Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway

Acta Pharmacologica Sinica

Volumn 30, Issue 8, 2009, Pages 1081-1091

  Wang, Min ^a   Zhang, Wen Bin ^a   Zhu, Jun Hui ^a   Fu, Guo Sheng ^a   Zhou, Bin Quan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Breviscapine; Cardiomegaly; Diabetic cardiomyopathy; Protein kinase C

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BREVISCAPINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN C FOS; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA 2; SODIUM CHLORIDE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CELL ULTRASTRUCTURE; CELL VOLUME; CONTROLLED STUDY; DRUG MECHANISM; ECHOCARDIOGRAPHY; HEART CELL CULTURE; HEART VENTRICLE HYPERTROPHY; HUMAN; LOW DRUG DOSE; MALE; MUSCLE FIBER CONTRACTION; NEWBORN; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; CELL SIZE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DOWN-REGULATION; FLAVONOIDS; GLUCOSE; HEART; HYPERTROPHY; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; NF-KAPPA B; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 68349085537     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.95     Document Type: Article

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