Modeling the inhibition of breast cancer growth by GM-CSF

Journal of Theoretical Biology

Volumn 303, Issue , 2012, Pages 141-151

  Szomolay, Barbara ^b   Eubank, Tim D ^a   Roberts, Ryan D ^a   Marsh, Clay B ^a   Friedman, Avner ^b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Angiogenesis; Mathematical modeling

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; OXYGEN;

CANCER; COMPUTER SIMULATION; DISEASE TREATMENT; INHIBITION; NUMERICAL MODEL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; DRUG DOSE REGIMEN; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIAL CELLS; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PATHOLOGIC; TUMOR CELLS, CULTURED;

MURINAE;

EID: 84860556311     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2012.03.024     Document Type: Article

References (64)

1. Acker T., Beck H., Plate K.H. Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization. Mech. Dev. 2001, 108:45-57.
2. Armstrong C.A., Botella R., Galloway T.H., et al. Antitumor effects of granulocyte macrophage colony stimulating factor production by melanoma cells. Cancer Res. 1996, 56:2191-2198.
3. Baj-Krzyworzeka M., Szatanek R., Weglarczyk K., Baran J., Zembala M. Tumour-derived microvesicles modulate biological activity of human monocytes. Immunol. Lett. 2007, 113(2):76-82.
4. Bosco M.C., Puppo M., Pastorino S., Mi Z., Melillo G., Massazza S., Rapisarda A., Varesio L. Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages. J. Immunol. 2004, 172(3):1681-1690.
5. Braunstein S., Karpisheva K., Pola C., Goldberg J., Hochman T., Yee H., Cangiarella J., Arju R., Formenti S.C., Schneider R.J. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol. Cell 2007, 28:501-512.
6. Breward C.J.W., Byrne H.M., Lewis C.E. Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour. Eur. J. Appl. Math. 2001, 12:529-556.
7. Butterworth A.E., Cater D.B. Effect of lysolecithin on the oxygen uptake of tumour cells, polymorphonuclear leucocytes, lymphocytes and macrophages in vitro. Br. J. Cancer 1967, 21(2):373-389.
8. Caldwell J., Locey B., Clarke M.F., Emerson S.G., et al. Influence of medium exchange schedules on metabolic growth, and GM-CSF secretion rates of genetically engineered NIH-3T3 cells. Biotechnol. Prog. 1991, 7(1):1-8.
9. Chaplain M.A.J., Giles S.M., Sleeman B.D., Jarvis R.J. A mathematical analysis of a model for tumour angiogenesis. J. Math. Biol. 1995, 33:744-770.
10. Chaplain M.A.J. The mathematical modeling of tumour angiogenesis and invasion. Acta Biotheoret. 1995, 43:387-402.
11. Chen Y., Cairns R., Papandreou I., Koong A., Denko N.C. Oxygen consumption can regulate the growth of tumors, a new perspective on the warburg effect. PLOS One 2009, 4(9):e7033.
12. Curry J.M., Eubank T.D., Roberts R.D., Wang Y., Pore N., Maity A., Marsh C.B. M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo. PLoS One 2008, 3(10):e3405.
13. DeVita V.T., Lawrence T.S., Rosenberg S.A., Weinberg R.A., DePinho R.A. DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology 2008, Lippincott Williams and Wilkins.
14. Eubank T., Roberts R.D., Khan M., Curry J.M., et al. GM-CSF inhibits breast cancer growth and metastases by invoking an anti-angiogenic program in tumor-educated macrophages. Cancer Res. 2008, 69(5):2133-2140.
15. Eubank T.D., Galloway M., Montague C.M., Waldman W.J., Marsh C.B. M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes. J. Immunol. 2003, 171(5):2637-2643.
16. Eubank T.D., Roberts R., Galloway M., Wang Y., et al. GM-CSF induces expression of soluble VEGF receptor 1 from human monocytes and inhibits angiogenesis in mice. Immunity 2004, 21:831-842.
17. Frankel A.E., Gillb P.S. VEGF and myeloid leukemias. Leukemia Res. 2004, 28(7):675-677.
18. Fujimoto H., Sangai T., Ishii G., Ikehara A., Nagashima T., Miyazaki M., Ochiai A. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int. J. Cancer 2009, 125(6):1276-1284.
