메뉴 건너뛰기




Volumn 4, Issue 5, 2007, Pages 769-781

Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy

Author keywords

Active targeting; Block copolymer micelles; Combination therapy; Drug delivery; Ellipticine; Epidermal growth factor (EGF)

Indexed keywords

COPOLYMER; ELLIPTICINE; EPIDERMAL GROWTH FACTOR;

EID: 35549013192     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0700559     Document Type: Article
Times cited : (63)

References (62)
  • 2
    • 0041386348 scopus 로고    scopus 로고
    • Targeting epidermal growth factor receptor signaling: Early results and future trends in oncology
    • Lage, A.; Crombet, T.; Gonzalez, G. Targeting epidermal growth factor receptor signaling: Early results and future trends in oncology. Ann. Med. 2003, 35 (5), 327-336.
    • (2003) Ann. Med , vol.35 , Issue.5 , pp. 327-336
    • Lage, A.1    Crombet, T.2    Gonzalez, G.3
  • 3
    • 0029742067 scopus 로고    scopus 로고
    • Quantitative estimation of epidermal growth factor receptor and c-erbB-2 in human breast cancer
    • Robertson, K. W.; Reeves, J. R.; Smith, G.; Keith, W. N.; Ozanne, B. W.; Cooke, T. G.; Stanton, P. D. Quantitative estimation of epidermal growth factor receptor and c-erbB-2 in human breast cancer. Cancer Res. 1996, 56 (16), 3823-3830.
    • (1996) Cancer Res , vol.56 , Issue.16 , pp. 3823-3830
    • Robertson, K.W.1    Reeves, J.R.2    Smith, G.3    Keith, W.N.4    Ozanne, B.W.5    Cooke, T.G.6    Stanton, P.D.7
  • 5
    • 0034988184 scopus 로고    scopus 로고
    • The epidermal growth factor receptor as a target for cancer therapy
    • Mendelsohn, J. The epidermal growth factor receptor as a target for cancer therapy. Endocr.-Relat. Cancer 2001, 8 (1), 3-9.
    • (2001) Endocr.-Relat. Cancer , vol.8 , Issue.1 , pp. 3-9
    • Mendelsohn, J.1
  • 6
    • 0024822342 scopus 로고
    • Epidermal growth-factor receptors in breast-cancer - Association with early relapse and death, poor response to hormones and interactions with neu
    • Harris, A. L.; Nicholson, S.; Sainsbury, J. R. C.; Farndon, J.; Wright, C. Epidermal growth-factor receptors in breast-cancer - Association with early relapse and death, poor response to hormones and interactions with neu. J. Steroid Biochem. Mol. Biol. 1989, 34 (1-6), 123-131.
    • (1989) J. Steroid Biochem. Mol. Biol , vol.34 , Issue.1-6 , pp. 123-131
    • Harris, A.L.1    Nicholson, S.2    Sainsbury, J.R.C.3    Farndon, J.4    Wright, C.5
  • 7
    • 0026571910 scopus 로고
    • The clinical-significance of epidermal growth-factor receptor (Egf-R) in human breast-cancer - A review on 5232 patients
    • Klijn, J. G. M.; Berns, P. M. J. J.; Schmitz, P. I. M.; Foekens, J. A. The clinical-significance of epidermal growth-factor receptor (Egf-R) in human breast-cancer - A review on 5232 patients. Endocr. Rev. 1992, 13 (1), 3-17.
    • (1992) Endocr. Rev , vol.13 , Issue.1 , pp. 3-17
    • Klijn, J.G.M.1    Berns, P.M.J.J.2    Schmitz, P.I.M.3    Foekens, J.A.4
  • 8
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon, D. S.; Brandt, R.; Ciardiello, F.; Normanno, N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 1995, 19 (3), 183-232.
    • (1995) Crit. Rev. Oncol. Hematol , vol.19 , Issue.3 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 9
    • 0022374645 scopus 로고
    • Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer
    • Sainsbury, J. R.; Malcolm, A. J.; Appleton, D. R.; Farndon, J. R.; Harris, A. L. Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer. J. Clin. Pathol. 1985, 38 (11), 1225-1228.
