Breviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca2+-cycling proteins in streptozotocin-induced diabetic rats

Acta Diabetologica

Volumn 47, Issue SUPPL. 1, 2010, Pages

  Wang, Min ^a   Zhang, Wen Bin ^a   Zhu, Jun Hui ^a   Fu, Guo Sheng ^a   Zhou, Bin Quan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Breviscapine; Diabetic cardiomyopathy; Protein kinase C

Indexed keywords

BREVISCAPINE; CALCIUM ION; GLUCOSE; PHOSPHOLAMBAN; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR 1; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA 2; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HEART FUNCTION; HEART PROTECTION; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; STRUCTURE ANALYSIS; TISSUE STRUCTURE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DRUGS, CHINESE HERBAL; FLAVONOIDS; GENE EXPRESSION; HEART; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 77955707550     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-009-0164-x     Document Type: Article

References (38)

1. S Wild G Roglic A Green R Sicree H King 2004 Global prevalence of diabetes: estimates for the year 2000, projections for 2030 Diabetes Care 27 5 1047 1053 10.2337/diacare.27.5.1047 15111519 (Pubitemid 38579764)
2. S Boudina ED Abel 2007 Diabetic cardiomyopathy revisited Circulation 115 25 3213 3223 10.1161/CIRCULATIONAHA.106.679597 17592090 (Pubitemid 47012236)
3. K Naruse GL King 2000 Protein kinase C and myocardial biology and function Circ Res 86 11 1104 1106 1:CAS:528:DC%2BD3cXkt1ejsr8%3D 10850959
4. K Okumura N Akiyama H Hashimoto K Ogawa T Satake 1988 Alteration of 1, 2-diacylglycerol content in myocardium from diabetic rats Diabetes 37 9 1168 1172 1:CAS:528:DyaL1cXlvVyhsLo%3D 10.2337/diabetes.37.9.1168 3044883
5. M Brownlee 2005 The pathobiology of diabetic complications: a unifying mechanism Diabetes 54 6 1615 1625 1:CAS:528:DC%2BD2MXltVaisbk%3D 10.2337/diabetes.54.6.1615 15919781 (Pubitemid 40770750)
6. LE Wold K Dutta MM Mason J Ren SE Cala ML Schwanke AJ Davidoff SER CA 2005 Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats J Mol Cell Cardiol 39 2 297 307 1:CAS:528:DC%2BD2MXmsVOrt7g%3D 10.1016/j.yjmcc.2005.03.014 15878173 (Pubitemid 40995019)
7. I Idris S Gray R Donnelly 2001 Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes Diabetologia 44 6 659 673 1:CAS:528:DC%2BD3MXjs1ylurs%3D 10.1007/s001250051675 11440359 (Pubitemid 32846021)
8. W Zhou XL Wang KG Lamping HC Lee 2006 Inhibition of protein kinase C beta protects against diabetes-induced impairment in arachidonic acid dilation of small coronary arteries J Pharmacol Exp Ther 319 1 199 207 1:CAS:528: DC%2BD28XhtVCksL3N 10.1124/jpet.106.106666 16861398 (Pubitemid 44455124)
9. MH Yousif 2006 Role of protein kinases in mediating diabetes-induced augmented vasoconstriction to endothelin-1 in the renal arteries of STZ-diabetic rats Cell Biochem Funct 24 5 397 405 1:CAS:528:DC%2BD28XpvF2qu78%3D 10.1002/cbf.1253 16170840 (Pubitemid 44379578)
10. RB Devereux MJ Roman M Paranicas MJ O'Grady ET Lee TK Welty RR Fabsitz D Robbins ER Rhoades BV Howard 2000 Impact of diabetes on cardiac structure and function: the strong heart study Circulation 101 19 2271 2276 1:STN:280:DC%2BD3c3ntFyhsw%3D%3D 10811594
11. KJ Way N Katai GL King 2001 Protein kinase C and the development of diabetic vascular complications Diabet Med 18 12 945 959 1:CAS:528: DC%2BD38Xks1ShsQ%3D%3D 10.1046/j.0742-3071.2001.00638.x 11903393 (Pubitemid 34042930)
