Medication-related falls in the elderly: Causative factors and preventive strategies

Drugs and Aging

Volumn 29, Issue 5, 2012, Pages 359-376

  Huang, Allen R ^a   Mallet, Louise ^a,b   Rochefort, Christian M ^c   Eguale, Tewodros ^c   Buckeridge, David L ^c   Tamblyn, Robyn ^c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Adverse drug reactions; Elderly; Injuries; Medication errors

Indexed keywords

ACETYLSALICYLIC ACID; ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ANTIPARKINSON AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FENTANYL; HYPNOTIC SEDATIVE AGENT; LOOP DIURETIC AGENT; MEMANTINE; MORPHINE; NEUROLEPTIC AGENT; NITRATE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE DERIVATIVE; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; THIAZIDE DIURETIC AGENT; TRANQUILIZER; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG;

ACCIDENT PREVENTION; AGED; BALANCE DISORDER; DAILY LIFE ACTIVITY; DRUG EFFECT; DRUG USE; FALLING; GAIT DISORDER; HUMAN; PATIENT MOBILITY; PATIENT SAFETY; POLYPHARMACY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; RISK REDUCTION; SIDE EFFECT;

ACCIDENT PREVENTION; ACCIDENTAL FALLS; AGE FACTORS; AGED; HIP FRACTURES; HOSPITALIZATION; HUMANS; PHARMACEUTICAL PREPARATIONS; PHYSICIAN'S PRACTICE PATTERNS; RISK FACTORS;

EID: 84860556379     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11599460-000000000-00000     Document Type: Review

References (136)

1. World Health organization (WHO). World Health Statistics 2011. Geneva: WHO Press, 2011
2. Hoyert DL, Kochanek KD, Murphy SL. Deaths: final data for 1997. Natl Vital Stat Rep 1999; 47 (19): 1-104
3. Tinetti ME, Baker DI, McAvay G, et al. A multifactorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med 1994; 331 (13): 821-7
4. Hanlon JT, Landerman LR, Fillenbaum GG, et al. Falls in African American and White community-dwelling elderly residents. J Gerontol A Biol SciMed Sci 2002; 57 (7): M473-8
5. Zecevic AA, Salmoni AW, Speechley M, et al. Defining a fall and reasons for falling: comparisons among the views of seniors, health care providers, and the research literature. Gerontologist 2006; 46 (3): 367-76
6. Violence and injury prevention: other injury topics: falls. Geneva: WHO [online]. Available from URL: http://www. who.int/violence-injury-prevention/ other-injury/falls/en/ index.html [Accessed 2012 Mar 26]
7. Crentsil V, Ricks MO, Xue QL, et al. A pharmacoepidemiologic study of community-dwelling, disabled older women: factors associated with medication use. Am J Geriatr Pharmac 2010; 8 (3): 215-24
8. Bjerrum L, Rosholm JU, Hallas J, et al. Methods for estimating the occurrence of polypharmacy by means of a prescription database. Eur J Clin Pharmacol 1997; 53 (1): 7-11
9. Tamblyn R, HuangA, Perreault R, et al. The medical office of the 21st century (MOXXI): effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. Can Med Assoc J 2003; 169 (6): 549-56
10. Vestal RE. Aging and pharmacology. Cancer 1997; 80 (7): 1302-10
11. Hammerlein A, Derendorf H, Lowenthal DT. Pharmacokinetic and pharmacodynamic changes in the elderly: clinical implications. Clin Pharmacokinet 1998; 35 (1): 49-64
12. Turnheim K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol 2003; 38 (8): 843-53
13. Campion EW, Avorn J, Reder VA, et al. Overmedication of the low-weight elderly. Arch Intern Med 1987; 147 (5): 945-7
14. Cusack BJ. Pharmacokinetics in older persons. Am J Geriatr Pharmac 2004; 2 (4): 274-302
15. Grenier L. Pharmacocinétique et pharmacodynamie. In: Mallet L, Grenier L, Guimond J, et al., editors. Manuel de soins pharmaceutiques en gé riatrie. Quebec (QC): Les presses de l université Laval, 2003: 77-98
