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Volumn 2, Issue 5, 2011, Pages 282-288

Ca2+-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells

Author keywords

B cells; Calcium; Erk MAPK; Lymphocytes; Negative selection; Protein kinase c delta; RasGRP; STIM 1

Indexed keywords

CALCIUM ION; DIACYLGLYCEROL; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C DELTA; RAS PROTEIN;

EID: 84860838638     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.2.5.17794     Document Type: Article
Times cited : (19)

References (65)
  • 1
    • 0034092777 scopus 로고    scopus 로고
    • Ras regulation and function in lymphocytes
    • PMID:10781411
    • Genot E, Cantrell DA. Ras regulation and function in lymphocytes. Curr Opin Immunol 2000; 12:289-294. PMID:10781411; http://dx.doi.org/10.1016/S0952-7915(00)00089-3.
    • (2000) Curr Opin Immunol , vol.12 , pp. 289-294
    • Genot, E.1    Cantrell, D.A.2
  • 2
    • 27644575157 scopus 로고    scopus 로고
    • Coordinating ERK/MAPK signaling through scaffolds and inhibitors
    • PMID:16227978
    • Kolch W. Coordinating ERK/MAPK signaling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005; 6:827-837. PMID:16227978; http://dx.doi.org/10.1038/nrm1743.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 827-837
    • Kolch, W.1
  • 3
    • 33646336602 scopus 로고    scopus 로고
    • MAPK signal specificity: The right place at the right time
    • PMID:16603362
    • Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci 2006; 31:268-275. PMID:16603362; http://dx.doi.org/10.1016/j.tibs.2006.03.009.
    • (2006) Trends Biochem Sci , vol.31 , pp. 268-275
    • Murphy, L.O.1    Blenis, J.2
  • 4
    • 0025193117 scopus 로고
    • Stimulation of p21ras upon T-cell activation
    • PMID:2201921
    • Downward J, Graves JD, Warne PH, Rayter S, Cantrell DA. Stimulation of p21ras upon T-cell activation. Nature 1990; 346:719-723. PMID:2201921; http://dx.doi.org/10.1038/346719a0.
    • (1990) Nature , vol.346 , pp. 719-723
    • Downward, J.1    Graves, J.D.2    Warne, P.H.3    Rayter, S.4    Cantrell, D.A.5
  • 5
    • 0034303470 scopus 로고    scopus 로고
    • T cells: Getting a GRP on Ras
    • PMID:11017094
    • Roose J, Weiss A. T cells: getting a GRP on Ras. Nat Immunol 2000; 1:275-276. PMID:11017094; http://dx.doi.org/10.1038/79713.
    • (2000) Nat Immunol , vol.1 , pp. 275-276
    • Roose, J.1    Weiss, A.2
  • 6
    • 9344264018 scopus 로고    scopus 로고
    • Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptormediated Ras activation
    • PMID:15545601
    • Aiba Y, Oh-hora M, Kiyonaka S, Kimura Y, Hijikata A, Mori Y, et al. Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptormediated Ras activation. Proc Natl Acad Sci USA 2004; 101:16612-16617. PMID:15545601; http://dx.doi.org/10.1073/pnas.0407468101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16612-16617
    • Aiba, Y.1    Oh-Hora, M.2    Kiyonaka, S.3    Kimura, Y.4    Hijikata, A.5    Mori, Y.6
  • 7
    • 0347593996 scopus 로고    scopus 로고
    • Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling
    • PMID:14676298
    • Oh-hora M, Johmura S, Hashimoto A, Hikida M, Kurosaki T. Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med 2003; 198:1841-18451. PMID:14676298; http://dx.doi.org/10.1084/jem.20031547.
    • (2003) J Exp Med , vol.198 , pp. 1841-18451
    • Oh-Hora, M.1    Johmura, S.2    Hashimoto, A.3    Hikida, M.4    Kurosaki, T.5
  • 8
    • 18244409902 scopus 로고    scopus 로고
    • Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells
    • PMID:15657177
    • Zheng Y, Liu H, Coughlin J, Zheng J, Li L, Stone JC. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. Blood 2005; 105:3648-3654. PMID:15657177; http://dx.doi.org/10.1182/blood-2004-10-3916.
