Psychotropic drugs and the risk of fractures in old age: A prospective population-based study

BMC Public Health

Volumn 10, Issue , 2010, Pages

  Nurminen, Janne ^a,b,c   Puustinen, Juha ^a,d   Piirtola, Maarit ^a   Vahlberg, Tero ^e   Kivelä, Sirkka Liisa ^a,d  

^a UNIVERSITY OF TURKU   (Finland)

^b Harkatie Health Center   (Finland)

^c Turku Headache Center   (Finland)

^d SATAKUNTA CENTRAL HOSPITAL   (Finland)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT;

AGED; ARTICLE; DRUG COMBINATION; FEMALE; FINLAND; FRACTURE; HUMAN; MALE; PROSPECTIVE STUDY; REGRESSION ANALYSIS; RISK; SEX DIFFERENCE;

AGED; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; DRUG THERAPY, COMBINATION; FEMALE; FINLAND; FRACTURES, BONE; HUMANS; MALE; PROSPECTIVE STUDIES; PSYCHOTROPIC DRUGS; REGRESSION ANALYSIS; RISK; SEX FACTORS;

EID: 77954200565     PISSN: None     EISSN: 14712458     Source Type: Journal    
DOI: 10.1186/1471-2458-10-396     Document Type: Article

References (37)