16. Hutchison LC, O'Brien CE. Changes in pharmacokinetics and pharmacodynamics in the elderly patient. J Pharm Pract 2007; 20 (1): 4-12
17. Kinirons MT, O'Mahony MS. Drug metabolism and ageing. Br J Clin Pharmacol 2004; 57 (5): 540-4
18. Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet 2007; 370 (9582): 185-91
19. Campbell N, Boustani M, Limbil T, et al. The cognitive impact of anticholinergics: a clinical review. Clin Interv Aging 2009; 4: 225-33
20. Minzenberg MJ, Poole JH, Benton C, et al. Association of anticholinergic load with impairment of complex attention and memory in schizophrenia. Am J Psychiat 2004; 161 (1): 116-24
21. Landi F, Russo A, Liperoti R, et al. Anticholinergic drugs and physical function among frail elderly population. Clin Pharmacol Ther 2006; 81 (2): 235-41
22. Cao YJ, Mager DE, Simonsick EM, et al. Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Clin Pharmacol Ther 2007; 83 (3): 422-9
23. Hilmer SN, Mager DE, Simonsick EM, et al. A drug burden index to define the functional burden of medications in older people. Arch Intern Med 2007; 167 (8): 781-7
24. Wilson NM, Hilmer SN, March LM, et al. Associations between drug burden index and falls in older people in residential aged care. J Am Geriatr Soc 2011; 59 (5): 875-80
25. Aizenberg D, Sigler M, Weizman A, et al. Anticholinergic burden and the risk of falls among elderly psychiatric inpatients: a 4-year case-control study. Int Psychogeriatr 2002; 14 (03): 307-10
26. Boss GR, Seegmiller JE. Age-related physiological changes and their clinical significance. Western J Med 1981; 135 (6): 434-40
27. Dalstra JAA, Kunst AE, Borrell C, et al. Socioeconomic differences in the prevalence of common chronic diseases: an overview of eight European countries. Int J Epidemiol 2005; 34 (2): 316-26
28. Hogan DB, Ebly EM, Fung TS. Disease, disability, and age in cognitively intact seniors: results from the Canadian Study of Health and Aging. J Gerontol A Biol Sci Med Sci 1999; 54 (2): M77-82
29. Jemal A, Ward E, Hao Y, et al. Trends in the leading causes of death in the United States, 1970-2002. JAMA 2005; 294 (10): 1255-9
30. Scuffham P, Chaplin S, Legood R. Incidence and costs of unintentional falls in older people in the United Kingdom. J Epidemiol Commun H 2003; 57 (9): 740-4
31. Public health and aging: nonfatal injuries among older adults treated in hospital emergency department: United States, 2001. MMWR Morb Mortal Wkly Rep 2003; 52 (42): 1019-22
32. Rubenstein LZ, Josephson KR. The epidemiology of falls and syncope. Clin Geriatr Med 2002; 18 (2): 141-58
33. Tinetti ME, Doucette J, Claus E, et al. Risk factors for serious injury during falls by older persons in the community. J Am Geriatr Soc 1995; 43 (11): 1214-21
34. Tinetti ME, Williams CS. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med 1997; 337 (18): 1279-84
35. Bates DW, Cullen DJ, Laird N, et al. Incidence of adverse drug events and potential adverse drug events: implications for prevention. JAMA 1995; 274 (1): 29-34
36. Baker GR, Norton PG, Flintoft V, et al. The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada. Can Med Assoc J 2004; 170 (11): 1678-86
37. King MB, Tinetti ME. Falls in community-dwelling older persons. J Am Geriatr Soc 1995; 43 (10): 1146-54
38. Hosseini H, Hosseini N. Epidemiology and prevention of fall injuries among the elderly. Hosp Top 2008; 86 (3): 15-20
39. Guelich MM. Prevention of falls in the elderly: a literature review. Top Geriatr Rehabil 1999; 15 (1): 15-25
40. Van der Velde N, Stricker BH, Pols HA, et al. Risk of falls after withdrawal of fall-risk-increasing drugs: a prospective cohort study. Br J Clin Pharmacol 2007; 63 (2): 232-7
41. Kragh A, Elmstahl S, Atroshi I. Older adults' medication use 6 months before and after hip fracture: a populationbased cohort study. J Am Geriatr Soc 2011; 59 (5): 863-8
42. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc 1999; 47 (1): 40-50
43. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 1999; 47 (1): 30-9
44. Woolcott JC, Richardson KJ, Wiens MO, et al. Metaanalysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 2009; 169 (21): 1952-60
45. Bloch F, Thibaud M, Dugue B, et al. Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis. J Aging Health 2011; 23 (2): 329-46
46. Liu B, Anderson G, Mittmann N, et al. Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 1998; 351 (9112): 1303-7
47. Nurminen J, Puustinen J, Piirtola M, et al. Psychotropic drugs and the risk of fractures in old age: a prospective population-based study. BMC Public Health 2010; 10: 396. doi:10.1186/1471-2458-10-396
48. Moden B, Merlo J, Ohlsson H, et al. Psychotropic drugs and falling accidents among the elderly: a nested case control study in the whole population of Scania, Sweden. J Epidemiol Commun H 2010; 64 (5): 440-6
49. Gill SS, Bronskill SE, Normand SL, et al. Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med 2007; 146 (11): 775-86
50. Vitry AI, Hoile AP, Gilbert AL, et al. The risk of falls and fractures associated with persistent use of psychotropic medications in elderly people. Arch Gerontol Geriatr 2010; 50 (3): e1-4
51. Sullivan MD, Edlund MJ, Fan MY, et al. Trends in use of opioids for non-cancer pain conditions 2000-2005 in commercial and Medicaid insurance plans: the TROUP study. Pain 2008; 138 (2): 440-9
52. Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis of benzodiazepine use in the treatment of insomnia. Can Med Assoc J 2000; 162 (2): 225-33
53. Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with the use of morphine and opiates. J Intern Med 2006; 260 (1): 76-87
54. Ensrud KE, Blackwell TL, Mangione CM, et al. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 2002; 50 (10): 1629-37
55. Ray WA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 1989; 262 (23): 3303-7
56. Passaro A, Volpato S, Romagnoni F, et al. Benzodiazepines with different half-life and falling in a hospitalized population: the GIFA study. Gruppo Italiano di Farmacovigilanza nell'Anziano. J Clin Epidemiol 2000; 53 (12): 1222-9
57. Herings RMC, Stricker BHC, De BA, et al. Benzodiazepines and the risk of falling leading to femur fractures: dosage more important than elimination half-life. Arch Intern Med 1995; 155 (16): 1801-7
58. Ray WA, Thapa PB, Gideon P. Benzodiazepines and the risk of falls in nursing residents home. J Am Geriatr Soc 2000; 48 (6): 682-5
59. Neutel CI, Perry S, Maxwell C. Medication use and risk of falls. Pharmacoepidemiol Drug Saf 2002; 11 (2): 97-104
60. Tamblyn R, Abrahamowicz M, du BR, et al. A 5-year prospective assessment of the risk associated with individual benzodiazepines and doses in new elderly users. J Am Geriatr Soc 2005; 53 (2): 233-41
61. Gauthier S, Cummings J, Ballard C, et al. Management of behavioral problems in Alzheimer's disease. Int Psychogeriatr 2010; 22 (3): 346-72
62. Hien le TT, Cumming RG, Cameron ID, et al. Atypical antipsychotic medications and risk of falls in residents of aged care facilities. J Am Geriatr Soc 2005; 53 (8): 1290-5
63. Mehta S, Chen H, Johnson ML, et al. Risk of falls and fractures in older adults using antipsychotic agents: a propensity-matched retrospective cohort study. Drugs Aging 2010; 27 (10): 815-29
64. Liperoti R, Onder G, Lapane KL, et al. Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. J Clin Psychiat 2007; 68 (6): 929-34
65. Thapa PB, Gideon P, Cost TW, et al. Antidepressants and the risk of falls among nursing home residents. N Engl J Med 1998; 339 (13): 875-82
