Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampus

Developmental Neuroscience

Volumn 23, Issue 2, 2001, Pages 100-106

  Albright, Craig D ^a   Mar, Mei Heng ^a   Friedrich, Claudia B ^a   Brown, Elliott C ^a   Zeisel, Steven H ^a,b  

^a University of North Carolina   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cell cycle; Choline; Dentate gyrus; Hippocampus; Memory; Nutrition; Pregnancy

Indexed keywords

CHOLINE; CYCLIN DEPENDENT KINASE INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN 1; PROTEIN P15; PROTEIN P27; VIMENTIN;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DENTATE GYRUS; FEMALE; FETUS; HIPPOCAMPUS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MATERNAL NUTRITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STAINING; VITAMIN DEFICIENCY;

ANIMAL NUTRITION PHYSIOLOGY; ANIMALS; CELL CYCLE PROTEINS; CHOLINE; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DENTATE GYRUS; FEMALE; MEMORY; MICROTUBULE-ASSOCIATED PROTEINS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TUMOR SUPPRESSOR PROTEINS; VIMENTIN;

EID: 0034892497     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048701     Document Type: Article

References (31)

1. Pre- and post-natal choline supplementation produces long-term facilitation of spatial memory
2. Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both
3. Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory
4. Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats
5. Perinatal choline supplementation increases the threshold for chunking in spatial memory
6. Choline availability alters embryonic development of the hippocampus and septum in the rat
7. Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum
8. Choline deficiency causes increased localization of transforming growth factor-β1 signaling proteins and apoptosis in the rat liver
9. Cell multiplication. Peering in and peering out: Regulation of and by the cell cycle
10. Principles of CDK regulation
11. 1 cyclin-dependent kinases
12. Maternal protein restriction early in rat pregnancy alters brain development in the progeny
13. Intermediate filament protein synemin is transiently expressed in a subset of astrocytes during development
14. Immunohistochemical evaluation of proliferating cell nuclear antigen, Ki-67 (MIB- 1), and p53 in predicting survival of primary and metastatic malignant melanomas
15. Imprinting of hippocampal metabolism of choline by its availability during gestation: Implications for cholinergic neurotransmission
16. Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus
17. Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: Comparison with expression of the cell cycle regulators p21Waf1/ Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene Bax
18. The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons
19. Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits
20. The cyclin-dependent kinase inhibitor p27Kip1 is localized to the cytosol in Swiss/3T3 cells
21. A cell cycle alteration precedes apoptosis of granule cell precursors in the weavermouse cerebellum
22. Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development
23. Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease
24. Cyclin-dependent kinase inhibitor p27Kip1 is expressed at high levels in cells that express a myelinating phenotype
25. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocytes progenitors but unaltered timing of differentiation
26. Ectopic expression of p27Kip1 in oligodendrocytes progenitor cells results in cell-cycle growth arrest
27. Distribution of glial fibrillary acidic protein and vimentin-immunopositive elements in the developing chicken brain from hatch to adulthood
28. Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases
29. Localisation of microtubule-associated protein 1B phosphorylation sites recognized by monoclonal antibody SMI-31