M.1    Figg, W.D.2
  • 22
    • 33845329915 scopus 로고    scopus 로고
    • TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer
    • DOI 10.1158/0008-5472.CAN-06-1871
    • Hermans KG, van Marion R, van Dekken H, Jenster G, van Weerden WM et al. TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer. Cancer Res 2006; 66: 10658-63. (Pubitemid 44876959)
    • (2006) Cancer Research , vol.66 , Issue.22 , pp. 10658-10663
    • Hermans, K.G.1    Van Marion, R.2    Van Dekken, H.3    Jenster, G.4    Van Weerden, W.M.5    Trapman, J.6
  • 26
    • 33749034498 scopus 로고    scopus 로고
    • Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer
    • DOI 10.1158/0008-5472.CAN-06-1966
    • Wang J, Cai Y, Ren C, IttmannM. Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer. Cancer Res 2006; 66: 8347-8351. (Pubitemid 44449142)
    • (2006) Cancer Research , vol.66 , Issue.17 , pp. 8347-8351
    • Wang, J.1    Cai, Y.2    Ren, C.3    Ittmann, M.4
  • 27
    • 38049123346 scopus 로고    scopus 로고
    • Duplication of the fusion of TMPRSS2to ERG sequences identifies fatal human prostate cancer
    • Attard G, Clark J, Ambroisine L, Fisher G, Kovacs G et al. Duplication of the fusion of TMPRSS2to ERG sequences identifies fatal human prostate cancer. Oncogene 2008; 27: 253-263.
    • (2008) Oncogene , vol.27 , pp. 253-263
    • Attard, G.1    Clark, J.2    Ambroisine, L.3    Fisher, G.4    Kovacs, G.5
  • 32
    • 34547626674 scopus 로고    scopus 로고
    • Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer
    • Winnes M, Lissbrant E, Damber JE, Stenman G. Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. Oncol Rep 2007; 17: 1033-1036.
    • (2007) Oncol. Rep. , vol.17 , pp. 1033-1036
    • Winnes, M.1    Lissbrant, E.2    Damber, J.E.3    Stenman, G.4
  • 33
    • 34547106024 scopus 로고    scopus 로고
    • Microdeletion and concurrent translocation associated with a complex TMPRSS2:ERG prostate cancer gene fusion
    • DOI 10.1002/gcc.20470
    • Yoshimoto M, Ludkovski O, Bayani J, Graham C, Zielenska M et al. Microdeletion and concurrent translocation associated with a complex TMPRSS2:ERG prostate cancer gene fusion. Genes Chromosomes Cancer 2007; 46: 861-863. (Pubitemid 47106190)
    • (2007) Genes Chromosomes and Cancer , vol.46 , Issue.9 , pp. 861-863
    • Squire, J.A.1    Yoshimoto, M.2    Ludkovski, O.3    Bayani, J.4    Graham, C.5    Zielenska, M.6
  • 38
    • 33745808783 scopus 로고    scopus 로고
    • Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement
    • DOI 10.1593/neo.06283
    • Yoshimoto M, Joshua AM, Chilton-Macneill S, Bayani J, Selvarajah S et al. Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. Neoplasia 2006; 8: 465-469. (Pubitemid 44035330)
    • (2006) Neoplasia , vol.8 , Issue.6 , pp. 465-469
    • Yoshimoto, M.1    Joshua, A.M.2    Chilton-MacNeill, S.3    Bayani, J.4    Selvarajah, S.5    Evans, A.J.6    Zielenska, M.7    Squire, J.A.8
  • 39
    • 34547936357 scopus 로고    scopus 로고
    • Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: Frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues
    • DOI 10.1038/modpathol.3800903, PII 3800903
    • Tu JJ, Rohan S, Kao J, Kitabayashi N, Mathew S et al. Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: Frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. Mod Pathol 2007; 20: 921-928. (Pubitemid 47267823)
    • (2007) Modern Pathology , vol.20 , Issue.9 , pp. 921-928
    • Tu, J.J.1    Rohan, S.2    Kao, J.3    Kitabayashi, N.4    Mathew, S.5    Chen, Y.-T.6
  • 42
    • 45549090259 scopus 로고    scopus 로고
    • Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer
    • Mehra R, Tomlins SA, Yu J, Cao X, Wang L et al. Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer. Cancer Res 2008; 68: 3584-3590.