66. Arfken CL, Wilson JG, Aronson SM. Retrospective review of selective serotonin reuptake inhibitors and falling in older nursing home residents. Int Psychogeriatr 2001; 13 (1): 86-91
67. Coupland C, Dhiman P, Morriss R, et al. Antidepressant use and risk of adverse outcomes in older people: population based cohort study. Br Med J 2011 Aug 2; 343: d4551. doi:10.1136/bmj.d4551
68. Mallet L. Les anticonvulsivants. In: Mallet L, Grenier L, Guimond J, et al., editors. Quebec (QC): Les Presses de l université Laval, 2003: 223-44
69. Kelly KD, Pickett W, Yiannakoulas N, et al. Medication use and falls in community-dwelling older persons. Age Ageing 2003; 32 (5): 503-9
70. Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with parkinsonism and anti-Parkinson drugs. Calcified Tissue Int 2007; 81 (3): 153-61
71. Kim DH, Brown RT, Ding EL, et al. Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials. J Am Geriatr Soc 2011; 59 (6): 1019-31
72. Takkouche B, Montes-Martinez A, Gill SS, et al. Psychotropic medications and the risk of fracture: a metaanalysis. Drug Saf 2007; 30 (2): 171-84
73. Guo Z, Wills P, Viitanen M, et al. Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 years old: a community-based prospective study. Am J Epidemiol 1998; 148 (9): 887-92
74. Ensrud KE, Blackwell T, Mangione CM, et al. Central nervous system active medications and risk for fractures in older women. Arch Intern Med 2003; 163 (8): 949-57
75. Hanlon JT, Boudreau RM, Roumani YF, et al. Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci 2009; 64 (4): 492-8
76. Buckeridge D, Huang A, Hanley J, et al. Risk of Injury associated with opioid use in older adults. J Am Geriatr Soc 2010; 58 (9): 1664-70
77. Koski K, Luukinen H, Laippala P, et al. Physiological factors and medications as predictors of injurious falls by elderly people: a prospective population-based study. Age Ageing 1996; 25 (1): 29-38
78. Nelson JM, Dufraux K, Cook PF. The relationship between glycemic control and falls in older adults. J Am Geriatr Soc 2007; 55 (12): 2041-4
79. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358 (24): 2545-59
80. Malmivaara A, Heliovaara M, Knekt P, et al. Risk factors for injurious falls leading to hospitalization or death in a cohort of 19,500 adults. Am J Epidemiol 1993; 138 (6): 384-94
81. Kurzthaler I, Wambacher M, Golser K, et al. Alcohol and benzodiazepines in falls: an epidemiological view. Drug Alcohol Depen 2005; 79 (2): 225-30
82. Onen SH, Onen F, Mangeon JP, et al. Alcohol abuse and dependence in elderly emergency department patients. Arch Gerontol Geriat 2005; 41 (2): 191-200
83. Baker SP, Haddon Jr W. Reducing injuries and their results: the scientific approach. Milbank Q1974; 52 (4): 377-89
84. Haddon J. Options for the prevention of motor vehicle crash injury. Israel J Med Sci 1980; 16 (1): 45-65
85. Haddon Jr W. On the escape of tigers: an ecologic note. Am J Public Health N 1970; 60 (12): 2229-34
86. Runyan CW. Using the Haddon matrix: introducing the third dimension. Injury Prev 1998; 4 (4): 302-7
87. Beers MH, Ouslander JG, Rollingher I, et al. Explicit criteria for determining inappropriate medication use in nursing home residents. Arch Intern Med 1991; 151 (9): 1825-32
88. Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly: an update. Arch Intern Med 1997; 157 (14): 1531-6
89. Fick DM, Cooper JW, Wade WE, et al. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 2003; 163 (22): 2716-24
90. McLeod PJ, Huang AR, Tamblyn RM, et al. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. Can Med Assoc J 1997; 156 (3): 385-91
91. The American Geriatrics Society. American geriatrics society updated Beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012; 60 (4): 616-31
