Renoprotective effect of breviscapine through suppression of renal macrophage recruitment in streptozotocin-induced diabetic rats

Nephron - Experimental Nephrology

Volumn 104, Issue 4, 2006, Pages

  Qi, Xiang Ming ^a   Wu, Guo Zhong ^a   Wu, Yong Gui ^a   Lin, Hui ^a   Shen, Ji Jia ^b   Lin, Shan Yan ^c  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Department of Pathobiology ^*  (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Breviscapine; Diabetic nephropathy; Intercellular adhesion molecule 1; Macrophages; Monocyte chemotactic protein 1

Indexed keywords

BREVISCAPINE; CATALASE; CREATININE; FLAVONOID; GLUTATHIONE PEROXIDASE; INTERCELLULAR ADHESION MOLECULE 1; ISOPHANE INSULIN; MALONALDEHYDE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE C; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL INFILTRATION; CHINESE HERB; CONTROLLED STUDY; CREATININE CLEARANCE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ERIGERON BREVISCAPUS; GLOMERULUS; HYPERTROPHY; KIDNEY CELL; KIDNEY TUBULE DAMAGE; MACROPHAGE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALS; CHEMOKINE CCL2; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FLAVONOIDS; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY GLOMERULUS; MACROPHAGES; MALE; OXIDATIVE STRESS; RATS;

EID: 33845356944     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094966     Document Type: Article

References (45)

