Toxic characteristics of methoxy poly(ethylene glycol)/poly(ε-caprolactone) nanospheres; In vitro and in vivo studies in the normal mice

Biomaterials

Volumn 24, Issue 1, 2003, Pages 55-63

  Kim, So Yeon ^a   Lee, Young Moo ^a   Baik, Doo J ^a   Kang, Ju S ^a  

^a Hanyang University   (South Korea)

Author keywords

Drug delivery system; Median lethal dose (LD50); Methoxypolyethylene glycol ploy( caprolactone) nanosphere; MTT assay; Organ toxicity

Indexed keywords

ASSAYS; BIOLOGICAL ORGANS; CELLS; DRUG PRODUCTS; ORGANIC COMPOUNDS; TOXICITY;

DRUG CARRIER;

POLYETHYLENE GLYCOLS;

DRUG CARRIER; INDOMETACIN; METHOXYPOLYETHYLENEGLYCOL POLY(EPSILON CAPROLACTONE); NANOPARTICLE; PACLITAXEL; UNCLASSIFIED DRUG; BIOMATERIAL; MACROGOL DERIVATIVE; METHOXY POLY(ETHYLENE GLYCOL CO EPSILON CAPROLACTONE); METHOXY POLY(ETHYLENE GLYCOL-CO-EPSILON-CAPROLACTONE); MICROSPHERE; POLYESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; FIBROBLAST; HEART; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LETHAL DOSE; LIVER; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY; ANIMAL; ANTIBODY SPECIFICITY; DRUG EFFECT; ELECTRON MICROSCOPY; HEART MUSCLE; INSTITUTE FOR CANCER RESEARCH MOUSE; LD 50; MATERIALS TESTING; MOUSE; PARTICLE SIZE; PATHOLOGY;

ANIMALS; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; FIBROBLASTS; HEART; HUMANS; INDOMETHACIN; KIDNEY; LETHAL DOSE 50; LUNG; MALE; MATERIALS TESTING; MICE; MICE, INBRED ICR; MICROSCOPY, ELECTRON; MICROSPHERES; MYOCARDIUM; ORGAN SPECIFICITY; PACLITAXEL; PARTICLE SIZE; POLYESTERS; POLYETHYLENE GLYCOLS;

EID: 0037210118     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(02)00248-X     Document Type: Article

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