Pulmonary Endothelial Cell Interactions with the Extracellular Matrix

The Pulmonary Endothelium: Function in health and disease

Volumn , Issue , 2009, Pages 51-72

  Grinell, Katie L ^a   Harrington, Elizabeth O ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

CELL ECM interactions; EC ECM interaction in pulmonary vasculature; EC ECM lung tissue arrangement; ECM remodeling; Final cell ECM adhesion complex; Focal adhesions focal contacts fibrillar adhesions; Pulmonary endothelial barrier function; Pulmonary endothelial cell interactions and extracellular matrix; Signaling molecules associated with CELL ECM structures

Indexed keywords

EID: 84860510082     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470747490.ch4     Document Type: Chapter

References (182)

1. Eggermont, J., Trouet, D., Carton, I., and Nil-ius, B. (2001) Cellular function and control of volume-regulated anion channels. Cell Biochemistry and Biophysics, 35, 263-74.
2. Knolle, P.A. (2006) Cognate interaction between endothelial cells and t cells. Results and Problems in Cell Differentiation, 43, 151-73.
3. Rao, R.M., Yang, L., Garcia-Cardena, G., and Lus-cinskas, F.W. (2007) Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circulation Research, 101, 234-47.
4. Berrier, A.L. and Yamada, K.M. (2007) Cell-matrix adhesion. Journal of Cellular Physiology, 213, 565-73.
5. Stupack, D.G. and Cheresh, D.A. (2003) Apoptotic cues from the extracellular matrix: regulators of angiogenesis. Oncogene, 22, 9022-29.
6. Kalluri, R. (2003) Basement membranes: structure, assembly and role in tumour angiogenesis. Nature Reviews: Cancer, 3, 422-33.
7. Rongish, B.J., Hinchman, G., Doty, M.K. et al. (1996) Relationship of the extracellular matrix to coronary neovascularization during development. Journal of Molecular and Cellular Cardiology, 28, 2203-15.
8. Majno, G. and Palade, G.E. (1961) Studies on inflammation. 1. The effect of histamine and serotonin on vascular permeability: an electron microscopic study. Journal ofBiophysical and Biochemical Cytology, 11, 571-605.
9. Paulsson, M. (1992) Basement membrane proteins: structure, assembly, and cellular interactions. Critical Reviews in Biochemistry and Molecular Biology, 27, 93-127.
10. Vakonakis, I. and Campbell, I.D. (2007) Extracellular matrix: from atomic resolution to ultrastructure. Current Opinion in Cell Biology, 19, 578-83.
11. Lucena, S., Arocha Pinango, C.L., and Guerrero, B. (2007) Fibronectin. Structure and functions associated to hemostasis [Review]. Investigacion Clínica, 48, 249-62.
12. Dallas, S.L., Chen, Q., and Sivakumar, P. (2006) Dynamics of assembly and reorganization of extracellular matrix proteins. Current Topics in Developmental Biology, 75, 1-24.
13. Aumailley, M., El Khal, A., Knoss, N., and Tung-gal, L. (2003) Laminin 5 processing and its integration into the ECM. Matrix Biology, 22, 49-54.
14. Paez, M.C., Gonzalez, M.J., Serrano, N.C. et al. (2007) Physiological and pathological implications of laminins: from the gene to the protein. Autoimmunity, 40, 83-94.
15. Hallmann, R., Horn, N., Selg, M. et al. (2005) Expression and function of laminins in the embryonic and mature vasculature. Physiological Review, 85, 979-1000.
16. Gupta, V. and Grande-Allen, K.J. (2006) Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovascular Research, 72, 375-83.
17. Ju, H. and Dixon, I.M. (1996) Extracellular matrix and cardiovascular diseases. Canadian Journal of Cardiology, 12, 1259-67.
18. Hohenester, E. and Engel, J. (2002) Domain structure and organization in extracellular matrix proteins. Matrix Biology, 21, 115-28.
19. Dziadek, M. (1995) Role of laminin-nidogen complexes in basement membrane formation during embryonic development. Experientia, 51, 901-13.