    • (2005) Blood , vol.105 , pp. 3648-3654
    • Zheng, Y.1    Liu, H.2    Coughlin, J.3    Zheng, J.4    Li, L.5    Stone, J.C.6
  • 9
    • 0344885558 scopus 로고    scopus 로고
    • Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
    • PMID:12628188
    • Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, et al. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 2003; 112:685-695. PMID:12628188; http://dx.doi.org/10.1016/S0092-8674(03)00149-1.
    • (2003) Cell , vol.112 , pp. 685-695
    • Margarit, S.M.1    Sondermann, H.2    Hall, B.E.3    Nagar, B.4    Hoelz, A.5    Pirruccello, M.6
  • 10
    • 58249092059 scopus 로고    scopus 로고
    • Digital signaling and hysteresis characterize ras activation in lymphoid cells
    • PMID:19167334
    • Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, et al. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 2009; 136:337-351. PMID:19167334; http://dx.doi.org/10.1016/j.cell.2008.11.051.
    • (2009) Cell , vol.136 , pp. 337-351
    • Das, J.1    Ho, M.2    Zikherman, J.3    Govern, C.4    Yang, M.5    Weiss, A.6
  • 11
    • 34147203741 scopus 로고    scopus 로고
    • Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes
    • PMID:17283063
    • Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol 2007; 27:2732-2745. PMID:17283063; http://dx.doi.org/10.1128/MCB.01882-06.
    • (2007) Mol Cell Biol , vol.27 , pp. 2732-2745
    • Roose, J.P.1    Mollenauer, M.2    Ho, M.3    Kurosaki, T.4    Weiss, A.5
  • 12
    • 0036274818 scopus 로고    scopus 로고
    • Integration of calcium and Ras signalling
    • PMID:11988768
    • Cullen PJ, Lockyer PJ. Integration of calcium and Ras signalling. Nat Rev Mol Cell Biol 2002; 3:339-348. PMID:11988768; http://dx.doi.org/10.1038/nrm808.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 339-348
    • Cullen, P.J.1    Lockyer, P.J.2
  • 15
    • 27144515996 scopus 로고    scopus 로고
    • 2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
    • PMID:16208375
    • 2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 2005; 437:902-905. PMID:16208375; http://dx.doi.org/10.1038/nature04147.
    • (2005) Nature , vol.437 , pp. 902-905
    • Zhang, S.L.1    Yu, Y.2    Roos, J.3    Kozak, J.A.4    Deerinck, T.J.5    Ellisman, M.H.6
  • 16
  • 17
    • 33748548406 scopus 로고    scopus 로고
    • The elementary unit of store-operated Ca2+ entry: Local activation of CRAC channels by STIM1 at ER-plasma membrane junctions
    • PMID:16966423
    • Luik RM, Wu MM, Buchanan J, Lewis RS. The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions. J Cell Biol 2006; 174:815-825. PMID:16966423; http://dx.doi.org/10.1083/jcb.200604015.
    • (2006) J Cell Biol , vol.174 , pp. 815-825
    • Luik, R.M.1    Wu, M.M.2    Buchanan, J.3    Lewis, R.S.4
  • 18
    • 33748569838 scopus 로고    scopus 로고
    • 2+ store depletion causes STIM1 to accumulate in ERregions closely associated with the plasma membrane
    • PMID:16966422
    • 2+ store depletion causes STIM1 to accumulate in ERregions closely associated with the plasma membrane. J Cell Biol 2006; 174:803-813. PMID:16966422; http://dx.doi.org/10.1083/jcb.200604014.
    • (2006) J Cell Biol , vol.174 , pp. 803-813
    • Wu, M.M.1    Buchanan, J.2    Luik, R.M.3    Lewis, R.S.4
  • 20
    • 34247247126 scopus 로고    scopus 로고
    • 2+-dye label reveals STIM1 surface exposure
    • PMID:17360414
    • 2+-dye label reveals STIM1 surface exposure. Proc Natl Acad Sci USA 2007; 104:3693-3697. PMID:17360414; http://dx.doi.org/10.1073/pnas.0611713104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3693-3697
    • Hauser, C.T.1    Tsien, R.Y.2
  • 21
    • 34547175313 scopus 로고    scopus 로고
    • Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion
    • PMID:17517596
    • Liou J, Fivaz M, Inoue T, Meyer T. Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci USA 2007; 104:9301-9306. PMID:17517596; http://dx.doi.org/10.1073/pnas.0702866104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9301-9306
    • Liou, J.1    Fivaz, M.2    Inoue, T.3    Meyer, T.4
  • 22
    • 61349137530 scopus 로고    scopus 로고
    • STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
    • PMID:19249086
    • Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, et al. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell 2009; 136:876-890. PMID:19249086; http://dx.doi.org/10.1016/j.cell.2009.02.014.