    • (1985) J. Clin. Pathol , vol.38 , Issue.11 , pp. 1225-1228
    • Sainsbury, J.R.1    Malcolm, A.J.2    Appleton, D.R.3    Farndon, J.R.4    Harris, A.L.5
  • 10
    • 33747154401 scopus 로고    scopus 로고
    • Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development
    • Kamath, S.; Buolamwini, J. K. Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development. Med. Res. Rev. 2006, 26 (5), 569-594.
    • (2006) Med. Res. Rev , vol.26 , Issue.5 , pp. 569-594
    • Kamath, S.1    Buolamwini, J.K.2
  • 13
    • 29244489232 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
    • Mamot, C.; Drummond, D. C.; Noble, C. O.; Kallab, V.; Guo, Z.; Hong, K.; Kirpotin, D. B.; Park, J. W. Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. Cancer Res. 2005, 65 (24), 11631-11638.
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11631-11638
    • Mamot, C.1    Drummond, D.C.2    Noble, C.O.3    Kallab, V.4    Guo, Z.5    Hong, K.6    Kirpotin, D.B.7    Park, J.W.8
  • 14
    • 33645469800 scopus 로고    scopus 로고
    • Epidermal growth factor-conjugated poly(ethylene glycol)-block-poly(δ-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics
    • Zeng, F.; Lee, H.; Allen, C. Epidermal growth factor-conjugated poly(ethylene glycol)-block-poly(δ-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics. Bioconjugate Chem. 2006, 17 (2), 399-409.
    • (2006) Bioconjugate Chem , vol.17 , Issue.2 , pp. 399-409
    • Zeng, F.1    Lee, H.2    Allen, C.3
  • 15
    • 1542648402 scopus 로고    scopus 로고
    • EGF mediates multiple signals: Dependence on the conditions
    • Kamer, A. R.; Sacks, P. G.; Vladutiu, A.; Liebow, C. EGF mediates multiple signals: Dependence on the conditions. Int. J. Mol. Med. 2004, 13 (1), 143-147.
    • (2004) Int. J. Mol. Med , vol.13 , Issue.1 , pp. 143-147
    • Kamer, A.R.1    Sacks, P.G.2    Vladutiu, A.3    Liebow, C.4
  • 17
    • 0021804944 scopus 로고
    • MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF
    • Filmus, J.; Pollak, M. N.; Cailleau, R.; Buick, R. N. MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF. Biochem. Biophys. Res. Commun. 1985, 128 (2), 898-905.
    • (1985) Biochem. Biophys. Res. Commun , vol.128 , Issue.2 , pp. 898-905
    • Filmus, J.1    Pollak, M.N.2    Cailleau, R.3    Buick, R.N.4
  • 19
    • 0000994406 scopus 로고
    • Analysis of combined drug effects - A new look at a very old problem
    • Chou, T. C.; Talalay, P. Analysis of combined drug effects - A new look at a very old problem. Trends Pharmacol. Sci. 1983, 4 (11), 450-454.
    • (1983) Trends Pharmacol. Sci , vol.4 , Issue.11 , pp. 450-454
    • Chou, T.C.1    Talalay, P.2
  • 20
    • 0033221068 scopus 로고    scopus 로고
    • Nano-engineering block copolymer aggregates for drug delivery
    • Allen, C.; Maysinger, D.; Eisenberg, A. Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf., B 1999, 16, 3-27.
    • (1999) Colloids Surf., B , vol.16 , pp. 3-27
    • Allen, C.1    Maysinger, D.2    Eisenberg, A.3
  • 21
    • 33751509349 scopus 로고    scopus 로고
    • Formulation of drugs in block copolymer micelles: Drug loading and release
    • Liu, J.; Lee, H.; Allen, C. Formulation of drugs in block copolymer micelles: Drug loading and release. Curr. Pharm. Des. 2006, 12 (36), 4685-4701.
    • (2006) Curr. Pharm. Des , vol.12 , Issue.36 , pp. 4685-4701
    • Liu, J.1    Lee, H.2    Allen, C.3
  • 22
    • 0346494420 scopus 로고    scopus 로고
    • Polymer-drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine
    • Liu, J. B.; Xiao, Y. H.; Allen, C. Polymer-drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine. J. Pharm. Sci. 2004, 93 (1), 132-143.
