Aryl hydrocarbon receptor is an ozone sensor in human skin

Journal of Investigative Dermatology

Volumn 129, Issue 10, 2009, Pages 2396-2403

  Afaq, Farrukh ^a   Zaid, Mohammad Abu ^a   Pelle, Edward ^b   Khan, Naghma ^a   Syed, Deeba N ^a   Matsui, Mary S ^b   Maes, Daniel ^b   Mukhtar, Hasan ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Estee Lauder Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OZONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ARTICLE; BIOSENSOR; BIOTRANSFORMATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; GENE EXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; KERATINOCYTE; POLLUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; KERATINOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OXIDATIVE STRESS; OZONE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN;

EID: 70349103239     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.85     Document Type: Article

References (39)

1. Ahmad N, Mukhtar H (2004) Cytochrome P450: a target for drug development for skin diseases. J Invest Dermatol 123:417-425
2. Baudouin C, Charveron M, Tarroux R, Gall Y (2002) Environmental pollutants and skin cancer. Cell Biol Toxicol 18:341-348
3. Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F (2004) Ozone and short-term mortality in 95 US urban communities, 1987-2000. JAMA 292:2372-2378
4. Cavalieri E, Frenkel K, Liehr JC, Rogan E, Roy D (2000) Chapter 4: estrogens as endogenous genotoxic agents-DNA adducts and mutations. J Natl Cancer Inst Monogr 27:75-93
5. Commission on Geosciences, Environment and Resources (CGER), Committee on tropospheric ozone formation and measurement (1991) Rethinking the Ozone Problem in Urban and Regional Air Pollution. Washington, DC: National Academy Press, 22-37
6. De Larco JE, Reynolds R, Carlberg K, Engle C, Todaro GT (1980) Sarcoma growth factor from mouse sarcoma virus-transformed cells: purification by binding and elution from epidermal growth factor receptor-rich cells. J Biol Chem 255:3685-3690
7. Enan E, Matsumura F (1996) Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway. Biochem Pharmacol 52:1599-1612
8. Falk HL, Kotin P, Mehler A (1964) Polycyclic hydrocarbons as carcinogens for man. Arch Environ Health 8:721-731
9. Fortino V, Maioli E, Torricelli C, Davis P, Valacchi G (2007) Cutaneous MMPs are differently modulated by environmental stressors in old and young mice. Toxicol Lett 173:73-79
10. Fritsche E, Schäfer C, Calles C, Bernsmann T, Bernshausen T, Wurm M et al. (2007) Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci USA 104:8851-8856
11. Gregory H (1975) Isolation and structure of urogastrone and its relationship to epidermal growth factor. Nature 257:325-327
12. Gruber JV, Tay A, Holtz R (2005) Protecting the skin against ozone. J Cosmet Sci 56:348-349
13. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70 He QC, Tavakkol A, Wietecha K, Begum-Gafur R, Ansari SA, Polefka T (2006) Effects of environmentally realistic levels of ozone on stratum corneum function. Int J Cosmet Sci 28:349-357
14. Katiyar SK, Matsui MS, Mukhtar H (2000) Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1. J Invest Dermatol 114:328-333
15. Kinoshita N, Gelboin HV (1972) The role of aryl hydrocarbon hydroxylase in 7,12-dimethylbenz (a) anthracene skin tumorigenesis: on the mechanism of 7,8-benzaflavone inhibition of tumorigenesis. Cancer Res 32:1329-1339
16. Kohle C, Gschaidmeier H, Lauth D, Topell S, Zitzer H, Bock KW (1999) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated membrane translocation ofc-Src protein kinase in liver WB-F344 cells. Arch Toxicol 73:152-158
17. Mustafa MG (1990) Biochemical basis of ozone toxicity. Free Radic Biol Med 9:245-265
18. Nebert DW, Dalton TP (2006) The role of cytochrome P450 enzymes in endogenous signaling pathways and environmental carcinogenesis. Nat Rev Cancer 6:947-960
19. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ (2004) Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 279:23847-23850
20. Nebert DW, Karp CL (2008) Endogenous functions of the Aryl hydrocarbon receptor: intersection of cytochromeP450 (CYP1)-metabolized eicosa-noids and AHR biology. J Biol Chem 283:36061-36065
21. Park S, Matsumura F (2006) Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A. Toxicology 217:139-146
22. Poland A, Knutson JC (1982) 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 22:517-554
23. Polosa R, Sapsford RJ, Dokic D, Cacciola RR, Prosperini G, Devalia JL et al. (2004) Induction of the epidermal growth factor receptor and its ligands in nasal epithelium by ozone. J Allergy Clin Immunol 113:120-126
24. Pryor WC (1979) Free radical reactions in biology: initiation of lipid autoxidation by ozone and nitrogen dioxide. Environ Health Perspect 16:180-181
25. Pryor WC, Church DF (1991) The reaction of ozone with unsaturated fatty acids: aldehydes and hydrogen peroxide as mediators of ozone toxicity. In: Oxidative Damage and Repair: Chemical, Biological and Medical Aspects. (Davies KJA, ed), New York: Pergamon Press 496-504
26. Schütze S, Tchikov V, Schneider-Brachert W (2008) Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat Rev Mol Cell Biol 9:655-662
27. She QB, Solit DB, Ye Q, O0Reilly KE, Lobo J, Rosen N (2005) The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell 8:287-297
28. Sitch S, Cox PM, Collins WJ, Huntingford C (2007) Indirect radiative forcing of climate change through ozone effects on the land-carbon sink. Nature 448:791-794
29. Thiele JJ, Podda M, Packer L (1997a) Tropospheric ozone: an emerging environmental stress to skin. Biol Chem 378:1299-1305
30. Thiele JJ, Traber MG, Podda M, Tsang K, Cross CE, Packer L (1997b) Ozone depletes tocopherols and tocotrienols topically applied to murine skin. FEBS Lett 401:167-170 (Pubitemid 27056109)
31. Thiele JJ, Traber MG, Polefka TG, Cross CE, Packer L (1997d) Ozone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum. J Invest Dermatol 108:753-757
32. Thiele JJ, Traber MG, Tsang K, Cross CE, Packer L (1997c) In vivo exposure to ozone depletes vitamins C and E and induces lipid peroxidation in epidermal layers of murine skin. Free Radic Biol Med 23:385-391
33. Valacchi G, Pagnin E, Corbacho AM, Olano E, Davis PA, Packer L et al. (2004) In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin. Free Radic Biol Med 36:673-681
34. Valacchi G, Pagnin E, Okamoto T, Corbacho AM, Olano E, Davis PA et al. (2003) Induction of stress proteins and MMP-9 by 0.8 ppm of ozone in murine skin. Biochem Biophys Res Commun 305:741-746
35. Valacchi G, van der Vliet A, Schock BC, Okamoto T, Obermuller-Jevic U, Cross CE et al. (2002) Ozone exposure activates oxidative stress responses in murine skin. Toxicology 179:163-170
36. Valacchi G, Weber SU, Luu C, Cross CE, Packer L (2000) Ozone potentiates vitamin E depletion by ultraviolet radiation in the murine stratum corneum. FEBS Lett 466:165-168
37. Valentine R (1985) An in vitro system for exposure of lung cells to gases: effects of ozone on rat macrophages. J Toxicol Environ Health 16:115-126
38. Wada T, Penninger JM (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23:2838-2849
39. Yarden Y, Sliwkowski MX (2001) Untangling the erbB signalling network. Nat Rev Mol Cell Biol 2:127-137