    • (2009) Cell , vol.136 , pp. 876-890
    • Park, C.Y.1    Hoover, P.J.2    Mullins, F.M.3    Bachhawat, P.4    Covington, E.D.5    Raunser, S.6
  • 23
    • 79955004049 scopus 로고    scopus 로고
    • STIM1, PKCdelta and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
    • PMID:21441934
    • Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, et al. STIM1, PKCdelta and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol 2011; 12:425-433. PMID:21441934; http://dx.doi.org/10.1038/ni.2016.
    • (2011) Nat Immunol , vol.12 , pp. 425-433
    • Limnander, A.1    Depeille, P.2    Freedman, T.S.3    Liou, J.4    Leitges, M.5    Kurosaki, T.6
  • 24
    • 18944383647 scopus 로고    scopus 로고
    • A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells
    • PMID:15899849
    • Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol 2005; 25:4426-4441. PMID:15899849; http://dx.doi.org/10.1128/MCB.25.11.4426-41.2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 4426-4441
    • Roose, J.P.1    Mollenauer, M.2    Gupta, V.A.3    Stone, J.4    Weiss, A.5
  • 25
    • 2442421056 scopus 로고    scopus 로고
    • RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis
    • PMID:14970203
    • Guilbault B, Kay RJ. RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis. J Biol Chem 2004; 279:19523-19530. PMID:14970203; http://dx.doi.org/10.1074/jbc.M314273200.
    • (2004) J Biol Chem , vol.279 , pp. 19523-19530
    • Guilbault, B.1    Kay, R.J.2
  • 26
    • 0035887778 scopus 로고    scopus 로고
    • Unique signaling properties of B cell antigen receptor in mature and immature B cells: Implications for tolerance and activation
    • PMID:11591737
    • Benschop RJ, Brandl E, Chan AC, Cambier JC. Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation. J Immunol 2001; 167:4172-4179.PMID:11591737.
    • (2001) J Immunol , vol.167 , pp. 4172-4179
    • Benschop, R.J.1    Brandl, E.2    Chan, A.C.3    Cambier, J.C.4
  • 27
    • 66949130737 scopus 로고    scopus 로고
    • Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance
    • PMID:19380785
    • Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol 2009; 182:5382-5392.PMID:19380785; http://dx.doi.org/10.4049/jimmunol.0803941.
    • (2009) J Immunol , vol.182 , pp. 5382-5392
    • Gross, A.J.1    Lyandres, J.R.2    Panigrahi, A.K.3    Prak, E.T.4    Defranco, A.L.5
  • 28
    • 33749535412 scopus 로고    scopus 로고
    • Transitional B cell fate is associated with developmental stage-specific regulationof diacylglycerol and calcium signaling upon B cell receptor engagement
    • PMID:17015726
    • Hoek KL, Antony P, Lowe J, Shinners N, Sarmah B, Wente SR, et al. Transitional B cell fate is associated with developmental stage-specific regulationof diacylglycerol and calcium signaling upon B cell receptor engagement. J Immunol 2006; 177:5405-5413. PMID:17015726.
    • (2006) J Immunol , vol.177 , pp. 5405-5413
    • Hoek, K.L.1    Antony, P.2    Lowe, J.3    Shinners, N.4    Sarmah, B.5    Wente, S.R.6
  • 29
    • 0033105841 scopus 로고    scopus 로고
    • Antigen receptorinduced signal transduction imbalances associated with the negative selection of immature B cells
    • PMID:10072508
    • King LB, Norvell A, Monroe JG. Antigen receptorinduced signal transduction imbalances associated with the negative selection of immature B cells. J Immunol 1999; 162:2655-2662. PMID:10072508.
    • (1999) J Immunol , vol.162 , pp. 2655-2662
    • King, L.B.1    Norvell, A.2    Monroe, J.G.3
  • 30
    • 1842609782 scopus 로고    scopus 로고
    • Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus
    • PMID:15060167
    • Perez de Castro I, Bivona TG, Philips MR, Pellicer A. Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol 2004; 24:3485-3496. PMID:15060167; http://dx.doi.org/10.1128/MCB.24.8.3485-96.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 3485-3496
    • de Perez, C.I.1    Bivona, T.G.2    Philips, M.R.3    Pellicer, A.4
  • 31
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • PMID:21358638
    • Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 2011; 12:295-303.PMID:21358638; http://dx.doi.org/10.1038/ni.2005.
