Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging

Mechanisms of Ageing and Development

Volumn 133, Issue 4, 2012, Pages 133-137

  Patterson, David ^a   Cabelof, Diane C ^b  

^a UNIVERSITY OF DENVER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Aging; DNA polymerase beta ( pol); Down syndrome; Folate; MicroRNA

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE BETA; FOLIC ACID; MICRORNA; MICRORNA 125B 2; MICRORNA 155; MICRORNA 802; MICRORNA 99A; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DISEASE ASSOCIATION; DNA DAMAGE; DOWN SYNDROME; ENZYME ACTIVITY; EXCISION REPAIR; FOLATE METABOLISM; FOLIC ACID DEFICIENCY; GENE OVEREXPRESSION; HAPLOINSUFFICIENCY; HETEROZYGOSITY; HUMAN; LEUKEMOGENESIS; MUTAGENESIS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN FUNCTION;

AGING; ANIMALS; DNA POLYMERASE BETA; DNA REPAIR; DOWN SYNDROME; FOLIC ACID; FOLIC ACID DEFICIENCY; GENETIC PREDISPOSITION TO DISEASE; GENOMIC INSTABILITY; HAPLOINSUFFICIENCY; HUMANS; LEUKEMIA; MICRORNAS; OXIDATIVE STRESS; PHENOTYPE;

EID: 84860768748     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2011.10.001     Document Type: Article

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