    • (2004) J. Pharm. Sci , vol.93 , Issue.1 , pp. 132-143
    • Liu, J.B.1    Xiao, Y.H.2    Allen, C.3
  • 23
    • 0034814014 scopus 로고    scopus 로고
    • N-(2-Hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation
    • Searle, F.; Gac-Breton, S.; Keane, R.; Dimitrijevic, S.; Brocchini, S.; Sausville, E. A.; Duncan, R. N-(2-Hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation. Bioconjugate Chem. 2001, 12 (5), 711-718.
    • (2001) Bioconjugate Chem , vol.12 , Issue.5 , pp. 711-718
    • Searle, F.1    Gac-Breton, S.2    Keane, R.3    Dimitrijevic, S.4    Brocchini, S.5    Sausville, E.A.6    Duncan, R.7
  • 24
    • 14844291676 scopus 로고    scopus 로고
    • Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent
    • Liu, J.; Zeng, F.; Allen, C. Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent. J. Controlled Release 2005, 103 (2), 481-497.
    • (2005) J. Controlled Release , vol.103 , Issue.2 , pp. 481-497
    • Liu, J.1    Zeng, F.2    Allen, C.3
  • 25
    • 33749677384 scopus 로고    scopus 로고
    • Synthesis of carboxy-functionalized hetero-bifunctional poly(ethylene glycol) by a thiol-anionic polymerization method
    • Zeng, F.; Allen, C. Synthesis of carboxy-functionalized hetero-bifunctional poly(ethylene glycol) by a thiol-anionic polymerization method. Macromolecules 2006, 39 (19), 6391-6398.
    • (2006) Macromolecules , vol.39 , Issue.19 , pp. 6391-6398
    • Zeng, F.1    Allen, C.2
  • 26
    • 28944442206 scopus 로고    scopus 로고
    • Methoxy poly(ethylene glycol)-block-poly(δ-valerolactone) copolymer micelles for formulation of hydrophobic drugs
    • Lee, H.; Zeng, F.; Dunne, M.; Allen, C. Methoxy poly(ethylene glycol)-block-poly(δ-valerolactone) copolymer micelles for formulation of hydrophobic drugs. Biomacromolecules 2005, 6 (6), 3119-3128.
    • (2005) Biomacromolecules , vol.6 , Issue.6 , pp. 3119-3128
    • Lee, H.1    Zeng, F.2    Dunne, M.3    Allen, C.4
  • 27
    • 0033572578 scopus 로고    scopus 로고
    • Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines
    • Soriano, A. F.; Helfrich, B.; Chan, D. C.; Heasley, L. E.; Bunn, P. A.; Chou, T. C. Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res. 1999, 59 (24), 6178-6184.
    • (1999) Cancer Res , vol.59 , Issue.24 , pp. 6178-6184
    • Soriano, A.F.1    Helfrich, B.2    Chan, D.C.3    Heasley, L.E.4    Bunn, P.A.5    Chou, T.C.6
  • 28
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou, T. C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol. Rev. 2006, 58 (3), 621-681.
    • (2006) Pharmacol. Rev , vol.58 , Issue.3 , pp. 621-681
    • Chou, T.C.1
  • 29
    • 33645472347 scopus 로고    scopus 로고
    • Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
    • Edwards, L. A.; Verreault, M.; Thiessen, B.; Dragowska, W. H.; Hu, Y.; Yeung, J. H.; Dedhar, S.; Bally, M. B. Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells. Mol. Cancer Ther. 2006, 5 (3), 645-654.
    • (2006) Mol. Cancer Ther , vol.5 , Issue.3 , pp. 645-654
    • Edwards, L.A.1    Verreault, M.2    Thiessen, B.3    Dragowska, W.H.4    Hu, Y.5    Yeung, J.H.6    Dedhar, S.7    Bally, M.B.8
  • 30
    • 1542329005 scopus 로고    scopus 로고
    • The erbB family: Targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors
    • Rowinsky, E. K. The erbB family: Targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors. Annu. Rev. Med. 2004, 55, 433-457.
    • (2004) Annu. Rev. Med , vol.55 , pp. 433-457
    • Rowinsky, E.K.1
  • 32
    • 18844370441 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and signal transduction: Potential targets for anti-cancer therapy
    • Pal, S. K.; Pegram, M. Epidermal growth factor receptor and signal transduction: Potential targets for anti-cancer therapy. Anticancer Drugs 2005, 16 (5), 483-494.