20. Kohling, R., Nischt, R., Vasudevan, A. et al. (2006) Nidogen and nidogen-associated basement membrane proteins and neuronal plasticity. Neu-rodegenerative Diseases, 3, 56-61.
21. Sephel, G.C., Kennedy, R., and Kudravi, S. (1996) Expression of capillary basement membrane components during sequential phases of wound angiogenesis. Matrix Biology, 15, 263-79.
22. Schenk, S., Chiquet-Ehrismann, R., and Battegay, E.J. (1999) The fibrinogen globe of tenascin-C promotes basic fibroblast growth factor-induced endothelial cell elongation. Molecular Biology of the Cell, 10, 2933-43.
23. Paik, D.C., Fu, C., Bhattacharya, J., and Tilson, M.D. (2004) Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm. Experimental and Molecular Medicine, 36, 524-33.
24. Jones, P.L. and Jones, F.S. (2000) Tenascin-C in development and disease: gene regulation and cell function. Matrix Biology, 19, 581-96.
25. Tremble, P.M., Lane, T.F., Sage, E.H., and Werb, Z. (1993) SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway. Journal of Cell Biology, 121, 1433-44.
26. Brekken, R.A. and Sage, E.H. (2001) SPARC, a matricellular protein: at the crossroads of cell-matrix communication. Matrix Biology, 19, 819-27.
27. Yung, S. and Chan, T.M. (2007) Glycosamino-glycans and proteoglycans: overlooked entities? Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 27 (Suppl 2), S104-9.
28. Pelosi, P., Rocco, P.R., Negrini, D., and Passi, A. (2007) The extracellular matrix of the lung and its role in edema formation. Anais da Academia Brasileira de Ciencias, 79, 285-97.
29. Hassell, J., Yamada, Y., and Arikawa-Hirasawa, E. (2002) Role of perlecan in skeletal development and diseases. Glycoconjugate Journal, 19, 263-67.
30. Albelda, S.M., Daise, M., Levine, E.M., and Buck, C.A. (1989) Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells. The Journal of Clinical Investigation, 83, 1992-2002.
31. 1 integrin as a laminin receptor. Journal of Cell Biology, 109, 2455-62.
32. Timpl, R. and Brown, J.C. (1996) Supramolecular assembly of basement membranes. BioEssays, 18, 123-32.
33. Adamson, I.Y., King, G.M., and Bowden, D.H. (1988) Collagen breakdown during acute lung injury. Thorax, 43, 562-68.
34. Durr, R.A., Dubaybo, B.A., and Thet, L.A. (1987) Repair of chronic hyperoxic lung injury: changes in lung ultrastructure and matrix. Experimental and Molecular Pathology, 47, 219-40.
35. Sawhney, R.S. and Bone, R.C. (1993) Endotoxin alters the expression of extracellular matrix proteins by cultured endothelial cells. Cellular and Molecular Biology Research, 39, 589-99.
36. Maniscalco, W.M., Watkins, R.H., Chess, P.R. et al. (1998) Cell-specific expression of fibronectin and eiiia and eiiib splice variants after oxygen injury. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 274, L599-609.
37. Sinkin, R.A., Roberts, M., LoMonaco, M.B. et al. (1998) Fibronectin expression in bronchopulmonary dysplasia. Pediatric and Developmental Pathology, 1, 494-502.
38. Rotundo, R.F., Curtis, T.M., Shah, M.D. et al. (2002) TNF-α disruption of lung endothelial integrity: reduced integrin mediated adhesion to fi-bronectin. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 282, L316-29.
39. Curtis, T.M., McKeown-Longo, P.J., Vincent, P.A. et al. (1995) Fibronectin attenuates increased endothelial monolayer permeability after RGD peptide, anti-α5β1, or TNF-α exposure. American Journal of Physiology: Lung Cellular and Molecular Physiology, 269, L248-60.
40. Kaarteenaho-Wiik, R., Kinnula, V.L., Herva, R. et al. (2002) Tenascin-C is highly expressed in respiratory distress syndrome and bronchopulmonary dysplasia. Journal of Histochemistry and Cytochemistry, 50, 423-31.
