Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action

Phytochemistry

Volumn 78, Issue , 2012, Pages 107-119

  Fronza, Marcio ^a   Lamy, Evelyn ^b   Günther, Stefan ^a   Heinzmann, Berta ^c   Laufer, Stefan ^d   Merfort, Irmgard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Abietane diterpenes; Apoptosis; Cell cycle; Cytotoxicity; DNA damage; MIA PaCa 2; Molecular modelling; Peltodon longipes; Topoisomerase

Indexed keywords

4 (4 NITROBENZYL)PYRIDINE; 4-(4-NITROBENZYL)PYRIDINE; ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DITERPENE; DNA TOPOISOMERASE INHIBITOR; HORMINONE; PYRIDINE DERIVATIVE; ROYLEANONE; SUGIOL;

ARTICLE; CELL CYCLE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HUMAN; ISOLATION AND PURIFICATION; MEDICINAL PLANT; PANCREAS TUMOR;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL CYCLE; DITERPENES; DITERPENES, ABIETANE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PANCREATIC NEOPLASMS; PLANTS, MEDICINAL; PYRIDINES; TOPOISOMERASE I INHIBITORS;

AGOUTI PACA;

EID: 84860660662     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2012.02.015     Document Type: Article

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