92. Berdot S, Bertrand M, Dartigues JF, et al. Inappropriate medication use and risk of falls: a prospective study in a large community-dwelling elderly cohort. BMC Geriatr 2009; 9: 30. doi:10.1186/1471-2318-9-30
93. Gallagher P, Baeyens JP, Topinkova E, et al. Inter-rater reliability of STOPP (Screening Tool of Older Persons' Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment) criteria amongst physicians in six European countries. Age Ageing 2009; 38 (5): 603-6
94. Gallagher P, O'Mahony D. STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers' criteria. Age Ageing 2008; 37 (6): 673-9
95. Gallagher P, Ryan C, Byrne S, et al. STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment): consensus validation. Int J Clin Pharm Ther 2008; 46 (2): 72-83
96. Gallagher PF, O'Connor MN, O'Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther 2011; 89 (6): 845-54
97. Hamilton H, Gallagher P, Ryan C, et al. Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Intern Med 2011; 171 (11): 1013-9
98. Pyszka LL, Seys Ranola TM, Milhans SM. Identification of inappropriate prescribing in geriatrics at a Veterans Affairs hospital using STOPP/START screening tools. Consult Pharm 2010; 25 (6): 365-73
99. Pugh MJ, Hanlon JT, Wang CP, et al. Trends in use of high-risk medications for older veterans: 2004 to 2006. J Am Geriatr Soc 2011; 59 (10): 1891-8
100. Tinetti ME, Baker DI, King M, et al. Effect of dissemination of evidence in reducing injuries from falls. N Engl J Med 2008; 359 (3): 252-61
101. Rubenstein LZ, Powers CM, MacLean CH. Quality indicators for the management and prevention of falls and mobility problems in vulnerable elders. Ann Intern Med 2001; 135 (8 Pt 2): 686-93
102. Chang JT, Ganz DA. Quality indicators for falls and mobility problems in vulnerable elders. J Am Geriatr Soc 2007; 55 Suppl.: S327-34
103. Chang JT, Morton SC, Rubenstein LZ, et al. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ 2004; 328 (7441): 680
104. Shaw FE, Bond J, Richardson DA, et al. Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial. BMJ 2003; 326 (7380): 73
105. Coussement J, De PL, Schwendimann R, et al. Interventions for preventing falls in acute- and chronic-care hospitals: a systematic review and meta-analysis. J AmGeriatr Soc 2008; 56 (1): 29-36
106. Cumming RG, Sherrington C, Lord SR, et al. Cluster randomised trial of a targeted multifactorial intervention to prevent falls among older people in hospital. BMJ 2008; 336
107. Van der Velde N, Meerding WJ, Looman CW, et al. Cost effectiveness of withdrawal of fall-risk-increasing drugs in geriatric outpatients. Drugs Aging 2008; 25 (6): 521-9
108. Van der Velde N, Stricker BH, Pols HA, et al. Withdrawal of fall-risk-increasing drugs in older persons: effect on mobility test outcomes. Drugs Aging 2007; 24 (8): 691-9
109. Campbell AJ, Robertson MC, Gardner MM, et al. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomized, controlled trial. J Am Geriatr Soc 1999; 47 (7): 850-3
110. Hartholt K, Van der Velde N, Van Lieshout E, et al. [Cost]effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of amulticenter randomized controlled trial (IMPROveFALLstudy). BMC Geriatr 2011; 11 (1): 48. doi:10.1186/1471-2318- 11-48
111. Joester J, Vogler CM, Chang K, et al. Hypnosedative use and predictors of successful withdrawal in new patients attending a falls clinic: a retrospective, cohort study. Drugs Aging 2010; 27 (11): 915-24
112. Lader M, Tylee A, Donoghue J. Withdrawing benzodiazepines in primary care. CNS Drugs 2009; 23 (1): 19-34
113. Salonoja M, Salminen M, Aarnio P, et al. One-time counselling decreases the use of benzodiazepines and related drugs among community-dwelling older persons. Age Ageing 2010; 39 (3): 313-9