41. Ihida-Stansbury, K., McKean, D.M., Gebb, S.A. et al. (2004) Paired-related homeobox gene prx1 is required for pulmonary vascular development. Circulation Research, 94, 1507-14.
42. Hoyt, D.G., Rizzo, M., Gerritsen, M.E. et al. (1997) Integrin activation protects pulmonary endothelial cells from the genotoxic effects of bleomycin. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 273, L612-17.
43. Hoyt, D.G., Mannix, R.J., Gerritsen, M.E. et al. (1996) Integrins inhibit LPS-induced DNA strand breakage in cultured lung endothelial cells. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 270, L689-94.
44. Demedts, I.K., Brusselle, G.G., Bracke, K.R. et al. (2005) Matrix metalloproteinases in asthma and COPD. Current Opinion in Pharmacology, 5, 257-63.
45. Gueders, M.M., Foidart, J.M., Noel, A., and Cataldo, D.D. (2006) Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. European Journal of Pharmacology, 533, 133-44.
46. Mott, J.D. and Werb, Z. (2004) Regulation of matrix biology by matrix metalloproteinases. Current Opinion in Cell Biology, 16, 558-64.
47. Steinberg, J., Halter, J., Schiller, H.J. et al. (2003) Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. Journal of Surgical Research, 111, 185-95.
48. Soccal, P.M., Gasche, Y., Miniati, D.N. et al. (2004) Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation. American Journal of Transplantation, 4, 41-50.
49. Carney, D.E., McCann, U.G., Schiller, H.J. et al. (2001) Metalloproteinase inhibition prevents acute respiratory distress syndrome. Journal ofSurgical Research, 99, 245-52.
50. Kim, S., Bakre, M., Yin, H., and Varner, J. (2002) Inhibition of endothelial cell survival and angio-genesis by protein kinase A. The Journal of Clinical Investigation, 110, 933-41.
51. Stupack, D.G., Puente, X.S., Boutsaboualoy, S. et al. (2001) Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. Journal of Cell Biology, 155, 459-70.
52. Ambesi, A., Klein, R.M., Pumiglia, K.M., and McKeown-Longo, P.J. (2005) Anastellin, a fragment of the first type III repeat of fibronectin, inhibits extracellular signal-regulated kinase and causes G1 arrest in human microvessel endothelial cells. Cancer Research, 65, 148-56.
53. 2βi integrin. Journal of Cell Biology, 166, 97-109.
54. Rocco, P.R.M., Negri, E.M., Kurtz, P.M. et al. (2001) Lung tissue mechanics and extracellular matrix remodeling in acute lung injury. American Journal of Respiratory and Critical Care Medicine, 164, 1067-71.
55. Rocco, P.R.M., Souza, A.B., Faffe, D.S. et al. (2003) Effect of corticosteroid on lung parenchyma remodeling at an early phase of acute lung injury. American Journal of Respiratory and Critical Care Medicine, 168, 677-84.
56. Miserocchi, G., Passi, A., Negrini, D. et al. (2001) Pulmonary interstitial pressure and tissue matrix structure in acute hypoxia. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 280, L881-87.
57. Johnson, Z., Proudfoot, A.E., and Handel, T.M. (2001) Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention. Cytokine and Growth Factor Reviews, 16, 625-36.
58. Wu, M.H. (2005) Endothelial focal adhesions and barrier function. The Journal of Physiology, 569, 359-66.
59. Zaidel-Bar, R., Cohen, M., Addadi, L., and Geiger, B. (2004) Hierarchical assembly of cell-matrix adhesion complexes. Biochemical Society Transactions, 32, 416-20.
60. Romer, L.H., Birukov, K.G., and Garcia, J.G. (2006) Focal adhesions: paradigm for a signaling nexus. Circulation Research, 98, 606-16.
61. Cheng, Y.F. and Kramer, R.H. (1989) Human microvascular endothelial cells express integrin-related complexes that mediate adhesion to the extracellular matrix. Journal of Cellular Physiology, 139, 275-86.
62. Dejana, E., Colella, S., Conforti, G. et al. (1988) Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells. Journal of Cell Biology, 107, 1215-23.