    • (2005) Anticancer Drugs , vol.16 , Issue.5 , pp. 483-494
    • Pal, S.K.1    Pegram, M.2
  • 34
    • 35548963986 scopus 로고    scopus 로고
    • Freitas, R. A. Cell membrane. In Nanomedicine; Landes Bioscience: Austin, TX, 1999; 1, section 8.5.3.2.
    • Freitas, R. A. Cell membrane. In Nanomedicine; Landes Bioscience: Austin, TX, 1999; Vol. 1, section 8.5.3.2.
  • 35
    • 0023836119 scopus 로고
    • Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines
    • Carlin, C. R.; Simon, D.; Mattison, J.; Knowles, B. B. Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines. Mol. Cell Biol. 1988, 8 (1), 25-34.
    • (1988) Mol. Cell Biol , vol.8 , Issue.1 , pp. 25-34
    • Carlin, C.R.1    Simon, D.2    Mattison, J.3    Knowles, B.B.4
  • 36
    • 0037731636 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells
    • Mamot, C.; Drummond, D. C.; Greiser, U.; Hong, K.; Kirpotin, D. B.; Marks, J. D.; Park, J. W. Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells. Cancer Res. 2003, 63 (12), 3154-3161.
    • (2003) Cancer Res , vol.63 , Issue.12 , pp. 3154-3161
    • Mamot, C.1    Drummond, D.C.2    Greiser, U.3    Hong, K.4    Kirpotin, D.B.5    Marks, J.D.6    Park, J.W.7
  • 37
    • 32044465218 scopus 로고    scopus 로고
    • EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice
    • Shir, A.; Ogris, M.; Wagner, E.; Levitzki, A. EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. PLoS Med. 2006, 3 (1), e6.
    • (2006) PLoS Med , vol.3 , Issue.1
    • Shir, A.1    Ogris, M.2    Wagner, E.3    Levitzki, A.4
  • 39
    • 0142212379 scopus 로고    scopus 로고
    • Antitumor effects and normal tissue toxicity of In-111-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast cancer xenografts
    • Chen, P.; Cameron, R.; Wang, J.; Vallis, K. A.; Reilly, R. M. Antitumor effects and normal tissue toxicity of In-111-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast cancer xenografts. J. Nucl. Med. 2003, 44 (9), 1469-1478.
    • (2003) J. Nucl. Med , vol.44 , Issue.9 , pp. 1469-1478
    • Chen, P.1    Cameron, R.2    Wang, J.3    Vallis, K.A.4    Reilly, R.M.5
  • 40
    • 0742304061 scopus 로고    scopus 로고
    • Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors
    • Rae, J. M.; Lippman, M. E. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res. Treat. 2004, 83 (2), 99-107.
    • (2004) Breast Cancer Res. Treat , vol.83 , Issue.2 , pp. 99-107
    • Rae, J.M.1    Lippman, M.E.2
  • 41
    • 0034090402 scopus 로고    scopus 로고
    • Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion
    • Cao, L.; Yao, Y.; Lee, V.; Kiani, C.; Spaner, D.; Lin, Z.; Zhang, Y.; Adams, M. E.; Yang, B. B. Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion. J. Cell. Biochem. 2000, 77 (4), 569-583.
    • (2000) J. Cell. Biochem , vol.77 , Issue.4 , pp. 569-583
    • Cao, L.1    Yao, Y.2    Lee, V.3    Kiani, C.4    Spaner, D.5    Lin, Z.6    Zhang, Y.7    Adams, M.E.8    Yang, B.B.9
  • 42
    • 20144384882 scopus 로고    scopus 로고
    • Lost in transcription: P21 repression, mechanisms, and consequences
    • Gartel, A. L.; Radhakrishnan, S. K. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res. 2005, 65 (10), 3980-3995.
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 3980-3995
    • Gartel, A.L.1    Radhakrishnan, S.K.2
  • 43
    • 0031916415 scopus 로고    scopus 로고
    • EGF-induced programmed cell death of human mammary carcinoma MDA-MB-468 cells is preceded by activation of AP-1
    • Schaerli, P.; Jaggi, R. EGF-induced programmed cell death of human mammary carcinoma MDA-MB-468 cells is preceded by activation of AP-1. Cell. Mol. Life Sci. 1998, 54 (2), 129-138.