12. DD Gutterman 2000 Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? Circ Res 9 1 5 7
13. DD Johnsen R Kacimi BE Anderson TA Thomas S Said AM Gerdes 2005 Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts Mol Cell Biochem 270 1-2 63 69 1:CAS:528:DC%2BD2MXitlClsL8%3D 10.1007/s11010-005-3781-x 15792354 (Pubitemid 40425236)
14. M Braun G Simonis K Birkner B Pauke RH Strasser 2003 Regulation of protein kinase C isozyme and calcineurin expression in isoproterenol induced cardiac hypertrophy J Cardiovasc Pharmacol 41 6 946 954 1:CAS:528: DC%2BD3sXksVGju7k%3D 10.1097/00005344-200306000-00018 12775975 (Pubitemid 36706145)
15. Y Koide K Tamura A Suzuki K Kitamura K Yokoyama T Hashimoto N Hirawa M Kihara S Ohno S Umemura 2003 Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats Hypertens Res 26 5 421 426 1:CAS:528:DC%2BD3sXlvFCiu7o%3D 10.1291/hypres.26.421 12887134 (Pubitemid 36701684)
16. M Guo MH Wu F Korompai SY Yuan 2003 Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes Physiol Genomics 12 2 139 146 1:CAS:528:DC%2BD3sXhtl2rtbc%3D 12441406
17. Z Vasanji EJ Cantor D Juric M Moyen T Netticadan 2006 Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance Am J Physiol Cell Physiol 291 4 C772 C780 1:CAS:528:DC%2BD28XhtFarsL7J 10.1152/ajpcell.00086.2005 16973823 (Pubitemid 44497602)
18. DD Belke EA Swanson WH Dillmann 2004 Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart Diabetes 53 12 3201 3208 1:CAS:528:DC%2BD2cXhtVOls7nE 10.2337/diabetes.53.12.3201 15561951 (Pubitemid 39564496)
19. S Sakata D Lebeche Y Sakata N Sakata ER Chemaly L Liang C Nakajima-Takenaka T Tsuji N Konishi F del Monte RJ Hajjar M Takaki 2007 Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model Am J Physiol Heart Circ Physiol 292 2 H1204 H1207 1:CAS:528:DC%2BD2sXjt1Gntbw%3D 10.1152/ajpheart.00892.2006 17012346
20. M Hambleton H Hahn ST Pleger MC Kuhn R Klevitsky AN Carr TF Kimball TE Hewett GW Dorn 2nd WJ Koch JD Molkentin 2006 Pharmacological- and gene therapy-based inhibition of protein kinase C alpha/beta enhances cardiac contractility and attenuates heart failure Circulation 114 6 574 582 1:CAS:528:DC%2BD28Xns1Snu78%3D 10.1161/CIRCULATIONAHA.105.592550 16880328 (Pubitemid 44199647)
21. H Zhou S Chen L Wang Q He X Fan 2002 Regulation of the expression of pulmonary arterial collagen by protein kinase C and breviscapine in chronic hypoxic rats Zhonghua Jie He He Hu Xi Za Zhi 25 6 347 351 12126559
22. XJ Chen DY Cheng L Yang XQ Xia J Guan 2006 Effect of breviscapine on fractalkine expression in chronic hypoxic rats Chin Med J (Engl) 119 17 1465 1468 1:CAS:528:DC%2BD28XhtVGitLjK
23. SJ Zhang Y Song WL Zhai JH Shi LS Feng YF Zhao S Chen 2007 Breviscapine alleviates hepatic injury and inhibits PKC-mRNA and its protein expression in brain-dead BA-Ma mini pigs Hepatobiliary Pancreat Dis Int 6 6 604 609 1:CAS:528:DC%2BD1cXhtVequ78%3D 18086626
24. JA Beckman AB Goldfine MB Gordon LA Garrett MA Creager 2002 Inhibition of protein kinase C beta prevents impaired endothelium-dependent vasodilation caused by hyperglycaemia in humans Circ Res 90 1 107 111 1:CAS:528: DC%2BD38XotlSnug%3D%3D 10.1161/hh0102.102359 11786526 (Pubitemid 34074616)