63. Mechtersheimer, G., Barth, T., Hartschuh, W. et al. (1994) In situ expression of βi, and in-tegrin subunits in non-neoplastic endothelium and vascular tumours. Virchows Archiv, 425, 375-84.
64. Tarone, G., Stefanuto, G., Mascarello, P. et al. (1990) Expression of receptors for extracellular matrix proteins in human endothelial cells. Journal of Lipid Mediators, 2, S45-S53.
65. Geiger, B., Bershadsky, A., Pankov, R., and Yamada, K.M. (2001) Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nature Reviews: Molecular Cell Biology, 2, 793-805.
66. Ezratty, E.J., Partridge, M.A., and Gundersen, G.G. (2005) Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nature Cell Biology, 7, 581-90.
67. Fukami, K., Endo, T., Imamura, M., and Tak-enawa, T. (1994) A-actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase. The Journal of Biological Chemistry, 269, 1518-22.
68. Crawford, A.W., Michelsen, J.W., and Beckerle, M.C. (1992) An interaction between zyxin and α-actinin. Journal of Cell Biology, 116, 1381-93.
69. Reinhard, M., Jouvenal, K., Tripier, D., and Walter, U. (1995) Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein). Proceedings of the National Academy of Sciences, 92, 7956-60.
70. Turner, C.E., Brown, M.C., Perrotta, J.A. et al. (1999) Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling. Journal of Cell Biology, 145, 851-63.
71. bcr/abl with paxillin in chronic myelogenous leukemia cells. The Journal of Biological Chemistry, 270, 29145-50.
72. Lo, S.H. (2004) Tensin. International Journal of Biochemistry and Cell Biology, 36, 31-4.
73. Ohta, Y., Suzuki, N., Nakamura, S. et al. (1999) The small GTPase rala targets filamin to induce filopodia. Proceedings of the National Academy of Sciences, 96, 2122-28.
74. Ueda, K., Ohta, Y., and Hosoya, H. (2003) The carboxy-terminal pleckstrin homology domain of rock interacts with filamin-A. Biochemical and Biophysical Research Communications, 301, 886-90.
75. Stahlhut, M. and van Deurs, B. (2000) Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton. Molecular Biology of the Cell, 11, 325-37.
76. Schlaepfer, D.D. and Mitra, S.K. (2004) Multiple connections link FAK to cell motility and invasion. Current Opinion in Genetics and Development, 14, 92-101.
77. Medley, Q.G., Buchbinder, E.G., Tachibana, K. et al. (2003) Signaling between focal adhesion kinase and Trio. The Journal of Biological Chemistry, 278, 13265-70.
78. Hildebrand, J.D., Taylor, J.M., and Parsons, J.T. (1996) An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Molecular Cell Biology, 16, 3169-78.
79. RhoGEF. The Journal of Biological Chemistry, 278, 24865-73.
80. Wu, X., Suetsugu, S., Cooper, L.A. et al. (2004) Focal adhesion kinase regulation of N-WASP sub-cellular localization and function. The Journal of Biological Chemistry, 279, 9565-76.
81. Erickson, J.W. and Cerione, R.A. (2001) Multiple roles for Cdc42 in cell regulation. Current Opinion in Cell Biology, 13, 153-57.
82. Millard, T.H., Sharp, S.J., and Machesky, L.M. (2004) Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. The Biochemical Journal, 380, 1-17.
83. cas. Proceedings of the National Academy ofSciences, 92, 10678-82.
84. src. Molecular Cell Biology, 14, 1680-88.
85. Xing, Z., Chen, H.C., Nowlen, J.K. et al. (1994) Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Molecular Biology of the Cell, 5, 413-21.
86. src. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 276, L989-98.
87. Shi, S., Garcia, J.G., Roy, S. et al. (2000) Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 279, L441-51.
88. Tiruppathi, C., Naqvi, T., Sandoval, R. et al. (2001) Synergistic effects of tumor necrosis factor-α and thrombin in increasing endothelial permeability. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 281, L958-68.
89. Becker, P.M., Verin, A.D., Booth, M.A. et al. (2001) Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 281, L1500-11.
90. Weis, S., Cui, J., Barnes, L., and Cheresh, D.A. (2004) Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. Journal of Cell Biology, 167, 223-29.