    • (2011) Nat Immunol , vol.12 , pp. 295-303
    • Delgoffe, G.M.1    Pollizzi, K.N.2    Waickman, A.T.3    Heikamp, E.4    Meyers, D.J.5    Horton, M.R.6
  • 32
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • PMID:12150925
    • Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110:163-175. PMID:12150925; http://dx.doi.org/10.1016/S0092-8674(02)00808-5.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 33
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycininsensitive and raptor-independent pathway that regulates the cytoskeleton
    • PMID:15268862
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycininsensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14:1296-1302. PMID:15268862; http://dx.doi.org/10.1016/j.cub.2004.06.054.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 34
    • 0033539527 scopus 로고    scopus 로고
    • Functional analysis of CNK in RAS signaling
    • PMID:10557308
    • Therrien M, Wong AM, Kwan E, Rubin GM. Functional analysis of CNK in RAS signaling. Proc Natl Acad Sci USA 1999; 96:13259-13263. PMID:10557308; http://dx.doi.org/10.1073/pnas.96.23.13259.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13259-13263
    • Therrien, M.1    Wong, A.M.2    Kwan, E.3    Rubin, G.M.4
  • 35
    • 0029850713 scopus 로고    scopus 로고
    • KSR modulates signal propagation within the MAPK cascade
    • PMID:8946910
    • Therrien M, Michaud NR, Rubin GM, Morrison DK. KSR modulates signal propagation within the MAPK cascade. Genes Dev 1996; 10:2684-695. PMID:8946910; http://dx.doi.org/10.1101/gad.10.21.2684.
    • (1996) Genes Dev , vol.10 , pp. 2684-2695
    • Therrien, M.1    Michaud, N.R.2    Rubin, G.M.3    Morrison, D.K.4
  • 36
    • 0032582663 scopus 로고    scopus 로고
    • CNK, a RAFbinding multidomain protein required for RAS signaling
    • PMID:9814705
    • Therrien M, Wong AM, Rubin GM. CNK, a RAFbinding multidomain protein required for RAS signaling. Cell 1998; 95:343-353. PMID:9814705;http://dx.doi.org/10.1016/S0092-8674(00)81766-3.
    • (1998) Cell , vol.95 , pp. 343-353
    • Therrien, M.1    Wong, A.M.2    Rubin, G.M.3
  • 37
    • 0032508538 scopus 로고    scopus 로고
    • MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
    • PMID:9733512
    • Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 1998; 281:1668-16671.PMID:9733512; http://dx.doi.org/10.1126/science.281.5383.1668.
    • (1998) Science , vol.281 , pp. 1668-16671
    • Schaeffer, H.J.1    Catling, A.D.2    Eblen, S.T.3    Collier, L.S.4    Krauss, A.5    Weber, M.J.6
  • 38
    • 4344682999 scopus 로고    scopus 로고
    • Sef is a spatial regulator for Ras/MAP kinase signaling
    • PMID:15239952
    • Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E. Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell 2004; 7:33-44.PMID:15239952; http://dx.doi.org/10.1016/j.devcel.2004.05.019.
    • (2004) Dev Cell , vol.7 , pp. 33-44
    • Torii, S.1    Kusakabe, M.2    Yamamoto, T.3    Maekawa, M.4    Nishida, E.5
  • 39
    • 0041488671 scopus 로고    scopus 로고
    • Phospholipase Cgamma activates Ras on the Golgi apparatusby means of RasGRP1
    • PMID:12845332
    • Bivona TG, Perez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, et al. Phospholipase Cgamma activates Ras on the Golgi apparatusby means of RasGRP1. Nature 2003; 424:694-698. PMID:12845332; http://dx.doi.org/10.1038/nature01806.
    • (2003) Nature , vol.424 , pp. 694-698
    • Bivona, T.G.1    de Perez, C.I.2    Ahearn, I.M.3    Grana, T.M.4    Chiu, V.K.5    Lockyer, P.J.6
  • 40
    • 34447579251 scopus 로고    scopus 로고
    • The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2
    • PMID:17486117
    • Mor A, Campi G, Du G, Zheng Y, Foster DA, Dustin ML, et al. The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol 2007; 9:713-719. PMID:17486117; http://dx.doi.org/10.1038/ncb1592.