    • (1998) Cell. Mol. Life Sci , vol.54 , Issue.2 , pp. 129-138
    • Schaerli, P.1    Jaggi, R.2
  • 45
    • 0022168220 scopus 로고
    • The EGF receptor: Structure, regulation and potential role in malignancy
    • Thompson, D. M.; Gill, G. N. The EGF receptor: Structure, regulation and potential role in malignancy. Cancer Surv. 1985, 4 (4), 767-788.
    • (1985) Cancer Surv , vol.4 , Issue.4 , pp. 767-788
    • Thompson, D.M.1    Gill, G.N.2
  • 46
    • 0345349786 scopus 로고
    • Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells
    • Willingham, M. C.; Hanover, J. A.; Dickson, R. B.; Pastan, I. Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells. Proc. Natl. Acad. Sci. U.S.A. 1984, 81 (1), 175-179.
    • (1984) Proc. Natl. Acad. Sci. U.S.A , vol.81 , Issue.1 , pp. 175-179
    • Willingham, M.C.1    Hanover, J.A.2    Dickson, R.B.3    Pastan, I.4
  • 47
    • 0023924799 scopus 로고
    • The endocytosis of epidermal growth factor in A431 cells: A pH of microenvironment and the dynamics of receptor complex dissociation
    • Sorkin, A. D.; Teslenko, L. V.; Nikolsky, N. N. The endocytosis of epidermal growth factor in A431 cells: A pH of microenvironment and the dynamics of receptor complex dissociation. Exp. Cell Res. 1988, 175 (1), 192-205.
    • (1988) Exp. Cell Res , vol.175 , Issue.1 , pp. 192-205
    • Sorkin, A.D.1    Teslenko, L.V.2    Nikolsky, N.N.3
  • 48
    • 0029979181 scopus 로고    scopus 로고
    • Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes
    • Futter, C. E.; Pearse, A.; Hewlett, L. J.; Hopkins, C. R. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes. J. Cell Biol. 1996, 132 (6), 1011-1023.
    • (1996) J. Cell Biol , vol.132 , Issue.6 , pp. 1011-1023
    • Futter, C.E.1    Pearse, A.2    Hewlett, L.J.3    Hopkins, C.R.4
  • 49
    • 0027290650 scopus 로고
    • Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
    • Baselga, J.; Norton, L.; Masui, H.; Pandiella, A.; Coplan, K.; Miller, W. H., Jr.; Mendelsohn, J. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J. Natl. Cancer Inst. 1993, 85 (16), 1327-1333.
    • (1993) J. Natl. Cancer Inst , vol.85 , Issue.16 , pp. 1327-1333
    • Baselga, J.1    Norton, L.2    Masui, H.3    Pandiella, A.4    Coplan, K.5    Miller Jr., W.H.6    Mendelsohn, J.7
  • 50
    • 1842638560 scopus 로고    scopus 로고
    • Folate receptor targeted biodegradable polymeric doxorubicin micelles
    • Yoo, H. S.; Park, T. G. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J. Controlled Release 2004, 96 (2), 273-283.
    • (2004) J. Controlled Release , vol.96 , Issue.2 , pp. 273-283
    • Yoo, H.S.1    Park, T.G.2
  • 51
    • 0036894384 scopus 로고    scopus 로고
    • Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo
    • Takahashi, N.; Li, W.; Banerjee, D.; Guan, Y.; Wada-Takahashi, Y.; Brennan, M. F.; Chou, T. C.; Scotto, K. W.; Bertino, J. R. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo. Cancer Res. 2002, 62 (23), 6909-6915.
    • (2002) Cancer Res , vol.62 , Issue.23 , pp. 6909-6915
    • Takahashi, N.1    Li, W.2    Banerjee, D.3    Guan, Y.4    Wada-Takahashi, Y.5    Brennan, M.F.6    Chou, T.C.7    Scotto, K.W.8    Bertino, J.R.9
  • 52
    • 19344363980 scopus 로고    scopus 로고
    • The mechanism of ellipticine-induced apoptosis and cell cycle arrest in human breast MCF-7 cancer cells
    • Kuo, P. L.; Hsu, Y. L.; Chang, C. H.; Lin, C. C. The mechanism of ellipticine-induced apoptosis and cell cycle arrest in human breast MCF-7 cancer cells. Cancer Lett. 2005, 223 (2), 293-301.