91. Hoyt, D.G., Rizzo, M., Gerritsen, M.E. et al. (1997) Integrin activation protects pulmonary endothelial cells from the genotoxic effects of bleomycin. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 273, L612-17.
92. vβ5 regulates lung vascular permeability and pulmonary endothelial barrier function. American Journal of Respiratory Cell and Molecular Biology, 36, 377-86.
93. v and in acute lung inflammation. Histochemistry and Cell Biology, 121, 383-90.
94. Shikata, Y., Birukov, K.G., and Garcia, J.G. (2003) S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. Journal of Applied Physiology, 94, 1193-203.
95. Lee, Y.H., Kayyali, U.S., Sousa, A.M. et al. (2007) Transforming growth factor-β1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. American Journal of Respiratory Cell and Molecular Biology, 37, 485-93.
96. Nobes, C.D. and Hall, A. (1995) Rho, Rac, and Cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell, 81, 53-62.
97. Zaidel-Bar, R., Ballestrem, C., Kam, Z., and Geiger, B. (2003) Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. Journal of Cell Science, 116, 4605-13.
98. Ren, X.D., Kiosses, W.B., Sieg, D.J. et al. (2000) Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. Journal of Cell Science, 113, 3673-78.
99. Zamir, E., Katz, B.Z., Aota, S. et al. (1999) Molecular diversity of cell-matrix adhesions. Journal of Cell Science, 112, 1655-69.
100. Zamir, E., Katz, M., Posen, Y. et al. (2000) Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nature Cell Biology, 2, 191-96.
101. Pankov, R., Cukierman, E., Katz, B.Z. et al. (2000) Integrin dynamics and matrix assembly: tensin-dependent translocation of α5β1 integrins promotes early fibronectin fibrillogenesis. Journal of Cell Biology, 148, 1075-90.
102. Tarone, G., Cirillo, D., Giancotti, F.G. et al. (1985) Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Experimental Cell Research, 159, 141-57.
103. David-Pfeuty, T. and Singer, S.J. (1980) Altered distributions of the cytoskeletal proteins vinculin and α-actinin in cultured fibroblasts transformed by rous sarcoma virus. Proceedings ofthe National Academy of Sciences, 77, 6687-91.
104. Gimona, M. and Buccione, R. (2006) Adhesions that mediate invasion. International Journal of Biochemistry and Cell Biology, 38, 1875-92.
105. Spinardi, L. and Marchisio, P.C. (2006) Po-dosomes as smart regulators of cellular adhesion. European Journal of Cell Biology, 85, 191-94.
106. Buccione, R., Orth, J.D., and McNiven, M.A. (2004) Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nature Reviews: Molecular Cell Biology, 5, 647-57.
107. Hidalgo, A. and Frenette, P.S. (2007) Leukocyte podosomes sense their way through the endothelium. Immunity, 26, 753-55.
108. Gimona, M., Buccione, R., Courtneidge, S.A., and Linder, S. (2008) Assembly and biological role of podosomes and invadopodia. Current Opinion in Cell Biology, 20, 235-41.
109. Carman, C.V., Sage, P.T., Sciuto, T.E. et al. (2007) Transcellular diapedesis is initiated by invasive podosomes. Immunity, 26, 784-97.
110. Linder, S. and Kopp, P. (2005) Podosomes at a glance. Journal of Cell Science, 118, 2079-82.
111. Adams, J.C. (2002) Molecular organization of cell-matrix contacts: essential multiprotein assemblies in cell and tissue function. Expert Reviews in Molecular Medicine, 4, 1-24.
112. Endo, T. and Manya, H. (2006) Defect in glyco-sylation that causes muscular dystrophy. Methods in Enzymology, 417, 137-52.
113. Durbeej, M., Henry, M.D., and Campbell, K.P. (1998) Dystroglycan in development and disease. Current Opinion in Cell Biology, 10, 594-601.
114. Del Zoppo, G.J., Milner, R., Mabuchi, T. et al. (2006) Vascular matrix adhesion and the blood-brain barrier. Biochemical Society Transactions, 34, 1261-66.