    • (2007) Nat Cell Biol , vol.9 , pp. 713-719
    • Mor, A.1    Campi, G.2    Du, G.3    Zheng, Y.4    Foster, D.A.5    Dustin, M.L.6
  • 41
    • 60549101661 scopus 로고    scopus 로고
    • Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain
    • PMID:19168098
    • Tazmini G, Beaulieu N, Woo A, Zahedi B, Goulding RE, Kay RJ. Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain. Biochim Biophys Acta 2009; 1793:447-461.PMID:19168098.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 447-461
    • Tazmini, G.1    Beaulieu, N.2    Woo, A.3    Zahedi, B.4    Goulding, R.E.5    Kay, R.J.6
  • 42
    • 33646560593 scopus 로고    scopus 로고
    • Diacylglycerol and protein kinase D localization during T lymphocyte activation
    • PMID:16713972
    • Spitaler M, Emslie E, Wood CD, Cantrell D. Diacylglycerol and protein kinase D localization during T lymphocyte activation. Immunity 2006; 24:535-546. PMID:16713972; http://dx.doi.org/10.1016/j.immuni.2006.02.013.
    • (2006) Immunity , vol.24 , pp. 535-546
    • Spitaler, M.1    Emslie, E.2    Wood, C.D.3    Cantrell, D.4
  • 43
    • 67349243386 scopus 로고    scopus 로고
    • Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells
    • PMID:19430478
    • Quann EJ, Merino E, Furuta T, Huse M. Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells. Nat Immunol 2009; 10:627-635. PMID:19430478; http://dx.doi.org/10.1038/ni.1734.
    • (2009) Nat Immunol , vol.10 , pp. 627-635
    • Quann, E.J.1    Merino, E.2    Furuta, T.3    Huse, M.4
  • 44
    • 70349090062 scopus 로고    scopus 로고
    • Formation of STIM and Orai complexes: Puncta and distal caps
    • PMID:19754895
    • Barr VA, Bernot KM, Shaffer MH, Burkhardt JK, Samelson LE. Formation of STIM and Orai complexes: puncta and distal caps. Immunol Rev 2009; 231:148-159. PMID:19754895; http://dx.doi.org/10.1111/j.1600-065X.2009.00812.x.
    • (2009) Immunol Rev , vol.231 , pp. 148-159
    • Barr, V.A.1    Bernot, K.M.2    Shaffer, M.H.3    Burkhardt, J.K.4    Samelson, L.E.5
  • 45
    • 51349085429 scopus 로고    scopus 로고
    • Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: Puncta and distal caps
    • PMID:18448669
    • Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, et al. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell 2008; 19:2802-2817. PMID:18448669;http://dx.doi.org/10.1091/mbc.E08-02-0146.
    • (2008) Mol Biol Cell , vol.19 , pp. 2802-2817
    • Barr, V.A.1    Bernot, K.M.2    Srikanth, S.3    Gwack, Y.4    Balagopalan, L.5    Regan, C.K.6
  • 46
    • 33845607123 scopus 로고    scopus 로고
    • Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
    • PMID:17086201
    • Daniels MA, Teixeiro E, Gill J, Hausmann B, Roubaty D, Holmberg K, et al. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 2006; 444:724-729. PMID:17086201; http://dx.doi.org/10.1038/nature05269.
    • (2006) Nature , vol.444 , pp. 724-729
    • Daniels, M.A.1    Teixeiro, E.2    Gill, J.3    Hausmann, B.4    Roubaty, D.5    Holmberg, K.6
  • 47
    • 62149114138 scopus 로고    scopus 로고
    • Dual-specificity phosphatases: Critical regulators with diverse cellular targets
    • PMID:19228121
    • Patterson KI, Brummer T, O'Brien PM, Daly RJ. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J 2009; 418:475-489.PMID:19228121.
    • (2009) Biochem J , vol.418 , pp. 475-489
    • Patterson, K.I.1    Brummer, T.2    O'Brien, P.M.3    Daly, R.J.4
  • 48
    • 33144460185 scopus 로고    scopus 로고
    • Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
    • PMID:16461893
    • Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, et al. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA 2006; 103:2274-2279. PMID:16461893;http://dx.doi.org/10.1073/pnas.0510965103.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2274-2279
    • Chi, H.1    Barry, S.P.2    Roth, R.J.3    Wu, J.J.4    Jones, E.A.5    Bennett, A.M.6
  • 49
    • 31344475056 scopus 로고    scopus 로고
    • Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
    • PMID:16380512
    • Hammer M, Mages J, Dietrich H, Servatius A, Howells N, Cato AC, et al. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 2006; 203:15-20. PMID:16380512;http://dx.doi.org/10.1084/jem.20051753.
