Atypical antipsychotic medications and risk of falls in residents of aged care facilities

Journal of the American Geriatrics Society

Volumn 53, Issue 8, 2005, Pages 1290-1295

  Hien, Le T T ^a   Cumming, Robert G ^a,b,d   Cameron, Ian D ^b   Chen, Jian S ^b   Lord, Stephen R ^c   March, Lyn M ^b   Schwarz, Jennifer ^b   Le Couteur, David G ^b   Sambrook, Philip N ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d Department of Microbiology and Infectious Diseases   (Australia)

Author keywords

Accidental falls; Aged care; Antipsychotics; Olanzapine; Psychotropic medications; Risperidone

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; OLANZAPINE; RISPERIDONE; BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT;

AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG USE; FALLING; FEMALE; FOLLOW UP; HOME FOR THE AGED; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PROSPECTIVE STUDY; RISK FACTOR; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; NURSING HOME; RANDOMIZED CONTROLLED TRIAL;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; COHORT STUDIES; FEMALE; HOMES FOR THE AGED; HUMANS; MALE; NURSING HOMES; PROSPECTIVE STUDIES; RISPERIDONE;

EID: 25144510914     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2005.53403.x     Document Type: Article

References (22)

1. Leipzig R, Cumming RG, Tinetti ME. Drugs and falls in older people: A systematic review and meta-analysis. I. Psychotropic drugs. J Am Geriatr Soc 1999;47:30-39.
2. De Deyn PP, Rabheru K, Rasmussen A et al. A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia. Neurology 1999;53:946-955.
3. Katz IR, Jeste DV, Mintzer JE et al. Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: A randomized, double-blind trial. J Clin Psychiatry 1999;60:107-115.
4. Street JS, Clark S, Gannon KS et al. Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities. Arch Gen Psychiatry 2000;57:968-976.
5. Brodaty H, Ames D, Snowdon J et al. A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J Clin Psychiatry 2003;64:134-143.
6. Lee PE, Gill SS, Freedman M et al. Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: Systematic review. BMJ 2004;329:75. Epub 2004 June 11.
7. Jeste DV, Rockwell E, Harris MJ et al. Conventional vs newer antipsychotics in elderly patients. Am J Geriatr Psychiatry 1999;7:70-76.
8. Zochling J, Sitoh YY, Lau TC et al. Quantitative ultrasound of the calcaneus and falls risk in the institutionalized elderly: Sex differences and relationship to vitamin D status. Osteoporos Int 2002;13:882-887.
9. Lord SR, March LM, Cameron ID et al. Differing risk factors for falls in nursing home and intermediate-care residents who can and cannot stand unaided. J Am Geriatr Soc 2003;51:1645-1650.
10. Holtzman J, Lurie N. Causes of increasing mortality in a nursing home population. J Am Geriatr Soc 1996;44:258-264.
11. Cuthbertson S, Lindsay-Smith U, Rosewarne R. Background Paper for a Review of the Resident Classification Scheme (RCS). Canberra: Australian Department of Health and Ageing, 1997.
12. Molloy DW, Alemayehu E, Roberts R. Validity of a standardized Mini-Mental State Examination compared with the traditional Mini-Mental State Examination. Am J Psychiatry 1991;148:102-105.
13. Verbaken JH, Johnson AW. Population norms for edge contrast sensitivity. Am J Optom Physiol Opt 1986;63:724-732.
14. Lord SR, Clark RD, Webster IW. Physiological factors associated with falls in an elderly population. J Am Geriatr Soc 1991;39:1194-1200.
15. Tandon R. Safety and tolerability: How do newer generation 'atypical' antipsychotics compare? Psychiatr Q 2002;73:297-311.
16. Liu B, Anderson G, Mittmann N et al. Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 1998;351:1303-1307.
17. Thapa PB, Gideon P, Cost TW et al. Antidepressants and the risk of falls among nursing home residents. N Engl J Med 1998;339:875-882.
18. Le Couteur DG, Fisher AA, Davis MW et al. Postprandial systolic blood pressure responses of older people in residential care: Association with risk of falling. Gerontology 2003;49:260-264.
19. Ray WA, Thapa PB, Gideon P. Misclassification of current benzodiazepine exposure by use of a single baseline measurement and its effects upon studies of injuries. Pharmacoepidemiol Drug Saf 2002;11:663-669.
20. Fontaine CS, Hynan LS, Koch K et al. A double-blind comparison of olanzapine versus risperidone in the acute treatment of dementia-related behavioral disturbances in extended care facilities. J Clin Psychiatry 2003;64: 726-730.
21. Martin H, Slyk MP, Deymann S et al. Safety profile assessment of risperidone and olanzapine in long-term care patients with dementia. J Am Med Dir Assoc 2003;4:183-188.
22. Chan W, Lam LC, Choy CN et al. A double-blind randomized comparison of risperidone and haloperidol in the treatment of behavioral and psychological symptoms in Chinese dementia patients. Int J Geriatr Psychiatry 2001;16: 1156-1162.