1. Shifting the focus in fracture prevention from osteoporosis to falls. TL Järvinen H Sievänen KM Khan A Heinonen P Kannus, BMJ 2008 336 124 6 10.1136/bmj.39428.470752.AD 18202065
2. Medication as a risk factor for falls: critical systematic review. S Hartikainen E Lönroos K Louhivuori, J Gerontol A Biol Sci Med Sci 2007 62 1172 81 17921433
3. A cohort study on the association between psychotropics and hip fracture in Korean elderly women. JM Bae HW Koo KO Jung BJ Park, J Korean Med Sci 2002 17 65 70 11850591
4. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. SR Cummings MC Nevitt WS Browner K Stone KM Fox KE Ensrud J Cauley D Black TM Vogt, N Engl J Med 1995 332 767 73 10.1056/NEJM199503233321202 7862179
5. Foot and ankle fractures in elderly white women. Incidence and risk factors. CT Hasselman MT Vogt KL Stone JA Cauley SF Conti, J Bone Joint Surg Am 2003 85 820 4 12728031
6. Benzodiazepine use and hip fractures in the elderly: who is at greatest risk? AK Wagner F Zhang SB Soumerai AM Walker JH Gurwitz RJ Glynn D Ross-Degnan, Arch Intern Med 2004 164 1567 72 10.1001/archinte.164.14.1567 15277291
7. Central nervous system active medications and risk for fractures in older women. KE Ensrud T Blackwell CM Mangione PJ Bowman DC Bauer A Schwartz JT Hanlon MC Nevitt MA Whooley Study of Osteoporotic Fractures Research Group, Arch Intern Med 2003 163 949 57 10.1001/archinte.163.8.949 12719205
8. Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life. RM Herings BH Stricker A de Boer A Bakker F Sturmans, Arch Intern Med 1995 155 1801 7 10.1001/archinte.155. 16.1801 7654115
9. Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture. PS Wang RL Bohn RJ Glynn H Mogun J Avorn, Am J Psychiatry 2001 158 892 8 11384896
10. Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture. P Vestergaard L Rejnmark L Mosekilde, Osteoporos Int 2006 17 807 16 10.1007/s00198-005-0065-y 16520889
11. Drugs and femoral neck fracture: a case-control study. J Jensen LH Nielsen N Lyhne J Hallas K Brønsen LF Gram, J Intern Med 1991 229 29 33 10.1111/j.1365-2796.1991.tb00302.x 1995760
12. Benzodiazepines and hip fractures in elderly people: case-control study. C Pierfitte G Macouillard M Thicope A Chaslerie F Pehourcq M Assou B Martinez R Lagnaoui A Fourrier B Bégaud J Dangoumau N Moore, BMJ 2001 322 704 8 10.1136/bmj.322.7288.704 11264208
13. Cyclic antidepressants and the risk of hip fracture. WA Ray MR Griffin E Malcolm, Arch Intern Med 1991 151 754 6 10.1001/archinte.151.4.754 2012459
14. Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people. B Liu G Anderson N Mittmann T To T Axcell N Shear, Lancet 1998 351 1303 7 10.1016/S0140-6736(97) 09528-7 9643791
15. Risk factors for fractures in the elderly. H Jacqmin-Gadda A Fourrier D Commenges JF Dartiques, Epidemiology 1998 9 417 23 10.1097/00001648-199807000- 00012 9647906
16. Risk factors associated with the occurrence of fractures in U.S. nursing homes: resident and facility characteristics and prescription medications. W Spector T Shaffer DE Potter R Correa-de-Araujo M Rhona Limcangco, J Am Geriatr Soc 2007 55 327 33 10.1111/j.1532-5415.2007.01081.x 17341233
17. Psychotropic drug use and the risk of hip fracture. WA Ray MR Griffin W Schaffner DK Baugh LJ Melton, N Engl J Med 3 1987 316 363 9 2880292
18. Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. R Liperoti G Onder KL Lapane V Mor JH Friedman R Bernabei G Gambassi, J Clin Psychiatry 2007 68 929 34 10.4088/JCP.v68n0616 17592919
19. Concomitant use of analgesics and psychotropics in home-dwelling elderly people-Kuopio 75+ study. S Hartikainen P Mäntyselkä K Louhivuori-Laako H Enlund R Sulkava, Br J Clin Pharmacol 2005 60 306 10 10.1111/j.1365-2125. 2005.02417.x 16120070
20. Prevalence of asthma in elderly Finns. R Isoaho H Puolijoki E Huhti SL Kivelä E Tala, J Clin Epidemiol 1994 47 1109 18 10.1016/0895-4356(94)90097- 3 7722544
21. Predictors of fractures among the aged: a population-based study with 12-years follow-up in a Finnish municipality. M Piirtola T Vahlberg R Isoaho P Aarnio SL Kivelä Aging Clin Exp Res 2008 20 242 52 18594192
22. Classification of Medicines (ATC) and Defined Daily Doses (DDD) 2000. NAF Medicines, Helsinki, Finland: National Agency of Medicines 2000
23. Epidemiology of medication-related falls and fractures in the elderly. RG Cumming, Drugs Aging 1998 12 43 53 10.2165/00002512-199812010-00005 9467686
24. Benzodiazepines and risk of hip fractures in older people: a review of the evidence. RG Cumming DG Le Couteur, CNS Drugs 2003 17 825 37 10.2165/00023210-200317110-00004 12921493
25. Maximal isometric muscle strenght and sosioeconomic status, health, and physical activity in 75-year-old persons. T Rantanen P Era M Kauppinen E Heikkinen, Journal of Aging and Physical Activity 1994 2 206 220
26. Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults? PM Cawthon KM Fox SR Gandra MJ Delmonico CF Chiou MS Anthony A Sewall B Goodpaster S Satterfield SR Cummings TB Harris, J Am Geriatr Soc 2009 57 1411 1419 10.1111/j.1532-5415.2009.02366.x 19682143
27. Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CH Ling D Taekema AJ de Craen J Gussekloo RG Westendorp AB Maier, CMAJ 2010 182 429 435 20142372
28. Psychotropic medications and the risk of fracture: a meta-analysis. B Takkouche A Montes-Martínez SS Gill M Etminan, Drug Saf 2007 30 171 84 10.2165/00002018-200730020-00006 17253881
29. Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study. ML Ancelin S Artero F Portet AM Dupuy J Touchon K Ritchie, BMJ 2006 332 455 9 10.1136/bmj.38740.439664.DE 16452102
30. Psychotropics among the home-dwelling elderly - increasing trends. T Linjakumpu S Hartikainen T Klaukka H Koponen SL Kivelä R Isoaho, Int J Geriatr Psychiatry 2002 17 874 83 10.1002/gps.712 12221663
31. Effect of selective serotonin reuptake inhibitors on the risk of fracture. JB Richards A Papaioannou JD Adachi L Joseph HE Whitson JC Prior D Goltzman Canadian Multicentre Osteoporosis Study Research Group, Arch Intern Med 2007 167 188 94 10.1001/archinte.167.2.188 17242321
32. Mental distress and risk of hip fracture. Do broken hearts lead to broken bones? L Forsén HE Meyer AJ Søgaard S Naess B Schei TH Edna, J Epidemiol Community Health 1999 53 343 7 10.1136/jech.53.6.343 10396480
33. Insomnia and hypnotic use, recorded in the minimum data set, as predictors of falls and hip fractures in Michigan nursing homes. AY Avidan BE Fries ML James KL Szafara GT Wright RD Chervin, J Am Geriatr Soc 2005 53 955 62 10.1111/j.1532-5415.2005.53304.x 15935017
34. Lower urinary tract symptoms increase the risk of falls in older men. JK Parsons J Mougey L Lambert TJ Wilt HA Fink M Garzotto E Barrett-Connor LM Marshall, BJU Int 2009 104 63 8 10.1111/j.1464-410X.2008.08317.x 19154508
35. Physical therapy approaches to reduce fall and fracture risk among older adults. S Karinkanta M Piirtola H Sievänen K Uusi-Rasi P Kannus, Nat Rev Endocrinol 2010 Advance online publication 1 June 2010; doi:10.1038/nrendo.2010. 70 20517287
36. Smoking and alcohol consumption among the elderly: trends and associations, 1985-2001. T Sulander S Helakorpi O Rahkonen A Nissinen A Uutela, Prev Med 2004 39 413 8 10.1016/j.ypmed.2004.02.049 15226054
37. Undertreatment of osteoporosis in men with hip fracture. GM Kiebzak GA Beinart K Perser CG Ambrose SJ Siff MH Heggeness, Arch Intern Med 2002 162 2217 22 10.1001/archinte.162.19.2217 12390065