    • (2005) Cancer Lett , vol.223 , Issue.2 , pp. 293-301
    • Kuo, P.L.1    Hsu, Y.L.2    Chang, C.H.3    Lin, C.C.4
  • 53
    • 33748326024 scopus 로고    scopus 로고
    • Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
    • Mayer, L. D.; Harasym, T. O.; Tardi, P. G.; Harasym, N. L.; Shew, C. R.; Johnstone, S. A.; Ramsay, E. C.; Bally, M. B.; Janoff, A. S. Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice. Mol. Cancer Ther. 2006, 5 (7), 1854-1863.
    • (2006) Mol. Cancer Ther , vol.5 , Issue.7 , pp. 1854-1863
    • Mayer, L.D.1    Harasym, T.O.2    Tardi, P.G.3    Harasym, N.L.4    Shew, C.R.5    Johnstone, S.A.6    Ramsay, E.C.7    Bally, M.B.8    Janoff, A.S.9
  • 54
    • 3242786628 scopus 로고    scopus 로고
    • Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells
    • Tyagi, A. K.; Agarwal, C.; Chan, D. C.; Agarwal, R. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol. Rep. 2004, 11 (2), 493-199.
    • (2004) Oncol. Rep , vol.11 , Issue.2 , pp. 493-199
    • Tyagi, A.K.1    Agarwal, C.2    Chan, D.C.3    Agarwal, R.4
  • 55
    • 33847246381 scopus 로고    scopus 로고
    • In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration
    • Liu, J.; Zeng, F.; Allen, C. In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration. Eur. J. Pharm. Biopharm. 2007, 65 (3), 309-319.
    • (2007) Eur. J. Pharm. Biopharm , vol.65 , Issue.3 , pp. 309-319
    • Liu, J.1    Zeng, F.2    Allen, C.3
  • 56
    • 0027294911 scopus 로고
    • In situ evaluation of the relationship between epidermal-growth-factor-receptor status and tumor-cell proliferation in colon carcinomas
    • Porschen, R.; Classen, S.; Kahle, Y.; Borchard, F. In situ evaluation of the relationship between epidermal-growth-factor-receptor status and tumor-cell proliferation in colon carcinomas. Int. J. Cancer 1993, 54 (2), 189-193.
    • (1993) Int. J. Cancer , vol.54 , Issue.2 , pp. 189-193
    • Porschen, R.1    Classen, S.2    Kahle, Y.3    Borchard, F.4
  • 57
  • 58
    • 0025618804 scopus 로고
    • Studies of EGF-mediated growth control and signal transduction using the MDA-MB-468 human breast cancer cell line
    • Buick, R. N.; Filmus, J.; Church, J. Studies of EGF-mediated growth control and signal transduction using the MDA-MB-468 human breast cancer cell line. Prog. Clin. Biol. Res. 1990, 354A, 179-191.
    • (1990) Prog. Clin. Biol. Res , vol.354 A , pp. 179-191
    • Buick, R.N.1    Filmus, J.2    Church, J.3
  • 59
    • 0031558243 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain, R. K. Delivery of molecular and cellular medicine to solid tumors. Adv. Drug Delivery Rev. 1997, 26 (2-3), 71-90.
    • (1997) Adv. Drug Delivery Rev , vol.26 , Issue.2-3 , pp. 71-90
    • Jain, R.K.1
  • 60
    • 33646037641 scopus 로고    scopus 로고
    • Bystander effect: Biological endpoints and microarray analysis
    • Chaudhry, M. A. Bystander effect: Biological endpoints and microarray analysis. Mutat. Res. 2006, 597 (1-2), 98-112.
    • (2006) Mutat. Res , vol.597 , Issue.1-2 , pp. 98-112
    • Chaudhry, M.A.1
  • 61
    • 0034095963 scopus 로고    scopus 로고
    • Bystander effects: A concept in need of clarification
    • Djordjevic, B. Bystander effects: A concept in need of clarification. BioEssays 2000, 22 (3), 286-290.
    • (2000) BioEssays , vol.22 , Issue.3 , pp. 286-290
    • Djordjevic, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.