The effectiveness of a new generation of computerized drug alerts in reducing the risk of injury from drug side effects: A cluster randomized trial

Journal of the American Medical Informatics Association

Volumn 19, Issue 4, 2012, Pages 635-643

  Tamblyn, Robyn ^a   Eguale, Tewodros ^a   Buckeridge, David L ^a   Huang, Allen ^a   Hanley, James ^a   Reidel, Kristen ^a   Shi, Sherry ^a   Winslade, Nancy ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT; OPIATE DERIVATIVE; PSYCHOTROPIC AGENT;

AGED; ARTICLE; AUTOMATION; CLINICAL EFFECTIVENESS; CLINICAL PRACTICE; CLUSTER ANALYSIS; CONTROLLED STUDY; DECISION SUPPORT SYSTEM; DRUG SURVEILLANCE PROGRAM; ELECTRONIC MEDICAL RECORD; FEMALE; FOLLOW UP; GENERAL PRACTITIONER; HUMAN; INJURY; MAJOR CLINICAL STUDY; MALE; PRESCRIPTION; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; RISK REDUCTION;

ACCIDENTAL FALLS; AGED; COMPUTER GRAPHICS; DECISION SUPPORT SYSTEMS, CLINICAL; DRUG THERAPY, COMPUTER-ASSISTED; FEMALE; HUMANS; MALE; MEDICAL ORDER ENTRY SYSTEMS; PHYSICIAN'S PRACTICE PATTERNS; PSYCHOTROPIC DRUGS; QUEBEC; RISK ASSESSMENT;

EID: 84860590551     PISSN: 10675027     EISSN: 1527974X     Source Type: Journal    
DOI: 10.1136/amiajnl-2011-000609     Document Type: Article

References (53)

