Withdrawal of fall-risk-increasing drugs in older persons: Effect on mobility test outcomes

Drugs and Aging

Volumn 24, Issue 8, 2007, Pages 691-699

  Van Der Velde, Nathalie ^a   Stricker, Bruno H Ch ^a   Pols, Huibert A P ^a   Van Der Cammen, Tischa J M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BODY EQUILIBRIUM; COHORT ANALYSIS; CONTROLLED STUDY; DRUG WITHDRAWAL; FALL RISK ASSESSMENT; FEMALE; FOLLOW UP; GERIATRIC PATIENT; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; MUSCLE ISOMETRIC CONTRACTION; OUTPATIENT; PATIENT MOBILITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUADRICEPS FEMORIS MUSCLE; WALKING;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; AUTONOMIC AGENTS; CARDIOVASCULAR AGENTS; COHORT STUDIES; FEMALE; GERIATRIC ASSESSMENT; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MOBILITY LIMITATION; PROSPECTIVE STUDIES; PSYCHOTROPIC DRUGS; RISK FACTORS; TASK PERFORMANCE AND ANALYSIS;

EID: 34548063444     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200724080-00006     Document Type: Article

References (40)

1. Rubenstein LZ, Josephson KR, Robbins AS. Falls in the nursing home. Ann Intern Med 1994; 121: 442-51
2. Tinetti ME, Williams TF, Mayewski R. Fall risk index for elderly patients based on number of chronic disabilities. Am J Med 1986; 80: 429-34
3. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988; 319: 1701-7
4. Tromp AM, Smith JH, Deeg DJH, et al. Predictors for falls and fractures in the longitudinal ageing study Amsterdam. J Bone Min Res 1998; 13: 1932-9
5. Tromp AM, Pluijm SM, Smit JH, et al. Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly. J Clin Epidemiol 2001; 54: 837-44
6. Graafmans WC, Ooms ME, Hofstee HM, et al. Falls in the elderly: a prospective study of risk factors and risk profiles. Am J Epidemiol 1996; 143: 1129-36
7. Tinetti ME, Speechley M. Prevention of falls among the elderly. N Engl J Med 1989; 320: 1055-9
8. Campbell AJ, Borrie MJ, Spears GF. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989; 44: M112-7
9. Campbell AJ, Borrie MJ, Spears GF, et al. Circumstances and consequences of falls experienced by a community population 70 years and over during a prospective study. Age Ageing 1990; 19: 136-41
10. American Geriatrics Society, British Geriatrics Society, and American Academy of Orthopedic Surgeons Panel on Falls Prevention. Guideline for the prevention of falls in older persons. J Am Geriatr Soc 2001; 49: 664-72
11. Institute for quality assurance in healthcare. Guideline for the prevention of falls in older persons [in Dutch]. Alphen aan den Rijn: Van Zuiden Communications BV, 2004
12. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systemic review and meta-analysis. I: psychotropic drugs. J Am Geriatr Soc 1999; 47: 30-9
13. Ensrud KE, Blackwell TL, Mangione CM, et al. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 2002; 50: 1629-37
14. Thapa PB, Gideon P, Cost TW, et al. Antidepressants and the risk of falls among nursing home residents. N Eng J Med 1998; 339: 875-82
15. Passaro A, Volpato S, Romangnoni F, et al. Benzodiazepines with different half-life and falling in a hospitalized population: the GIFA study. J Clin Epidemiol 2000; 53: 1222-9
16. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systemic review and meta-analysis. II: cardiac and analgesic drugs. J Am Geriatr Soc 1999; 47: 40-50
17. Van der Velde N, Stricker BHCh, Pols HAP, et al. Risk of falls after withdrawal of fall-risk-increasing drugs: a prospective cohort study. Br J Clin Pharm 2007; 63: 232-7
18. Campbell AJ, Robertson AC, Gardner MM, et al. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomized, controlled trial. J Am Geriatr Soc 1999; 47: 850-3
19. Shumway-Cook A, Brauer S, Woollacott M. Predicting the probability of falls in community-dwelling older adults using the timed up and go test. Phys Ther 2000; 80: 896-903
20. Rose DJ, Jones CJ, Lucchese N. Predicting the probability of falls in community-residing older adults using the 8-foot up-and-go: a new measure of functional mobility. J Aging Phys Act 2002; 10: 466-75
21. Gunter KB, White KN, Hayes WC, et al. Functional mobility discriminates nonfallers from one-time and frequent fallers. J Gerontol Med Sci 2000; 55A: M672-6
22. Tinetti ME. Preventing falls in elderly persons. N Engl J Med 2003; 348: 42-8
23. Lord SR, Anstey KJ, Williams P, et al. Psychoactive medication use, sensorimotor function and falls in older women. Br J Clin Pharmacol 1995; 39: 227-34
24. Allain H, Bentúe-Ferrer D, Tarral A, et al. Effects on postural oscillation and memory functions of a single dose of zolpidem 5 mg, zopiclone 3.75 mg and lormetazepam 1mg in elderly healthy subjects: a randomized, cross-over double-blind study versus placebo. Eur J Clin Pharmacol 2003; 59: 179-88
25. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98
26. Cummings SR, Nevitt MC, Kidd S. Forgetting falls: the limited accuracy of recall of falls in the elderly. J Am Geriatr Soc 1988; 36: 613-6
27. Campbell AJ, Reinken J, Allan BC, et al. Falls in old age: a study of frequency and related clinical factors. Age Ageing 1981; 10: 264-70
28. Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc 1986; 34: 119-26
29. Gill TM, Williams CS, Tinetti ME. Assessing risk for the onset of functional dependence among older adults: the role of physical performance. J Am Geriatr Soc 1995; 43: 603-9
30. Podsiadlo D, Richardson S. The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991; 39: 142-8
31. Duncan PW, Studenski SA, Chandler J, et al. Functional reach: predictive validity in a sample of elderly male veterans. J Gerontol 1992; 47: M93-8
32. Duncan PW, Weiner DK, Chandler J, et al. Functional reach: a new clinical measure of balance. J Gerontol 1990; 45: M192-7
33. Bohannon RW. Alternatives for measuring knee extension strength of the elderly at home. Clin Rehabil 1998; 12: 434-40
34. Roy MA, Doherty TJ. Reliability of hand-held dynamometry in assessment of knee extensor strength after hip fracture. Am J Phys Med Rehabil 2004; 83: 813-8
35. Maki BE, Holliday PJ, Topper AK. A prospective study of postural balance and risk of falling in an ambulatory and independent elderly population. J Gerontol 1994; 49: M72-84
36. Melzer I, Benjuya N, Kaplanski J. Effects of regular walking on postural stability in the elderly. Gerontology 2002; 13: 240-5
37. Katz S, Downs TD, Cash HR, et al. Progress in development of the index of ADL. Gerontologist 1970; 10: 20-30
38. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969; 9: 279-85
39. Malone M, Hill A, Smith G. Three-month follow-up of patients discharged from a geriatric day hospital. Age Ageing 2002; 31: 471-5
40. Li F, Harmer P, Fisher KJ, et al. Tai Chi and fall reductions in older adults: a randomized controlled trial. J Gerontol Biol Med Sci 2005; 2: 187-94