    • (2008) Cancer Res. , vol.68 , pp. 3584-3590
    • Mehra, R.1    Tomlins, S.A.2    Yu, J.3    Cao, X.4    Wang, L.5
  • 43
    • 68049101459 scopus 로고    scopus 로고
    • Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States
    • Mosquera JM, Mehra R, Regan MM, Perner S, Genega EM et al. Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States. Clin Cancer Res 2009; 15: 4706-4711.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4706-4711
    • Mosquera, J.M.1    Mehra, R.2    Regan, M.M.3    Perner, S.4    Genega, E.M.5
  • 44
    • 34548863661 scopus 로고    scopus 로고
    • Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer
    • DOI 10.1158/1078-0432.CCR-07-0700
    • Hessels D, Smit FP, Verhaegh GW, Witjes JA, Cornel EB et al. Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer. Clin Cancer Res 2007; 13: 5103-5108. (Pubitemid 47502077)
    • (2007) Clinical Cancer Research , vol.13 , Issue.17 , pp. 5103-5108
    • Hessels, D.1    Smit, F.P.2    Verhaegh, G.W.3    Witjes, J.A.4    Cornel, E.B.5    Schalken, J.A.6
  • 45
    • 33846785860 scopus 로고    scopus 로고
    • Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer
    • Laxman B, Tomlins SA, Mehra R, Morris DS, Wang L et al. Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer. Neoplasia 2006; 8: 885-888.
    • (2006) Neoplasia , vol.8 , pp. 885-888
    • Laxman, B.1    Tomlins, S.A.2    Mehra, R.3    Morris, D.S.4    Wang, L.5
  • 46
  • 47
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet 2009; 41: 619-624.
    • (2009) Nat. Genet. , vol.41 , pp. 619-624
    • Carver, B.S.1    Tran, J.2    Gopalan, A.3    Chen, Z.4    Shaikh, S.5
  • 48
    • 66749100105 scopus 로고    scopus 로고
    • Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
    • King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet 2009; 41: 524-526.
    • (2009) Nat. Genet. , vol.41 , pp. 524-526
    • King, J.C.1    Xu, J.2    Wongvipat, J.3    Hieronymus, H.4    Carver, B.S.5
  • 52
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • DOI 10.1038/1235
    • Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumour suppression. Nat Genet 1998; 19: 348-355. (Pubitemid 28357906)
    • (1998) Nature Genetics , vol.19 , Issue.4 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 53
    • 56649091295 scopus 로고    scopus 로고
    • Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome
    • Yoshimoto M, Joshua AM, Cunha IW, Coudry RA, Fonseca FP et al. Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome. Mod Pathol 2008; 21: 1451-1460.