1. Mensah-Brown EP, Obineche EN, Galadari S, Chandranath E, Shahin A, Ahmed I, Patel SM, Adem A: Streptozotocin-induced diabetic nephropathy in rats: the role of inflammatory cytokines. Cytokine 2005;31:180-190.
2. Galkina E, Ley K: Leukocyte recruitment and vascular injury in diabetic nephropathy. J Am Soc Nephrol 2006;17:368-377.
3. Chow FY, Nikolic-Paterson DJ, Atkins RC, Tesch GH: Macrophages in streptozocin-induced diabetic nephropathy: potential role in renal fibrosis. Nephrol Dial Transplant 2004;19:2987-2996.
4. Furuta T, Saito T, Ootaka T, Soma J, Obara K, Abe K, Yoshinaga K: The role of macrophages in diabetic glomerulosclerosis. Am J Kidney Dis 1993;21:480-485.
5. Sassy-Prigent C, Heudes D, Mandet C, Belair MF, Michel O, Perdereau B, Bariety J, Bruneval P: Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats. Diabetes 2000;49:466-475.
6. Chow F, Ozols E, Nikolic-Paterson DJ, Atkins RC, Tesch G: Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int 2004;65:116-128.
7. Fujisawa G, Okada K, Muto S, Fujita N, Itabashi N, Kusano E, Ishibashi S: Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats. Kidney Int 2004;66:1493-1502.
8. Romero F, Rodriguez-Iturbe B, Parra G, Gonzalez L, Herrera-Acosta J, Tapia E: Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats. Kidney Int 1999;55:945-955.
9. Utimura R, Fujihara CK, Mattar AL, Malheiros DM, Noronha IL, Zatz R: Mycophenolate mofetil prevents the development of glomerular injury in experiment diabetes. Kidney Int 2003;63:209-216.
10. Kikuchi Y, Imakiire T, Yamada M, Saigusa T, Hyodo T, Hyodo N, Suzuki S, Miura S: Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic rats. Nephrol Dial Transplant 2005;20:1573-1581.
11. Zhang RW, Zhang YL, Wang JS, Lin YY, Shang B: Isolation and identification of flavoroids from shortscape fleabane (Erigeron breviscapus) (in Chinese). Chin Trad Herb Drugs 1988;19:199-201.
12. Chen XX, He B, Chen YY: Mechanisms of inhibitory effects of breviscapine on lipid peroxidation in rat brain mitochondria (in Chinese). J Chin Pharm Sci 1998;7:209-213.
13. Ali A, Gan L, Liu Q, Liu H, Xu HB: Antioxidant effect of scutellarin and its antagonistic action on the liver toxicity of Se in rats (in Chinese). Chin Pharmacol Bull 2003;19:113-115.
14. Shuai J, Dong WW: Experimental research of PKC inhibitor, erigeron breviscapus on the ischemic/reperfusion brain injury (in Chinese). Chin Pharmacol Bull 1998;14:75-77.
15. Ha H, Yu MR, Choi YJ, Kitamura M, Lee HB: Role of high glucose-induced nuclear factor-κB activation in monocyte chemoattractant protein-1 expression by mesangial cells. J Am Soc Nephrol 2002;13:894-902.
16. Horie K, Miyata T, Maeda K, Miyata S, Sugiyama S, Sakai H, Strihou CY, Monnier VM, Witztum JL, Kurokawa K: Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy. J Clin Invest 1997;100:2995-3004.
17. Trachtman H, Futterweit S, Maesaka J, Ma C, Valderrama E, Fuchs A, Tarectecan AA, Rao PS, Sturman JA, Boles TH: Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats. Am J Physiol 1995;269:F429-F438.
18. Ha H, Yu M-R, Kim KH: Melatonin and taurine reduce early glomerulopathy in diabetic rats. Free Radical Bio Med 1999;26:944-950.
19. Kim SS, Gallaher DD, Csallany AS: Vitamin E and probucol reduce urinary lipophilic aldehydes and renal enlargement in streptozotocin-induced diabetic rats. Lipids 2000;35:1225-1237.
20. Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, King GL, Kikkawa R: Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 2000;14:439-447.
21. Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA: Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2002;28:1456-1462.
22. Park CW, Kim JH, Lee JH, Kim YS, Ahn HJ, Shin YS, Kim SY, Choi EJ, Chang YS, Bang BK: High glucose-induced intercellular adhesion molecule-1(ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-κB-dependent. Diabetologia 2000;43:1544-1553.
23. Kelly DJ, Chanty A, Gow RM, Zhang Y, Gilbert RE: Protein kinase C beta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy. J Am Soc Nephrol 2005;16:1654-1660.
24. Wu YG, Lin H, Qian H, Zhao M, Zhou D, Liang WN, Xu M, Zhang BK: Experimental study of effect of breviscapine on expression of transforming growth factor β1and connective tissue growth factor in kidney in diabetic rats (in Chinese). Chin Pharmacol Bull 2004;20:1050-1054.
25. He W, Liu YM, Chen H, Zeng FD: Effect of breviscapine on brain edema and neutrophil infiltration induced by focal cerebral ischemia and reperfusion in rats (in Chinese). Chin J Pharmacol Toxicol 2004;18:161-165.
26. Weibel ER: Stereological Methods: Practical Methods for Biological Morphometry. London, Academic Press, 1979, pp 162-203.
27. Cao Z, Cooper ME, Wu LL, Cox AJ, Jandeleit-Dahm K, Kelly DJ, Gilbert RE: Blockade of the renin angiotensin and endothelin systems on progressive renal injury. Hypertension 2000;36:561-568.
28. Bradford MM: A rapid and sensitive method of the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-254.
29. Kikkawa R, Haneda M, Uzu T, Koya D, Sugimoto T, Shigeta Y: Translocation of protein kinase C alpha and zeta in rat glomerular mesangial cells cultured under high glucose conditions. Diabetologia 1994;37:838-841.
30. Heasley LE, Johnson GL: Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells. J Biol Chem 1989;264:8646-8652.
31. Mai M, Geiger H, Hilgers KF, Veelken R, Mann JF, Dammrich J, Luft FC: Early interstitial changes in hypertension-induced renal injury. Hypertension 1993;22:754-765.
32. Bonnet F, Cooper ME, Kawachi H, Allen TJ, Boner G, Cao Z: Irbesartan normalizes the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia 2001;44:874-877.
33. Kato S, Luyckx VA, Ots M, Lee KW, Ziai F, Troy JL, Brenner BM, MacKenzie HS: Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int 1999;56:1037-1048.
34. Aoyama I, Shimokata K, Niwa T: An oral adsorbent downregulates renal expression of genes that promote interstitial inflammation and fibrosis in diabetic rats. Nephron 2002;92:635-651.
35. Rothlein R, Wegner C: Role of intercellular adhesion molecule-1 in the inflammatory response. Kidney Int 1992;41:617-627.
36. Sugimoto H, Shikata K, Hirata K, Akiyama K, Matsuda M, Kushiro M, Shikata Y, Miyatake N, Miyasaka M, Makino H: Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli: glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation. Diabetes 1997;46:2075-2081.
37. Okada S, Shikata K, Matsuda M, Ogawa D, Usui H, Kido Y, Nagase R, Wada J, Shikata Y, Makino H: Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. Diabetes 2003;52:2586-2593.
38. Banba N, Nakamura T, Matsumura M, Kuroda H, Hattori Y, Kasai K: Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int 2000;58:684-690.
39. Ueda A, Okuda K, Ohno S, Shirai A, Igarashi T, Matsunaga K, Fukushima J, Kawamoto S, Ishigatsubo Y, Okubo T: NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol 1994;153:2052-2063.
40. Koya D, King GL: Protein kinase C activation and the development of diabetic complications. Diabetes 1998;47:859-866.
41. Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 2000;49:1939-1945.
42. Studer RK, Craven PA, DeRubertix FR: Antioxidant inhibition of protein kinase C-signaled increase in transforming growth factor-beta in mesangial cells. Metabolism 1997;46:918-925.
43. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M: Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404:787-790.
44. Chen S, Jim B, Ziyadeh FN: Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up. Semin Nephrol 2003;23:532-543.
45. Chneider A, Panzer U, Zahner G, Wenzel U, Wolf G, Thaiss F, Helmchen U, Stahl, RA: Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-β. Kidney Int 1999;56:135-144.