New vistas on macrophage differentiation and activation

European Journal of Immunology

Volumn 37, Issue 1, 2007, Pages 14-16

  Mantovani, Alberto ^a,b   Sica, Antonio ^a   Locati, Massimo ^a,b  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Cellular activation; Innate immunity; Macrophages; Polarization

Indexed keywords

ACTIVIN A; CHEMOKINE RECEPTOR CCR4; CYTOKINE; GAMMA INTERFERON; GLUCOCORTICOID; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 21; INTERLEUKIN 4; SECOSTEROID;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL STIMULATION; CYTOKINE RELEASE; EVIDENCE BASED MEDICINE; GIANT CELL; HUMAN; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MONONUCLEAR PHAGOCYTE; MYCOBACTERIOSIS; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL POLARITY; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES;

EID: 33846352854     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636910     Document Type: Article

References (23)

1. Meghari, S., Berruyer, C., Lepidi, H., Galland, F., Naquet, P. and Mege, J-L., Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. Eur. J. Immunol. 2007. 37: DOI 10.1002/ eji.200636054
2. Helming, L. and Gordon, S., Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. Eur. J. Immunol. 2007. 37: DOI 10.1002/eji.200636788
3. Gordon, S., Alternative activation of macrophages. Nat. Rev. Immunol. 2003. 3: 23-35.
4. Gordon, S. and Taylor, P.R., Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 2005. 5: 953-964.
5. Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A. and Locati, M., The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004. 25: 677-686.
6. Mantovani, A., Sozzani, S., Locati, M., Allavena, P. and Sica, A., Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002. 23: 549-555.
7. Gallina, G., Dolcetti, L., Serafini, P., De Santo, C., Marigo, I., Colombo, M.P., Basso, G. et al., Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J. Clin. Invest. 2006. 116: 2777-2790.
8. Kzhyshkowska, J., Workman, G., Cardo-Vila, M., Arap, W., Pasqualini, R., Gratchev, A., Krusell, L. et al., Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. J. Immunol. 2006. 176: 5825-5832.
9. Martinez, F.O., Gordon, S., Locati, M. and Mantovani, A., Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 2006. 177: 7303-7311.
10. Ogawa, K., Funaba, M., Chen, Y. and Tsujimoto, M., Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol. 2006. 177: 6787-6794.
11. Pesce, J., Kaviratne, M., Ramalingam, T. R., Thompson, R. W., Urban, J. F., Jr., Cheever, A. W., Young, D. A. et al., The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J. Clin. Invest. 2006. 116: 2044-2055.
12. Lemaire, I., Falzoni, S., Leduc, N., Zhang, B., Pellegati, P., Adinolfi, E., Chiozzi, P. and Di Virgilio, F., Involvement of the Purinergic P2X7 Receptor in the formation of multinucleated giant cells. J. Immunol. 2006. 177: 7257-7265.
13. Ness, T. L., Ewing, J. E., Hogaboam, C. M., Kunkel, S. L., CCR4 is a key modulator of innate immune responses. J. Immunol. 2006. 177: 7531-7539.
14. Noel, W., Raes, G., Hassanzadeh Ghassabeh, G., De Baetselier, P. and Beschin, A., Alternatively activated macrophages during parasite infections. Trends Parasitol. 2004. 20: 126-133.
15. Wynn, T. A., Fibrotic disease and the Th1/Th2 paradigm. Nat. Rev. Immunol. 2004. 4: 583-594.
16. Sangaletti, S., Stoppacciaro, A., Guiducci, C., Torrisi, M. R. and Colombo, M. P., Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma. J. Exp. Med. 2003. 198: 1475-1485.
17. Biswas, S. K., Gangi, L., Paul, S., Schioppa, T., Saccani, A., Sironi, M., Bottazzi, B. et al., A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood 2006. 107: 2112-2122.
18. Tsuda, Y., Takahashi, H., Kobayashi, M., Hanafusa, T., Herndon, D. N. and Suzuki, F., Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus. Immunity 2004. 21: 215-226.
19. Desnues, B., Lepidi, H., Raoult, D. and Mege, J. L., Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/ alternatively activated macrophages. J. Infect. Dis. 2005. 192: 1642-1646.
20. Ghassabeh, G. H., De Baetselier, P., Brys, L., Noel, W., Van Ginderachter, J. A., Meerschaut, S., Beschin, A. et al., Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions. Blood 2006. 108: 575-583.
21. Takahashi, H., Tsuda, Y., Takeuchi, D., Kobayashi, M., Herndon, D. N. and Suzuki, F., influence of systemic inflammatory response syndrome on host resistance against bacterial infections. Crit. Care Med. 2004. 32: 1879-1885.
22. Scotton, C. J., Martinez, F. O., Smelt, M. J., Sironi, M., Locati, M., Mantovani, A. and Sozzani, S., Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J. Immunol. 2005. 174: 834-845.
23. Zhu, Z., Zheng, T., Homer, R. J., Kim, Y. K., Chen, N. Y., Cohn, L., Hamid, Q. and Elias, J. A., Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004. 304: 1678-1682.