    • (2008) Mod. Pathol. , vol.21 , pp. 1451-1460
    • Yoshimoto, M.1    Joshua, A.M.2    Cunha, I.W.3    Coudry, R.A.4    Fonseca, F.P.5
  • 54
    • 33644830601 scopus 로고    scopus 로고
    • Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
    • Marcucci G, Baldus CD, Ruppert AS, Radmacher MD, Mrozek K et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study. J Clin Oncol 2005; 23: 9234-42.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 9234-42
    • Marcucci, G.1    Baldus, C.D.2    Ruppert, A.S.3    Radmacher, M.D.4    Mrozek, K.5
  • 55
    • 33745236059 scopus 로고    scopus 로고
    • 25-Year Prostate Cancer Control and Survival Outcomes: A 40-Year Radical Prostatectomy Single Institution Series
    • DOI 10.1016/j.juro.2006.03.094, PII S0022534706007749
    • Porter CR, Kodama K, Gibbons RP, Correa R Jr, Chun FK et al. 25-year prostate cancer control and survival outcomes: A 40-year radical prostatectomy single institution series. J Urol 2006; 176: 569-574. (Pubitemid 43927880)
    • (2006) Journal of Urology , vol.176 , Issue.2 , pp. 569-574
    • Porter, C.R.1    Kodama, K.2    Gibbons, R.P.3    Correa Jr., R.4    Chun, F.K.-H.5    Perrotte, P.6    Karakiewicz, P.I.7
  • 56
    • 33745283388 scopus 로고    scopus 로고
    • Long-term outcome following radical prostatectomy in men with clinical stage T3 prostate cancer
    • DOI 10.1016/j.juro.2006.03.093, PII S0022534706007816
    • Carver BS, Bianco FJ Jr, Scardino PT, Eastham JA. Long-Term outcome following radical prostatectomy in men with clinical stage T3 prostate cancer. J Urol 2006; 176: 564-568. (Pubitemid 43927886)
    • (2006) Journal of Urology , vol.176 , Issue.2 , pp. 564-568
    • Carver, B.S.1    Bianco Jr., F.J.2    Scardino, P.T.3    Eastham, J.A.4
  • 57
    • 0141919737 scopus 로고    scopus 로고
    • The long-term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy
    • DOI 10.1097/01.ju.0000091876.13656.2e
    • Ward JF, Blute ML, Slezak J, Bergstralh EJ, Zincke H. The long-Term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy. J Urol 2003; 170: 1872-1876. (Pubitemid 37254948)
    • (2003) Journal of Urology , vol.170 , Issue.5 , pp. 1872-1876
    • Ward, J.F.1    Blute, M.L.2    Slezak, J.3    Bergstralh, E.J.4    Zincke, H.5
  • 58
    • 2442719288 scopus 로고    scopus 로고
    • Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate
    • DOI 10.1002/cncr.20243
    • Arora R, Koch MO, Eble JN, Ulbright TM, Li L et al. Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate. Cancer 2004; 100: 2362-2366. (Pubitemid 38657883)
    • (2004) Cancer , vol.100 , Issue.11 , pp. 2362-2366
    • Arora, R.1    Koch, M.O.2    Eble, J.N.3    Ulbright, T.M.4    Li, L.5    Cheng, L.6
  • 60
    • 0025954906 scopus 로고
    • A comparison of the morphological features of cancer arising in the transition zone and in the peripheral zone of the prostate
    • Greene DR, Wheeler TM, Egawa S, Dunn JK, Scardino PT. A comparison of the morphological features of cancer arising in the transition zone and in the peripheral zone of the prostate. J Urol 1991; 146: 1069-1076.
    • (1991) J. Urol. , vol.146 , pp. 1069-1076
    • Greene, D.R.1    Wheeler, T.M.2    Egawa, S.3    Dunn, J.K.4    Scardino, P.T.5
  • 61
    • 0028849282 scopus 로고
    • Chromosomal anomalies in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization
    • Qian J, Bostwick DG, Takahashi S, Borell TJ, Herath JF et al. Chromosomal anomalies in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization. Cancer Res 1995; 55: 5408-5414.
