Psychotropic medications and the risk of fracture: A meta-analysis

Drug Safety

Volumn 30, Issue 2, 2007, Pages 171-184

  Takkouche, Bahi ^a   Montes Martínez, Agustín ^a   Gill, Sudeep S ^b   Etminan, Mahyar ^c  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b QUEEN S UNIVERSITY   (Canada)

^c VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; HYPNOTIC AGENT; OPIATE; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; ZOLPIDEM; ZOPICLONE;

ARTICLE; CLINICAL TRIAL; DATA BASE; FRACTURE; FRAGILITY FRACTURE; HUMAN; META ANALYSIS; PRIORITY JOURNAL; RISK FACTOR; SYSTEMATIC REVIEW;

ADULT; AGED; ANALGESICS, OPIOID; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; BENZODIAZEPINES; FEMALE; FRACTURES, BONE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; OSTEOPOROSIS; PSYCHOTROPIC DRUGS; RISK ASSESSMENT; RISK FACTORS;

EID: 33846662216     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-200730020-00006     Document Type: Article

References (74)

1. Gullberg B, Johnell O, Kanis JA. World-wide projections for hip fracture. Osteoporos Int 1997; 7: 407-13
2. Stevens JA, Olson S. Reducing falls and resulting hip fractures among older women. MMWR Recomm Rep 2000; 49 (RR-2): 3-12
3. Cumming RG, Le Couteur DG. Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS drugs 2003; 17: 825-37
4. International Osteoporosis Foundation. Osteoporosis in Europe. Indicators of progress and outcomes from the European Parliament Osteoporosis Interest Group and European Union Osteoporosis Consultation Panel Meeting, 2004, p2 [online]. Available from URL: http://www.osteofound.org/advocacy_policy/ eu_policy_project/pdf/indicators_of_progress.pdf. [Accessed 2006 Sep 21]
5. Chrischilles E, Shireman T, Wallace R. Costs and health effects of ostoporotic fracture. Bone 1994; 15: 377-86
6. Centers for Disease Control and Prevention. Hip fractures among older adults [online]. Available from URL: http://www.cdc.gov/ncipc/factsheets/ adulthipfx.htm [Accessed 2006 Dec 2]
7. Campbell AJ, Robertson MC, Gardner MM, et al. Psychotropic medicine withdrawal and a home-based exercise program to prevent falls: a randomized controlled trial. J Am Geriatr Soc 1999; 47: 850-3
8. Tinetti ME. Preventing falls in elderly persons. N Engl J Med 2003; 348: 42-9
9. Kannus P, Sievanen H, Palvanen M, et al. Prevention of falls and consequent injuries in elderly people. Lancet 2005; 366: 1885-93
10. Schoofs M, vand der Klift M, Hofman A, et al. Thiazide diuretics and the risk for hip fracture. Ann Intern Med 2003; 139: 476-82
11. Paulose-Ram R, Jonas BS, Orwig D, et al. Prescription psychotropic medication use among the U.S. adult population: results from the third National Health and Nutrition Examination Survey, 1988-1994. J Clin Epidemiol 2004; 57: 309-17
12. Ohayon MM, Lader MH. Use of psychotropic medication in the general population of France, Germany, Italy and the United Kingdom. J Clin Psychiatry 2002; 63: 817-25
13. Forsén L, Meyer HE, Søgaard AJ, et al. Mental distress and risk of hip fracture. Do broken hearts lead to broken bones? J Epidemiol Community Health 1999; 53: 343-7
14. Pierfitte C, Macouillard G, Thicoêpe M, et al. Benzodiazepines and hip fractures in elderly people : case-control study. BMJ 2001; 322: 704-8
15. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 1999; 47: 30-9
16. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-12
17. French DD, Campbell R, Spehar A, et al. Outpatient medications and hip fractures in the US. A national veterans study. Drugs aging 2005; 22: 877-85
18. Bhutta AT, Cleves MA, Casey PH, et al. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA. 2002; 288: 728-37
19. Takkouche B, Etminan M, Montes-Martínez A. Personal use of hair dyes and risk of cancer: A meta-analysis. JAMA 2005; 293: 2516-25