115. Loufrani, L., Dubroca, C., You, D. et al. (2004) Absence of dystrophin in mice reduces NO-dependent vascular function and vascular density: total recovery after a treatment with the aminoglycoside gentamicin. Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 24, 671-76.
116. Ramirez-Sanchez, I., Ceballos-Reyes, G., Rosas-Vargas, H. et al. (2007) Expression and function of utrophin associated protein complex in stretched endothelial cells: dissociation and activation of eNOS. Frontiers in Bioscience: A Journal and Virtual Library, 12, 1956-62.
117. Litjens, S.H., de Pereda, J.M., and Sonnenberg, A. (2006) Current insights into the formation and breakdown of hemidesmosomes. Trends in Cell Biology, 16, 376-83.
118. 4 cytoplasmic tail. Journal of Cell Science, 111 (Pt 18), 2717-28.
119. Gonzales, M., Weksler, B., Tsuruta, D. et al. (2001) Structure and function of a vimentin-associated matrix adhesion in endothelial cells. Molecular Biology of the Cell, 12, 85-100.
120. Kip1, and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Molecular Biology of the Cell, 9, 3179-93.
121. kip1 pathway and the Gļ/S transition. The Journal of Biological Chemistry, 279, 26323-30.
122. Mettouchi, A., Klein, S., Guo, W. et al. (2001) Integrin-specific activation of Rac controls progression through the G1 phase of the cell cycle. Molecular Cell, 8, 115-27.
123. Mahabeleshwar, G.H., Feng, W., Reddy, K. et al. (2007) Mechanisms of integrin vascular endothelial growth factor receptor cross-activation in an-giogenesis. Circulation Research, 101, 570-80.
124. Soldi, R., Mitola, S., Strasly, M. et al. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. The EMBO Journal, 18, 882-92.
125. Meredith, J.E. Jr., Fazeli, B., and Schwartz, M.A. (1993) The extracellular matrix as a cell survival factor. Molecular Biology of the Cell, 4, 953-61.
126. Hoyt, D.G., Mannix, R.J., Rusnak, J.M. et al. (1995) Collagen is a survival factor against LPS-induced apoptosis in cultured sheep pulmonary artery endothelial cells. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 269, L171-77.
127. Aoudjit, F. and Vuori, K. (2001) Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-FLIP and implications for anoikis. Journal of Cell Biology, 152, 633-43.
128. Isik, F.F., Gibran, N.S., Jang, Y.C. et al. (1998) Vitronectin decreases microvascular endothelial cell apoptosis. Journal of Cellular Physiology, 175, 149-55.
129. Bieler, G., Hasmim, M., Monnier, Y. et al. (2007) Distinctive role of integrin-mediated adhesion in TNF-induced PKB/AKT and NF-κB activation and endothelial cell survival. Oncogene, 26, 5722-32.
130. Freyberg, M.A., Kaiser, D., Graf, R. et al. (2001) Proatherogenic flow conditions initiate endothelial apoptosis via thrombospondin-1 and the integrin-associated protein. Biochemical and Biophysical Research Communications, 286, 141-49.
131. Urbich, C., Walter, D.H., Zeiher, A.M., and Dim-meler, S. (2000) Laminar shear stress upregulates integrin expression: role in endothelial cell adhesion and apoptosis. Circulation Research, 87, 683-89.
132. vβ3 for angiogenesis. Science, 264, 569-71.
133. Bourdoulous, S., Orend, G., MacKenna, D.A. et al. (1998) Fibronectin matrix regulates activation of Rho and Cdc42 GTPases and cell cycle progression. Journal of Cell Biology, 143, 267-76.
134. Ilic, D., Almeida, E.A.C., Schlaepfer, D.D. et al. (1998) Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. Journal of Cell Biology, 143, 547-60.
135. 2-terminal kinase. Journal of Cell Biology, 149, 741-54.
136. Harrington, E.O., Smeglin, A., Newton, J. et al. (2001) Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 280, L342-53.
137. Bellas, R.E., Harrington, E.O., Sheahan, K.L. et al. (2002) FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 282, L1135-42.
138. Harrington, E.O., Loffler, J., Nelson, P.R. et al. (1997) Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδ in capillary endothelial cells. The Journal of Biological Chemistry, 272, 7390-97.