    • (1995) Cancer Res. , vol.55 , pp. 5408-5414
    • Qian, J.1    Bostwick, D.G.2    Takahashi, S.3    Borell, T.J.4    Herath, J.F.5
  • 65
    • 35648948853 scopus 로고    scopus 로고
    • TMPRSS2-ERG Fusion Heterogeneity in Multifocal Prostate Cancer: Clinical and Biologic Implications
    • DOI 10.1016/j.urology.2007.08.032, PII S0090429507020146
    • Barry M, Perner S, Demichelis F, Rubin MA. Interfocal heterogeneity for TMPRSS2-ERG fusion in multifocal prostate cancer. Urology 2007; 70: 630-633. (Pubitemid 350030260)
    • (2007) Urology , vol.70 , Issue.4 , pp. 630-633
    • Barry, M.1    Perner, S.2    Demichelis, F.3    Rubin, M.A.4
  • 66
    • 34548572763 scopus 로고    scopus 로고
    • Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: Molecular evidence for an independent group of diseases
    • DOI 10.1158/0008-5472.CAN-07-2043
    • Mehra R, Han B, Tomlins SA, Wang L, Menon A et al. Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: Molecular evidence for an independent group of diseases. Cancer Res 2007; 67: 7991-7995. (Pubitemid 47395131)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 7991-7995
    • Mehra, R.1    Han, B.2    Tomlins, S.A.3    Wang, L.4    Menon, A.5    Wasco, M.J.6    Shen, R.7    Montie, J.E.8    Chinnaiyan, A.M.9    Shah, R.B.10
  • 69
    • 66149098947 scopus 로고    scopus 로고
    • Characterization of ERG,AR and PTEN gene status in circulating tumor cells from patients with castrationresistant prostate cancer
    • Attard G, Swennenhuis JF, Olmos D, Reid AH, Vickers E et al. Characterization of ERG,AR and PTEN gene status in circulating tumor cells from patients with castrationresistant prostate cancer. Cancer Res 2009; 69: 2912-2918.
    • (2009) Cancer Res. , vol.69 , pp. 2912-2918
    • Attard, G.1    Swennenhuis, J.F.2    Olmos, D.3    Reid, A.H.4    Vickers, E.5
  • 70
    • 53749090666 scopus 로고    scopus 로고
    • Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    • Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 2008; 26: 4563-4571.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4563-4571
    • Attard, G.1    Reid, A.H.2    Yap, T.A.3    Raynaud, F.4    Dowsett, M.5
  • 71
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Oct
    • Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008 Oct; 7: 3129-3140.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3    Villanueva, A.4    Llovet, J.M.5
  • 75
    • 78549278708 scopus 로고    scopus 로고
    • Triggers for genomic rearrangements: Insights into genomic, cellular and environmental influences
    • Mani RS, Chinnaiyan AM. Triggers for genomic rearrangements: Insights into genomic, cellular and environmental influences. Nat Rev Genet 2010; 11: 819-829.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 819-829
    • Mani, R.S.1    Chinnaiyan, A.M.2
  • 77
    • 77955069195 scopus 로고    scopus 로고
    • Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    • Haffner MC, Aryee MJ, Toubaji A, Esopi DM, Albadine R et al. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nat Genet 2010; 42: 668-675.
    • (2010) Nat. Genet. , vol.42 , pp. 668-675
    • Haffner, M.C.1    Aryee, M.J.2    Toubaji, A.3    Esopi, D.M.4    Albadine, R.5
  • 78
    • 78649966606 scopus 로고    scopus 로고
    • Androgen-induced TMPRSS2:ERG fusion in nonmalignant prostate epithelial cells
    • Bastus NC, Boyd LK, Mao X, Stankiewicz E, Kudahetti SC et al. Androgen-induced TMPRSS2:ERG fusion in nonmalignant prostate epithelial cells. Cancer Res 2010; 70: 9544-9548.
    • (2010) Cancer Res. , vol.70 , pp. 9544-9548
    • Bastus, N.C.1    Boyd, L.K.2    Mao, X.3    Stankiewicz, E.4    Kudahetti, S.C.5
  • 79
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • Lin C, Yang L, Tanasa B, Hutt K, Ju BG et al. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 2009; 139: 1069-1083.
    • (2009) Cell , vol.139 , pp. 1069-1083
    • Lin, C.1    Yang, L.2    Tanasa, B.3    Hutt, K.4    Ju, B.G.5
  • 80
    • 70849135782 scopus 로고    scopus 로고
    • Induced chromosomal proximity and gene fusions in prostate cancer
    • Mani RS, Tomlins SA, Callahan K, Ghosh A, Nyati MK et al. Induced chromosomal proximity and gene fusions in prostate cancer. Science 2009; 326: 1230.
    • (2009) Science , vol.326 , pp. 1230
    • Mani, R.S.1    Tomlins, S.A.2    Callahan, K.3    Ghosh, A.4    Nyati, M.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.