    • (2006) J Exp Med , vol.203 , pp. 15-20
    • Hammer, M.1    Mages, J.2    Dietrich, H.3    Servatius, A.4    Howells, N.5    Cato, A.C.6
  • 50
    • 33646192473 scopus 로고    scopus 로고
    • Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
    • PMID:16474395
    • Jeffrey KL, Brummer T, Rolph MS, Liu SM, Callejas NA, Grumont RJ, et al. Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nat Immunol 2006; 7:274-83.PMID:16474395; http://dx.doi.org/10.1038/ni1310.
    • (2006) Nat Immunol , vol.7 , pp. 274-283
    • Jeffrey, K.L.1    Brummer, T.2    Rolph, M.S.3    Liu, S.M.4    Callejas, N.A.5    Grumont, R.J.6
  • 51
    • 33751566645 scopus 로고    scopus 로고
    • DUSP meet immunology: Dual specificity MAPK phosphatases in control of the inflammatory response
    • PMID:17114416
    • Lang R, Hammer M, Mages J. DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol 2006; 177:7497-504. PMID:17114416
    • (2006) J Immunol , vol.177 , pp. 7497-7504
    • Lang, R.1    Hammer, M.2    Mages, J.3
  • 52
    • 31144452241 scopus 로고    scopus 로고
    • Essential role of MAPK phosphatase-1 in the negative control of innate immune responses
    • PMID:16424221
    • Salojin KV, Owusu IB, Millerchip KA, Potter M, Platt KA, Oravecz T. Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol 2006; 176:1899-1907.PMID:16424221.
    • (2006) J Immunol , vol.176 , pp. 1899-1907
    • Salojin, K.V.1    Owusu, I.B.2    Millerchip, K.A.3    Potter, M.4    Platt, K.A.5    Oravecz, T.6
  • 53
    • 4043076210 scopus 로고    scopus 로고
    • Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
    • PMID:15306813
    • Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, et al. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature 2004; 430:793-797. PMID:15306813; http://dx.doi.org/10.1038/nature02764.
    • (2004) Nature , vol.430 , pp. 793-797
    • Zhang, Y.1    Blattman, J.N.2    Kennedy, N.J.3    Duong, J.4    Nguyen, T.5    Wang, Y.6
  • 54
    • 31344442772 scopus 로고    scopus 로고
    • MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
    • PMID:16380513
    • Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, et al. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med 2006; 203:131-140. PMID:16380513; http://dx.doi.org/10.1084/jem.20051794.
    • (2006) J Exp Med , vol.203 , pp. 131-140
    • Zhao, Q.1    Wang, X.2    Nelin, L.D.3    Yao, Y.4    Matta, R.5    Manson, M.E.6
  • 55
    • 0037171439 scopus 로고    scopus 로고
    • Protein kinase Cdelta controls self-antigen-induced B-cell tolerance
    • PMID:11976686
    • Mecklenbräuker I, Saijo K, Zheng NY, Leitges M, Tarakhovsky A. Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature 2002; 416:860-865.PMID:11976686; http://dx.doi.org/10.1038/416860a.
    • (2002) Nature , vol.416 , pp. 860-865
    • Mecklenbräuker, I.1    Saijo, K.2    Zheng, N.Y.3    Leitges, M.4    Tarakhovsky, A.5
  • 56
    • 28244476478 scopus 로고    scopus 로고
    • RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling
    • PMID:16301621
    • Coughlin JJ, Stang SL, Dower NA, Stone JC. RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol 2005; 175:7179-7184. PMID:16301621.
    • (2005) J Immunol , vol.175 , pp. 7179-7184
    • Coughlin, J.J.1    Stang, S.L.2    Dower, N.A.3    Stone, J.C.4
  • 57
    • 0034303371 scopus 로고    scopus 로고
    • RasGRP is essential for mouse thymocyte differentiation and TCR signaling
    • PMID:11017103
    • Dower NA, Stang SL, Bottorff DA, Ebinu JO, Dickie P, Ostergaard HL, et al. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol 2000; 1:317-321. PMID:11017103; http://dx.doi.org/10.1038/80799.