139. Harrington, E.O., Brunelle, J.L., Shannon, C.J. et al. (2003) Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. American Journal of Respiratory Cell and Molecular Biology, 28, 626-36.
140. kip1. The Journal of Biological Chemistry, 274, 20805-11.
141. Wiebe, B.M. and Laursen, H. (1998) Lung morphometry by unbiased methods in emphysema: bronchial and blood vessel volume, alveolar surface area and capillary length. Acta Patholog-ica Microbiologica, et Immunologica Scandinav-ica, 106, 651-56.
142. Segura-Valdez, L., Pardo, A., Gaxiola, M. et al. (2000) Upregulation of gelatinases A and B, col-lagenases 1 and 2, and increased parenchymal cell death in COPD. Chest, 117, 684-94.
143. Kasahara, Y., Tuder, R.M., Cool, C.D. et al. (2001) Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. American Journal of Respiratory and Critical Care Medicine, 163, 737-44.
144. Imai, K., Mercer, B.A., Schulman, L.L. et al. (2005) Correlation of lung surface area to apopto-sis and proliferation in human emphysema. European Respiratory Journal, 25, 250-58.
145. LeRoy, E.C. (1974) Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. The Journal of Clinical Investigation, 54, 880-89.
146. Schachna, L. and Wigley, F.M. (2002) Targeting mediators of vascular injury in scleroderma. Current Opinion in Rheumatology, 14, 686-93.
147. Carvalho, D., Savage, C.O., Black, C.M., and Pearson, J.D. (1996) IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. The Journal of Clinical Investigation, 97, 111-19.
148. Nishijima, C., Hayakawa, I., Matsushita, T. et al. (2004) Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis. Clinical and Experimental Immunology, 138, 357-63.
149. Sato, S., Hayakawa, I., Hasegawa, M. et al. (2003) Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis. Journal of Investigative Dermatology, 120, 542-47.
150. Voelkel, N.F., Douglas, I.S., and Nicolls, M. (2007) Angiogenesis in chronic lung disease. Chest, 131, 874-79.
151. Li, X. and Wilson, J.W. (1997) Increased vascularity of the bronchial mucosa in mild asthma. American Journal ofRespiratory and Critical Care Medicine, 156, 229-33.
152. Kuwano, K., Bosken, C.H., Pare, P.D. et al. (1993) Small airways dimensions in asthma and in chronic obstructive pulmonary disease. American Review of Respiratory Disease, 148, 1220-25.
153. Salvato, G. (2001) Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax, 56, 902-6.
154. Zheng, L., Orsida, B.E., Ward, C. et al. (1999) Airway vascular changes in lung allograft recipients. Journal of Heart and Lung Transplantation, 18, 231-38.
155. Le Cras, T.D., Fernandez, L.G., Pastura, P.A., and Laubach, V.E. (2005) Vascular growth and remodeling in compensatory lung growth following right lobectomy. Journal of Applied Physiology, 98, 1140-48.
156. Tuder, R.M., Groves, B., Badesch, D.B., and Voelkel, N.F. (1994) Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. American Journal of Pathology, 144, 275-85.
157. Wagner, E.M., Petrache, I., Schofield, B., and Mitzner, W. (2006) Pulmonary ischemia induces lung remodeling and angiogenesis. Journal of Applied Physiology, 100, 587-93.
158. Karsner, H.T. and Ghoreyeb, A.A. (1913) Studies in infarction: III. The circulation in experimen tal pulmonary embolism. Journal of Experimental Medicine, 18, 507-11.
159. Fadel, E., Riou, J.Y., Mazmanian, M. et al. (1999) Pulmonary thromboendartectomy for chronic thromboembolic obstruction of the pulmonary artery in piglets. Journal of Thoracic and Cardiovascular Surgery, 117, 787-93.
160. Charan, N.B. and Carvalho, P. (1997) Angiogene-sis in bronchial circulatory system after unilateral pulmonary artery obstruction. Journal of Applied Physiology, 82, 284-91.
161. Stenmark, K.R., Fasules, J., Hyde, D.M. et al. (1987) Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. Journal of Applied Physiology, 62, 821-30.
