Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 733, Issue 1-2, 2012, Pages 34-38

  Zeisel, Steven H ^a  

^a IL   (United States)

Author keywords

Choline; DNA; Epigenetics; Methylation; Mitochondria; Reactive oxygen species; SNP

Indexed keywords

CHOLINE; DNA; ESTROGEN; FATTY ACID; FOLIC ACID; HISTONE; PHOSPHATIDYLCHOLINE; REACTIVE OXYGEN METABOLITE; THYMIDINE PHOSPHATE; URACIL;

AMINO ACID METABOLISM; APOPTOSIS; BREAST CANCER; CANCER RISK; CARCINOGENESIS; DIETARY REFERENCE INTAKE; DNA DAMAGE; DNA METHYLATION; DNA MODIFICATION; DNA REPAIR; DNA STRAND BREAKAGE; EPIGENETICS; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HUMAN; LIVER CARCINOMA; LIVER DISEASE; MISMATCH REPAIR; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MUSCLE DISEASE; MUTATION RATE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN DEFICIENCY; VITAMIN METABOLISM;

ANIMALS; CHOLINE; CHOLINE DEFICIENCY; DNA BREAKS; DNA DAMAGE; EPIGENESIS, GENETIC; GENOMIC INSTABILITY; HISTONES; HUMANS; MUTATION; NEOPLASMS; NUTRITIONAL REQUIREMENTS;

RODENTIA;

EID: 84860589182     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2011.10.008     Document Type: Review

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