MTBITC mediates cell cycle arrest and apoptosis induction in human hepg2 cells despite its rapid degradation kinetics in the in vitro model

Environmental and Molecular Mutagenesis

Volumn 50, Issue 3, 2009, Pages 190-200

  Lamy, Evelyn ^a   Mersch Sundermann, Volker ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Apoptosis; Degradation kinetics; Erucin; HepG2 cells; MTBITC

Indexed keywords

4 METHYLTHIOBUTYL ISOTHIOCYANTE; GLUTATHIONE; ISOTHIOCYANIC ACID DERIVATIVE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; ERUCIN; REACTIVE OXYGEN METABOLITE; SULFIDE; THIOCYANIC ACID DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSTASIS; DNA DETERMINATION; DNA FRAGMENTATION; DRUG DEGRADATION; DRUG MECHANISM; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; BIOLOGICAL MODEL; BRASSICA; CELL CYCLE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG STABILITY; IMMUNOBLOTTING; ISOLATION AND PURIFICATION; KINETICS; MASS FRAGMENTOGRAPHY; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; TANDEM MASS SPECTROMETRY; TIME; TUMOR CELL LINE;

APOPTOSIS; BRASSICA; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; HUMANS; IMMUNOBLOTTING; KINETICS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, BIOLOGICAL; REACTIVE OXYGEN SPECIES; SULFIDES; TANDEM MASS SPECTROMETRY; THIOCYANATES; TIME FACTORS;

EID: 63049122191     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20448     Document Type: Article

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