20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trial. 1986; 7: 177-88
21. Takkouche B, Cadarso-Suarez C, Spiegelman D. Evaluation of old and new tests of heterogeneity in epidemiologic meta-analysis. Am J Epidemiol 1999; 150: 206-15
22. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-34
23. Costa-Bouzas J, Takkouche B, Cadarso-Suarez C, et al. HepiMA: software for the identification of heterogeneity in meta-analysis. Comput Methods Programs Biomed 2001; 64: 101-7
24. Wysowski DK, Baum C, Ferguson WJ, et al. Sedative-hynotic and the risk of hip fracture. J Clin Epidemiol 1996; 49: 111-3
25. Grisso JA, Kelsey JL, Strom BL, et al. Risk factors for falls as a cause of hip fracture in women. N Eng J Med 1991; 324: 1326-31
26. Ray WA, Griffin MR, Schaffner W, et al. Psychotropic drug use and the risk of hip fracture. N Eng J Med 1987; 316: 363-9
27. Sernbo I, Hansson A, Johnell O. Drug consumption in patients with hip fractures compared with controls. Compr Gerontol [A] 1987; 1: 93-6
28. Ray WA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 1989; 262: 3303-7
29. Stevens A, Mulrow C. Drugs affecting postural stability and other risk factors in the hip fracture epidemic: case-control study. Community Med 1989; 11: 27-34
30. Jensen J, Nielsen LH, Lyhne N, et al. Drugs and femoral neck fracture: a case-control study. J Intern Med 1991; 229: 29-33
31. Cumming RG, Klineberg RJ. Psychotropics, thiazide diuretics and hip fractures in the elderly. Med J Aust 1993; 158: 414-7
32. Lichtenstein MJ, Griffin MR, Cornell JE, et al. Risk factors for hip fractures occurring in the hospital. Am J Epidemiol 1994; 140: 830-8
33. Herings R, Stricker BH, de Boer A, et al. Benzodiazepines and the risk of falling leading to femur fractures: Dosage more important than elimination half-life. Arch Intern Med 1995; 155: 1801-7
34. Schwab M, Roder F, Aleker T, et al. Psychotropic drug use, falls and hip fracture in the elderly. Aging Clin Exp Res 2000; 12: 234-9
35. Sgadari A, Lapane K, Mor V, et al. Oxidative and nonoxidative benzodiazepines and the risk of femur fracture. J Clin Psychopharmacol 2000; 20: 234-9
36. Wang PS, Bohm RL, Glynn RJ, et al. Zolpidem use and hip fractures in older people. J Am Geriatr Soc 2001; 49: 1685-90
37. da Silva Freire Coutinho E, Dutra Da Silva S. Uso de medicamentos como fator de risco para fratura grave decorrente de queda em idosos. Cad Saúde Publica 2002; 18: 1359-66
38. Schlienger RG, Kraenzlin ME, Jick SS, et al. Use of β-blockers and risk of fractures. JAMA 2004; 292: 1326-32
39. Vestergaard P, Rejmark L, Mosekilde L. Fracture associated with use of antepileptic drugs. Epilepsia 2004; 45: 1330-7
40. Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women. N Engl J Med 1995; 332: 767-73
41. Guo Z, Wills P, Viitanen M, et al. Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 year old: a community-based prospective study. Am J Epidemiol 1998; 148: 887-92
42. Jacqmin-Gadda H, Fourrier A, Commenges D, et al. Risk factors for fractures in the elderly. Epidemiol 1998; 9: 417-23
43. Vestergaard P, Tigaran S, Rejnmark L, et al. Fracture risk is increased in epilepsy. Acta Neurol Scand 1999; 99: 269-75
44. Ensrud KE, Blackwell T, Mangione CM, et al. Central nervous system active medication and risk of fractures in older women. Arch Intern Med 2003; 163: 949-57
45. Hasselman CT, Vogt MT, Stone KL, et al. Foot and ankle fractures in elderly white women. J Bone Joint Surg 2003; 85A: 820-4
46. Wagner AK, Zhang F, Soumerai SB, et al. Benzodiazepine use and hip fractures in the elderly. Arch Intern Med 2004; 164: 1567-72
47. Ray WA, Griffin MR, Malcolm E. Cyclic antidepressants and the risk of hip fracture. Arch Intern Med 1991; 151: 754-6