25. JC Braz K Gregory A Pathak W Zhao B Sahin R Klevitsky TF Kimball JN Lorenz AC Nairn SB Liggett I Bodi S Wang A Schwartz EG Lakatta AA DePaoli-Roach J Robbins TE Hewett JA Bibb MV Westfall EG Kranias JD Molkentin 2004 PKC-alpha regulates cardiac contractility and propensity toward heart failure Nat Med 10 3 248 254 1:CAS:528:DC%2BD2cXhs1Wntbk%3D 10.1038/nm1000 14966518 (Pubitemid 38667614)
26. HS Hahn Y Marreez A Odley A Sterbling MG Yussman KC Hilty I Bodi SB Liggrtt A Schwartz GW Dorn 2nd 2003 Protein kinase C alpha negatively regulates systolic and diastolic function in pathological hypertrophy Circ Res 93 11 1111 1119 1:CAS:528:DC%2BD3sXptVCksLo%3D 10.1161/01.RES.0000105087.79373.17 14605019 (Pubitemid 37485043)
27. RV Farese MP Sajan ML Standaert 2005 Atypical protein kinase C in insulin action and insulin resistance Biochem Soc Trans 33 Pt 2 350 353 1:CAS:528:DC%2BD2MXivFWjsLY%3D 15787604
28. N Das Evcimen GL King 2007 The role of protein kinase C activation and the vascular complications of diabetes Pharmacol Res 55 6 498 510 1:CAS:528:DC%2BD2sXntFyht74%3D 10.1016/j.phrs.2007.04.016 17574431 (Pubitemid 46962309)
29. A Pathak F del Monte W Zhao JE Schultz JN Lorenz I Bodi D Weiser H Hahn AN Carr F Syed N Mavila L Jha J Qian Y Marreez G Chen DW McGraw EK Heist JL Guerrero AA DePaoli-Roach RJ Hajjar EG Kranias 2005 Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1 Circ Res 96 7 756 766 1:CAS:528:DC%2BD2MXjtVWntLo%3D 10.1161/01.RES.0000161256.85833.fa 15746443 (Pubitemid 40559515)
30. P Rodriguez B Mitton JR Waggoner EG Kranias 2006 Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function J Biol Chem 281 50 38599 38608 1:CAS:528:DC%2BD28Xht12msrzK 10.1074/jbc.M604139200 17046826 (Pubitemid 46041984)
31. B Sahin H Shu J Fernandez A El-Armouche JD Molkentin AC Nairn JA Bibb 2006 Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C J Biol Chem 281 34 24322 24335 1:CAS:528:DC%2BD28Xot1eqsLw%3D 10.1074/jbc. M603282200 16772299 (Pubitemid 44274205)
32. XL Li YQ Li WM Yan HY Li H Xu XX Zheng DW Guo LK Tang 2004 A study of the cardioprotective effect of breviscapine during hypoxia of cardiomyocytes Planta Med 70 11 1039 1044 1:CAS:528:DC%2BD2cXhtVOmsbbN 10.1055/s-2004-832644 15549659 (Pubitemid 39587037)
33. Z Xiong C Liu F Wang C Li W Wang J Wang J Chen 2006 Protective effects of breviscapine on ischemic vascular dementia in rats Biol Pharm Bull 29 9 1880 1885 1:CAS:528:DC%2BD28XhtFCgtb7E 10.1248/bpb.29.1880 16946502 (Pubitemid 44338411)
34. LL Lin AJ Liu JG Liu XH Yu LP Qin DF Su 2007 Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats J Cardiovasc Pharmacol 50 3 327 332 1:CAS:528:DC%2BD2sXhtVCktbnF 10.1097/FJC.0b013e3180cbd0e7 17878763 (Pubitemid 47428983)
35. XD Liu YZ Chen 2004 The effects of breviscapine on cardiac myocyte apoptosis and expression of Bcl-2 during myocardial ischemia/reperfusion course in rats J GuiYang Med Coll 29 2 102 104
36. FQ Li YZ Chen 2002 Effects of scutellarein on cardiomyocyte apoptosis and ventricular remodeling in spontaneously hypertensive rats J Chongqing Med Univ 27 4 400 402
37. YG Wu GH Wu XM Qi H Lin H Qian JJ Shen S Lin 2006 Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats J Pharmacol Sci 101 4 335 343 1:CAS:528:DC%2BD28XovFOhsrY%3D 10.1254/jphs.FP0050896 16891764 (Pubitemid 44285182)
38. MA Cotter AM Jack NE Cameron 2002 Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin -induced diabetes Clin Sci (Lond) 103 3 311 321 1:CAS:528:DC%2BD38XntVelsbg%3D