The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 427, Issue 2, 1999, Pages 79-87

  Branda, Richard F ^a   Lafayette, Amy R ^a   O'Neill, J Patrick ^a   Nicklas, Janice A ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Alkylating agent; DNA repair; Folate; hprt

Indexed keywords

ALKYLATING AGENT; FOLIC ACID;

ANIMAL CELL; ARTICLE; CELL LINE; CHO CELL; CONTROLLED STUDY; DNA DAMAGE; FOLIC ACID DEFICIENCY; GENE MUTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

ALKYLATING AGENTS; ANIMALS; BASE PAIRING; CHO CELLS; CRICETINAE; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; DNA REPAIR; ETHYL METHANESULFONATE; ETHYLNITROSOUREA; FOLIC ACID DEFICIENCY; GUANINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENS; MUTATION; POLYMERASE CHAIN REACTION; THIOGUANINE;

EID: 0033009253     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00095-0     Document Type: Article

References (56)

1. Lashner B., Heidenreich P., Su G., Kane S., Hanauer S. The effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. Gastroenterology. 97:1989;255-259.
2. Benito E., Stiggelbout A., Bosch F.X., Obrador A., Kaldor J., Mulet M., Munoz N. Nutritional factors in colorectal cancer risk: a case-control study in Majorca. Int. J. Cancer. 49:1991;161-167.
3. Giovannucci E., Rimm E.B., Ascherio A., Stampfer M.J., Colditz G.A., Willett W.C. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J. Natl. Cancer Inst. 87:1995;265-273.
4. Giovannucci E., Stampfer M.J., Coditz G.A., Hunter D.J., Fuchs C., Rosner B.A., Speizer F.E., Willett W.C. Multivitamin use, folate and colon cancer in women in the Nurses' Health Study. Ann. Int. Med. 129:1998;517-524.
5. Kim Y.-I., Salomon R.N., Graeme-Cook F., Choi S.-W., Smith D.E., Dallal G.E., Mason J.B. Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats. Gut. 39:1996;732-740.
6. Cravo M., Mason J., Dayal Y., Smith D., Selhub J., Rosenberg I.H. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res. 52:1992;5002-5006.
7. Glynn S.A., Albanes D. Folate and cancer: a review of the literature. Nutr. Cancer. 22:1994;101-119.
8. Mason J.B., Levesque T. Folate: effects on carcinogenesis and the potential for cancer prevention. Oncology. 10:1996;1727-1743.
9. Koury M.J., Park D.J., Martincic D., Horne D.W., Kravtsoc V., Whitlock J.A., del Pilar Aguinaga M., Kopsombut P. Folate deficiency delays the onset but increases the incidence of leukemia in Friend Virus-infected mice. Blood. 90:1997;4054-4061.
10. Hoffbrand A.V., Ganeshaguru K., Hooton J.W.L., Tripp E. Megaloblastic anaemia. Initiation of DNA synthesis in excess of DNA chain elongation as the underlying mechanism. Clin. Haematol. 5:1976;727-745.
11. Wickremasinghe R.G., Hoffbrand A.V. Reduced rate of DNA replication fork movement in megaloblastic anemia. J. Clin. Invest. 65:1980;26-36.
12. Michel B., Ehrlich S.D., Uzest M. DNA double-strand breaks caused by replication arrest. EMBO J. 16:1997;430-438.
13. Bierne H., Ehrlich S.D., Michel B. Deletions at stalled replication forks occur by two different pathways. EMBO J. 16:1997;3332-3340.
14. Wickramsinghe S.N., Fida S. Misincorporation of uracil into the DNA of folate- and B12-deficient HL60 cells. Eur. J. Haematol. 50:1993;127-132.
15. Blount B.C., Mack M.M., Wehr C.M., MacGregor J.T., Hiatt R.A., Want G., Wickramsinghe S.N., Everson R.B., Ames B.N. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94:1997;3290-3295.
16. Duthie S.J., McMillan P. Uracil misincorporation in human DNA detected using single cell gel electrophoresis. Carcinogenesis. 18:1997;1709-1714.
17. Dianov G.L., Timchenko T.V., Sinitsina O.I., Kuzminov A.V., Medvedev O.A., Salganik R.I. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol. Gen. Genet. 225:1991;448-452.
18. James S.J., Basnakian A.G., Miller B.J. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res. 54:1994;5075-5080.
19. S.J. James, L. Yin, Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats, Carcinogenesis (1989) 1209-1214.
20. Kunz B.A., Kohalmi S.E., Kunkel T.A., Mathews C.K., McIntosh E.M., Reidy J.A. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability. Mutat. Res. 318:1994;1-64.
21. Branda R.F., Blickensderfer D.B. Folate deficiency increases genetic damage caused by alkylating agents and γ-irradiation in Chinese hamster ovary cells. Cancer Res. 53:1993;5401-5408.
22. Borchers A.H., Kennedy K.A., Straw J.A. Inhibition of DNA excision repair by methotrexate in Chinese hamster ovary cells following exposure to ultraviolet irradiation or ethylmethanesulfonate. Cancer Res. 50:1990;1786-1789.
23. Choi S.-W., Kim Y.-I., Weitzel J.N., Mason J.B. Folate depletion impairs DNA excision repair in the colon of the rat. Gut. 43:1998;93-99.
24. Pogribny I.P., Miller B.J., James S.J. Alterations in hepatic p53 gene methylation patterns during tumor progression in folate/methyl deficiency in the rat. Cancer Lett. 115:1997;31-38.