    • (2000) Nat Immunol , vol.1 , pp. 317-321
    • Dower, N.A.1    Stang, S.L.2    Bottorff, D.A.3    Ebinu, J.O.4    Dickie, P.5    Ostergaard, H.L.6
  • 58
    • 0042432047 scopus 로고    scopus 로고
    • Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1
    • PMID:12932358
    • Layer K, Lin G, Nencioni A, Hu W, Schmucker A, Antov AN, et al. Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity 2003; 19:243-255. PMID:12932358; http://dx.doi.org/10.1016/S1074-7613(03)00209-7.
    • (2003) Immunity , vol.19 , pp. 243-255
    • Layer, K.1    Lin, G.2    Nencioni, A.3    Hu, W.4    Schmucker, A.5    Antov, A.N.6
  • 59
    • 0034634534 scopus 로고    scopus 로고
    • Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
    • PMID:10934204
    • Rebhun JF, Castro AF, Quilliam LA. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. J Biol Chem 2000; 275:34901-3498.PMID:10934204; http://dx.doi.org/10.1074/jbc.M005327200
    • (2000) J Biol Chem , vol.275 , pp. 3498-34901
    • Rebhun, J.F.1    Castro, A.F.2    Quilliam, L.A.3
  • 60
    • 2442683012 scopus 로고    scopus 로고
    • Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3
    • PMID:15143162
    • Stope MB, Vom Dorp F, Szatkowski D, Bohm A, Keiper M, Nolte J, et al. Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3. Mol Cell Biol 2004; 24:4664-4676; PMID:15143162; http://dx.doi.org/10.1128/MCB.24.11.4664-76.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 4664-4676
    • Stope, M.B.1    Vom, D.F.2    Szatkowski, D.3    Bohm, A.4    Keiper, M.5    Nolte, J.6
  • 61
    • 73649089980 scopus 로고    scopus 로고
    • ERK and cell death: Mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence
    • PMID:19843174
    • Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J 2010; 277:2-21.PMID:19843174; http://dx.doi.org/10.1111/j.1742-4658.2009.07366.x.
    • (2010) FEBS J , vol.277 , pp. 2-21
    • Cagnol, S.1    Chambard, J.C.2
  • 62
    • 15244352198 scopus 로고    scopus 로고
    • Emerging role for ERK as a key regulator of neuronal apoptosis
    • Cheung EC, Slack RS. Emerging role for ERK as a key regulator of neuronal apoptosis. Sci STKE 2004; 2004:45.
    • (2004) Sci STKE , vol.2004 , pp. 45
    • Cheung, E.C.1    Slack, R.S.2
  • 63
    • 2442608520 scopus 로고    scopus 로고
    • ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3
    • PMID:15123736
    • Subramaniam S, Zirrgiebel U, von Bohlen, Und Halbach O, Strelau J, Laliberte C, et al. ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol 2004; 165:357-369. PMID:15123736; http://dx.doi.org/10.1083/jcb.200403028.
    • (2004) J Cell Biol , vol.165 , pp. 357-369
    • Subramaniam, S.1    Zirrgiebel, U.2    von Bohlen3    Und, H.O.4    Strelau, J.5    Laliberte, C.6
  • 64
    • 0031026133 scopus 로고    scopus 로고
    • Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
    • PMID:9032266
    • Fam NP, Fan WT, Wang Z, Zhang LJ, Chen H, Moran MF. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. Mol Cell Biol 1997; 17:1396-1406.PMID:9032266.
    • (1997) Mol Cell Biol , vol.17 , pp. 1396-1406
    • Fam, N.P.1    Fan, W.T.2    Wang, Z.3    Zhang, L.J.4    Chen, H.5    Moran, M.F.6
  • 65
    • 0029098537 scopus 로고
    • Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF
    • PMID:7637786
    • Farnsworth CL, Freshney NW, Rosen LB, Ghosh A, Greenberg ME, Feig LA. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 1995; 376:524-527. PMID:7637786; http://dx.doi.org/10.1038/376524a0.
    • (1995) Nature , vol.376 , pp. 524-527
    • Farnsworth, C.L.1    Freshney, N.W.2    Rosen, L.B.3    Ghosh, A.4    Greenberg, M.E.5    Feig, L.A.6


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