Breviscapine inhibits high glucose-induced proliferation and migration of cultured vascular smooth muscle cells of rats via suppressing the ERK1/2 MAPK signaling pathway

Acta Pharmacologica Sinica

Volumn 33, Issue 5, 2012, Pages 606-614

  He, Meng ^a   Xue, Zhi Min ^a   Li, Juan ^a   Zhou, Bin Quan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Breviscapine; Cell migration; Cell proliferation; MAP kinase; Protein kinase C; Vascular smooth muscle cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BREVISCAPINE; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL CULTURE; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CLINICAL EVALUATION; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; THORACIC AORTA; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLAVONOIDS; GLUCOSE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84860741789     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.6     Document Type: Article

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