19. Girgis-Gabardo A., Hassell J.A. Scale-up of breast cancer stem cell aggregate cultures to suspension bioreactors. Biotechnol. Prog. 2008, 22:801-810.
20. Getman F.H. Laboratory Exercises in Physical Chemistry 1908, John Wiley & Sons, New York.
21. Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3(1):23-35.
22. Hagemann T., Robinson S.C., Schulz M., Trümper L., et al. Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis 2004, 25:1543-1549.
23. Hashizume H., et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am. J. Pathol. 2000, 156(4):1363-1380.
24. Kanda H., Tateya S., Tamori Y., Kotani K., Hiasa K., Kitazawa R., Kitazawa S., Miyachi H., Maeda S., Egashira K., Kasuga M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 2006, 116(6):1494-1505.
25. Kelly C.E., Leek R.D., Byrne H.M., Cox S.M., Harris A.L., Lewis C.E. Modelling macrophage infiltration into avascular tumours. J. Theoret. Med. 2002, 4(1):21-38.
26. Koshikawa N., Iyozumi A., Gassmann M., Takenaga K. Constitutive upregulation of hypoxia-inducible factor-1a mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure. Oncogene 2003, 22:6717-6724.
27. Lane N. Oxygen: The Molecule that Made the World 2002, Oxford University Press.
28. ławicki S., Szmitkowski M., Wojtukiewicz M. The pretreatment plasma level and diagnostic utility of M-CSF in benign breast tumor and breast cancer patients. Clin. Chim. Acta 2006, 371:112-116.
29. Leitzel, K., Ettenberg, S., Walsh, R., Abraham, J., Modur, V., Braendle, E., Evans, D.B., Ali, S.M., Demers, L., Lipton, A., 2007. Elevated serum M-CSF level predicts reduced survival in metastatic breast cancer patients. Journal of Clinical Oncology, ASCO Annual Meeting Proceedings I, vol. 25(18S).
30. Leonard E.J., Skeel A., Yoshimura T., Rankin J. Adv. Exp. Med. Biol. 1991, 351:55-64.
31. Less J.R., Skalak T.C., Sevick E.M., Jain R.K. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res. 1991, 51:265-273.
32. Levine H.A., Nilsen-Hamilton M. Angiogenesis-a biochemical/mathematical prospective. Springer Lecture Notes in Mathematics. Tutorials in Mathematical Biosciences III 2006, vol. 1872.
33. Lewis C., Murdoch C. Macrophage responses to hypoxia. Am. J. Pathol. 2005, 167(3):627-635.
34. Lin E.Y., Nguyen A.V., Russell R.G., Pollard J.W. Colony stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 2001, 193:727-740.
35. Lin E.Y., Pollard J.W. Macrophages: modulators of breast cancer progression. Novartis Found. Symp. 2004, 256:158-168.
36. Mantovani A., Sica A., Locati M. New vistas on macrophage differentiation and activation. Eur. J. Immunol. 2007, 37(1):14-16.
37. Mantovani A., Sica A., Locati M. Macrophage polarization comes of age. Immunity 2005, 23(4):344-346.
38. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002, 23(11):549-555.
39. Marino S., Hogue I.B., Ray Ch.J., Kirschner D.E. A methodology for performing global uncertainty and sensitivity analysis in systems biology. J. Theoret. Biol. 2008, 254:178-196.
40. Melillo G., Sausville E.A., Cloud K., Lahusen T., Varesio L., Senderowicz A.M. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res. 1999, 59:5433-5437.
41. Nalwaya N., Deen W.M. Nitric oxide, oxygen, and superoxide formation and consumption in macrophage cultures. Chem. Res. Toxicol. 2008, 18:486-493.
42. Oren H., Duman N., Abacioglu H., Ozkan H., Irken G. Association between serum macrophage colony-stimulating factor levels and monocyte and thrombocyte counts in healthy, hypoxic, and septic term neonates. Pediatrics 2001, 108(2):329-332.
43. Owen M.R., Byrne H.M., Lewis C.E. Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites. J. Theoret. Biol. 2004, 226:377-391.
44. Owen M.R., Sherratt J.A. Pattern formation and spatiotemporal irregularity in a model for macrophage-tumor interactions. J. Theoret. Biol. 1997, 189:63-80.