114. Smith AJ, Tett SE. Improving the use of benzodiazepines: is it possible? A non-systematic review of interventions tried in the last 20 years.BMCHealth ServRes 2010; 10: 321
115. Schiff GD, Galanter WL. Promoting more conservative prescribing. JAMA 2009; 301 (8): 865-7
116. Schiff GD, Rucker TD. Computerized prescribing: building the electronic infrastructure for better medication usage. JAMA 1998; 279 (13): 1024-9
117. Schnipper JL. Medication safety: are we there yet? Comment on ''Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients''. Arch Intern Med 2011; 171 (11): 1019-20
118. Agostini JV, Zhang Y, Inouye SK. Use of a computer-based reminder to improve sedative-hypnotic prescribing in older hospitalized patients. J Am Geriatr Soc 2007; 55 (1): 43-8
119. Ball MJ, Lillis J. E-health: transforming the physician/ patient relationship. Int J Med Inform 2001; 61 (1): 1-10
120. Dickerson S, Reinhart AM, Feeley TH, et al. Patient internet use for health information at three urban primary care clinics. J Am Med Inform Assoc 2004; 11 (6): 499-504
121. Weingart SN, Toth M, Sands DZ, et al. Physicians' decisions to override computerized drug alerts in primary care. Arch Intern Med 2003; 163 (21): 2625-31
122. Tamblyn R, Huang A, Taylor L, et al. A randomized trial of the effectiveness of on-demand versus computertriggered drug decision support in primary care. J Am Med Inform Assoc 2008; 15 (4): 430-8
123. van der Sijs H, Aarts J, Vulto A, et al. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc 2006; 13 (2): 138-47
124. Julien M, Hanley JA. Profile-specific survival estimates: making reports of clinical trials more patient-relevant. Clin Trials 2008; 5 (2): 107-15
125. Tamblyn RM, Eguale T, Buckeridge D, et al. The effectiveness of a new generation of computerized drug alerts in reducing the risk of injury from drug side effects: a cluster randomized trial. J Am Med Inform Assoc. Epub 2012 Jan 12. doi:10.1136/amiajnl-2011-000609
126. Hill S, Spink J, Cadilhac D, et al. Absolute risk representation in cardiovascular disease prevention: comprehension and preferences of health care consumers and general practitioners involved in a focus group study. BMC Public Health 2010; 10: 108
127. Edwards A, Elwyn G, Mulley A. Explaining risks: turning numerical data into meaningful pictures. BMJ 2002; 324 (7341): 827-30
128. Tzeng HM, Yin CY, Grunawalt J. Effective assessment of use of sitters by nurses in inpatient care settings. J Adv Nurs 2008; 64 (2): 176-83
129. Jaworowski S, Raveh D, Lobel E, et al. Constant observation in the general hospital: a review. Isr J Psychiatr Rel 2008; 45 (4): 278-84
130. Rausch DL, Bjorklund P. Decreasing the costs of constant observation. J Nurs Admin 2010; 40 (2): 75-81
131. Donoghue J, Graham J, Mitten-Lewis S, et al. A volunteer companion-observer intervention reduces falls on anacute aged care ward. Int J Health Care Qual Assur Inc Leadersh Health Serv 2005; 18 (1): 24-31
132. Worley LL, Kunkel EJ, Gitlin DF, et al. Constant observation practices in the general hospital setting: a national survey. Psychosomatics 2000; 41 (4): 301-10
133. Torkelson DJ, Dobal MT. Constant observation in medical- surgical settings: a multihospital study. Nurs Econ 1999; 17 (3): 149-55
134. Rochefort CM, Ward L, Ritchie JA, et al. Registered nurses' job demands in relation to sitter use: nested casecontrol study. Nurs Res 2011; 60 (4): 221-30
135. Rochefort CM, Ward L, Ritchie JA, et al. Patient and nurse staffing characteristics associated with high sitter use costs. J Adv Nurs. Epub 2011 Nov 3. doi:10.1111/ j.1365-2648.2011.05864.x
136. Charbonneau-Allard A-M, Fluet J, Lessard A, et al. Mé - canismes pharmacologiques comme facteurs modifiables de la prescription de sitters. 2011. Montré al (QC): Faculté de pharmacie, Université de Montré al, 2011