162. Davie, N.J., Crossno, J.T. Jr., Frid, M.G. et al. (2004) Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 286, L668-78.
163. 2. The American Journal of Physiology: Heart and Circulatory Physiology, 250, H434-42.
164. Mura, M., dos Santos, C.C., Stewart, D., and Liu, M. (2004) Vascular endothelial growth factor and related molecules in acute lung injury. Journal of Applied Physiology, 97, 1605-17.
165. Thickett, D.R., Armstrong, L., and Millar, A.B. (2002) A role for vascular endothelial growth factor in acute and resolving lung injury. American Journal of Respiratory and Critical Care Medicine, 166, 1332-37.
166. Chi, J.T., Chang, H.Y., Haraldsen, G. et al. (2003) Endothelial cell diversity revealed by global expression profiling. Proceedings of the National Academy of Sciences, 100, 10623-28.
167. Lowe, K., Alvarez, D., King, J., and Stevens, T. (2007) Phenotypic heterogeneity in lung capillary and extra-alveolar endothelial cells. Increased extra-alveolar endothelial permeability is sufficient to decrease compliance. Journal of Surgical Research, 143, 70-77.
168. Parker, J.C., Stevens, T., Randall, J. et al. (2006) Hydraulic conductance of pulmonary microvascu-lar and macrovascular endothelial cell monolayers. The American Journal of Physiology: Lung Cellular and Molecular Physiology, 291, L30-37.
169. Pugin, J., Verghese, G., Widmer, M.C., and Matthay, M.A. (1999) The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Critical Care Medicine, 27, 304-12.
170. Lois, M., Brown, L.A.S., Moss, I.M. et al. (1999) Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute en-dotoxemia. American Journal of Respiratory and Critical Care Medicine, 160, 1354-60.
171. D'Ortho, M.P., Jarreau, P.H., Delacourt, C. et al. (1994) Matrix metalloproteinase and elastase activities in LPS-induced acute lung injury in guinea pigs. The American Journal ofPhysiology: Lung Cellular and Molecular Physiology, 266, L209-16.
172. Steinberg, J., Halter, J., Schiller, H. et al. (2005) Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model. Shock, 24, 348-56.
173. Lampugnani, M.G., Resnati, M., Dejana, E., and Marchisio, P.C. (1991) The role of integrins in the maintenance of endothelial monolayer integrity. Journal of Cell Biology, 112, 479-90.
174. Wu, M.H., Ustinova, E., and Granger, H.J. (2001) Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules. The Journal of Physiology, 532, 785-91.
175. Qiao, R.L., Yan, W., Lum, H., and Malik, A.B. (1995) Arg-Gly-Asp peptide increases endothelial hydraulic conductivity: comparison with thrombin response. The American Journal of Physiology: Cell Physiology, 269, C110-17.
176. vβ3 integrin increases capillary hydraulic conductivity of rat lung. Circulation Research, 77, 651-59.
177. Schaphorst, K.L., Pavalko, F.M., Patterson, C.E., and Garcia, J.G.N. (1997) Thrombin-mediated focal adhesion plaque reorganization in endothelium: role of protein phosphorylation. American Journal of Respiratory Cell and Molecular Biology, 17, 443-55.
178. van Nieuw Amerongen, G.P., Natarajan, K., Yin, G. et al. (2004) GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. Circulation Research, 94, 1041-49.
179. Ingber, D.E. (2002) Mechanical signaling and the cellular response to extracellular matrix in angio-genesis and cardiovascular physiology. Circulation Research, 91, 877-87.
180. Dudek, S.M. and Garcia, J.G.N. (2001) Cytoskele-tal regulation of pulmonary vascular permeability. Journal of Applied Physiology, 91, 1487-500.
181. Klinger, J.R., Murray, J.D., Casserly, B. et al. (2007) Rottlerin causes pulmonary edema in vivo: a possible role for PKCδ. Journal of Applied Physiology, 103, 2084-94.
182. Harrington, E.O., Shannon, C.J., Morin, N. et al. (2005) PKCδ regulates endothelial basal barrier function through modulation of RhoA GTPase activity. Experimental Cell Research, 308, 407-21.