45. Plank M.J., Sleeman B.D., Jones P.F. A mathematical model of tumour angiogenesis, regulated by vascular endothelial growth factor and the angiopoietins. J. Theoret. Biol. 2004, 229:435-454.
46. Pollard J.W. Role of colony stimulating factor-1 in reproduction and development. Mol. Reprod. Dev. 1997, 46(54).
47. Pyaskovskaya O.N., Kolesnik D.L., Kolobov A.V., Vovyanko S.I., Solyanik G.I. Analysis of growth kinetics and proliferative heterogeneity of Lewis lung carcinoma cells growing as unfed culture. Exp. Oncol. 2008, 30(4):269-275.
48. Qian B., Deng Y., Im J.H., Muschel R.J., Zou Y., Li J., Lang R.A., Pollard J.W. A distinct macrophage population mediates metastatic breast cancer cell extravasation. Establishment and growth. PLOS One 2009, 4(8):e6562.
49. Rapella A., Negrioli A., Melillo G., Pastorino S., Varesio L., Bosco M.C. Flavopirisol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. Int. J. Cancer 2002, 99:658-664.
50. Ribatti D., Nico B., Crivellato E., Vacca A. Macrophages and tumor angiogenesis. Leukemia 2007, 21:2085-2089.
51. Sapi E. The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp. Biol. Med. (Maywood.) 2004, 229:1-11.
52. Shang Z.-J., Li Z.-B., Li J.-R. VEGF is up-regulated by hypoxic stimulation and related to tumour angiogenesis and severity of disease in oral squamous cell carcinoma: in vitro and in vivo studies. Int. J. Oral Maxillofac. Surg. 2006, 35:533-538.
53. Schugart R., Friedman A., Zhao R., Sen C.K. Wound angiogenesis as a function of tissue oxygen tension: a mathematical model. Proc. Natl. Acad. Sci. 2008, 105(7):2628-2633.
54. Seghezzi G., Patel S., Ren C.J., Gualandris A., Pintucci G., Robbins E.S., Shapiro R.L., Galloway A.C., Rifkin D.B., Mignatti P. Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J. Cell Biol. 1998, 141(7):1659-1673.
55. Sottnik J.L., Guth A.M., Mitchell L.A., Dow S.W. Minimally invasive assessment of tumor angiogenesis by fine needle aspiration and flow cytometry. Angiogenesis 2010, 13(3):251-258.
56. Tang R., Beuvon F., Ojeda M., Mosseri V., et al. M-CSF (monocyte colony stimulating factor) and M-CSF receptor expression by breast tumour cells: M-CSF mediated recruitment of tumour infiltrating monocytes. J. Cell. Biochem. 1992, 50:350-356.
57. Tang S., et al. Internalization and half-life of membrane-bound macrophage colony-stimulating factor. Chin. Sci. Bull. 2000, 45(18):1697-1703.
58. Utting J.C., Flanagan A.M., Brandao-Burch A., Orriss I.R., Arnett T.R. Hypoxia stimulates osteoclast formation from human peripheral blood. Cell Biochem. Funct. 2010, 28(5):374-380.
59. Varney M.L., Olsen K.J., Mosley R.L., Singh R.K. Paracrine regulation of vascular endothelial growth factor-a expression during macrophage-melanoma cell interaction: role of monocyte chemotactic protein-1 and macrophage colony-stimulating factor. J. Interferon Cytokine Res. 2005, 25(11):674-683.
60. Vaupel P., Mayer A., Briest S., Höckel M. Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res. 2003, 63:7634-7637.
61. Vincensini D., Dedieub V., Eliat P.A., Vincent C., Bailly C., de Certainese J., Joffref F. Magnetic resonance imaging measurements of vascular permeability and extracellular volume fraction of breast tumors by dynamic Gd-DTPA-enhanced relaxometry. Magn. Reson. Imaging 2007, 25:293-302.
62. Vicioso L., Gonzalez F.J., Alvarez M., Ribelles N., Molina M., Marquez A., Perez L., Matilla A., Alba E. Elevated serum levels of vascular endothelial growth factor are associated with tumor-associated macrophages in primary breast cancer. Am. J. Clin. Pathol. 2006, 125:111-118.
63. Ward J.P., King J.R. Mathematical modeling of avascular tumor growth. IMA J. Math. Appl. Med. Biol. 1997, 14:39-69.
64. Williams M.A., Kelsey S.M., Newland A.C. GM-CSF and stimulation of monocyte/macrophage function in vivo relevance and in vitro observations. Eur. J. Cancer 1999, 35(3):S1-S22.