Breviscapine alleviates hepatic injury and inhibits PKC-mRNA and its protein expression in brain-dead BA-Ma mini pigs

Hepatobiliary and Pancreatic Diseases International

Volumn 6, Issue 6, 2007, Pages 604-609

  Zhang, Shui Jun ^a   Song, Yan ^a   Zhai, Wen Long ^a   Shi, Ji Hua ^a   Feng, Liu Shun ^a   Zhao, Yong Fu ^a   Chen, Shi ^b  

^a ZHENGZHOU UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

BA Ma mini pigs; Brain death; Breviscapine; Protein kinase C

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BREVISCAPINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PROTEIN KINASE C ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; INTRACRANIAL PRESSURE; LIVER CELL; LIVER FUNCTION TEST; LIVER INJURY; LIVER PROTECTION; MINIPIG; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSLATION INITIATION;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BRAIN DEATH; FLAVONOIDS; INTERLEUKIN-6; LIVER; PROTEIN KINASE C; RNA, MESSENGER; SWINE; SWINE, MINIATURE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 37849041374     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Zhang SJ, Ma TW, Ma XX, Gou JJ, Shi JH, Guo WZ. Protective effects of N-acetylcysteine on brain-dead rat liver. Hepatobiliary Pancreat Dis Int 2006;5:428-431.
2. Zhang SJ, Shi JH, Tang Z, Wu Y, Chen S. Protective effects of glycine pretreatment on brain-death donor liver. Hepatobiliary Pancreat Dis Int 2005;4:37-40.
3. Pratschke J, Wilhelm MJ, Kusaka M, Laskowski I, Tilney NL. A model of gradual onset brain death for transplant-associated studies in rats. Transplantation 2000;69:427-430.
4. Lanza RP, Cooper DK, Novitzky D, Barnard CN. Survival after cardiac transplantation. S Afr Med J 1983;64:1007.
5. Blaine EM, Tallman RD Jr, Frolicher D, Jordan MA, Bluth LL, Howie MB. Vasopressin supplementation in a porcine model of brain-dead potential organ donors. Transplantation 1984;38:459-464.
6. Amado JA, Lopez-Espadas F, Vazquez-Barquero A, Salas E, Riancho JA, Lopez-Cordovilla JJ, et al. Blood levels of cytokines in brain-dead patients: relationship with circulating hormones and acute-phase reactants. Metabolism 1995;44:812-816.
7. Takada M, Nadeau KC, Hancock WW, Mackenzie HS, Shaw GD, Waaga AM, et al. Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation 1998;65:1533-1542.
8. Jassem W, Koo DD, Cerundolo L, Rela M, Heaton ND, Fuggle SV. Leukocyte infiltration and inflammatory antigen expression in cadaveric and living-donor livers before transplant. Transplantation 2003;75:2001-2007.
9. Flohe SB, Brüggemann J, Herder C, Goebel C, Kolb H. Enhanced proinflammatory response to endotoxin after priming of macrophages with lead ions. J Leukoc Biol 2002;71:417-424.
10. Shishodia S, Shrivastava A, Sodhi A. Protein kinase C: a potential pathway of macrophage activation with cisplatin. Immunol Lett 1998;61:179-186.
11. Wang QJ, Acs P, Goodnight J, Blumberg PM, Mischak H, Mushinski JF. The catalytic domain of PKC-epsilon, in reciprocal PKC-delta and -epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation. Oncogene 1998;16:53-60.
12. Togashi H, Hirshman CA, Emala CW. Qualitative immunoblot analysis of PKC isoforms expressed in airway smooth muscle. Am J Physiol 1997;272:L603-607.
13. Hsu HY, Twu YC. Tumor necrosis factor-alpha-mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage. J Biol Chem 2000;275:41035-41048.
14. Yang T, Huang QB, Jin CH. The activation and translocation of protein kinase C induced by burn serum. Chinese Critical Care Medicine 2001;13:427-429.
15. Ward C, Chilvers ER, Lawson MF, Pryde JG, Fujihara S, Farrow SN, et al. NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J Biol Chem 1999;274:4309-4318.
16. Whiteside ST, Israel A. I kappa B proteins: structure, function and regulation. Semin Cancer Biol 1997;8:75-82.
17. May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today 1998;19:80-88.
18. Han Y, Weinman S, Boldogh I, Walker RK, Brasier AR. Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. J Biol Chem 1999;274:787-794.
19. Mora A, Paya M, Rios JL, Alcaraz MJ. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Pharmacol 1990;40:793-797.
20. Bai J, Li WF, Li SL. Protective effects of breviscapine on experimental liver fibrosis in rats. Chin J Inf TCM 2000; 7:34-35.
21. Ali Abdella, Gan L, Liu Q, Liu H, Xu HB. Antioxidant effect of scutellarin and its antagonistic action on the liver toxicity of Se in rats. Chinese Pharmacological Bulletin 2003;19:113-115.
22. Shuai J, Dong WW. Experimental research of PKC inhibitor, erigeron breviscapine on the ischemia/reperfusional brain injury. Chinese Pharmacological Bulletin 1998;14:75-77.
23. Xu G, Zhang LP, Shen HP, Hu CQ. Inhibition of protein kinase C by scutellarein and its analogues. J Shanghai Med Univ 1993;20:187-191.
24. Ding YP, Xu YJ, Zhang ZX, Duan QH, Chen J. Effects of breviscapine on PKC Ca mRNA expression in smooth muscular cells of hypoxic pulmonary artery. Chin J Tuberc Respir Dis 2001;24: 436-437.
25. Zhou H, Chen SX, Wang LX, Wang QJ, He QS, Fan XF. Regulation of the expression of pulmonary arterial collagen by protein kinase C and breviscapine in chronic hypoxic rats. Chin J Tuberc Respir Dis 2002;25: 347-351.