25. Kim Y.I., Pogribny I.P., Basnakian A.G., Miller J.W., Selhub J., James S.J., Mason J.B. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am. J. Clin. Nutr. 65:1997;46-52.
26. Hansen R.S., Ellis N.A., Gartler S.M. Demethylation of specific sites in the 5′ region of the inactive X-linked human phosphoroglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression. Mol. Cell Biol. 8:1988;4692-4699.
27. Leteurtre F., Kohlhage G., Fesen M.R., Tanizawa A., Kohn K.W., Pommier Y. Effects of DNA methylation on topoisomerase I and II cleavage activities. J. Biol. Chem. 269:1994;7893-7900.
28. R.F. Branda, Effects of folic acid deficiency on tumor cell biology, in: M.M. Jacobs (Ed.), Vitamins and Minerals in the Prevention and Treatment of Cancer, CRC Press, Boca Raton, FL, 1991, pp. 136-160.
29. Everson R.B., Wehr C.M., Erexson G.L., MacGregor J.T. Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes. J. Natl. Cancer Inst. 80:1988;525-529.
30. Branda R.F., Hacker M., Lafayette A., Nigels E., Sullivan L., Nicklas J.A., O'Neill J.P. Nutritional folate deficiency augments the in vivo mutagenic and lymphocytotoxic activities of alkylating agents. Environ. Mol. Mutagen. 32:1998;33-38.
31. Branda R.F., Lafayette A.R., O'Neill J.P., Nicklas J.A. Effect of folate deficiency on mutations at the hprt locus in Chinese hamster ovary cells exposed to monofunctional alkylating agents. Cancer Res. 57:1997;2586-2588.
32. Xu Z., Yu Y., Gibbs R.A., Caskey C.T., Hsie A.W. Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells. Mutat. Res. 288:1993;237-248.
33. Cariello N.F., Skopek T.R. Analysis of mutations occurring at the human hprt locus. J. Mol. Biol. 231:1993;41-57.
34. Beranek D.T. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res. 231:1990;11-30.
35. Vogel E.W., Nivard M.J.M. The subtlety of alkylating agents in reactions with biological macromolecules. Mutat. Res. 305:1994;13-32.
36. Laval J., Pierre J., Laval F. Release of 7-methylguanine residues from alkylated DNA by extracts of Micrococcus luteus and Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 78:1981;852-855.
37. 6-alkylguanines or 1-alkyladenines. Proc. Natl. Acad. Sci. U.S.A. 78:1981;856-860.
38. Margison G.P., Pegg A.E. Enzymatic release of 7-methyl-guanine from methylated DNA by rodent liver extracts. Proc. Natl. Acad. Sci. U.S.A. 78:1981;861-865.
39. 4-alkylthymine and the mutagenic properties of these bases. Mutat. Res. 233:1990;81-94.
40. 6-alkylguanine. Cancer Res. 40:1980;2623-2624.
41. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis. 12:1991;1857-1867.
42. Op het Veld C., van Hees-Stuivenberg S., van Zeeland A.A., Jansen J.G. Effect of nucleotide excision repair on hprt gene mutations in rodent cells exposed to DNA ethylating agents. Mutagenesis. 12:1997;417-424.
43. Maher V.M., Domoradzki J., Bhattacharya N.P., Tsujimura T., Corner R.C., McCormick J.J. Alkylation damage, DNA repair and mutagenesis in human cells. Mutat. Res. 233:1990;235-245.
44. Op het Veld C.W., Zdzienicka M.Z., Vrieling H., Lohman P.H.M., van Zeeland A.A. Molecular analysis of ethyl methanesulfonate-induced mutations at the hprt gene in the ethyl methanesulfonate-sensitive Chinese hamster cell line EM-C11 and its parental line CHO9. Cancer Res. 54:1994;3001-3006.
45. A. Sitaram, G. Plitas, W. Wang, D.A. Scicchitano, Functional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells, Mol. Cell. Biol. (1997) 564-570.
46. 6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrososurea, or N-ethyl-N-nitrosourea. Cancer Res. 55:1995;1875-1882.
47. Op het Veld C.W., Jansen J., Zdzienicka M.Z., Vrieling H., van Zeeland A.A. Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11. Mutat. Res. 398:1998;83-92.
48. Sakumi K., Sekiguchi M. Structures and functions of DNA glycosylases. Mutat. Res. 236:1990;161-172.
49. Shibuya T., Morimoto K. A review of the genotoxicity of 1-ethyl-1-nitrosurea. Mutat. Res. 297:1993;3-38.
50. - diploid human fibroblasts. Carcinogenesis. 15:1994;939-945.
51. Jansen J.G., Mohn G.R., Vrirling H., van Teijlingen C.M.M., Lohman P.H.M., van Zeeland A.A. Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Cancer Res. 54:1994;2478-2485.
52. Mittelstaedt R.A., Smith B.A., Heflich R.H. Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes. Environ. Mol. Mutagen. 26:1995;261-269.
53. Harbach P.R., Mattano S.S., Zimmer D.M., Filipunas A.L., Wang Y., Aaron C.S. DNA sequence analysis of hprt mutants persisting in peripheral blood of cynomolgus monkeys more than two years after ENU treatment. Environ. Mol. Mutagen. 33:1999;42-48.
54. Schmutte C., Jones P.A. Involvement of DNA methylation in human carcinogenesis. Biol. Chem. 379:1998;377-388.
55. Shen J.C., Rideout W.M., Jones P.A. High-frequency mutagenesis by a DNA methyltransferase. Cell. 71:1992;1073-1080.
56. Singer B. O-Alkyl pyrimidines in mutagenesis and carcinogenesis: occurrence and significance. Cancer Res. 46:1986;4879-4885.