48. Herings RMC, Stricker BHC, de Boer A, et al. Current use of thiazide diuretics and prevention of femur fractures. J Clin Epidemiol 1996; 49: 115-19
49. Gambassi G, Lapane KL, Sgadari A, et al. Elderly patients, use of antidepressants, and hip fracture [letter]. Lancet 1998; 352: 400
50. Liu B, Anderson G, Mittman N, et al. Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 1998; 351: 1303-7
51. Partanen J, Heikkinen J, Jämsä T, et al. Characteristics of lifetime factors, bone metabolism and bone mineral density in patients with hip fracture. J Bone Miner Metab 2002; 20: 367-75
52. Hubbard R, Farrington P, Smith C, et al. Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture. Am J Epidemiol 2003; 158: 77-84
53. Hugenholtz GWK, Heerdink ER, van Staa TP, et al. Risk of hip/femur in patients using antipsychotics. Bone 2005; 37: 864-70
54. Brocklehurst JC, Exton-Smith AN, Lempert Barber SM, et al. Barbiturates and fractures. BMJ 1977; 2: 699-700
55. Paganini-Hill A, Ross RK, Gerkins VR, et al. Menopausal estrogen therapy and hip fractures. Ann Intern Med 1981; 95: 28-31
56. Heidrich FE, Stergachis A, Gross KM. Diuretic drug use and the risk for hip fracture. Ann Intern Med 1991; 115: 1-6
57. Jackson JA, Riggs MW, Spiekerman AM. Testosterone deficiency as a risk factor for hip fractures in men: a case-control study. Am J Med Sci 1992; 304: 4-8
58. Poor G, Atkinson EJ, O'Fallon WM, et al. Predictors of hip fractures in elderly men. J Bone Miner Res 1995; 10: 1900-7
59. Scane AC, Francis RM, Sutcliffe AM, et al. Case-control study of the pathogenesis and sequelae of symtomatica vertebral fractures in men. Osteoporos Int 1999; 9: 91-7
60. Bischof F, Basu D, Pettifor JM. Pathological long-bone fractures in residents with cerebral palsy in a long-term care facility in South Africa. Develop Med Child Neurol 2002; 44: 119-22
61. Ryder KM, Williams J, Womack C, et al. Appendicular fractures: a significant problem among institutionalized adults with developmental disabilities. Am J Ment Retard 2003; 108: 340-6
62. Annegers JF, Melton LJ, Sun C, et al. Risk of age-related fractures in patients with unprovoked seizures. Epilepsia 1989; 30: 348-55
63. Rashiq S, Logan RFA. Role of drugs in fractures of the femoral neck. BMJ 1986; 292: 861-3
64. Shorr RI, Griffin MR, Daugherty JR, et al. Opioid analgesics and the risk of hip fracture in the elderly: codeine and propoxyphene. J Gerontol 1992; 47: 111-5
65. Card T, West J, Hubbard R, et al. Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use: a population based cohort study. Gut 2004; 53: 251-5
66. Taggart HM. Do drugs affect the risk of hip fracture in elderly women? J Am Geriatr Soc 1988; 36: 1006-10
67. Grisso JA, Kelsey JL, O'Brien LA, et al. Risk factors for hip fracture in men. Am J Epidemiol 1997; 145: 786-93
68. Bae JM, Koo HW, Jung KO, et al. A cohort study of the association between psychotropics and hip fracture in Korean elderly women. J Korean Med Sci 2002; 17: 65-70
69. Sutton AJ, Abrams KR, Jones DR, et al. Methods for meta-analysis in medical research. Chichester: Wiley, 2000: 118
70. Coursol A, Wagner EE. Effect of positive findings on submission and acceptance rates: a note on meta-analysis bias. Prof Psychol-Res Pr 1986; 17: 136-7
71. Shorr RI. Review: psychotropic drugs increase the risk of falls in older people. Evid Based Ment Health 1999; 2: 95
72. Seeger JD, Williams PL, Walker AM. An application of propensity score matching using claims data. Pharmacoepidemiol Drug Saf 2005; 14: 465-76
73. Kinjo M, Setoguchi S, Schneeweiss S, et al. Bone mineral density in subjects using central nervous system-active medications. Am J Med 2005; 118: 1414
74. Schneeweiss S, Wang PS. Association between SSRI use and hip fractures and the effect of residual confounding bias in claims database studies. J Clin Psychopharmacol 2004; 24: 632-8