1. Jemal A, Ward E, Hao Y, et al. Trends in the leading causes of death in the United States, 1970-2002. JAMA 2005;294:1255-9.
2. Scuffham P, Chaplin S, Legood R. Incidence and costs of unintentional falls in older people in the United Kingdom. J Epidemiol Community Health 2003;57:740-4.
3. Centers for Disease Control and Prevention (CDC). Public health and aging: nonfatal injuries among older adults treated in hospital emergency departments-United States, 2001. MMWR Morb Mortal Wkly Rep 2003;52:1019-22.
4. Rubenstein LZ, Josephson KR. The epidemiology of falls and syncope. Clin Geriatr Med 2002;18:141-58.
5. Tinetti ME, Doucette J, Claus E, et al. Risk factors for serious injury during falls by older persons in the community. J Am Geriatr Soc 1995;43:1214-21.
6. Tinetti ME, Williams CS. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med 1997;337:1279-84.
7. Bloch F, Thibaud M, Dugue B, et al. Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis. J Aging Health 2011;23:329-46.
8. Liu B, Anderson G, Mittmann N, et al. Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 1998;351:1303-7.
9. Nurminen J, Puustinen J, Piirtola M, et al. Psychotropic drugs and the risk of fractures in old age: a prospective population-based study. BMC Public Health 2010;10:396.
10. Moden B, Merlo J, Ohlsson H, et al. Psychotropic drugs and falling accidents among the elderly: a nested case control study in the whole population of Scania, Sweden. J Epidemiol Community Health 2010;64:440-6.
11. Kragh A, Elmstahl S, Atroshi I. Older adults' medication use 6 months before and after hip fracture: a population-based cohort study. J Am Geriatr Soc 2011;59:863-8.
12. Gill SS, Bronskill SE, Normand SL, et al. Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med 2007;146:775-86.
13. Vitry AI, Hoile AP, Gilbert AL, et al. The risk of falls and fractures associated with persistent use of psychotropic medications in elderly people. Arch Gerontol Geriatr 2010;50:e1-4.
14. Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ 2000;162:225-33.
15. Sullivan MD, Edlund MJ, Fan MY, et al. Trends in use of opioids for non-cancer pain conditions 2000-2005 in commercial and Medicaid insurance plans: the TROUP study. Pain 2008;138:440-9.
16. Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with the use of morphine and opiates. J Intern Med 2006;260:76-87.
17. Stroke Unit TC. Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev 2002;(1):CD000197.
18. Tamblyn R, Abrahamowicz M, du BR, et al. A 5-year prospective assessment of the risk associated with individual benzodiazepines and doses in new elderly users. J Am Geriatr Soc 2005;53:233-41.
19. Simoni-Wastila L. Increases in opioid medication use: balancing the good with the bad. Pain 2008;138:245-6.
20. Mort JR, Aparasu RR. Prescribing potentially inappropriate medications to the ambulatory elderly. Arch Intern Med 2000;160:2825-31.
21. Curtis LH, Ostbye T, Sendersky V, et al. Inappropriate prescribing for elderly Americans in a large outpatient population. Arch Intern Med 2004;164:1621-5.
22. Pugh MJ, Fincke BG, Bierman AS, et al. Potentially inappropriate prescribing in elderly veterans: are we using the wrong drug, wrong dose, or wrong duration? J Am Geriatr Soc 2005;53:1282-9.
23. Tamblyn RM, McLeod PJ, Abrahamowicz M, et al. Do too many Cooks Spoil the Broth? Multiple physician Involvement in medical management and inappropriate prescribing in the elderly. Can Med Assoc J 1996;154:1177-84.
24. Weingart SN, Toth M, Sands DZ, et al. Physicians' decisions to override computerized drug alerts in primary care. Arch Intern Med 2003;163:2625-31.
25. van der Sijs H, Aarts J, Vulto A, et al. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc 2006;13:138-47.
26. Taylor LK, Kawasumi Y, Bartlett G, et al. Inappropriate prescribing practices: the challenge and opportunity for patient safety. Healthc Q 2005;(8 Spec No):81-5.
27. Tamblyn R, Huang A, Taylor L, et al. A randomized trial of the effectiveness of on-demand versus computer-triggered drug decision support in primary care. J Am Med Inform Assoc 2008;15:430-8.
28. Grizzle AJ, Mahmood MH, Ko Y, et al. Reasons provided by prescribers when overriding drug-drug interaction alerts. Am J Manag Care 2007;13:573-8.
29. Kuperman GJ, Reichley RM, Bailey TC. Using commercial knowledge bases for clinical decision support: opportunities, hurdles, and recommendations. J Am Med Inform Assoc 2006;13:369-71.
30. Julien M, Hanley JA. Profile-specific survival estimates: making reports of clinical trials more patient-relevant. Clin Trials 2008;5:107-15.
31. Wilchesky M, Tamblyn RM, Huang A. Validation of diagnostic codes in medical services claims data. Can J Clin Pharmacol 2001;8:39.
32. Tamblyn RM, Reid T, Mayo N, et al. Using medical services claims to assess injuries in the elderly: the sensitivity of diagnostic and procedure codes for injury ascertainment. J Clin Epidemiol 2000;53:183-94.
33. Levy AR, Tamblyn RFD, McLeod P, et al. Coding accuracy of hospital discharge data for elderly survivors of myocardial infarction. Can J Cardiol 1999;15:1277-82.
34. Tamblyn RM, Lavoie G, Petrella L, et al. The use of prescription claims databases in Pharmacoepidemiological research: the accuracy and Comprehensiveness of the prescription claims database in Quebec. J Clin Epidemiol 1995;48:999-1009.
35. Tamblyn R, Huang A, Perreault R, et al. The medical office of the 21st century (MOXXI): effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. CMAJ 2003;169:549-56.
36. Tamblyn R, Huang A, Kawasumi Y, et al. The development and evaluation of an integrated electronic prescribing and drug management system for primary care. J Am Med Inform Assoc 2006;13:148-59.
37. Tamblyn R, Reidel K, Huang A, et al. Increasing the detection and response to adherence problems with cardiovascular medication in primary care through computerized drug management systems: a randomized controlled trial. Med Decis Making 2010;30:176-88.
38. Buckeridge D, Huang A, Hanley J, et al. Risk of injury associated with opioid use in older adults. J Am Geriatr Soc 2010;58:1664-70.
39. Poissant L, Taylor L, Huang A, et al. Assessing the accuracy of an inter-institutional automated patient-specific health problem list. BMC Med Inform Decis Mak 2010;10:10.
40. Tamblyn R, Huang A, Kawasumi Y, et al. The development and evaluation of an integrated electronic prescribing and drug Managment system for primary care. J Am Med Inform Assoc 2006;13:148-59.
41. Greenblatt DJ, Harmatz JS, Shader RI. Clinical Pharmacokinetics of Anxiolytics and Hypnotics in the elderly: therapeutic Considerations (Part 1). Clin Pharmacokinet 1991;21:165-77.
42. Greenblatt DJ. Pharmacology of benzodiazepine Hypnotics. J Clin Psychiatry 1992;53(Suppl 6):7-13.
43. Tamblyn R, Abrahamowicz M, Brailovsky C, et al. The association between licensing examination scores and resource use and quality of care in primary care practice. JAMA 1998;280:989-96.
44. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-83.
45. Haas JS, Cleary PD, Guadagnoli E, et al. The impact of socioeconomic status on the intensity of ambulatory treatment and health outcomes after hospital discharge for adults with asthma. J Gen Intern Med 1994;9:121-6.
46. WHO Collaborating Centre for Drug Statistics Methodology. Anatomical Therapeutic Chemical Classification Index with Defined Daily Doses. Oslo: World Health Organization, 2000.
47. Campbell MK, Elbourne DR, Altman DG. CONSORT statement: extension to cluster randomised trials. Br Med J 2004;328:702-8.
48. Paterno MD, Maviglia SM, Gorman PN, et al. Tiering drug-drug interaction alerts by severity increases compliance rates. J Am Med Inform Assoc 2009;16:40-6.
49. Shah NR, Seger AC, Seger DL, et al. Improving acceptance of computerized prescribing alerts in ambulatory care. J Am Med Inform Assoc 2006;13:5-11.
50. Mayo NE, Wood-Dauphinee S, Cote R, et al. There's no place like home: an evaluation of early supported discharge for stroke.[comment]. Stroke 2000;31:1016-23.
51. Isaac T, Weissman JS, Davis RB, et al. Overrides of medication alerts in ambulatory care. Arch Intern Med 2009;169:305-11.
52. Grant EN, Lyttle CS, Weiss KB. The relation of socioeconomic factors and racial/ethnic differences in US asthma mortality. Am J Public Health 2000;90:1923-5.
53. Sweidan M, Reeve JF, Brien JA, et al. Quality of drug interaction alerts in prescribing and dispensing software. Med J Aust 2009;190:251-4.